SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 07/JUN/2005
Date Updated: 28/APR/2004
Version 1.3
According to 91/155/EEC
1 - Product and Company Information
Product Name TWEEN 80
Product Number 63161
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Australia
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
POLYOXYETHYLENE SORBITAN MONOLEATE 9005-65-6 None None
Synonyms Armotan pmo-20 * Atlox 1087 * Atlox 8916TF *
Capmul poe-O * Crill 10 * Crill 11 * Crillet 4 *
Crill S 10 * Drewmulse poe-smo * Durfax 80 *
Emsorb 6900 * Ethoxylated sorbitan monooleate *
Glycosperse O-20 * Glycosperse O-20 VEG *
Glycosperse O-20X * Hodag SVO 9 * MO 55F *
Monitan * Montanox 80 * NCI-C60286 * Nikkol TO *
Nikkol TO 10 * Olothorb * Polyethylene oxide
sorbitan mono-oleate * Polyoxyethylene sorbitan
monooleate * Polyoxyethylene (20) sorbitan
mono-oleate * Polyoxyethylene sorbitan oleate *
Polysorban 80 * Polysorbate 80 * Polysorbate 81
* Polysorbate 80 B.P.C. * Polysorbate 80, U.S.P.
* Protasorb O-20 * Romulgin O * Sorbimacrogol
oleate * Sorbimacrogol oleate 300 * Sorbital 0
20 * Sorbitan mono-9-octadecenoate
poly(oxy-1,2-ethanediyl) derivatives * Sorbon T
80 * Sorethytan (20) monooleate * Sorlate * SVO
9 * TO 10 * Tween 80 * Tween 81 * Tween 80 A
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Not hazardous according to Directive 67/548/EEC.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If breathing becomes difficult,
call a physician.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
METHODS FOR CLEANING UP
Absorb on sand or vermiculite and place in closed containers for
disposal. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Avoid inhalation. Avoid contact
with eyes, skin, and clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
PERSONAL PROTECTIVE EQUIPMENT
Hand Protection: Protective gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Liquid
Color: Yellow
Property Value At Temperature or Pressure
pH N/A
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BP/BP Range 100 掳C
MP/MP Range N/A
Flash Point 113 掳C Method: closed cup
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure < 1 mmHg 20 掳C
SG/Density 1.064 g/cm3
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:soluble
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Bases, Heavy metal salts, Strong oxidizing
agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: WG2932500
ACUTE TOXICITY
LD50
Oral
> 15,000 mg/kg
LD50
Oral
Rat
34500 UL/KG
LD50
Intraperitoneal
Rat
6804 MG/KG
LD50
Intravenous
Rat
1790 MG/KG
LD50
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Oral
Mouse
25000 mg/kg
LD50
Intraperitoneal
Mouse
7600 MG/KG
LD50
Intravenous
Mouse
4500 MG/KG
LD50
Oral
Mammal
25000 mg/kg
LD50
Intravenous
Mammal
5800 MG/KG
IRRITATION DATA
Eyes
Rabbit
Remarks: Mild irritation effect
Skin
Rabbit
24 HOUR
Remarks: Mild irritation effect
Eyes
Rabbit
150 mg
Remarks: Mild irritation effect
SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that is not
classifiable as to its carcinogenicity based on its IARC, ACGIH,
NTP, or EPA classification.
Rat
Route of Application: Oral
Exposure Time: 2Y
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Endocrine:Adrenal cortex tumors.
Rat
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Route of Application: Subcutaneous
Exposure Time: 27W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Tumorigenic:Tumors at site or application.
CHRONIC EXPOSURE - MUTAGEN
Human
20 PPM
Cell Type: lymphocyte
DNA inhibition
Mouse
20 PPM
Cell Type: Other cell types
DNA inhibition
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 635 GM/KG
Route of Application: Oral
Exposure Time: (MULTIGENERATIONS)
Result: Effects on Newborn: Viability index (e.g., # alive at
day 4 per # born alive). Effects on Newborn: Weaning or
lactation index (e.g., # alive at weaning per # alive at day 4).
Species: Rat
Dose: 1270 GM/KG
Route of Application: Oral
Exposure Time: (84D PRE-21D POST)
Result: Effects on Newborn: Viability index (e.g., # alive at
day 4 per # born alive).
Species: Rat
Dose: 80 UL/KG
Route of Application: Intraperitoneal
Exposure Time: (4D POST)
Result: Maternal Effects: Uterus, cervix, vagina. Maternal
Effects: Menstrual cycle changes or disorders. Effects on
Newborn: Physical.
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
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IATA
Non-hazardous for air transport.
15 - Regulatory Information
Not hazardous according to Directive 67/548/EEC.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 1
SWITZERLAND
SWISS POISON CLASS: FREI
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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