Mater ial S afety Data S heet
Os mium T etr ox ide, 2 wt% S olution in Water
S ection 1 - Chemical Pr oduct and Company I dentification
MS D S N am e: Os mium T etr ox ide, 2 wt% S olution in Water
Cat alog N u m ber s : 19152, 19153, 19172, 19173, 19192, 19193
S yn on ym s : Os mic acid, Os mium tetr ox ide, Per os mic ox ide.
Com pan y I den t if icat ion :
Electr on Micr os copy S ciences
321 Mor r is Road
For t Was hington, PA 19034
T el: 215- 646- 1566 or 800- 523- 5874
Fax : 215- 646- 8931
F or em er gen cies in t h e U S , call CH E MT R E C: 800- 424- 9300
S ection 2 - Compos ition, I nfor mation on I ngr edients
CAS # Ch em i cal N am e P er cen t E I N E CS / E L I N CS
7732- 18- 5 Water B alance 231- 791- 2
20816- 12- 0 Os mium tetr ox ide 2 WT % 244- 058- 7
H az ar d S ym bols : T + C
R is k P h r as es : 26/27/28 34
S ection 3 - Hazar ds I dentification
E ME R GE N CY OVE R VI E W
Appear ance: pale yellow. D an ger ! Cor r os ive. As pir ation haz ar d. Caus es eye and
s kin bur ns . Caus es diges tive and r es pir ator y tr act bur ns . Can caus e r epr oductive
effects .
T ar get Or gan s : K idneys .
P ot en t ial H ealt h E f f ect s
E ye: Caus es eye bur ns . May r es ult in cor neal inj ur y. May caus e blindnes s .
S kin : Caus es s kin bur ns .
I n ges t ion : As pir ation haz ar d. Caus es gas tr ointes tinal tr act bur ns . May caus e kidney
damage. Caus es cough, s or e thr oat, ches t pain, and lightheadednes s .
I n h alat ion : Caus es chemical bur ns to the r es pir ator y tr act. May caus e
br onchopneumonia and pos s ible death.
Osmium Tetroxide 2% Solution
Page 1 of 1
Ch r on ic: Pr olonged or r epeated s kin contact may caus e der matitis . Pr olonged or
r epeated ex pos ur e may caus e adver s e r epr oductive effects .
S ection 4 - Fir s t Aid Meas ur es
E yes : I mmediately flus h eyes with plenty of water for at leas t 15 minutes ,
occas ionally lifting the upper and lower eyelids . Get medical aid immediately.
S kin : Get medical aid immediately. I mmediately flus h s kin with plenty of s oap and
water for at leas t 15 minutes while r emoving contaminated clothing and s hoes . Was h
clothing befor e r eus e. Des tr oy contaminated s hoes .
I n ges t ion : Do NOT induce vomiting. I f victim is cons cious and aler t, give 2- 4
cupfuls of milk or water . Never give anything by mouth to an uncons cious per s on.
Get medical aid immediately.
I n h alat ion : Get medical aid immediately. Remove fr om ex pos ur e to fr es h air
immediately. I f not br eathing, give ar tificial r es pir ation. I f br eathing is difficult, give
ox ygen. DO NOT us e mouth- to- mouth r es pir ation.
N ot es t o P h ys ician : T r eat s ymptomatically.
S ection 5 - Fir efighting Meas ur es
Gen er al I n f or m at ion : Evacuate ar ea and fight fir e fr om a s afe dis tance. As in any
fir e, wear a s elf- contained br eathing appar atus in pr es s ur e- demand, MS HA/NI OS H
(appr oved or equivalent), and full pr otective gear . Us e water s pr ay to keep fir e-
ex pos ed container s cool. Ox idiz er . Gr eatly incr eas es the bur ning r ate of combus tible
mater ials . Container s may ex plode in the heat of a fir e. Contact with metals may
evolve flammable hydr ogen gas .
E x t in gu is h in g Media: Do NOT get water ins ide container s . For lar ge fir es , us e dr y
chemical, car bon diox ide, alcohol- r es is tant foam, or water s pr ay. For s mall fir es , us e
dr y chemical, car bon diox ide, water s pr ay or r egular foam. Cool container s with
flooding quantities of water until well after fir e is out.
S ection 6 - Accidental Releas e Meas ur es
Gen er al I n f or m at ion : Us e pr oper per s onal pr otective equipment as indicated in
S ection 8.
S pills / L eaks : Reduce air bor ne dus t and pr event s catter ing by mois tening with
water . Wear a s elf contained br eathing appar atus and appr opr iate Per s onal
pr otection. (S ee Ex pos ur e Contr ols , Per s onal Pr otection s ection). S weep up, then
place into a s uitable container for dis pos al. Avoid gener ating dus ty conditions .
Remove all s our ces of ignition. Pr ovide ventilation. Do not get water ins ide
container s .
Osmium Tetroxide 2% Solution
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S ection 7 - Handling and S tor age
H an dlin g: Was h thor oughly after handling. Remove contaminated clothing and was h
befor e r eus e. Us e with adequate ventilation. Minimiz e dus t gener ation and
accumulation. K eep container tightly clos ed. Do not get on s kin or in eyes . Do not
inges t or inhale.
S t or age: Do not s tor e near combus tible mater ials . S tor e in a tightly clos ed
container . S tor e in a cool, dr y, well- ventilated ar ea away fr om incompatible
s ubs tances . Cor r os ives ar ea. Do not s tor e in metal container s .
S ection 8 - Ex pos ur e Contr ols , Per s onal Pr otection
E n gin eer in g Con t r ols : Us e adequate gener al or local ex haus t ventilation to keep
air bor ne concentr ations below the per mis s ible ex pos ur e limits .
E x pos u r e L im it s
Ch em i cal N am e ACGI H N I OS H OS H A - F i n al P E L s
Water none lis ted none lis ted none lis ted
as Os : 0.002 mg/m3
as Os : 0.0002 ppm; as T WA; 0.0002 ppm as Os : 0.002 mg/m3
Os mium tetr ox ide
Os : 0.0006 ppm S T EL T WA as Os : 1 mg/m3 T WA
I DLH
OS H A Vacat ed P E L s : Water : No OS HA Vacated PELs ar e lis ted for this chemical.
Os mium tetr ox ide: as Os : 0.0002 ppm T WA; 0.002 mg/m3 T WA
P er s on al P r ot ect ive E qu ipm en t
E yes : Wear appr opr iate pr otective eyeglas s es or chemical s afety goggles as
des cr ibed by OS HA's eye and face pr otection r egulations in 29 CFR 1910.133 or
Eur opean S tandar d EN166.
S kin : Wear appr opr iate pr otective gloves to pr event s kin ex pos ur e.
Clot h in g: Wear a chemical apr on. Wear appr opr iate pr otective clothing to pr event
s kin ex pos ur e.
R es pir at or s : Follow the OS HA r es pir ator r egulations found in 29CFR 1910.134 or
Eur opean S tandar d EN 149. Always us e a NI OS H or Eur opean S tandar d EN 149
appr oved r es pir ator when neces s ar y.
S ection 9 - Phys ical and Chemical Pr oper ties
P h ys ical S t at e: S olid
Osmium Tetroxide 2% Solution
Page 3 of 3
Appear an ce: pale yellow
Odor : Chlor ine- like odor
pH : Not available.
Vapor P r es s u r e: 7 mm Hg @ 20C
Vapor D en s it y: Not available.
E vapor at ion R at e: Negligible.
Vis cos it y: Not available.
B oilin g P oin t : 130 deg C @ 760.00mmHg
F r eez in g/ Melt in g P oin t : 39.50 - 41.00 deg C
D ecom pos it ion T em per at u r e: Not available.
Au t oign it ion T em per at u r e: Not available.
F las h P oin t : Not available.
N F P A R at in g: Not publis hed.
E x plos ion L im it s , L ow er : N/A
U pper : N/A
S olu bilit y: 7.24g/100ml (25 c)
S pecif ic Gr avit y/ D en s it y: 4.9
Molecu lar F or m u la: O4Os
Molecu lar W eigh t : 254.20
S ection 10 - S tability and Reactivity
Ch em ical S t abilit y: S table under nor mal temper atur es and pr es s ur es .
Con dit ion s t o Avoid: I ncompatible mater ials , acids , metals , ex ces s heat, bas es .
I n com pat ibilit ies w it h Ot h er Mat er ials : Combus tible mater ials , Hydr ogen
chlor ide, Reducing agents , S tr ong ox idiz ing agents .
H az ar dou s D ecom pos it ion P r odu ct s : Car bon monox ide, ir r itating and tox ic fumes
and gas es , car bon diox ide.
H az ar dou s P olym er iz at ion : Has not been r epor ted.
S ection 11 - T ox icological I nfor mation
R T E CS # :
CAS # 7732- 18- 5: Z C0110000
CAS # 20816- 12- 0: RN1140000
L D 5 0 / L C5 0 :
CAS # 7732- 18- 5:
Or al, r at: LD50 = > 90 ml/kg; < B R.
CAS # 20816- 12- 0:
Or al, mous e: LD50 = 162 mg/kg;
Or al, r at: LD50 = 7050 mg/kg; < B R.
Car cin ogen icit y:
CAS # 7732- 18- 5: Not lis ted by ACGI H, I ARC, NI OS H, NT P, or OS HA. CAS # 20816-
Osmium Tetroxide 2% Solution
Page 4 of 4
12- 0: Not lis ted by ACGI H, I ARC, NI OS H, NT P, or OS HA.
E pidem iology: No infor mation available.
T er at ogen icit y: No infor mation available.
R epr odu ct ive E f f ect s : Pater nal Effects : S per matogenes is and T es tes /s per m
duct/epididymis , intr ates ticular - r at T DLo= 20336ug/kg.
N eu r ot ox icit y: No infor mation available.
Mu t agen icit y: Uns cheduled DNA S ynthes is : hams ter embr yo 200umol/L
Ot h er S t u dies : Pleas e r efer to RT ECS # RN1140000 for additional infor mation.
S ection 12 - Ecological I nfor mation
E cot ox icit y: No infor mation available.
E n vir on m en t al F at e: No infor mation r epor ted.
P h ys ical/ Ch em ical: No infor mation available.
Ot h er : None.
S ection 13 - Dis pos al Cons ider ations
Chemical was te gener ator s mus t deter mine whether a dis car ded chemical is
clas s ified as a haz ar dous was te. US EPA guidelines for the clas s ification
deter mination ar e lis ted in 40 CFR Par ts 261.3. Additionally, was te gener ator s mus t
cons ult s tate and local haz ar dous was te r egulations to ens ur e complete and accur ate
clas s ification.
R CR A P -S er ies : CAS # 20816- 12- 0: was te number P087.
R CR A U -S er ies : None lis ted.
S ection 14 - T r ans por t I nfor mation
Can ada
U S D OT I AT A R I D / AD R I MO
T DG
T OXI C T OXI C
LI QUI D, LI QUI D,
ORGANI C, ORGANI C, No
S h i ppi n g
N.O.S . N.O.S . infor mation
N am e:
(CONT AI NS : (CONT AI NS : available.
OS MI UM OS MI UM
T ET ROXI DE) T ET ROXI DE)
H az ar d Cl as s : 6.1 6.1
U N N u m ber : UN2810 UN2810
P acki n g Gr ou p: III III
Osmium Tetroxide 2% Solution
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S ection 15 - Regulator y I nfor mation
U S F E D E R AL
T S CA
CAS # 7732- 18- 5 is lis ted on the T S CA inventor y.
CAS # 20816- 12- 0 is lis ted on the T S CA inventor y.
H ealt h & S af et y R epor t in g L is t
None of the chemicals ar e on the Health & S afety Repor ting Lis t.
Ch em ical T es t R u les
None of the chemicals in this pr oduct ar e under a Chemical T es t Rule.
S ect ion 1 2 b
None of the chemicals ar e lis ted under T S CA S ection 12b.
T S CA S ign if ican t N ew U s e R u le
None of the chemicals in this mater ial have a S NUR under T S CA.
S AR A
S ect ion 3 0 2 ( R Q)
CAS # 20816- 12- 0: final RQ = 1000 pounds (454 kg)
S ect ion 3 0 2 ( T P Q)
None of the chemicals in this pr oduct have a T PQ.
S AR A Codes
CAS # 20816- 12- 0: acute, flammable.
S ect ion 3 1 3
T his mater ial contains Os mium tetr ox ide (CAS # 20816- 12- 0, 4% ),which is s ubj ect to
the r epor ting r equir ements of S ection 313 of S ARA T itle I I I and 40 CFR Par t 373.
Clean Air Act :
T his mater ial does not contain any haz ar dous air pollutants . T his mater ial does not
contain any Clas s 1 Oz one depletor s . T his mater ial does not contain any Clas s 2
Oz one depletor s .
Clean W at er Act :
None of the chemicals in this pr oduct ar e lis ted as Haz ar dous S ubs tances under the
CWA. None of the chemicals in this pr oduct ar e lis ted as Pr ior ity Pollutants under the
CWA. None of the chemicals in this pr oduct ar e lis ted as T ox ic Pollutants under the
CWA.
OS H A:
CAS # 20816- 12- 0 is cons ider ed highly haz ar dous by OS HA.
S T AT E
CAS # 7732- 18- 5 is not pr es ent on s tate lis ts fr om CA, PA, MN, MA, FL, or NJ.
CAS # 20816- 12- 0 can be found on the following s tate r ight to know lis ts : Califor nia,
New Jer s ey, Flor ida, Penns ylvania, Minnes ota, Mas s achus etts .
Califor nia No S ignificant Ris k Level: None of the chemicals in this pr oduct ar e lis ted.
E u r opean / I n t er n at ion al R egu lat ion s
E u r opean L abelin g in Accor dan ce w it h E C D ir ect ives
H az ar d S ym bols :
T+ C
R is k P h r as es :
Osmium Tetroxide 2% Solution
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R 26/27/28 Ver y tox ic by inhalation, in contact with s kin and if s wallowed. R 34
Caus es bur ns .
S af et y P h r as es :
S 26 I n cas e of contact with eyes , r ins e immediately with plenty of water and s eek
medical advice. S 45 I n cas e of accident or if you feel unwell, s eek medical advice
immediately (s how the label wher e pos s ible). S 7/9 K eep container tightly clos ed and
in a well- ventilated place.
W GK ( W at er D an ger / P r ot ect ion )
CAS # 7732- 18- 5: No infor mation available.
CAS # 20816- 12- 0: 2
Can ada
CAS # 7732- 18- 5 is lis ted on Canada's DS L/NDS L Lis t.
CAS # 20816- 12- 0 is lis ted on Canada's DS L/NDS L Lis t.
WHMI S : Not available.
CAS # 7732- 18- 5 is not lis ted on Canada's I ngr edient Dis clos ur e Lis t.
CAS # 20816- 12- 0 is not lis ted on Canada's I ngr edient Dis clos ur e Lis t.
E x pos u r e L im it s
CAS # 20816- 12- 0: OEL- ARAB Republic of Egypt: T WA 0.0002 ppm (0.002 mg
/m3) OEL- AUS T RALI A: T WA 0.0002 ppm (0.002 mg/m3); S T EL 0.0006 ppm OEL-
B ELGI UM: T WA 0.0002 ppm (0.0016 mg/m3); S T EL 0.0006 ppm OEL- DENMARK : T WA
0.0002 ppm (0.002 mg/m3) OEL- FI NLAND: T WA 0.0002 mg/m3; S T EL 0.002 mg/
m3 OEL- FRANCE: T WA 0.0002 ppm (0.002 mg/m3) OEL- GERMANY: T WA 0.0002 pp
m (0.002 mg/m3) OEL- HUNGARY: T WA 0.002 mg/m3; S T EL 0.003 mg/m3 JAN9 OE
L- T HE NET HERLANDS : T WA 0.0002 ppm (0.002 mg/m3) OEL- T HE PHI LI PPI NES : T W
A 0.002 mg/m3 OEL- S WI T Z ERLAND: T WA 0.0002 ppm (0.002 mg/m3); S T EL 0.000
4 ppm OEL- UNI T ED K I NGDOM: T WA 0.0002 ppm (0.002 mg/m3); S T EL 0.0006 ppm
(0.006 mg/m3) OEL I N B ULGARI A, COLOMB I A, JORDAN, K OREA check ACGI H T
LV OEL I N NEW Z EALAND, S I NGAPORE, VI ET NAM check ACGI T LV
S ection 16 - Additional I nfor mation
T he infor mation above is believed to be accur ate and r epr es ents the bes t infor mation cur r ently available to us .
However , we make no war r anty of mer chantability or any other war r anty, ex pr es s or implied, with r es pect to
s uch infor mation, and we as s ume no liability r es ulting fr om its us e. Us er s s hould make their own inves tigations to
deter mine the s uitability of the infor mation for their par ticular pur pos es . I n no way s hall Electr on Micr os copy
S ciences be liable for any claims , los s es , or damages of any thir d par ty or for los t pr ofits or any s pecial, indir ect,
incidental, cons equential or ex emplar y damages , hows oever ar is ing, even if Electr on Micr os copy S ciences r has
been advis ed of the pos s ibility of s uch damages .
Osmium Tetroxide 2% Solution
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