PRODUCT #: 18960 NAME: 1,4-BUTANEDIOL
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Monday, March 10, 1903 3:37PM
Sigma Chemical Co. Aldrich Chemical Co., Inc. Fluka Chemical Corp.
P.O. Box 14508 1001 West St. Paul 1001 West St. Paul
St. Louis, MO 63178 Milwaukee, WI 53233 Milwaukee, WI 53233
Phone: 314-771-5765 Phone: 414-273-3850 Phone: 414-273-3850
SECTION 1. - - - - - - - - - CHEMICAL IDENTIFICATION- - - - - - - - - -
CATALOG #: 18960
NAME: 1,4-BUTANEDIOL
SECTION 2. - - - - - COMPOSITION/INFORMATION ON INGREDIENTS - - - - - -
CAS #: 110-63-4
MF: C4H10O2
EC NO: 203-786-5
SYNONYMS
AGRISYNTH B1D * BUTANEDIOL * BUTANE-1,4-DIOL * 1,4-BUTYLENE GLYCOL *
1,4-DIHYDROXYBUTANE * DIOL 14B * SUCOL B * TETRAMETHYLENE 1,4-DIOL *
1,4-TETRAMETHYLENE GLYCOL *
SECTION 3. - - - - - - - - - - HAZARDS IDENTIFICATION - - - - - - - - -
LABEL PRECAUTIONARY STATEMENTS
HARMFUL
HARMFUL BY INHALATION, IN CONTACT WITH SKIN AND IF SWALLOWED.
IRRITATING TO EYES, RESPIRATORY SYSTEM AND SKIN.
TARGET ORGAN(S):
KIDNEYS
CENTRAL NERVOUS SYSTEM
IN CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF
WATER AND SEEK MEDICAL ADVICE.
WEAR SUITABLE GLOVES AND EYE/FACE PROTECTION.
SECTION 4. - - - - - - - - - - FIRST-AID MEASURES- - - - - - - - - - -
IN CASE OF CONTACT, IMMEDIATELY FLUSH EYES WITH COPIOUS AMOUNTS OF
WATER FOR AT LEAST 15 MINUTES.
IN CASE OF CONTACT, IMMEDIATELY WASH SKIN WITH SOAP AND COPIOUS
AMOUNTS OF WATER.
IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING GIVE ARTIFICIAL
RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.
IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS.
CALL A PHYSICIAN.
WASH CONTAMINATED CLOTHING BEFORE REUSE.
SECTION 5. - - - - - - - - - FIRE FIGHTING MEASURES - - - - - - - - - -
EXTINGUISHING MEDIA
WATER SPRAY.
CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM.
SPECIAL FIREFIGHTING PROCEDURES
WEAR SELF-CONTAINED BREATHING APPARATUS AND PROTECTIVE CLOTHING TO
PREVENT CONTACT WITH SKIN AND EYES.
UNUSUAL FIRE AND EXPLOSIONS HAZARDS
EMITS TOXIC FUMES UNDER FIRE CONDITIONS.
SECTION 6. - - - - - - - - ACCIDENTAL RELEASE MEASURES- - - - - - - - -
WEAR RESPIRATOR, CHEMICAL SAFETY GOGGLES, RUBBER BOOTS AND HEAVY
RUBBER GLOVES.
COVER WITH DRY LIME OR SODA ASH, PICK UP, KEEP IN A CLOSED CONTAINER
AND HOLD FOR WASTE DISPOSAL.
VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE.
SECTION 7. - - - - - - - - - - HANDLING AND STORAGE- - - - - - - - - - -
REFER TO SECTION 8.
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PRODUCT #: 18960 NAME: 1,4-BUTANEDIOL
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Monday, March 10, 1903 3:37PM
SECTION 8. - - - - - - EXPOSURE CONTROLS/PERSONAL PROTECTION- - - - - -
CHEMICAL SAFETY GOGGLES.
COMPATIBLE CHEMICAL-RESISTANT GLOVES.
NIOSH/MSHA-APPROVED RESPIRATOR.
SAFETY SHOWER AND EYE BATH.
MECHANICAL EXHAUST REQUIRED.
DO NOT BREATHE VAPOR.
AVOID CONTACT WITH EYES, SKIN AND CLOTHING.
AVOID PROLONGED OR REPEATED EXPOSURE.
WASH THOROUGHLY AFTER HANDLING.
IRRITANT.
HARMFUL LIQUID AND FUMES.
KEEP TIGHTLY CLOSED.
STORE IN A COOL DRY PLACE.
SECTION 9. - - - - - - - PHYSICAL AND CHEMICAL PROPERTIES - - - - - - -
APPEARANCE AND ODOR
LIQUID.
PHYSICAL PROPERTIES
BOILING POINT: 120 TO 122C/10MM
MELTING POINT: 19 TO 21C
FLASHPOINT 273.20F
134C
AUTOIGNITION TEMPERATURE: 698 F 369C
SPECIFIC GRAVITY: 1.014
VAPOR DENSITY: 3.1
SECTION 10. - - - - - - - - -STABILITY AND REACTIVITY - - - - - - - - -
INCOMPATIBILITIES
STRONG OXIDIZING AGENTS
ACID CHLORIDES
ACID ANHYDRIDES
REDUCING AGENTS
HAZARDOUS COMBUSTION OR DECOMPOSITION PRODUCTS
TOXIC FUMES OF:
CARBON MONOXIDE, CARBON DIOXIDE
SECTION 11. - - - - - - - - - TOXICOLOGICAL INFORMATION - - - - - - - -
ACUTE EFFECTS
HARMFUL IF SWALLOWED.
MAY BE HARMFUL IF INHALED.
MAY BE HARMFUL IF ABSORBED THROUGH THE SKIN.
VAPOR OR MIST IS IRRITATING TO THE EYES, MUCOUS MEMBRANES AND UPPER
RESPIRATORY TRACT.
CAUSES SKIN IRRITATION.
TARGET ORGAN(S):
KIDNEYS
CENTRAL NERVOUS SYSTEM
TO THE BEST OF OUR KNOWLEDGE, THE CHEMICAL, PHYSICAL, AND
TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED.
RTECS #: EK0525000
1,4-BUTANEDIOL
TOXICITY DATA
UNR-WMN LDLO:300 MG/KG PHARAT 3,110,1948
REC-MAN LDLO:429 MG/KG PHARAT 3,110,1948
ORL-RAT LD50:1525 MG/KG HYSAAV
33(1-3),41,1968
IPR-RAT LD50:1070 MG/KG JPPMAB 26,597,1974
ORL-MUS LD50:2062 MG/KG HYSAAV
33(1-3),41,1968
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PRODUCT #: 18960 NAME: 1,4-BUTANEDIOL
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Monday, March 10, 1903 3:37PM
IPR-MUS LD50:1650 MG/KG TXAPA9 49,385,1979
ORL-RBT LD50:2531 MG/KG HYSAAV
33(1-3),41,1968
ORL-GPG LD50:1200 MG/KG HYSAAV
33(1-3),41,1968
TARGET ORGAN DATA
SENSE ORGANS AND SPECIAL SENSES (OTHER OLFACTION EFFECTS)
BEHAVIORAL (ALTERED SLEEP TIME)
BEHAVIORAL (SOMNOLENCE)
LUNGS, THORAX OR RESPIRATION (OTHER CHANGES)
BLOOD (OTHER CHANGES)
NUTRITIONAL AND GROSS METABOLIC (WEIGHT LOSS OR DECREASED WEIGHT GAIN)
ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES
(RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR
COMPLETE INFORMATION.
SECTION 12. - - - - - - - - - ECOLOGICAL INFORMATION - - - - - - - - - -
DATA NOT YET AVAILABLE.
SECTION 13. - - - - - - - - - DISPOSAL CONSIDERATIONS - - - - - - - - -
DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE SOLVENT AND BURN IN A
CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER.
OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS.
SECTION 14. - - - - - - - - - - TRANSPORT INFORMATION - - - - - - - - -
CONTACT FLUKA CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION.
SECTION 15. - - - - - - - - - REGULATORY INFORMATION - - - - - - - - - -
EUROPEAN INFORMATION
HARMFUL
R 20/21/22
HARMFUL BY INHALATION, IN CONTACT WITH SKIN AND IF SWALLOWED.
R 36/37/38
IRRITATING TO EYES, RESPIRATORY SYSTEM AND SKIN.
S 26
IN CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF
WATER AND SEEK MEDICAL ADVICE.
S 37/39
WEAR SUITABLE GLOVES AND EYE/FACE PROTECTION.
TLV AND SOURCE
FOR 1,4-BUTANEDIOL:
MANUFACTURER'S EXPOSURE LIMIT: 30 PPM, 8 & 12 HR. TWA
REVIEWS, STANDARDS, AND REGULATIONS
OEL=MAK
NOHS 1974: HZD M0752; NIS 7; TNF 226; NOS 22; TNE 16785
NOES 1983: HZD M0752; NIS 21; TNF 759; NOS 25; TNE 16811; TFE 3870
EPA GENETOX PROGRAM 1988, INCONCLUSIVE: D MELANOGASTER SEX-LINKED
LETHAL
EPA TSCA SECTION 8(B) CHEMICAL INVENTORY
EPA TSCA SECTION 8(D) UNPUBLISHED HEALTH/SAFETY STUDIES
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, APRIL 1997
NTP TOXICITY STUDIES, RPT# TOX-54, APRIL 1997
SECTION 16. - - - - - - - - - - OTHER INFORMATION- - - - - - - - - - - -
THE ABOVE INFORMATION IS BELIEVED TO BE CORRECT BUT DOES NOT PURPORT TO
BE ALL INCLUSIVE AND SHALL BE USED ONLY AS A GUIDE. SIGMA, ALDRICH,
FLUKA SHALL NOT BE HELD LIABLE FOR ANY DAMAGE RESULTING FROM HANDLING
OR FROM CONTACT WITH THE ABOVE PRODUCT. SEE REVERSE SIDE OF INVOICE OR
PACKING SLIP FOR ADDITIONAL TERMS AND CONDITIONS OF SALE.
COPYRIGHT 1997 SIGMA CHEMICAL CO., ALDRICH CHEMICAL CO., INC.,
FLUKA CHEMIE AG
LICENSE GRANTED TO MAKE UNLIMITED PAPER COPIES FOR INTERNAL USE ONLY
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PRODUCT #: 18960 NAME: 1,4-BUTANEDIOL
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Monday, March 10, 1903 3:37PM
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