EMS CATALOG NO: 18006-18009
EMS PRODUCT: Cytoseal
DATE: 08/14/2002
PAGE NUMBER: One of 7
MATERIAL SAFETY DATA SHEET
The information contained herein is based on data considered
accurate. However, no warranty is expressed or implied
regarding the accuracy of these data or the results to be
obtained from the use thereof.
Electron Microscopy Sciences assumes no responsibility for
personal injury or property damage to vendees, users or
third parties caused by the material. Such vendees or users
assume all risks associated with the use of the material.
ELECTRON MICROSCOPY SCIENCES
321 MORRIS ROAD
P.O. BOX 251
FORT WASHINGTON, PA 19034 24 HOUR EMERGENCY PHONE NUMBER
(215) 646-1566 CHEMTREC: (800) 424-9300
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FOR PRODUCT AND SALES INFORMATION
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CONTACT ELECTRON MICROSCOPY SCIENCES OFFICE ABOVE.
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PRODUCT IDENTIFICATION
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PRODUCT NAME: Cytoseal Mounting Medium
SYNONYMS: Accumount 60 Mounting Medium
CHEMICAL FAMILY: Aromatic Hydrocarbon
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COMPOSITION AND INGREDIENTS INFORMATION
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Toluene CAS# 108-88-3 -65%
Acrylic Resin CAS# 28262-63-7 -35%
Antioxidant CAS# 128-37-0
Butyl Benzyl Phthalate CAS# 85-68-7
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HAZARDS IDENTIFICATION
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NPFA RATINGS (SCALE 0-4): HEALTH=2 FIRE =3 REACTIVITY=0
DANGER, FLAMMABLE: HARMFUL, IRRITANT
CytosealTM 60 is a mixture of acrylic resin suspended in toluene. The
toluene content is approximately 65%. Cytoseal is a colorless,
viscous solution with a characteristic aromatic odor. Cytoseal can be
toxic if swallowed. Systemic effects by inhalation are most commonly
seen. Symptoms from mild exposure may include dizziness, weakness,
euphoria, headache, nausea and vomiting. Repeated or prolonged
exposure increases the toxic effects.
PRIMARY ROUTES OF EXPOSURE: Inhalation, ingestion, skin and eye
contact.
ACUTE EFFECTS: Acute effects due to inhalation or ingestion range from
headache, nausea, vomiting, tightness of the chest and
staggering to visual blurring, tremors, shallow and
rapid respiration and ventricular irregularities.
Kidney or liver damage may occur.
CHRONIC EFFECTS:
Repeated or prolonged exposure to toluene may cause headache, loss of
appetite, drowsiness, nervousness, and pallor. Continue repeated
inhalation of toluene to the point of euphoria has caused irreversible
encephalopathy with ataxis, tremulosness, emotional lability, and
diffuse cerebral atrophy.
POTENTIAL HEALTH EFFECTS:
INHALATION: May cause dizziness, headache, nausea or vomiting.
EYE CONTACT: May cause irritation and damage to eyes.
SKIN CONTACT: May cause skin irritation.
INGESTION: Harmful, may be fatal if swallowed. May cause nausea or
vomiting.
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FIRST-AID PROCEDURES
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INHALATION: Remove from exposure area to fresh air immediately. If
breathing has stopped, give artificial respiration. If
breathing is difficult, give oxygen. Keep affected
person warm and at rest. Get medical attention
immediately.
EYE CONTACT:
Wash eyes immediately with large amounts of water, occasionally
lifting upper and lower lids, until no evidence of chemical
remains (at least 15-20 minutes). Get medical attention.
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SKIN CONTACT: Remove contaminated clothing and shoes immediately. Wash
affected area with soap or mild detergent and large
amounts of water until no evidence of chemical remains
(at least 15-20 minutes). Get medical attention if
irritation persists.
INGESTION: If swallowed. Do not induce vomiting. If vomiting does
occur, insure victims head is lower than hips in order
to prevent aspiration. Call a physician immediately.
ANTIDOTE: No specific antidote. Treat symptomatically and
supportively.
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FIREFIGHTING PROCEDURES
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FIRE AND EXPLOSION HAZARD: Flammable Liquid
FLASH POINT: 40oF (4.5oC) UPPER EXPLOSIVE LIMIT: For Toluene 7.1%
LOWER EXPLOSIVE LIMIT: For Toluene 1.2%
FIRE FIGHTING MEDIA:
Dry chemical, carbon dioxide, water spray or regular foam (1993
Dot P 5800.5). For larger fires, use water spray, fog or regular
foam (1993 Emergency Response Guidebook, Dot P 5800.5).
FIRE RESPONSE PROCEDURES:
Provide respiratory protection by wearing a self-contained
breathing apparatus. Use water spray to reduce vapors and keep
fire-exposed containers cool.
UNUSUAL FIRE AND EXPLOSION HAZARDS:
Vapors form explosive mixtures with air. Vapor may travel a
considerable distance to a source of ignition and flash back. Not
soluble with water.
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ACCIDENTAL RELEASE PROCEDURES
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SMALL SPILL: Remove all ignition sources. Wear protective equipment,
appropriate gloves, safety glasses and apron. Absorb
liquids in vermiculite, dry sand or similar material and
deposit in sealed container.
LARGE SPILL:
Wear an approved respirator. Follow the above procedure.
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HANDLING AND STORAGE
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GENERAL HANDLING: FLAMMABLE
Store in a cool, dry place away from heat sparks and open flames.
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Do not get in eyes. Avoid contact with skin and clothing. Avoid
breathing vapor. Keep container tightly closed and in an upright
position to prevent leakage. Use only with adequate ventilation.
Wash thoroughly after handling. Do not store next to oxidizing
materials. Empty containers retain product residue.
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EXPOSURE CONTROL-PERSONAL PROTECTIVE EQUIPMENT
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VENTILATION: Provide local exhaust or process enclosure ventilation.
RESPIRATOR: In the event of a very large spill, an appropriate
respirator should be worn for clean up procedures.
FOR FIRE FIGHTING AND OTHER IMMEDIATELY DANGEROUS TO LIFE AND HEALTH
CONDITIONS:
Any self-contained breathing apparatus that has a full facepiece
and is operated in a pressure-demand or other positive-pressure
mode.
Any supplied-air respirator that has a full facepiece and is
operated in a pressure-demand or other positive-pressure mode in
combination with an auxiliary self-contained breathing apparatus
operated in pressure-demand or other positive-NEED pressure mode.
CLOTHING: Employees should wear protective outer garment when spill or
splattering is likely.
GLOVES: Wear resistant gloves for prolonged or repeated contact.
EYE PROTECTION:
Employee must wear splash-proof or dust-resistant safety goggles
to prevent contact with this substance.
EMERGENCY WASH FACILITIES:
Where there is any possibility that an employee's eyes and/or skin may
be exposed to this substance, the employer should provide an eye wash
fountain and quick drench shower within the immediate work area for
emergency use. Protective eye equipment should meet the requirements
for protective clothing and equipment in 29 CFR 1910.1048(H).
EXPOSURE GUIDELINES
Toluene: ACGIH TLVs TWA 50ppm (188mg/m3)
OSHA PELs TWA 100ppm (375mg/m3)
OSHA PELs STEL/CEIL 150ppm (560mg/m3)
NIOSH RELs TWA 100ppm (375mg/m3)
NIOSH RELs STEL/CEIL 150ppm (560mg/m3)
DFG MAKs TWA 50ppm (190mg/m3)
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PHYSICAL AND CHEMICAL PROPERTIES
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DESCRIPTION: Colorless liquid with a characteristic aromatic odor.
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SPECIFIC GRAVITY: (H2O=1@25oC): 0.97 Kg/l
BOILING POINT: 231oF (110oC)
VAPOR PRESSURE: Approximately 47 mm/Hg @ 68oF
SOLUBILITY IN WATER: Insoluble
VAPOR DENSITY: Heavier than air
EVAPORATION RATE(Butyl Acetate=1): Slower than ether
FLASH POINT: 40oF (4.5oC)
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STABILITY AND REACTIVITY INFORMATION
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REACTIVITY: Cytoseal Mounting Media is stable in closed containers
under normal temperatures and pressues: Toluene may
evaporate on exposure to air.
INCOMPATIBILITIES: Strong Acids, Oxidizing materials.
TOLUENE:
ALLYL + DICHLOROETHYL ALUMINUM OR ETHYLALUMINUM SESQUICHLORIDE.
Possible explosion.
BROMINE TRIFLUORIDE(SOLID): Violent reaction
1,3-DICHLORO-5.5-DIMETHYL-2,4-IMIDAZOLIDIDIONE: Explosive reaction.
DINITROGEN TETROFLUORIDE: Forms explosive mixture.
NITRIC ACID: Vigorous reaction.
NITRIC ACID + SULFURIC ACID: Violent decomposition possible.
NITROGEN TETROXIDE: Explosive reaction.
OXIDIZERS (STRONG): Fire and explosion hazard.
PLASTICS, RUBBER, AND COATINGS: May be attacked.
SILVER PERCHLORATE: Forms shock-sensitive mixture.
SULFUR DICHLORIDE: Violent reaction, greatly accelerated in the
presence of iron or ferric chloride.
SULFURIC ACID: Exothermic reaction.
TETRANITROMETHANE: Forms explosive mixture.
URANIUM HEXAFLUORIDE: Violent reaction.
DECOMPOSITION: Thermal decomposition products may create acrid
smoke and irritating fumes.
POLYMERIZATION: Hazardous polymerization will not occur.
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TOXICOLOGICAL INFORMATION
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TOLUENE
IRRITATION DATA:
300 ppm eye-human; 870 ug eye-rabbit mild; 2 mg/24 hours eye-rabbit
severe; 100 mg/30 seconds rinsed.
eye-rabbit mild; 435 mg skin-rabbit mild; 500mg skin-rabbit moderate;
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20 mg/24 hours skin-rabbit moderate.
TOXICITY DATA:
200 ppm inhalation-human TCLO: 100 ppm inhalation-man TCLO; 26,700;
26,700 ppm/1 hour inhalation-rat LC50; 400 ppm/24 hours inhalation
mouse LC50; 55,000 ppm/40 minutes inhalation-rabbit LCLO; 1600 ppm
inhalation-guinea pig LCLO; 12,124 mg/kg skin-rabbit LD50; 50mg/Kg
oral-human LDLO; 636 mg/kg oral-rat LD50; 2250 mg/kg subcutaneous
mouse LD50: 1960 mg/kg Intravenous-rat LD50; 130 mg/kg
intravenous-rabbit ldlo; 500 mg/kg intraperitoneal-guinea pig LD50;
1332 mg/kg intraperitoneal-rat LD50; 59 mg/kg intraperitoneal-mouse
LD50; 1750 mg/kg intraperitoneal-mammal LDLO; 6900 mg/kg
unreported-rat LD50; 2000 mg/kg unreported-mouse LD50; mutagenic data
(RTECS); reproductive effects data (RTECS).
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ECOLOGICAL INFORMATION
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Acute toxic effects may include the death of animals, birds, or fish,
and death or low growth rate in plants. Acute effects are seen two to
four days after animals or plants come in contact with a toxic chemical
substance. Toluene has moderate acute toxicity to aquatic life.
Toluene has caused leaf membrane damage in plants.
Chronic toxic effects may include shortened lifespan, reproductive
problems, lower fertility, and changes in appearance or behavior.
Chronic effects can be seen long after exposure(s) to a toxic chemical.
Toluene has moderate chronic toxicity to aquatic life. (AQUIRE
database, ERL-Duluth, U.S. EPA., phytotox).
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DISPOSAL GUIDELINES
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Dispose mounting media as toluene-an EPA hazardous waste. Hazardous
waste numbers: U220 (toxic), D001(ignitable). Follow local, State and
Federal regulations.
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TRANSPORT INFORMATION
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Proper Shipping Name: TOLUENE SOLUTIONS
Hazard Class or Division: 3
Identification Numbers: UN1294
Packing Group: II
Label(s) Required (if not excepted): None
Exception 1 liter or less (LTD.QTY)
Special Provisions:
Packaging authorizations: Exceptions: 173.150
Non-bulk packaging: 173.202
Quantity Limitations: Passenger aircraft or railcar: 5L
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Cargo aircraft only: 60L
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REGULATORY INFORMATION
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SARA TITLE III (Superfund Amendment and Reauthorization Act)
SECTION 302 and 304: Extremely Hazardous Substance List (40 CFR 355-
Not Listed
SECTION 311: Hazard Categorization (40 CFR 370)- Acute, Chronic, and
Fire
SECTION 313: Toxic Chemicals Listing (40 CFR 372.65)- Listed as a
toxic chemical
CERCLA (Comprehensive Environmental Responses, Compensation, and
Liability Act)
SECTION 102(A) Hazardous Substances (40 CFR 302.4)- Listed
Reportable Quantity - 1,000 pounds.
SECTION 101(14) Reportable Quantity: 1,000 lbs
RCRA (Resource Conservation and Recovery Act)
40 CFR 261.33 Hazardous Waste Number. U220
NJ-RTK (New Jersey-STATE RIGHT TO KNOW)
Environmental Hazardous Substance List: Listed, Substance # 1866
TSCA (Toxic Substance Control Act) Toluene is listed on the
TSCA Inventory
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