EMS CATALOG NO: 19600
EMS PRODUCT: Dichloromethane
DATE: April 24, 1998
PAGE NUMBER: One of 9
MATERIAL SAFETY DATA SHEET
The information contained herein is based on data considered
accurate. However, no warranty is expressed or implied
regarding the accuracy of these data or the results to be
obtained from the use thereof.
Electron Microscopy Sciences assumes no responsibility for
personal injury or property damage to vendees, users or
third parties caused by the material. Such vendees or users
assume all risks associated with the use of the material.
ELECTRON MICROSCOPY SCIENCES
321 MORRIS ROAD
P.O. BOX 251
FORT WASHINGTON, PA 19034 24 HOUR EMERGENCY PHONE NUMBER
(215) 646-1566 CHEMTREC: (800) 424-9300
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FOR PRODUCT AND SALES INFORMATION
_________________________________________________________________
CONTACT ELECTRON MICROSCOPY SCIENCES OFFICE ABOVE.
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PRODUCT IDENTIFICATION
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PRODUCT NAME: Methylene Chloride
CAS NUMBER: 75-09-2
% BY WEIGHT: 100
CHEMICAL FORMULA: CH2C12
EXPOSURE LIMITS: TWA(mg/m3) 174
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TOXICOLOGICAL DATA ON INGREDIENTS
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ORAL LD50: Acute: 1600 mg/kg (Rat).
VAPOR LC50: Acute: 52000 ppm (Rat) (1 hour(s)).
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HAZARDS IDENTIFICATION
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POTENTIAL ACUTE HEALTH EFFECTS:
Very dangerous in case of eye contact (irritant), of
ingestion, of inhalation. Slightly dangerous to dangerous
in case of skin contact (irritant, permeator). This product
is an eye irritant. Severe over-exposure can result in
death. Can be fatal if inhaled or ingested. This product
may irritate eyes and skin upon contact. Inflammation of
the eye is characterized by redness, watering, and itching.
POTENTIAL CHRONIC HEALTH EFFECTS:
CARCINOGENIC EFFECTS: Classified + by OSHA/NIOSH.
Classified 2B by IARC.
MUTAGENIC EFFECTS: Not available.
TERATOGENIC EFFECTS: Not available.
The substance is toxic to lungs, the nervous system, liver,
mucous membranes.
TOXICITY OF THE PRODUCT TO THE REPRODUCTIVE SYSTEM: Not
available.
Repeated or prolonged exposure to the substance can produce
target organs damage. Repeated exposure to an highly toxic
material may produce general deterioration of health by an
accumulation in one or many human organs.
WARNING: This product contains a chemical known to the State
of California to cause cancer.
Chemical ingredient(s) requiring this warning:
METHYLENE CHLORIDE
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FIRST AID MEASURES
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EYE CONTACT:
Check for and remove any contact lenses. IMMEDIATELY flush
eyes with running water for at least 15 minutes, keeping
eyelids open. COLD water may be used. DO NOT use an eye
ointment. Seek medical attention.
SKIN CONTACT:
If the chemical got onto the clothed portion of the body,
remove the contaminated clothes as quickly as possible,
protecting your own hands and body. Place the victim under
a deluge shower. If the chemical touches the victim's
exposed skin, such as the hands: Gently and thoroughly
wash the contaminated skin with running water and
non-abrasive soap. Be particularly careful to clean folds,
crevces, creases and groin. COLD water may be used. Cover
the irritated skin with an emollient. If irritation
persists, seek medical attention. Wash contaminated
clothing before reusing.
SERIOUS SKIN CONTACT:
Wash with a disinfectant soap and cover the contaminated
skin with an anti-bacterial cream. Seek immediate medical
attention.
INHALATION:
Allow the victim to rest in a well ventilated area. Seek
immediate medical attention.
SERIOUS INHALATION:
Evacuate the victim to a safe area as soon as possible.
Loosen tight clothing such as a collar, tie, belt or
waistband. If breathing is difficult, administer oxygen.
If the victim is not breathing, perform mouth-to-mouth
resuscitation. WARNING: It may be dangerous to the person
providing aid to give mouth-to-mouth resuscitation when the
inhaled material is toxic, infectious or corrosive. Seek
immediate medical attention.
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INGESTION:
Remove dentures if any. Watch for an obstruction in the
victim's mouth. Remove if possible what is causing the
obstruction but do not force fingers or a hard object
between the victim's teeth. Have conscious person drink
several glasses of water or milk. INDUCE VOMITING by
sticking finger in throat. Seek immediate medical
attention.
SERIOUS INGESTION:
Examine the lips and mouth to ascertain whether the tissues
are damaged, a possible indication that the toxic material
was ingested; the absence of such signs, however, is not
conclusive. Remove dentures if any. Watch for an
obstruction in the victim's mouth. Remove if possible what
is causing the obstruction but do not force fingers or a
hard object between the victim's teeth. If a soft pad can
be inserted between the victim's teeth, it will protect the
tongue from being bitten. A badly bleeding tongue immensely
complicates the patient's problems. Have a conscious person
drink several glasses of water or milk. INDUCE VOMITING by
sticking finger in throat. Lower the head so that the vomit
will not reenter the mouth and throat. If convulsions
occur, do not restrain the victim, but do remove objects
with which he (she) might injure himself (herself) or orient
the victim to prevent him (her) from striking fixed heavy
objects. If the convulsions cease, turn the victim on the
side or face down so that any fluid in the mouth will
drain. Seek immediate medical attention.
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FIRE AND EXPLOSION DATA
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FLAMMABILITY OF THE PRODUCT: Combustible.
AUTO-IGNITION TEMPERATURE: 556oC (1032.8oF)
FLASH POINTS: Not available.
FLAMMABLE LIMITS: Lower: 12%
Upper: 19%
PRODUCTS OF COMBUSTION: These products are carbon oxides
(CO/CO2), halogenated compounds.
FIRE HAZARDS IN PRESENCE OF VARIOUS SUBSTANCES: No specific
information is available in our database regarding the
flammability of this product in presence of various
materials.
EXPLOSION HAZARDS IN PRESENCE OF VARIOUS SUBSTANCES:
RISKS OF EXPLOSION OF THE PRODUCT IN PRESENCE OF MECHANICAL
IMPACT: Not available.
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RISKS OF EXPLOSION OF THE PRODUCT INN PRESENCE OF STATIC
DISCHARGE: Not available.
No specific information is available in our database
regarding the product's risks of explosion in the presence
of various materials.
FIRE FIGHTING MEDIA AND INSTRUCTIONS:
SMALL FIRE: Use DRY chemicals, CO2, water spray or foam.
LARGE FIRE: Use water spray, fog or foam. DO NOT use water
jet.
SPECIAL REMARKS ON FIRE HAZARDS: No additional remark.
SPECIAL REMARKS ON EXPLOSION HAZARDS: No additional remark.
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ACCIDENTAL RELEASE MEASURES
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SMALL SPILL:
Dilute with water and mop up, or absorb with an
inert DRY material and place in an appropriate waste
disposal container.
LARGE SPILL:
Combustible material. Poisonous liquid.
Keep away from heat. Keep away from sources of ignition.
Stop leak if without risk. DO NOT get water inside
container. DO NOT touch spilled material. Use water spray
to reduce vapors. Prevent entry into sewers, basements or
confined areas; dike if needed. Eliminate all sources of
ignition. Call for assistance on disposal.
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HANDLING AND STORAGE
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PRECAUTIONS:
Keep locked up. Keep away from heat. Keep away from
sources of ignition. Empty containers pose a fire risk,
evaporate the residue under a fume hood. Ground all
equipment containing material. DO NOT ingest. Do not
breathe gas, fumes, vapor or spray. In case of insufficient
ventilation, wear suitable respiratory equipment. If
ingested, seek medical advice immediately and show the
container or the label. Avoid contact with skin and eyes.
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STORAGE:
Keep container dry. Keep in a cool place. Ground all
equipment containing material. Keep container tightly
closed. Keep in a cool, well-ventilated place. Highly
toxic or infectious materials should be stored in a separate
locked safety storage cabinet or room.
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EXPOSURE CONTROLS/PERSONAL PROTECTION
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ENGINEERING CONTROLS:
Provide exhaust ventilation or other engineering controls to
keep the airborne concentrations of vapors below their
respective threshold limit value. Ensure that eyewash
station and safety shower is proximal to the work-station
location.
PERSONAL PROTECTION:
Splash goggles. Lab coat. Vapor respirator. Be sure to use
a MSHA/NIOSH approved respirator or equivalent. Gloves
(impervious). Wear appropriate respirator when ventilation
is inadequate.
PERSONAL PROTECTION IN CASE OF A LARGE SPILL:
Splash goggles. Full suit. Vapor respirator. Boots. Gloves.
A self contained breathing apparatus should be used to avoid
inhalation of the product. Suggested protective clothing
might not be sufficient; consult a specialist BEFORE
handling this product.
EXPOSURE LIMITS:
TWA: 50 (ppm) from ACGIH
TWA: 174 (mg/m3) from ACGIH
Consult local authorities for acceptable exposure limits.
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PHYSICAL AND CHEMICAL PROPERTIES
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PHYSICAL STATE AND APPEARANCE: Liquid
ODOR: Not available.
TASTE: Not available.
COLOR: Not available.
MOLECULAR WEIGHT: 84.93
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pH(1% SOLN/WATER): Not available
BOILING POINT: 39.75oC (103.5oF)
MELTING POINT: -96.7oC (-142.1oF)
CRITICAL TEMPERATURE: Not available.
SPECIFIC GRAVITY: 1.3266 (Water = 1)
VAPOR PRESSURE: 348.75 mm of Hg (@20oC)
VAPOR DENSITY: 2.93 (Air = 1)
VOLATILITY: Not available.
ODOR THRESHOLD: 214 ppm
WATER/OIL DIST. COEFF.: 0.0562341
IONICITY (IN WATER): Not available.
DISPERSION PROPERTIES: See solubility in water, methanol, diethyl
ether, n-octanol, acetone.
SOLUBILITY: Easily soluble in methanol, diethyl ether, n-octanol,
acetone. Partially soluble in cold water.
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STABILITY AND REACTIVITY DATA
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STABILITY: The product is stable.
INSTABILITY TEMPERATURE: Not available.
CONDITIONS OF INSTABILITY: No additional remark.
INCOMPATIBILITY WITH VARIOUS SUBSTANCES: No specific information
is available in our database regarding the reactivity of
this material in presence of various other materials.
CORROSIVITY: Non-corrosive in presence of glass.
SPECIAL REMARKS ON REACTIVITY: No additional remark.
SPECIAL REMARKS ON CORROSIVITY: No additional remark.
POLYMERIZATION: No.
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TOXICOLOGICAL INFORMATION
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ROUTES OF ENTRY: Ingestion. Skin contact. Inhalation.
TOXICITY TO ANIMALS:
WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE
BASIS OF A 4-HOUR EXPOSURE.
Acute oral toxicity (LD50): 1600 mg/kg (Rat).
Acute toxicity of the vapor (LC50): 26000 ppm (Rat).
CHRONIC EFFECTS ON HUMANS:
CARCINOGENIC EFFECTS: Classified + by OSHA/NIOSH.
Classified 2B by IARC.
The substance is toxic to lungs, the nervous system, liver,
mucous membranes.
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TOXICITY OF THE PRODUCT TO THE REPRODUCTIVE SYSTEM: Not
available.
OTHER TOXIC EFFECTS ON HUMANS:
Very dangerous in case of eye contact (irritant), of
ingestion, of inhalation. Slightly dangerous to dangerous
in case of skin contact (irritant, permeator).
SPECIAL REMARKS ON TOXICITY TO ANIMALS: No additional remark.
SPECIAL REMARKS ON CHRONIC EFFECTS ON HUMANS: Human: passes
through the placenta, excreted in maternal milk.
SPECIAL REMARKS ON OTHER TOXIC EFFECTS ON HUMANS: No additional
remark.
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ECOLOGICAL INFORMATION
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ECOTOXICITY: Not available.
BOD5 AND COD: Not available.
PRODUCTS OF BIODEGRADATION: These products are carbon oxides (CO,
CO2), halogenated compounds.
TOXICITY OF THE PRODUCTS OF BIODEGRADATION: The products of
degradation are more toxic.
SPECIAL REMARKS ON THE PRODUCTS OF BIODEGRADATION: No additional
remark.
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DISPOSAL CONSIDERATIONS
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WASTE DISPOSAL: Recycle to process, if possible. Consult your
local or regional authorities.
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TRANSPORT INFORMATION
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DOT CLASSIFICATION: DOT CLASS 6.1: Poisonous material.
IDENTIFICATION: Dichloromethane UN1593 III
SPECIAL PROVISIONS FOR TRANSPORT: No additional remark.
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OTHER REGULATORY INFORMATION
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FEDERAL AND STATE REGULATIONS:
The following product(s) is (are) listed by the State of
California: [Cancer] Methylene chloride
The following product(s) is (are) listed by CERCLA:
Methylene chloride
The following product(s) is (are) listed on SARA 313:
Methylene chloride
The following product(s) is (are) listed by the State of
Massachusetts: Methylene chloride
The following product(s) is (are) listed by the State of
Pennsylvania: Methylene chloride
The following product(s) is (are) listed on TSCA: Methylene
chloride
CALIFORNIA PROPOSITION 65 WARNINGS:
WARNING: this product contains a chemical known to the State
of California to cause cancer.
Chemical ingredient(s) requiring this warning:
METHYLENE CHLORIDE
OTHER REGULATIONS:
OSHA: Hazardous by definition of Hazard Communication
Standard (29 CFR 1910.1200).
CANADIAN ENVIRONMENTAL PROTECTION ACT (CEPA): This product
is on the Domestic Substances List (DSL), and is acceptable
for use under the provisions of CEPA.
OTHER CLASSIFICATIONS:
WHMIS (Canada):
WHMIS CLASS D-1B: Material causing immediate and serious
toxic effects (TOXIC).
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WHMIS CLASS D-2A: Material causing other toxic effects (VERY
TOXIC).
DSCL (EEC): R22-Harmful if ingested.
R39-Danger of very serious irreversible effects.
R42-May cause sensitization by inhalation.
R45-May cause cancer.
R36/37-Irritating to eyes and respiratory
system.
HMIS (U.S.A.)
HEALTH HAZARD 2
FIRE HAZARD 1
REACTIVITY 0
PERSONAL PROTECTION j
NATIONAL FIRE PROTECTION ASSOCIATION (U.S.A.)
HEALTH 2
FLAMMABILITY 1
REACTIVITY 0
SPECIFIC HAZARD
PROTECTIVE EQUIPMENT: Gloves (impervious).
Lab Coat.
Vapor respirator. Be sure to use a
MSHA/NIOSH approved respirator or
equivalent. Wear appropriate respirator
when ventilation is inadequate.
Splash goggles.
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