SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 02/JUN/2005
Date Updated: 20/MAR/2004
Version 1.3
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name TRI REAGENT
Product Number T9424
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
TRI REAGENT None None None
Ingredient Name Percent CAS # EC no Annex I
Index Number
PHENOL 50 108-95-2 203-632-7 604-001-00-2
Muta. Cat.3
Symbols: T C
R-Phrases: 23/24/25 34 48/20/21/22 68
Toxic by inhalation, in contact with skin and if swallowed. Causes
burns. Harmful: danger of serious damage to health by prolonged
exposure through inhalation in contact with skin, and if
swallowed. Possible risk of irreversible effects.
GUANIDINE THIOCYANATE 30 593-84-0 209-812-1 615-004-00-3
Symbols: Xn
R-Phrases: 20/21/22 32 52/53
Harmful by inhalation, in contact with skin and if swallowed.
Contact with acids liberates very toxic gas. Harmful to aquatic
organisms, may cause long-term adverse effects in the aquatic
environment.
NON-HAZARDOUS COMPONENTS 20 None None None
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Causes burns. Contact with acids liberates toxic gas. Toxic in
contact with skin and if swallowed.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician. Do not induce vomiting.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Cover with dry lime or soda ash, pick up, keep in a closed
container, and hold for waste disposal. Ventilate area and wash
spill site after material pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Do not get
in eyes, on skin, on clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Keep away from heat,
sparks, and open flame. Store in a cool dry place.
Store at 2-8掳C
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use only in a chemical fume hood.
GENERAL HYGIENE MEASURES
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Wash contaminated clothing before reuse. Discard contaminated
shoes. Wash thoroughly after handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
Special Protective Measures: Faceshield (8-inch minimum).
9 - Physical and Chemical Properties
Appearance Physical State: Liquid
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range N/A
Flash Point 79 掳C Method: closed cup
Flammability N/A
Autoignition Temp 715 掳C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure 0.35 mmHg
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Soluble.
Other Solvents: GLCERIN, DIMETHYL SULFOXIDE
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions of Instability: May discolor on exposure to light.
Conditions to Avoid: Light.
Materials to Avoid: Strong oxidizing agents, Heating to
decomposition or contact with acids or acid vapors can liberate
poisonous cyanide vapors, Strong bases, Strong acids.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Hydrogen cyanide, Sulfur oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
ACUTE TOXICITY
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LD50
Intraperitoneal
Mouse
263 MG/KG
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Behavioral:Excitement. Lungs, Thorax, or Respiration:Dyspnea.
SIGNS AND SYMPTOMS OF EXPOSURE
Material is extremely destructive to tissue of the mucous
membranes and upper respiratory tract, eyes, and skin.
Inhalation may result in spasm, inflammation and edema of the
larynxand bronchi, chemical pneumonitis, and pulmonary edema.
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting. Exposure can cause: Dermatitis. Ingestion can cause
circulatory collapse, tachypnea, paralysis, convulsions, coma,
necrosis of mouth and G.I. tract, jaundice, death from
respiratory failure, sometimes from cardiac arrest.
ROUTE OF EXPOSURE
Skin Contact: Causes burns.
Skin Absorption: Toxic if absorbed through skin. Readily
absorbed through skin.
Eye Contact: Causes burns.
Inhalation: Material is extremely destructive to the tissue of
the mucous membranes and upper respiratory tract. May be harmful
if inhaled.
Ingestion: Toxic if swallowed.
TARGET ORGAN INFORMATION
Central nervous system. Kidneys. Liver. Pancreas. Spleen.
CONDITIONS AGGRAVATED BY EXPOSURE
May cause nervous system disturbances.
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
This combustible material may be burned in a chemical incinerator
equipped with an afterburner and scrubber. Contact a licensed
professional waste disposal service to dispose of this material.
Observe all federal, state, and local environmental regulations.
14 - Transport Information
RID/ADR
UN#: 1760
Class: 8
PG: II
Proper Shipping Name: Corrosive liquid, n.o.s.
IMDG
UN#: 1760
Class: 8
PG: II
Proper Shipping Name: Corrosive liquid, n.o.s.
Marine Pollutant: No
Severe Marine Pollutant: No
SIGMA - T9424 www.sigma-aldrich.com Page 4
Technical Name: Required
IATA
UN#: 1760
Class: 8
PG: II
Proper Shipping Name: Corrosive liquid, n.o.s.
Inhalation Packing Group I: No
Technical Name: Required
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: T
Toxic.
R-PHRASES: 34 31 24/25
Causes burns. Contact with acids liberates toxic gas. Toxic in
contact with skin and if swallowed.
S-PHRASES: 45 26 27 36/37/39
In case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible). In case of contact
with eyes, rinse immediately with plenty of water and seek
medical advice. Take off immediately all contaminated clothing.
Wear suitable protective clothing, gloves, and eye/face
protection.
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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