PRODUCT #: A0500 NAME: ACETAMIDE
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Monday, March 10, 1903 8:14AM
Sigma Chemical Co. Aldrich Chemical Co., Inc. Fluka Chemical Corp.
P.O. Box 14508 1001 West St. Paul 1001 West St. Paul
St. Louis, MO 63178 Milwaukee, WI 53233 Milwaukee, WI 53233
Phone: 314-771-5765 Phone: 414-273-3850 Phone: 414-273-3850
SECTION 1. - - - - - - - - - CHEMICAL IDENTIFICATION- - - - - - - - - -
CATALOG #: A0500
NAME: ACETAMIDE
SECTION 2. - - - - - COMPOSITION/INFORMATION ON INGREDIENTS - - - - - -
CAS #: 60-35-5
MF: C2H5NO
EC NO: 200-473-5
SYNONYMS
ACETIC ACID AMIDE * ACETIMIDIC ACID * AMID KYSELINY OCTOVE (CZECH) *
ETHANAMIDE * METHANECARBOXAMIDE * NCI-C02108 *
SECTION 3. - - - - - - - - - - HAZARDS IDENTIFICATION - - - - - - - - -
LABEL PRECAUTIONARY STATEMENTS
TOXIC
MAY CAUSE CANCER.
MAY CAUSE HERITABLE GENETIC DAMAGE.
IRRITATING TO EYES, RESPIRATORY SYSTEM AND SKIN.
TARGET ORGAN(S):
LIVER
IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE
IMMEDIATELY (SHOW THE LABEL WHERE POSSIBLE).
IN CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF
WATER AND SEEK MEDICAL ADVICE.
DO NOT BREATHE DUST.
WEAR SUITABLE PROTECTIVE CLOTHING, GLOVES AND EYE/FACE
PROTECTION.
SECTION 4. - - - - - - - - - - FIRST-AID MEASURES- - - - - - - - - - -
IN CASE OF CONTACT, IMMEDIATELY FLUSH EYES OR SKIN WITH COPIOUS
AMOUNTS OF WATER FOR AT LEAST 15 MINUTES WHILE REMOVING CONTAMINATED
CLOTHING AND SHOES.
IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING GIVE ARTIFICIAL
RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.
IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS.
CALL A PHYSICIAN.
WASH CONTAMINATED CLOTHING BEFORE REUSE.
SECTION 5. - - - - - - - - - FIRE FIGHTING MEASURES - - - - - - - - - -
EXTINGUISHING MEDIA
WATER SPRAY.
CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM.
SPECIAL FIREFIGHTING PROCEDURES
WEAR SELF-CONTAINED BREATHING APPARATUS AND PROTECTIVE CLOTHING TO
PREVENT CONTACT WITH SKIN AND EYES.
UNUSUAL FIRE AND EXPLOSIONS HAZARDS
EMITS TOXIC FUMES UNDER FIRE CONDITIONS.
SECTION 6. - - - - - - - - ACCIDENTAL RELEASE MEASURES- - - - - - - - -
WEAR SELF-CONTAINED BREATHING APPARATUS, RUBBER BOOTS AND HEAVY
RUBBER GLOVES.
SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL.
AVOID RAISING DUST.
VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE.
Page 1
PRODUCT #: A0500 NAME: ACETAMIDE
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Monday, March 10, 1903 8:14AM
SECTION 7. - - - - - - - - - - HANDLING AND STORAGE- - - - - - - - - - -
REFER TO SECTION 8.
SECTION 8. - - - - - - EXPOSURE CONTROLS/PERSONAL PROTECTION- - - - - -
CHEMICAL SAFETY GOGGLES.
RUBBER GLOVES.
NIOSH/MSHA-APPROVED RESPIRATOR.
SAFETY SHOWER AND EYE BATH.
USE ONLY IN A CHEMICAL FUME HOOD.
AVOID INHALATION.
DO NOT GET IN EYES, ON SKIN, ON CLOTHING.
AVOID PROLONGED OR REPEATED EXPOSURE.
WASH THOROUGHLY AFTER HANDLING.
CARCINOGEN.
MUTAGEN.
IRRITANT.
KEEP TIGHTLY CLOSED.
STORE IN A COOL DRY PLACE.
SECTION 9. - - - - - - - PHYSICAL AND CHEMICAL PROPERTIES - - - - - - -
APPEARANCE AND ODOR
SOLID.
PHYSICAL PROPERTIES
BOILING POINT: 221 C
MELTING POINT: 79 C TO 81 C
VAPOR PRESSURE: 1MM 65 C
SECTION 10. - - - - - - - - -STABILITY AND REACTIVITY - - - - - - - - -
INCOMPATIBILITIES
STRONG OXIDIZING AGENTS
STRONG ACIDS
STRONG BASES
STRONG REDUCING AGENTS
PROTECT FROM MOISTURE.
HAZARDOUS COMBUSTION OR DECOMPOSITION PRODUCTS
TOXIC FUMES OF:
CARBON MONOXIDE, CARBON DIOXIDE
NITROGEN OXIDES
SECTION 11. - - - - - - - - - TOXICOLOGICAL INFORMATION - - - - - - - -
ACUTE EFFECTS
HARMFUL IF SWALLOWED, INHALED, OR ABSORBED THROUGH SKIN.
CAUSES EYE AND SKIN IRRITATION.
MATERIAL IS IRRITATING TO MUCOUS MEMBRANES AND UPPER
RESPIRATORY TRACT.
CHRONIC EFFECTS
CARCINOGEN.
MAY ALTER GENETIC MATERIAL.
TARGET ORGAN(S):
LIVER
TO THE BEST OF OUR KNOWLEDGE, THE CHEMICAL, PHYSICAL, AND
TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED.
RTECS #: AB4025000
ACETAMIDE
TOXICITY DATA
ORL-RAT LD50:7 GM/KG JRPFA4 4,219,1962
IPR-RAT LD50:10300 MG/KG ARZNAD 20,1242,1970
SCU-RAT LD50:10 GM/KG OYYAA2 4,451,1970
IVN-RAT LD50:12500 MG/KG NYKZAU 64(1),42S,1968
UNR-RAT LD50:2300 MG/KG ARZNAD 18,645,1968
ORL-MUS LD50:12900 MG/KG NYKZAU 64(1),42S,1968
Page 2
PRODUCT #: A0500 NAME: ACETAMIDE
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Monday, March 10, 1903 8:14AM
IPR-MUS LD50:1 GM/KG JJIND8 62,911,1979
SCU-MUS LD50:8300 MG/KG OYYAA2 4,451,1970
IVN-MUS LD50:10 GM/KG NYKZAU 64(1),42S,1968
IVN-RBT LD50:7500 MG/KG NYKZAU 64(1),42S,1968
ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES
(RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR
COMPLETE INFORMATION.
SECTION 12. - - - - - - - - - ECOLOGICAL INFORMATION - - - - - - - - - -
DATA NOT YET AVAILABLE.
SECTION 13. - - - - - - - - - DISPOSAL CONSIDERATIONS - - - - - - - - -
DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE SOLVENT AND BURN IN A
CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER.
OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS.
SECTION 14. - - - - - - - - - - TRANSPORT INFORMATION - - - - - - - - -
CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION.
SECTION 15. - - - - - - - - - REGULATORY INFORMATION - - - - - - - - - -
EUROPEAN INFORMATION
EC INDEX NO: 616-022-00-4
TOXIC
R 40
POSSIBLE RISK OF IRREVERSIBLE EFFECTS.
S 36/37
WEAR SUITABLE PROTECTIVE CLOTHING AND GLOVES.
REVIEWS, STANDARDS, AND REGULATIONS
OEL=MAK
IARC CANCER REVIEW:ANIMAL SUFFICIENT EVIDENCE IMSUDL 7,389,1987
IARC CANCER REVIEW:HUMAN NO ADEQUATE DATA IMEMDT 7,197,1974
IARC CANCER REVIEW:GROUP 2B IMSUDL 7,56,1987
OEL-FINLAND;CARCINOGEN JAN 1993
OEL-GERMANY;CARCINOGEN JAN 1993
NOHS 1974: HZD 81686; NIS 17; TNF 404; NOS 21; TNE 4668
NOES 1983: HZD 81686; NIS 4; TNF 132; NOS 4; TNE 2074; TFE 1148
EPA GENETOX PROGRAM 1988, POSITIVE: CARCINOGENICITY-MOUSE/RAT;
SHE-CLONAL ASSAY
EPA GENETOX PROGRAM 1988, POSITIVE: CELL TRANSFORM.-MOUSE EMBRYO
EPA GENETOX PROGRAM 1988, POSITIVE: CELL TRANSFORM.-RLV F344 RAT EMBRYO
EPA GENETOX PROGRAM 1988, NEGATIVE: HOST-MEDIATED ASSAY; E COLI POLA
WITH S9
EPA GENETOX PROGRAM 1988, NEGATIVE: HISTIDINE REVERSION-AMES TEST;
SPERM MORPHOLOGY-MOUSE
EPA GENETOX PROGRAM 1988, NEGATIVE: S CEREVISIAE-HOMOZYGOSIS
EPA GENETOX PROGRAM 1988, INCONCLUSIVE: E COLI POLA WITHOUT S9
EPA TSCA SECTION 8(B) CHEMICAL INVENTORY
EPA TSCA SECTION 8(D) UNPUBLISHED HEALTH/SAFETY STUDIES
ON EPA IRIS DATABASE
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, APRIL 1997
U.S. INFORMATION
THIS PRODUCT IS SUBJECT TO SARA SECTION 313 REPORTING REQUIREMENTS.
CALIFORNIA PROPOSITION 65:
THIS PRODUCT IS OR CONTAINS CHEMICAL(S) KNOWN TO THE STATE OF
CALIFORNIA TO CAUSE CANCER.
SECTION 16. - - - - - - - - - - OTHER INFORMATION- - - - - - - - - - - -
THE ABOVE INFORMATION IS BELIEVED TO BE CORRECT BUT DOES NOT PURPORT TO
BE ALL INCLUSIVE AND SHALL BE USED ONLY AS A GUIDE. SIGMA, ALDRICH,
FLUKA SHALL NOT BE HELD LIABLE FOR ANY DAMAGE RESULTING FROM HANDLING
OR FROM CONTACT WITH THE ABOVE PRODUCT. SEE REVERSE SIDE OF INVOICE OR
PACKING SLIP FOR ADDITIONAL TERMS AND CONDITIONS OF SALE.
Page 3
PRODUCT #: A0500 NAME: ACETAMIDE
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Monday, March 10, 1903 8:14AM
COPYRIGHT 1997 SIGMA CHEMICAL CO., ALDRICH CHEMICAL CO., INC.,
FLUKA CHEMIE AG
LICENSE GRANTED TO MAKE UNLIMITED PAPER COPIES FOR INTERNAL USE ONLY
Page 4
|