SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 21/APR/2005
Date Updated: 10/FEB/2005
Version 1.3
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name (+/-)-VERAPAMIL HCL
Product Number V102
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
VALERONITRILE, 152-11-4 205-800-5 None
5-((3,4-DIMETHOXYPHENETHYL)METHYLA
MINO)-2-(3,4-DIMETHOXYPHENYL)-2-IS
OPROPYL-, MONOHYDROCHLORIDE
Formula C27H38N2O4.ClH
Molecular Weight 491.1 AMU
Synonyms Calan * Cordilox * D-365 hydrochloride *
Finoptin * Iproveratril hydrochloride * Izoptin
hydrochloride * LU 20175 * Manidon * Verapamil
chloridrate * Verapamil hydrochloride *
(+/-)-verapamil hydrochloride
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Toxic by inhalation, in contact with skin and if swallowed.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Do not get in
eyes, on skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
SPECIAL REQUIREMENTS: Heat and light sensitive.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Color: White
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Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range 142 掳C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions of Instability: Light sensitive. May decompose on
exposure to light.
Materials to Avoid: Bases.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides, Hydrogen chloride gas.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: YV8320000
ACUTE TOXICITY
LDLO
Oral
Man
3.429 mg/kg
Remarks: Cardiac:Arrythmias (including changes it conduction).
Gastrointestinal:Necrotic changes.
LDLO
Oral
Man
103 mg/kg
Remarks: Cardiac:Arrythmias (including changes it conduction).
Vascular:BP lowering not charactertized in autonomic section.
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Blood:Other changes.
LDLO
Intravenous
Man
256 UG/KG
1H-I
Remarks: Cardiac:Arrythmias (including changes it conduction).
LD50
Oral
Rat
108 mg/kg
LD50
Intraperitoneal
Rat
60 MG/KG
LD50
Subcutaneous
Rat
107 MG/KG
LD50
Intravenous
Rat
16 MG/KG
LD50
Intramuscular
Rat
47 MG/KG
LD50
Oral
Mouse
163 mg/kg
LD50
Intraperitoneal
Mouse
41 MG/KG
LD50
Subcutaneous
Mouse
68 MG/KG
LD50
Intravenous
Mouse
5795 UG/KG
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Etosis. Gastrointestinal:Hypermotility, diarrhea.
LD50
Intramuscular
Mouse
45 MG/KG
LD50
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Oral
Dog
> 400 mg/kg
LD50
Intramuscular
Dog
25 MG/KG
LD50
Oral
Guinea pig
140 mg/kg
SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
Exposure can cause: Nausea, dizziness, and headache. Other
symptoms of exposure can include flushing rash, constipation,
bradycardia, hypotension, and atrioventricular block.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: Toxic if absorbed through skin.
Eye Contact: May cause eye irritation.
Inhalation: Toxic if inhaled. Material may be irritating to
mucous membranes and upper respiratory tract.
Ingestion: Toxic if swallowed.
TARGET ORGAN INFORMATION
Cardiovascular system.
CHRONIC EXPOSURE - MUTAGEN
Human
30 UMOL/L
Cell Type: lymphocyte
Cytogenetic analysis
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 264 MG/KG
Route of Application: Oral
Exposure Time: (1-22D PREG/22D POST)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Cardiovascular (circulatory) system. Specific Developmental
Abnormalities: Blood and lymphatic system (including spleen and
marrow).
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Man
Dose: 128 MG/KG
Route of Application: Oral
Exposure Time: (28D MALE)
Result: Paternal Effects: Impotence.
12 - Ecological Information
No data available.
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13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
UN#: 2811
Class: 6.1
PG: III
Proper Shipping Name: Toxic solid, organic, n.o.s.
IMDG
UN#: 2811
Class: 6.1
PG: III
Proper Shipping Name: Toxic solid, organic, n.o.s.
Marine Pollutant: No
Severe Marine Pollutant: No
Technical Name: Required
IATA
UN#: 2811
Class: 6.1
PG: III
Proper Shipping Name: Toxic solid, organic, n.o.s.
Inhalation Packing Group I: No
Technical Name: Required
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: T
Toxic.
R-PHRASES: 23/24/25
Toxic by inhalation, in contact with skin and if swallowed.
S-PHRASES: 36/37 45
Wear suitable protective clothing and gloves. In case of
accident or if you feel unwell, seek medical advice immediately
(show the label where possible).
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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