REAGENTS, INC.鈥擬SDS鈥擳.I.S.A.B. II, WITH CDTA PAGE 1 OF 5
T.I.S.A.B. II, WITH CDTA (Total Ionic Strength Adjustment Buffer)
Company Information
Company's Name: REAGENTS, INC.
Company's P. O. Box: 240746
Company's City: CHARLOTTE
Company's State: NC
Company's Country: US
Company's Zip Code: 28224
Company's Info Ph #: 704/554-7474, 800/732-8484
Emergencies, call CHEMTREC: 800-424-9300
Date MSDS Prepared: August 24, 2006
1. Product Identification
Synonyms: Total Ionic Strength Adjustment Buffer; TISAB II.
CAS No.: See Section 2.
Molecular Weight: Not applicable for mixtures
Chemical Formula: Not applicable
Product Codes: 7-34021
2. Composition/Information on Ingredients
Ingredient CAS No Percent Hazardous
--------------------------------------- ------------ ------------ ---------
Sodium Chloride 7647-14-5 5.8% (w/v) Yes
Acetic Acid 64-19-7 5.7% (v/v) Yes
Sodium Hydroxide 1310-73-2 3.0% (w/v) Yes
CDTA 123333-90-4 0.4% (w/v) Yes
Water 7732-18-5 Remainder No
3. Hazards Identification
Emergency Overview
--------------------------
Causes skin and eye irritation. Causes irritation to the gastrointestinal tract. Avoid all unnecessary exposure
to the chemical substance and ensure prompt removal from skin, eyes and clothing.
-----------------------------------------------------------------------------------------------------------
Health Rating: 2 - Moderate
Flammability Rating: 0 鈥? None
Reactivity Rating: 0 - None
Contact Rating: 1 - Slight
Lab Protective Equip: GLOVES; GOGGLES; LAB COAT
REAGENTS, INC.鈥擬SDS鈥擳.I.S.A.B. II, WITH CDTA PAGE 2 OF 5
Storage Color Code: Green (General Storage)
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Potential Health Effects
----------------------------------
Inhalation: May cause irritation of the respiratory tract with burning pain in the nose and throat, coughing,
wheezing, shortness of breath and pulmonary edema.
Ingestion: Causes irritation to gastrointestinal tract. Contact a physician immediately.
Skin Contact: Causes skin irritation.
Eye Contact: Causes eye irritation. Contact a physician if irritation develops.
Chronic Exposure: Prolonged or repeated skin contact may cause dermatitis.
4. First Aid Measures
Inhalation: Remove to fresh air. Get medical attention for any breathing difficulty.
Ingestion: Give water to drink and get medical advice.
Skin Contact: Wash exposed area with soap and water. Get medical advice if irritation develops.
Eye Contact: Wash thoroughly with running water for at least 15 minutes. Get medical advice if irritation
develops.
5. Fire Fighting Measures
Fire: Not expected to be a fire hazard.
Explosion: Not expected to be an explosion hazard.
Fire Extinguishing Media: If involved in a fire, use water spray.
Special Information: As in any fire, wear full protective clothing and NIOSH-approved self-contained
breathing apparatus with full-facepiece operated in the pressure demand or other positive pressure mode.
6. Accidental Release Measures
Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste
disposal facility. Processing, use or contamination of this product may change the waste management options.
State and local disposal regulations may differ from federal disposal regulations. Dispose of container and
unused contents in accordance with federal, state and local requirements.
7. Handling and Storage
Keep in a tightly closed container. Protect from physical damage. Containers of this material may be hazardous
when empty since they retain product residues; observe all warnings and precautions listed for the product.
8. Exposure Controls/Personal Protection
Airborne Exposure Limits:
Sodium Chloride: None established.
Acetic Acid, Glacial: -OSHA Permissible Exposure Limit (PEL):10 ppm (TWA).
-ACGIH Threshold Limit Value (TLV):10 ppm (TWA); 15 ppm (STEL).
REAGENTS, INC.鈥擬SDS鈥擳.I.S.A.B. II, WITH CDTA PAGE 3 OF 5
Sodium Hydroxide: - OSHA Permissible Exposure Limit (PEL): 2 mg/m3 Ceiling. - ACGIH Threshold Limit
Value (TLV): 2 mg/m3 Ceiling
CDTA: None established
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures
below the Airborne Exposure Limits. Local exhaust ventilation is generally preferred because it can control the
emissions of the contaminant at its source, preventing dispersion of it into the general work area. Please refer
to the ACGIH document, Industrial Ventilation, a Manual of Recommended Practices, most recent edition, for
details.
Personal Respirators (NIOSH-Approved): If the exposure limit is exceeded and engineering controls are not
feasible, a half-facepiece particulate respirator (NIOSH type N95 or better filters) may be worn for up to ten
times the exposure limit or the maximum use concentration specified by the appropriate regulatory agency or
respirator supplier, whichever is lowest.. A full-facepiece particulate respirator (NIOSH type N100 filters) may
be worn up to 50 times the exposure limit, or the maximum use concentration specified by the appropriate
regulatory agency, or respirator supplier, whichever is lowest. If oil particles (e.g. lubricants, cutting fluids,
glycerine, etc.) are present, use a NIOSH type R or P filter. For emergencies or instances where the exposure
levels are not known, use a full-facepiece positive-pressure, air-supplied respirator. WARNING: Air-purifying
respirators do not protect workers in oxygen-deficient atmospheres.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles. Maintain eye wash fountain and quick-drench facilities in work
area.
9. Physical and Chemical Properties
Appearance: Colorless liquid.
Odor: Slight Acetic Acid Odor.
Solubility: Complete.
Specific Gravity: No information found.
pH: 5.0 鈥? 5.5
Boiling Point: No information found.
Melting Point: No information found.
Vapor Density (Air=1): No information found.
Vapor Pressure (mm Hg): No information found.
Evaporation Rate (BuAc=1): No information found.
10. Stability and Reactivity
Stability: Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products: No information found.
Hazardous Polymerization: Will not occur.
Conditions to Avoid: Incompatibilities.
Incompatibilities: Reacts with mineral acids to form corresponding salts; reacts with weak acids to yield gases
such as, hydrogen sulfide, sulfur dioxide, and carbon dioxide; and reacts with a mixture of chloroform and
methane. May cause formation of flammable hydrogen gas.
11. Toxicological Information
Sodium Chloride: Oral rat LD50: 3000 mg/kg. Inhalation rat LC50: > 42 gm/m3 /1H. Skin rabbit LD50: > 10
gm/kg. Investigated as a mutagen, reproductive effector.
REAGENTS, INC.鈥擬SDS鈥擳.I.S.A.B. II, WITH CDTA PAGE 4 OF 5
Acetic Acid, Glacial : Oral rat LD50: 3310 mg/kg; skin rabbit LD50: 1.06 g/kg; inhalation mouse LC50:
5620ppm/1-hr; investigated as a mutagen, reproductive effector.
Sodium Hydroxide: Irritation data: skin, rabbit: 500 mg/24H severe; eye rabbit: 50 ug/24H severe;
investigated as a mutagen.
CDTA: No LD50/LC50 information found relating to normal routes of occupational exposure.
--------\Cancer Lists\------------------------------------------------------
---NTP Carcinogen---
Ingredient Known Anticipated IARC Category
------------------------------------ ----- ----------- -------------
Sodium Chloride (7647-14-5) No No None
Acetic Acid (64-19-7) No No None
Sodium Hydroxide (1310-73-2) No No None
CDTA (123333-90-4) No No None
Water (7732-18-5) No No None
12. Ecological Information
Environmental Fate: No information found.
Environmental Toxicity: No information found.
13. Disposal Considerations
Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste
disposal facility. Processing, use or contamination of this product may change the waste management options.
State and local disposal regulations may differ from federal disposal regulations. Dispose of container and
unused contents in accordance with federal, state and local requirements.
14. Transport Information
Not regulated.
15. Regulatory Information
--------\Chemical Inventory Status - Part 1\---------------------------------
Ingredient TSCA EC Japan Australia
----------------------------------------------- ---- --- ----- ---------
Sodium Chloride (7647-14-5) Yes Yes Yes Yes
Acetic Acid (64-19-7) Yes Yes Yes Yes
Sodium Hydroxide (1310-73-2) Yes Yes Yes Yes
CDTA (123333-90-4) Exempt Yes No No
Water (7732-18-5) Yes Yes Yes Yes
--------\Chemical Inventory Status - Part 2\---------------------------------
--Canada--
Ingredient Korea DSL NDSL Phil.
----------------------------------------------- ----- --- ---- -----
Sodium Chloride (7647-14-5) Yes Yes No Yes
Acetic Acid (64-19-7) Yes Yes No Yes
Sodium Hydroxide (1310-73-2) Yes Yes No Yes
CDTA (123333-90-4) No Yes No No
Water (7732-18-5) Yes Yes No Yes
--------\Federal, State & International Regulations - Part 1\----------------
-SARA 302- ------SARA 313------
REAGENTS, INC.鈥擬SDS鈥擳.I.S.A.B. II, WITH CDTA PAGE 5 OF 5
Ingredient RQ TPQ List Chemical Catg.
----------------------------------------- --- ----- ---- --------------
Sodium Chloride (7647-14-5) No No No No
Acetic Acid (64-19-7) No No No No
Sodium Hydroxide (1310-73-2) No No No No
CDTA (123333-90-4) No No No No
Water (7732-18-5) No No No No
--------\Federal, State & International Regulations - Part 2\----------------
-RCRA- -TSCA-
Ingredient CERCLA 261.33 8(d)
----------------------------------------- ------ ------ ------
Sodium Chloride (7647-14-5) No No No
Acetic Acid (64-19-7) 5000 No No
Sodium Hydroxide (1310-73-2) 1000 No No
CDTA (123333-90-4) No No No
Water (7732-18-5) No No No
Chemical Weapons Convention: No TSCA 12(b): No CDTA: No
SARA 311/312: Acute: Yes Chronic: No Fire: No Pressure: No
Reactivity: No (Mixture / Liquid)
WHMIS: This MSDS has been prepared according to the hazard criteria of the Controlled Products
Regulations (CPR) and the MSDS contains all of the information required by the CPR.
16. Other Information
NFPA Ratings: Health: 1 Flammability: 0 Reactivity: 0
Label Hazard Warning: Do not get in eyes, on skin, or on clothing. Keep container closed. Use only with
adequate ventilation. Wash thoroughly after handling.
Label Precautions: May cause skin and eye irritation. Harmful if swallowed. Avoid contact with eyes, skin and
clothing. Do not take internally. Avoid breathing solution mist. Use with adequate ventilation. Wash
thoroughly after handling.
First Aid: If contacted, flush skin or eyes with plenty of water for at least 15 minutes. If swallowed, consult a
physician immediately. If inhaled, remove to fresh air. Give oxygen if breathing is difficult. Call a physician.
Product Use: Laboratory Reagent.
Disclaimer:
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Reagents, Inc. provides the information contained herein in good faith but makes no representation as to its
comprehensiveness or accuracy. This document is intended only as a guide to the appropriate precautionary
handling of the material by a properly trained person using this product. Individuals receiving the
information must exercise their independent judgment in determining its appropriateness for a particular
purpose. REAGENTS, INC. MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESS
OR IMPLIED, INCLUDING WITHOUT LIMITATION ANY WARRANTIES OF MERCHANTABILITY,
FITNESS FOR A PARTICULAR PURPOSE WITH RESPECT TO THE INFORMATION SET FORTH
HEREIN OR THE PRODUCT TO WHICH THE INFORMATION REFERS. ACCORDINGLY,
REAGENTS, INC. WILL NOT BE RESPONSIBLE FOR DAMAGES RESULTING FROM USE OF OR
RELIANCE UPON THIS INFORMATION.
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