The MSDS format adheres to the standards and regulatory requirements
of the United States and may not meet regulatory requirements
in other countries.
DuPont Page 1
Material Safety Data Sheet
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"FREON" 22
2008FR Revised 28-APR-2004
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CHEMICAL PRODUCT/COMPANY IDENTIFICATION
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Material Identification
Corporate MSDS Number : DU000025
Formula : CHClF2
Molecular Weight : 86.47
CAS Name : "FREON" 22
Tradenames and Synonyms
Freon 22
CHLORODIFLUOROMETHANE
HCFC-22
CC0335
Dymel 22
Company Identification
MANUFACTURER/DISTRIBUTOR
DuPont Fluoroproducts
1007 Market Street
Wilmington, DE 19898
PHONE NUMBERS
Product Information : 1-800-441-7515 (outside the U.S.
302-774-1000)
Transport Emergency : CHEMTREC 1-800-424-9300(outside U.S.
703-527-3887)
Medical Emergency : 1-800-441-3637 (outside the U.S.
302-774-1000)
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COMPOSITION/INFORMATION ON INGREDIENTS
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Components
Material CAS Number %
*"FREON" 22 METHANE, CHLORODIFLUORO- 75-45-6 100
* Disclosure as a toxic chemical is required under Section 313 of
Title III of the Superfund Amendments and Reauthorization Act of 1986
and 40 CFR part 372.
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Material Safety Data Sheet
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HAZARDS IDENTIFICATION
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# Potential Health Effects
Inhalation of high concentrations of vapor is harmful and
may cause heart irregularities, unconsciousness or death.
Intentional misuse or deliberate inhalation can be fatal.
Vapors are heavier than air and pose a threat of suffocation
if trapped in enclosed or low places. Liquid contact can
cause frostbite. Inhalation may cause dizziness, headache,
confusion, incoordination, and loss of consciousness.
Immediate effects of overexposure by inhalation may include
central nervous system depression with dizziness, confusion,
incoordination, drowsiness or unconsciousness. Gross
overexposure may cause irregular heart beat with a strange
sensation in the chest, "heart thumping", apprehension,
lightheadedness, feeling of fainting, dizziness, weakness,
sometimes progressing to loss of consciousness and death.
Other effects include fatality from gross over-exposure.
Short-term overexposure by skin contact may cause frostbite,
if liquid or escaping vapor contacts the skin. Repeated
and/or prolonged exposure may cause defatting of the skin
with itching, redness or rash. Data to evaluate the skin
permeation hazard of this compound are insufficient. There
are no reports of human sensitization.
Contact with the vapor or aerosol may cause eye irritation
with tearing, pain or blurred vision.
Increased susceptibility to the effects of this material may
be observed in persons with pre-existing disease of the
central nervous system, cardiovascular system.
Carcinogenicity Information
None of the components present in this material at concentrations
equal to or greater than 0.1% are listed by IARC, NTP, OSHA or ACGIH
as a carcinogen.
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FIRST AID MEASURES
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First Aid
INHALATION
If inhaled, immediately remove to fresh air. Keep person
calm. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen. Call a physician.
SKIN CONTACT
In case of contact, flush area with lukewarm water. Do not
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Material Safety Data Sheet
(FIRST AID MEASURES - Continued)
use hot water. If frostbite has occurred, call a physician.
EYE CONTACT
In case of contact, immediately flush eyes with plenty of
water for at least 15 minutes. Call a physician.
INGESTION
Ingestion is not considered a potential route of exposure.
Notes to Physicians
THIS MATERIAL MAY MAKE THE HEART MORE SUSCEPTIBLE TO
ARRHYTHMIAS. Catecholamines such as adrenaline, and other
compounds having similar effects, should be reserved for
emergencies and then used only with special caution.
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FIRE FIGHTING MEASURES
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Flammable Properties
Flash Point : Will not burn
Autodecomposition : 632 C (1170 F)
Other burning materials may cause "FREON" 22 to burn weakly.
Chlorodifluoromethane is not flammable at ambient
temperatures and atmospheric pressure. However,
chlorodifluoromethane has been shown in tests to be
combustible at pressures as low as 60 psig at ambient
temperature when mixed with air at concentrations of 65
volume % air. Experimental data have also been reported
which indicate combustibility of "FREON" 22 in the presence
of certain concentrations of chlorine.
Fire and Explosion Hazards:
Cylinders may rupture under fire conditions. Decomposition
may occur.
Extinguishing Media
As appropriate for combustibles in area. Extinguishant
for other burning material in area is sufficient to stop
burning.
Fire Fighting Instructions
Use water spray or fog to cool containers. Self-contained
breathing apparatus (SCBA) is required if cylinders rupture
or contents are released under fire conditions. Water
runoff should be contained and neutralized prior to release.
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Material Safety Data Sheet
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ACCIDENTAL RELEASE MEASURES
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Safeguards (Personnel)
NOTE: Review FIRE FIGHTING MEASURES and HANDLING (PERSONNEL)
sections before proceeding with clean-up. Use appropriate
PERSONAL PROTECTIVE EQUIPMENT during clean-up.
Accidental Release Measures
Ventilate area, especially low or enclosed places where
heavy vapors might collect. Remove open flames. Use
self-contained breathing apparatus (SCBA) for large spills
or releases.
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HANDLING AND STORAGE
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Handling (Personnel)
Use with sufficient ventilation to keep employee exposure
below recommended limits. "FREON" 22 should not be mixed
with air for leak testing. In general, it should not be
used or allowed to be present with high concentrations of
air above atmospheric pressure. Contact with chlorine or
other strong oxidizing agents should also be avoided.
Storage
Clean, dry area. Do not heat above 52 C (125 F).
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EXPOSURE CONTROLS/PERSONAL PROTECTION
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Engineering Controls
Normal ventilation for standard manufacturing procedures is
generally adequate. Local exhaust should be used when large
amounts are released. Mechanical ventilation should be
used in low or enclosed places.
Personal Protective Equipment
Impervious gloves and chemical splash goggles should be used
when handling liquid. Under normal manufacturing
conditions, no respiratory protection is required when
using this product. Self-contained breathing apparatus
(SCBA) is required if a large release occurs.
Exposure Guidelines
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Material Safety Data Sheet
Exposure Limits
"FREON" 22
PEL (OSHA) : None Established
TLV (ACGIH) : 1,000 ppm, 3,540 mg/m3, 8 Hr. TWA, A4
AEL * (DuPont) : None Established
* AEL is DuPont鈥檚 Acceptable Exposure Limit. Where governmentally
imposed occupational exposure limits which are lower than the AEL
are in effect, such limits shall take precedence.
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PHYSICAL AND CHEMICAL PROPERTIES
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Physical Data
Boiling Point : -40.8 C (-41.4 F)
Vapor Pressure : 151 psig @ 25 C (77 F)
Vapor Density : 3.03 (Air=1.0) @ 25 C (77 F)
% Volatiles : 100 WT%
Evaporation Rate : >1 (CCl4=1.0)
Solubility in Water : 0.3 WT% @ 25 C (77 F)
pH : Neutral
Odor : Slight ethereal
Form : Liquified Gas.
Color : Clear, Colorless.
Liquid Density : 1.194 g/cm3 @ 25 C (77 F)
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STABILITY AND REACTIVITY
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Chemical Stability
Material is stable. However, avoid open flames and high
temperatures.
Incompatibility with Other Materials
Incompatible with alkali or alkaline earth metals--powdered
Al, Zn, Be, etc.
Decomposition
Decomposition products are hazardous. "FREON" 22 can be
decomposed by high temperatures (open flames, glowing metal
surfaces, etc.) forming hydrochloric and hydrofluoric acids,
and possibly carbonyl halides. These materials are toxic
and irritating. Contact should be avoided.
Polymerization
Polymerization will not occur.
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Material Safety Data Sheet
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TOXICOLOGICAL INFORMATION
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# Animal Data
INHALATION:
4 hour, LC50, rat: 220,000 ppm.
Inhalation 4 hour, LC50, rat: 220,000 ppm
Animal testing indicates this material is a slight eye
irritant.
Animal testing indicates this material is a skin irritant,
but not a skin sensitizer.
Long-term exposure by ingestion caused no significant
toxicological effects.
Single inhalation exposure to high doses caused central nerv
depression. inactivity or anaesthesia, lung noise, altered
respiratory rate, histopathological changes of the liver,
cardiac sensitization, a potentially fatal disturbance of
heart rhythm associated with a heightened sensitivity to the
action of epinephrine. Repeated exposure caused no
significant toxicological effects. Long-term exposure
caused reduced weight gain, increased adrenals, kidney,
liver, and pituitary weight.
In chronic inhalation studies, HCFC-22, at a concentration
of 50,000 ppm (v/v), produced a small, but statistically
significant increase of late-occurring tumors involving
salivary glands in male rats, but not female rats or male or
female mice. In the same studies, no increased incidence of
tumors was seen in either species at concentrations of
10,000 ppm or 1000 ppm (v/v). Animal data show
developmental effects only at exposure levels producing
other toxic effects in the adult animal. This material is
not considered a unique developmental hazard to the
conceptus. Reproductive data on male animals show no change
in reproductive performance. Specific studies to evaluate
the effect on female reproductive performance have not been
conducted; however, limited information obtained from
studies on developmental toxicity do not indicate adverse
effects on female reproductive performance. This material
produces genetic damage in bacterial cell cultures. In
mammalian cell cultures and animals, this material has not
produced genetic toxicity. In animal testing, this material
has not caused permanent genetic damage in reproductive
cells of mammals (has not produced heritable genetic
damage).
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Material Safety Data Sheet
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ECOLOGICAL INFORMATION
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Ecotoxicological Information
Aquatic Toxicity:
"FREON" 22
48 hour EC50 - Daphnia magna: 433 mg/L
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DISPOSAL CONSIDERATIONS
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Waste Disposal
Comply with Federal, State, and local regulations. Reclaim
by distillation or remove to a permitted waste disposal
facility.
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TRANSPORTATION INFORMATION
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Shipping Information
DOT/IMO
Proper Shipping Name : CHLORODIFLUOROMETHANE
Hazard Class : 2.2
UN No. : 1018
DOT/IMO Label : NONFLAMMABLE GAS
Shipping Containers
Tank Cars.
Tank Trucks.
Cylinders.
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REGULATORY INFORMATION
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U.S. Federal Regulations
TSCA Inventory Status : Reported/Included.
TITLE III HAZARD CLASSIFICATIONS SECTIONS 311, 312
Acute : Yes
Chronic : No
Fire : No
Reactivity : No
Pressure : Yes
HAZARDOUS CHEMICAL LISTS
SARA Extremely Hazardous Substance: No
CERCLA Hazardous Substance : No
2008FR DuPont Page 8
Material Safety Data Sheet
(REGULATORY INFORMATION - Continued)
SARA Toxic Chemical - See Components Section
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OTHER INFORMATION
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NFPA, NPCA-HMIS
NPCA-HMIS Rating
Health :1
Flammability :0
Reactivity :1
Personal Protection rating to be supplied by user depending on use
conditions.
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The data in this Material Safety Data Sheet relates only to the
specific material designated herein and does not relate to use in
combination with any other material or in any process.
Responsibility for MSDS : MSDS Coordinator
> : DuPont Fluoroproducts
Address : Wilmington, DE 19898
Telephone : (800) 441-7515
# Indicates updated section.
This information is based upon technical information believed to be
reliable. It is subject to revision as additional knowledge and
experience is gained.
End of MSDS
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