EMS CATALOG NO: 13030
EMS PRODUCT: DER 332
DATE: 09/02/02
PAGE NUMBER: One of 8
MATERIAL SAFETY DATA SHEET
The information contained herein is based on data considered accurate. However, no
warranty is expressed or implied regarding the accuracy of these data or the results to be
obtained from the use thereof.
Electron Microscopy Sciences assumes no responsibility for personal injury or property
damage to vendees, users or third parties caused by the material. Such vendees or users
assume all risks associated with the use of the material.
ELECTRON MICROSCOPY SCIENCES
321 MORRIS ROAD
P.O. BOX 251
FORT WASHINGTON, PA 19034 24 HOUR EMERGENCY PHONE NUMBER
(215) 646-1566 CHEMTREC: (800) 424-9300
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FOR PRODUCT AND SALES INFORMATION
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CONTACT ELECTRON MICROSCOPY SCIENCES OFFICE ABOVE.
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PRODUCT IDENTIFICATION
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PRODUCT NAME: D.E.R.(R) 332 Epoxy Resin
Diglycidyl Ether of Bisphenol A 100%
CAS NUMBER: 001675-54-3
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HEALTH HAZARD DATA
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EMERGENCY OVERVIEW
Colorless-yellow liquid to semi-solid. Epoxy odor. Can cause allergic skin reaction.
POTENTIAL HEALTH EFFECTS (See Section-Toxicological Data):
EYE:
May cause slight transient (temporary) eye irritation. Corneal injury is unlikely.
SKIN:
Has caused allergic skin reactions in humans. Prolonged exposure not likely to cause
significant skin irritation.
Repeated exposure may cause skin irritation. A single prolonged exposure is not likely to
result in the material being absorbed through skin in harmful amounts.
INGESTION:
Single dose oral toxicity is considered to be extremely low. No hazards anticipated from
swallowing small amounts incidental to normal handling operations.
INHALATION: Vapors are unlikely due to physical properties.
SYSTEMIC (OTHER TARGET ORGAN) EFFECTS:
Except for skin sensitization, repeated exposures to low molecular weight epoxy resins of
this type are not anticipated to cause any significant adverse effects.
CANCER INFORMATION:
Several studies have been conducted to assess the potential carcinogenicity of diglycidyl
ether of bisphenol A (DGEBPA)-based epoxy resins. In one of these, a DGEBPA-based
resin (containing high levels of several impurities, including a known animal skin car-
cinogen) was reported to produce a weak carcinogenic response in the skin of one of two
strains of mice tested. Recent studies have suggested slight increases in two systemic
tumor types following repeated application of certain DGEBPA-containing resins (or
pure DGEBPA), although the response was not uniform among practically identical res-
ins. Based on these data, and the other studies which have not shown cancer, the cause-
effect relationship between DGEBPA-treatment and these tumor increases is question-
able. Indeed, a recent review of the available data by the International Agency for Re-
search on Cancer (IARC) has concluded that DGEBPA is not classifiable as to its car-
cinogenicity.
TERATOLOGY (BIRTH DEFECTS):
DGEBPA did not cause birth defects or other adverse effects on the fetus when pregnant
rabbits were exposed by skin contact, the most likely route of exposure, or when pregnant
rats or rabbits were exposed orally.
REPRODUCTIVE EFFECTS:
In animal studies, has been shown not to interfere with reproduction.
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FIRST AID
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EYES: Flush eyes with plenty of water.
SKIN: Wash off in flowing water or shower.
INGESTION: No adverse effects anticipated by this route of exposure incidental to
proper industrial handling.
INHALATION: No adverse effects anticipated by this route of exposure.
NOTE TO PHYSICIAN:
No specific antidote. Supportive care. Treatment based on judgement of the physician in
response to reactions of the patient.
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FIRE FIGHTING MEASURES
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FLAMMABLE PROPERTIES:
485oF (252oC)
FLASH POINT:
METHOD USED: PMCC
AUTOIGNITION TEMPERATURE: Not applicable.
FLAMMABLE LIMITS: LFL: Not applicable
UFL: Not applicable
HAZARDOUS COMBUSTION PRODUCTS:
The by-products expected in incomplete pyrolysis or combustion of epoxy resins are
mainly phenolics, carbon monoxide and water. The thermal decomposition products of
epoxy resins therefore should be treated as potentially hazardous substances, and appro-
priate precautions should be taken.
EXTINGUISHING MEDIA: Foam, CO2, dry chemical.
OTHER FLAMMABILITY INFORMATION: None known.
FIRE FIGHTING INSTRUCTIONS:
Use water spray to cool fire exposed containers and fire affected zone until fire is out and
danger of re-ignition is passed.
FIRE-FIGHTING EQUIPMENT:
Wear positive pressure self-contained breathing apparatus.
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ACCIDENTAL RELEASE MEASURES
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PROTECT PEOPLE:
Keep unnecessary people away; isolate hazard area and deny unnecessary entry.
PROTECT THE ENVIRONMENT:
For large spills, evacuate upwind of spills and contain with dike. Keep out of sewers,
storm drains, surface water and soil.
CLEANUP:
Soak up in absorbent material such as sand, or poly-propylene or polyethylene fiber
products and collect in suitable containers. Residual resin may be removed using steam
or hot soapy water. Use of methylene chloride or other solvents in cleanup poses a dis-
tinct hazard and therefore should be avoided.
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HANDLING AND STORAGE
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HANDLING:
Practice good caution and personal cleanliness to avoid skin and eye contact. Avoid
breathing vapors of heated material.
STORAGE:
Recommended pumping and storage temperature is 50oC.
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EXPOSURE CONTROLS/PERSONAL PROTECTION
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ENGINEERING CONTROLS:
Good general ventilation should be sufficient for most conditions.
PERSONAL PROTECTIVE EQUIPMENT EYE/FACE PROTECTION:
Use safety glasses.
SKIN PROTECTION:
Use protective clothing impervious to this material. Selection of specific items such as
faceshield, gloves, boots, apron, or full-body suit will depend on operation. Remove
contaminated clothing immediately, wash skin area with soap and water, and launder
clothing before reuse.
RESPIRATORY PROTECTION:
No respiratory protection should be needed.
EXPOSURE GUIDELINE(S): None established.
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PHYSICAL AND CHEMICAL PROPERTIES
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APPEARANCE: Colorless to yellow liquid to semi-solid.
ODOR: Not available.
VAPOR PRESSURE: Not applicable.
VAPOR DENSITY: Not applicable.
SOLUBILITY IN WATER: None.
SPECIFIC GRAVITY: 1.16
BOILING POINT: Not applicable.
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STABILITY AND REACTIVITY
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CHEMICAL STABILITY: Stable at ambient temperatures.
CONDITIONS TO AVOID:
Excess heating above 60oC over long periods of time degrades the resin.
INCOMPATIBILITY WITH OTHER MATERIALS:
Acids, bases, amines and oxidizing materials.
HAZARDOUS POLYMERIZATION:
Will not occur by itself, but masses of more than 1 pound of product plus an aliphatic
amine will cause irreversible polymerization with considerable heat buildup.
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TOXICOLOGICAL INFORMATION
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SKIN: The LD50 for skin absorption in rabbits is 20,000 mg/kg.
INGESTION: The oral LD50 for rats is >5000 mg/kg.
MUTAGENICITY (EFFECTS ON GENETIC MATERIAL):
Animal mutagenicity studies were negative. In vitro mutagenicity studies were
negative in some in some cases and positive in others.
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ECOLOGICAL INFORMATION
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ENVIRONMENTAL FATE
MOVEMENT & PARTITIONING:
Bioconcentration potential is moderate (BCF between 100 and 3000 or Log Pow between
3 and 5). Measured log octanol/water partition coefficient (log Pow) is 3.7-3.9. Potential
for mobility in soil is low (Koc betweeen 500 and 2000). Soil organic carbon/water parti-
tion coefficient (Koc) is estimated to be 1767. Henry's Law Constant (H) is estimated to
be 6.94E-09 atm/m3 mole. Log octanol/water partition coefficient (log Pow) is estimated
using a structural fragment method to be 3.84.
DEGRADATION & TRANSFORMATION: Biodegradation under aerobic laboratory
conditions is below detectable limits. Theoretical oxygen demand (ThOD) is calculated to
be 2.35 p/p. The atmospheric half-life is 1.92 hr. Biodegradation reached in modified
Zhan-Wellens/EMPA Test (OECD Test No. 302B) after 28 days: 12%.
ECOTOXICOLOGY: Material is moderately toxic to aquatic organisms on an acute ba-
sis (LC50/EC50 between 1 and 10 mg/L in most sensitive species). Acute LC50 for wa-
ter flea Daphnia Magna is 1.3 mg/L. Acute LC50 for fathead minnow (Pimephales
promelas) is 3.1 mg/L. Toxicity to aquatic species occurs at concentrations greater than
water solubility. Maximum acceptable toxicant concentration (MATC) in water flea
Daphnia magna is 0.55 mg/L. Growth inhibition threshold in bacteria is >42.6 mg C/L.
Inhibitory concentration (LC50) in OECD Activated Sludge Respiration inhibition Test
(OECD Test No. 209 is >100 mg/L).
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DISPOSAL CONSIDERATIONS
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DISPOSAL: DO NOT DUMP INTO ANY SEWERS, ON THE GROUND, OR INTO
ANY BODY OF WATER. All disposal methods must be in compliance with all Federal,
State/Provincial and local laws and regulations. Regulations may vary in different loca-
tions. Waste characterizations and compliance with applicable laws are the responsibility
solely of the waste generator.
FOR UNUSED AND UNCONTAMINATED PRODUCT, the preferred options include
sending to a licensed, permitted incinerator or other thermal destruction device.
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TRANSPORT INFORMATION
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U.S. DEPARTMENT OF TRANSPORTATION (DOT):
For DOT regulatory information, if required, consult transportation regulations product
shipping papers.
CANADIAN TDG INFORMATION:
For TDG regulatory information, if required, consult transportation regulations.
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REGULATORY INFORMATION
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U.S. REGULATIONS:
SARA 313 INFORMATION:
To the best of our knowledge, this product contains no chemical subject to SARA Title
III Section 313 supplier notification requirements.
SARA HAZARD CATEGORY:
This product has been reviewed according to the EPA "Hazard Categories" promulgated
under Sections 311 and 312 of the Superfund Amendment and Reauthorization Act of
1986 (SARA Title III) and is considered, under applicable definitions, to meet the follow-
ing categories.
AN IMMEDIATE HEALTH HAZARD:
This product has been categorized as "AN IMMEDIATE HEALTH HAZARD" due to
potential for allergic skin reaction.
TOXIC SUBSTANCES CONTROL ACT (TSCA):
All ingredients are on the TSCA inventory or are not required to be listed on the TSCA
inventory
OSHA HAZARD COMMUNICATION STANDARD:
This product is a "Hazardous Chemical" as defined by the OSHA Hazard Communication
Standard, 29 CFR 1910.1200.
CANADIAN REGULATIONS:
WHMIS INFORMATION: The Canadian Workplace Hazardous Materials Information
System (WHMIS) Classification for this product is:
D2B - Skin sensitizer
Refer elsewhere in the MSDS for specific warnings and
safe handling information. Refer to the employer's
workplace education program.
CPR STATEMENT:
This product has been classified in accordance with the hazard criteria of the Canadian
Controlled Products Regulations (CPR) and the MSDS contains all the information re-
quired by the CPR.
HAZARDOUS PRODUCTS ACT INFORMATION:
This product contains the following ingredients which are Controlled Products and/or on
the Ingredient Disclosure List (Canadian HPA section 13 and 14):
DIGLYCIDYL ETHER OF BISPHENOL A
CAS # 001675-54-3
AMOUNT (%w/w) 100%
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