Material Safety Data Sheet
Section I: Identification & Information
Name: Trifluoroacetic Acid Chemical Family: Acid
Synonyms: TFA
Formula: C2HF3O2 M.W.: 114
DOT Proper Shipping Name: Trifluoroacetic Acid
DOT Identification No.: UN2699 CAS No.: 76-05-1
DOT Hazard Class: Corrosive
Section II: Physical Properties
Appearance: Colorless liquid Water Reactive: n/a
Vapor Pressure (@20掳C): 97.5mm Specific Gravity (H2O=1): 1.48
Vapor Density (air=1): 3.9 Evaporation Rate: n/a
Boiling Point: 72掳C Melting point: -15.4掳C
Stability: Stable
Solubility in water: n/a
Section III: Reactivity Hazard Data
Materials to avoid: strong oxidizing agents
Toxic fumes of carbon monoxide, carbon dioxide, and hydrogen fluoride are produced on
combustion or decomposition.
Hazardous polymerization does not occur.
Section IV: Fire and Explosion Hazard Data
Flashpoint: none Autoignition temperature: n/a
Flammable limits: n/a
Extinguishing Media: Noncombustible. Use extinguishing media appropriate for
surrounding fire conditions.
Special Fire Fighting Procedures: Wear full protective clothing and self-contained
breathing apparatus.
Unusual Fire and Explosion Hazards: Toxic fumes are emitted under fire conditions.
Section V: Hazardous Ingredients
Trifluoroacetic Acid ca 100%
Section VI: Toxicity and Health Hazard Data
See Registry of Toxic Effects of Chemical Substances (RTECS).
Corrosive, causes severe burns.
Primary routes of entry: Inhalation, skin absorption, ingestion.
鈥? Inhalation: Material is extremely destructive to mucous membranes and upper
respiratory tract. Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea and vomiting. Inhalation
may be fatal as a result of spasm, inflammation and edema of the larynx and
bronchi, chemical pneumonitis and pulmonary edema.
鈥? Ingestion: Toxic. Extremely harmful if swallowed; destructive to tissues.
鈥? Eye contact: Extremely destructive to eyes.
鈥? Skin contact: Extremely destructive to skin.
To the best of our knowledge, the chemical, physical and toxological properties have not
been thoroughly investigated.
Target Organs: sense organs, lungs, thorax, specific developmental abnormalities, effects
on newborns, as well as, behavioral effects (motor activity and somnolence).
Emergency First Aid:
鈥? Ingestion: Wash out mouth with water provided person is conscious. Get
emergency medical assistance.
鈥? Eye contact: Rinse with copious amounts of water for at least 15 minutes. Assure
adequate flushing by separating the eyelids with fingers. Get emergency medical
assistance.
鈥? Skin contact: Flush thoroughly with water for at least 15 minutes. Wash
contaminated clothing before reuse. Discard contaminated shoes. Get emergency
medical assistance.
鈥? Inhalation: Immediately remove to fresh air. If breathing is difficult, give
oxygen. If not breathing, give artificial respiration. Keep patient warm and at rest.
Trifluoroacetic Acid -2-
Section VII: Special Protection
Ventilation: Use only in a local exhaust chemical fume hood system.
Respiratory Protection: A supplied air, full facepiece respirator, air-lined hood, or self -
contained breathing apparatus is recommended.
Skin Protection: Protective rubber gloves and clothing are recommended. The choice of
material must be based on chemical resistance and other user requirements.
Eye Protection: Laboratory safety glasses are minimum protection. Splash-proof goggles
preferred. Faceshield recommended.
Emergency eye wash fountains and safety showers should be available in the vicinity of
any potential exposure. Wash thoroughly after handling. Avoid contact, inhalation, or
prolonged or repeated exposure.
Section VIII: Spill and Disposal Procedures
If a spill occurs, evacuate the area. Wear rubber boots, heavy rubber gloves, and use
approved respiration equipment. Absorb the spill on sand or vermiculite and place in a
closed container for disposal. Ventilate area and wash spill site after material pickup is
complete.
Waste Disposal: Dissolve or mix the material with a combustible solvent and burn in a
chemical incinerator equipped with an afterburner and a scrubber. Observe all local, state,
and federal laws.
Section IX: Storage
Trifluoroacetic acid should be stored in a tightly sealed container, protected from physical
damage and stored in a cool, dry, ventilated area away from incompatible substances.
Incompatible with bases, oxidizing agents, reducing agents. Hygroscopic.
The information provided herein is based on sources believed to be reliable as of 4/5/01 and pertains only to
the material designated. Glen Research Corporation makes no warranty or representation to its completeness,
accuracy, or currency. This material is intended for use by persons with pertinent technical skills and at their
discretion and risk. It is the responsibility of the user to determine the product's suitability for its intended use,
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the product's safe use, and the product's proper disposal. Disposal of hazardous material may be subject to
federal, state or local laws or regulations.
Key:
ca: Approximately n/a: not available
PEL:Permissible Exposure Level
STEL: Short Term Exposure Level BuAc: Butyl Acetate
TLV: Threshold Limit Value TWA: Time Weighted Average
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