SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 02/JUN/2005
Date Updated: 19/MAR/2004
Version 1.1
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name TRI(ETHYLENE GLYCOL), REAGENTPLUS(TM),
99%
Product Number T59455
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
TRI(ETHYLENE GLYCOL), 99% 112-27-6 203-953-2 None
Formula C6H14O4
Molecular Weight 150.17 AMU
Synonyms 1,2-Bis(2-hydroxyethoxy)ethane *
Di-beta-hydroxyethoxyethane *
3,6-Dioxaoctane-1,8-diol *
2,2'-(1,2-Ethanediylbis(oxy))bisethanol *
Ethanol, 2,2'-(ethylenedioxy)di- *
2,2'-Ethylenedioxybis(ethanol) *
2,2'-Ethylenedioxydiethanol *
2,2'-Ethylenedioxyethanol * Ethylene
glycol-bis-(2-hydroxyethyl ether) * Ethylene
glycol dihydroxydiethyl ether * Glycol
bis(hydroxyethyl) ether * TEG * Triethylenglykol
(Czech) * Trigen * Triglycol
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Irritating to eyes, respiratory system and skin.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact, immediately flush eyes with copious amounts
of water for at least 15 minutes.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
ENVIRONMENTAL PRECAUTION(S)
Do not allow material to enter drains or water courses.
METHODS FOR CLEANING UP
Absorb on sand or vermiculite and place in closed containers for
disposal. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Avoid
contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
SPECIAL REQUIREMENTS: Hygroscopic.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Mechanical exhaust required. Safety shower and eye bath.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
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Appearance Color: Colorless
Form: Clear viscous liquid
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 125 - 127 掳C 0.1 mmHg
MP/MP Range -7 掳C
Flash Point 166 掳C Method: closed cup
Flammability N/A
Autoignition Temp 371 掳C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 0.9 %
Upper: 9.2 %
Vapor Pressure < 1 mmHg 20 掳C
SG/Density 1.125 g/cm3
Partition Coefficient N/A
Viscosity N/A
Vapor Density 5.2 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content < 0.08 %
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Complete Soluble.
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents, Strong acids.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: YE4550000
ACUTE TOXICITY
LDLO
Oral
Human
5000 mg/kg
LD50
Oral
Rat
17000 mg/kg
LD50
Intravenous
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Rat
11700 MG/KG
LD50
Intraperitoneal
Mouse
8141 MG/KG
Remarks: Lungs, Thorax, or Respiration:Chronic pulmonary edema.
Kidney, Ureter, Bladder:Changes in both tubules and glomeruli.
Blood:Changes in spleen.
LD50
Subcutaneous
Mouse
8750 MG/KG
LD50
Intravenous
Mouse
6500 MG/KG
LD50
Intravenous
Dog
>4500 MG/KG
LD50
Oral
Rabbit
8400 mg/kg
LD50
Skin
Rabbit
>20 ML/KG
LD50
Intravenous
Rabbit
1900 MG/KG
LD50
Oral
Guinea pig
7900 mg/kg
LD50
Intravenous
Guinea pig
10600 MG/KG
LD50
Oral
Mammal
8150 mg/kg
IRRITATION DATA
Skin
Rabbit
500 mg
24H
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Remarks: Mild irritation effect
Eyes
Rabbit
500 mg
Remarks: Mild irritation effect
SIGNS AND SYMPTOMS OF EXPOSURE
Prolonged exposure can cause: Nausea, headache, and vomiting. To
the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes eye irritation.
Inhalation: Material is irritating to mucous membranes and upper
respiratory tract. May be harmful if inhaled.
Ingestion: May be harmful if swallowed.
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 103 GM/KG
Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Musculoskeletal system.
Species: Mouse
Dose: 56370 MG/KG
Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Musculoskeletal system.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Mouse
Dose: 90160 MG/KG
Route of Application: Oral
Exposure Time: (7-14D PREG)
Result: Effects on Newborn: Growth statistics (e.g., reduced
weight gain).
Species: Mouse
Dose: 323 GM/KG
Route of Application: Oral
Exposure Time: (MULTIGENERATION)
Result: Effects on Newborn: Growth statistics (e.g., reduced
weight gain).
Species: Mouse
Dose: 57820 MG/KG
Route of Application: Oral
Exposure Time: (MULTIGENERATION)
Result: Effects on Newborn: Physical.
12 - Ecological Information
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ELIMINATION
Elimination: > 70 %
ECOTOXICOLOGICAL EFFECTS
Test Type: LC50 Fish
Species: Leuciscus idus
Time: 96 h
Value: > 100 mg/l
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: Xi
Irritant.
R-PHRASES: 36/37/38
Irritating to eyes, respiratory system and skin.
S-PHRASES: 26 36
In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice. Wear suitable protective
clothing.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 1
SWITZERLAND
SWISS POISON CLASS: FREI
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
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Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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