PRODUCT #: D47404 NAME: 2,6-DI-TERT-BUTYL-4-METHYLPHENOL, 99%
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Thursday, March 20, 1903 12:53PM
Sigma Chemical Co. Aldrich Chemical Co., Inc. Fluka Chemical Corp.
P.O. Box 14508 1001 West St. Paul 1001 West St. Paul
St. Louis, MO 63178 Milwaukee, WI 53233 Milwaukee, WI 53233
Phone: 314-771-5765 Phone: 414-273-3850 Phone: 414-273-3850
SECTION 1. - - - - - - - - - CHEMICAL IDENTIFICATION- - - - - - - - - -
CATALOG #: D47404
NAME: 2,6-DI-TERT-BUTYL-4-METHYLPHENOL, 99%
SECTION 2. - - - - - COMPOSITION/INFORMATION ON INGREDIENTS - - - - - -
CAS #: 128-37-0
MF: C15H24O
EC NO: 204-881-4
SYNONYMS
ADVASTAB 401 * AGIDOL * AGIDOL 1 * ALKOFEN BP * ANTIOXIDANT DBPC *
ANTIOXIDANT 4 * ANTIOXIDANT 29 * ANTIOXIDANT 30 * ANTIOXIDANT 4K *
ANTIOXIDANT KB * ANTRANCINE 8 * AO 29 * AO 4K * BHT * BHT (FOOD GRADE)
* 2,6-BIS(1,1-DIMETHYLETHYL)-4-METHYLPHENOL * BUKS * BUTYLATED
HYDROXYTOLUENE * BUTYLHYDROXYTOLUENE * BUTYLOHYDROKSYTOLUENU (POLISH)
* CAO 1 * CAO 3 * CATALIN CAO-3 * CHEMANOX 11 * DALPAC * DBMP * DBPC *
DBPC (TECHNICAL GRADE) * DEENAX * DIBUNOL * DIBUTYLATED
HYDROXYTOLUENE * 2,6-DI-TERT-BUTYL-P-CRESOL (ACGIH) * 2,6-DI-TERC.
BUTYL-P-KRESOL (CZECH) * 2,6-DI-TERT-BUTYL-1-HYDROXY-4-METHYLBENZENE *
3,5-DI-TERT-BUTYL-4-HYDROXYTOLUENE * 2,6-DI-TERT-BUTYL-P-
METHYLPHENOL * 2,6-DI-TERT-BUTYL-4-METHYLPHENOL * 4-HYDROXY-3,5-DI-
TERT-BUTYLTOLUENE * IMPRUVOL * IONOL * IONOL 1 * IONOL (ANTIOXIDANT) *
IONOL CP * IONOLE * KERABIT * 4-METHYL-2,6-DI-TERC. BUTYLFENOL
(CZECH) * METHYLDI-TERT-BUTYLPHENOL * 4-METHYL-2,6-DI-TERT-
BUTYLPHENOL * NCI-C03598 * NOCRAC 200 * NONOX TBC * P 21 * PARABAR
441 * PARANOX 441 * PHENOL, 2,6-BIS(1,1-DIMETHYLETHYL)-4-METHYL- (9CI)
* STAVOX * SUMILIZER BHT * SUSTANE BHT * SWANOX BHT * TENAMENE 3 *
TENOX BHT * TOPANOL * TOPANOL O * TOPANOL OC * TOXOLAN P * VANLUBE PC
* VANLUBE PCX * VIANOL * VULKANOX KB *
SECTION 3. - - - - - - - - - - HAZARDS IDENTIFICATION - - - - - - - - -
LABEL PRECAUTIONARY STATEMENTS
HARMFUL
HARMFUL BY INHALATION, IN CONTACT WITH SKIN AND IF SWALLOWED.
IRRITATING TO EYES, RESPIRATORY SYSTEM AND SKIN.
RISK OF SERIOUS DAMAGE TO EYES.
TARGET ORGAN(S):
LUNGS
IN CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF
WATER AND SEEK MEDICAL ADVICE.
WEAR SUITABLE PROTECTIVE CLOTHING.
DO NOT BREATHE DUST.
SECTION 4. - - - - - - - - - - FIRST-AID MEASURES- - - - - - - - - - -
IN CASE OF CONTACT, IMMEDIATELY FLUSH EYES OR SKIN WITH COPIOUS
AMOUNTS OF WATER FOR AT LEAST 15 MINUTES WHILE REMOVING CONTAMINATED
CLOTHING AND SHOES.
ASSURE ADEQUATE FLUSHING OF THE EYES BY SEPARATING THE EYELIDS
WITH FINGERS.
IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING GIVE ARTIFICIAL
RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.
IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS.
CALL A PHYSICIAN.
Page 1
PRODUCT #: D47404 NAME: 2,6-DI-TERT-BUTYL-4-METHYLPHENOL, 99%
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Thursday, March 20, 1903 12:53PM
WASH CONTAMINATED CLOTHING BEFORE REUSE.
SECTION 5. - - - - - - - - - FIRE FIGHTING MEASURES - - - - - - - - - -
EXTINGUISHING MEDIA
CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM.
SPECIAL FIREFIGHTING PROCEDURES
WEAR SELF-CONTAINED BREATHING APPARATUS AND PROTECTIVE CLOTHING TO
PREVENT CONTACT WITH SKIN AND EYES.
UNUSUAL FIRE AND EXPLOSIONS HAZARDS
EMITS TOXIC FUMES UNDER FIRE CONDITIONS.
SECTION 6. - - - - - - - - ACCIDENTAL RELEASE MEASURES- - - - - - - - -
EVACUATE AREA.
WEAR SELF-CONTAINED BREATHING APPARATUS, RUBBER BOOTS AND HEAVY
RUBBER GLOVES.
COVER WITH DRY LIME OR SODA ASH, PICK UP, KEEP IN A CLOSED CONTAINER
AND HOLD FOR WASTE DISPOSAL.
VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE.
SECTION 7. - - - - - - - - - - HANDLING AND STORAGE- - - - - - - - - - -
REFER TO SECTION 8.
SECTION 8. - - - - - - EXPOSURE CONTROLS/PERSONAL PROTECTION- - - - - -
WEAR APPROPRIATE NIOSH/MSHA-APPROVED RESPIRATOR, CHEMICAL-RESISTANT
GLOVES, SAFETY GOGGLES, OTHER PROTECTIVE CLOTHING.
SAFETY SHOWER AND EYE BATH.
USE ONLY IN A CHEMICAL FUME HOOD.
DO NOT BREATHE DUST.
DO NOT GET IN EYES, ON SKIN, ON CLOTHING.
AVOID PROLONGED OR REPEATED EXPOSURE.
WASH THOROUGHLY AFTER HANDLING.
HARMFUL SOLID.
IRRITANT.
KEEP TIGHTLY CLOSED.
STORE IN A COOL DRY PLACE.
SECTION 9. - - - - - - - PHYSICAL AND CHEMICAL PROPERTIES - - - - - - -
APPEARANCE AND ODOR
WHITE CRYSTALS
PHYSICAL PROPERTIES
BOILING POINT: 265 C
MELTING POINT: 69 C TO 70 C
AUTOIGNITION TEMPERATURE: 878 F 469C
VAPOR PRESSURE: 0.01MM 20 C
VAPOR DENSITY: 7.6
SECTION 10. - - - - - - - - -STABILITY AND REACTIVITY - - - - - - - - -
INCOMPATIBILITIES
ACID CHLORIDES
ACID ANHYDRIDES
OXIDIZING AGENTS
BASES
CORRODES STEEL
BRASS
COPPER, COPPER ALLOYS
HAZARDOUS COMBUSTION OR DECOMPOSITION PRODUCTS
TOXIC FUMES OF:
CARBON MONOXIDE, CARBON DIOXIDE
SECTION 11. - - - - - - - - - TOXICOLOGICAL INFORMATION - - - - - - - -
ACUTE EFFECTS
HARMFUL IF SWALLOWED, INHALED, OR ABSORBED THROUGH SKIN.
CAUSES EYE AND SKIN IRRITATION.
MATERIAL IS IRRITATING TO MUCOUS MEMBRANES AND UPPER
Page 2
PRODUCT #: D47404 NAME: 2,6-DI-TERT-BUTYL-4-METHYLPHENOL, 99%
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Thursday, March 20, 1903 12:53PM
RESPIRATORY TRACT.
DEPENDING ON THE INTENSITY AND DURATION OF EXPOSURE, EFFECTS MAY
VARY FROM MILD IRRITATION TO SEVERE DESTRUCTION OF TISSUE.
PROLONGED CONTACT CAN CAUSE:
DAMAGE TO THE EYES
NAUSEA, DIZZINESS AND HEADACHE
CHRONIC EFFECTS
TARGET ORGAN(S):
LUNGS
RTECS #: GO7875000
P-CRESOL, 2,6-DI-TERT-BUTYL-
IRRITATION DATA
SKN-HMN 500 MG/48H MLD AMIHBC 5,311,1952
SKN-RBT 500 MG/48H MOD AMIHBC 5,311,1952
EYE-RBT 100 MG/24H MOD 85JCAE -,229,1986
TOXICITY DATA
ORL-RAT LD50:890 MG/KG NEOLA4 24,253,1977
ORL-MUS LD50:650 MG/KG SRTCAC
36(1-4),10,1989
IPR-MUS LD50:138 MG/KG TXAPA9 61,475,1981
IVN-MUS LD50:180 MG/KG JMCMAR 23,1350,1980
ORL-GPG LD50:10700 MG/KG AMIHAB 11,93,1955
TARGET ORGAN DATA
BEHAVIORAL (SLEEP)
BEHAVIORAL (TREMOR)
BEHAVIORAL (COMA)
LUNGS, THORAX OR RESPIRATION (CHRONIC PULMONARY EDEMA OR CONGESTION)
LUNGS, THORAX OR RESPIRATION (RESPIRATORY DEPRESSION)
LUNGS, THORAX OR RESPIRATION (OTHER CHANGES)
LUNGS, THORAX OR RESPIRATION (TUMORS)
GASTROINTESTINAL (GASTRITIS)
GASTROINTESTINAL (HYPERMOTILITY, DIARRHEA)
GASTROINTESTINAL (NAUSEA OR VOMITING)
GASTROINTESTINAL (TUMORS)
LIVER (TUMORS)
BLOOD (HEMORRHAGE)
SPECIFIC DEVELOPMENTAL ABNORMALITIES (MUSCULOSKELETAL SYSTEM)
TUMORIGENIC (CARCINOGENIC BY RTECS CRITERIA)
TUMORIGENIC (NEOPLASTIC BY RTECS CRITERIA)
ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES
(RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR
COMPLETE INFORMATION.
SECTION 12. - - - - - - - - - ECOLOGICAL INFORMATION - - - - - - - - - -
DATA NOT YET AVAILABLE.
SECTION 13. - - - - - - - - - DISPOSAL CONSIDERATIONS - - - - - - - - -
DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE SOLVENT AND BURN IN A
CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER.
OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS.
SECTION 14. - - - - - - - - - - TRANSPORT INFORMATION - - - - - - - - -
CONTACT ALDRICH CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION.
SECTION 15. - - - - - - - - - REGULATORY INFORMATION - - - - - - - - - -
EUROPEAN INFORMATION
HARMFUL
R 20/21/22
HARMFUL BY INHALATION, IN CONTACT WITH SKIN AND IF SWALLOWED.
R 36/37/38
IRRITATING TO EYES, RESPIRATORY SYSTEM AND SKIN.
Page 3
PRODUCT #: D47404 NAME: 2,6-DI-TERT-BUTYL-4-METHYLPHENOL, 99%
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Thursday, March 20, 1903 12:53PM
R 41
RISK OF SERIOUS DAMAGE TO EYES.
S 26
IN CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF
WATER AND SEEK MEDICAL ADVICE.
S 36
WEAR SUITABLE PROTECTIVE CLOTHING.
S 22
DO NOT BREATHE DUST.
REVIEWS, STANDARDS, AND REGULATIONS
OEL=MAK
ACGIH TLV-NOT CLASSIFIABLE AS A HUMAN CARCINOGEN DTLVS* TLV/BEI,1996
ACGIH TLV-TWA 10 MG/M3 DTLVS* TLV/BEI,1996
IARC CANCER REVIEW:ANIMAL LIMITED EVIDENCE IMEMDT 40,161,1986
IARC CANCER REVIEW:HUMAN NO ADEQUATE DATA IMEMDT 40,161,1986
IARC CANCER REVIEW:GROUP 3 IMSUDL 7,56,1987
OEL-AUSTRALIA:TWA 10 MG/M3 JAN 1993
OEL-BELGIUM:TWA 10 MG/M3 JAN 1993
OEL-FINLAND:TWA 10 MG/M3;STEL 20 MG/M3;SKIN JAN 1993
OEL-FRANCE:TWA 10 MG/M3 JAN 1993
OEL-THE NETHERLANDS:TWA 10 MG/M3 JAN 1993
OEL-SWITZERLAND:TWA 10 MG/M3 JAN 1993
OEL-UNITED KINGDOM:TWA 10 MG/M3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA CHECK ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM CHECK ACGIH TLV
NIOSH REL TO 2,6-DI-T-BUTYL-P-CRESOL-AIR:10H TWA 10 MG/M3
NIOSH* DHHS #92-100,1992
NOHS 1974: HZD 83383; NIS 32; TNF 1526; NOS 39; TNE 28860
NOES 1983: HZD 83383; NIS 210; TNF 27242; NOS 154; TNE 591238; TFE
163774
EPA GENETOX PROGRAM 1988, POSITIVE: D MELANOGASTER-WHOLE SEX CHROM.
LOSS
EPA GENETOX PROGRAM 1988, NEGATIVE: HISTIDINE REVERSION-AMES TEST;
MOUSE SPECIFIC LOCUS
EPA GENETOX PROGRAM 1988, NEGATIVE: D MELANOGASTER SEX-LINKED LETHAL
EPA GENETOX PROGRAM 1988, INCONCLUSIVE: D MELANOGASTER-RECIPROCAL
TRANSLOCATION
EPA GENETOX PROGRAM 1988, INCONCLUSIVE: MAMMALIAN MICRONUCLEUS; SPERM
MORPHOLOGY-MOUSE
EPA TSCA SECTION 8(B) CHEMICAL INVENTORY
EPA TSCA SECTION 8(D) UNPUBLISHED HEALTH/SAFETY STUDIES
EPA TSCA SECTION 8(E) RISK NOTIFICATION, 8EHQ-0892-9076
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, APRIL 1997
NCI CARCINOGENESIS BIOASSAY (FEED);NO EVIDENCE:MOUSE,RAT
NCITR* NCI-TR-150,79
SECTION 16. - - - - - - - - - - OTHER INFORMATION- - - - - - - - - - - -
THE ABOVE INFORMATION IS BELIEVED TO BE CORRECT BUT DOES NOT PURPORT TO
BE ALL INCLUSIVE AND SHALL BE USED ONLY AS A GUIDE. SIGMA, ALDRICH,
FLUKA SHALL NOT BE HELD LIABLE FOR ANY DAMAGE RESULTING FROM HANDLING
OR FROM CONTACT WITH THE ABOVE PRODUCT. SEE REVERSE SIDE OF INVOICE OR
PACKING SLIP FOR ADDITIONAL TERMS AND CONDITIONS OF SALE.
COPYRIGHT 1997 SIGMA CHEMICAL CO., ALDRICH CHEMICAL CO., INC.,
FLUKA CHEMIE AG
LICENSE GRANTED TO MAKE UNLIMITED PAPER COPIES FOR INTERNAL USE ONLY
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