PRODUCT #: 4902A NAME: ANILINE
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Monday, March 10, 1903 10:59AM
Sigma Chemical Co. Aldrich Chemical Co., Inc. Fluka Chemical Corp.
P.O. Box 14508 1001 West St. Paul 1001 West St. Paul
St. Louis, MO 63178 Milwaukee, WI 53233 Milwaukee, WI 53233
Phone: 314-771-5765 Phone: 414-273-3850 Phone: 414-273-3850
SECTION 1. - - - - - - - - - CHEMICAL IDENTIFICATION- - - - - - - - - -
CATALOG #: 4902A
NAME: ANILINE
SECTION 2. - - - - - COMPOSITION/INFORMATION ON INGREDIENTS - - - - - -
CAS #: 62-53-3
EC NO: 200-539-3
SYNONYMS
AMINOBENZENE * AMINOPHEN * ANILIN (CZECH) * ANILINA (ITALIAN, POLISH)
* ANILINE (DOT) * ANILINE AND HOMOLOGUES (ACGIH:OSHA) * ANILINE OIL *
ANYVIM * BENZENAMINE * BENZENE, AMINO * BENZIDAM * BLUE OIL * C.I.
76000 * C.I. OXIDATION BASE 1 * CYANOL * HUILE D'ANILINE (FRENCH) *
KRYSTALLIN * KYANOL * NCI-C03736 * PHENYLAMINE * RCRA WASTE NUMBER
U012 * UN1547 (DOT) *
SECTION 3. - - - - - - - - - - HAZARDS IDENTIFICATION - - - - - - - - -
LABEL PRECAUTIONARY STATEMENTS
HIGHLY TOXIC (USA)
TOXIC (EU)
TOXIC BY INHALATION, IN CONTACT WITH SKIN AND IF SWALLOWED.
IRRITATING TO EYES, RESPIRATORY SYSTEM AND SKIN.
RISK OF SERIOUS DAMAGE TO EYES.
POSSIBLE RISK OF IRREVERSIBLE EFFECTS.
CALIF. PROP. 65 CARCINOGEN.
POSSIBLE CARCINOGEN.
POSSIBLE MUTAGEN.
CYANOTIC REAGENT.
COMBUSTIBLE.
POSSIBLE SENSITIZER.
TARGET ORGAN(S):
BLOOD
CENTRAL NERVOUS SYSTEM
READILY ABSORBED THROUGH SKIN.
IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE
IMMEDIATELY (SHOW THE LABEL WHERE POSSIBLE).
IN CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF
WATER AND SEEK MEDICAL ADVICE.
WEAR SUITABLE PROTECTIVE CLOTHING, GLOVES AND EYE/FACE
PROTECTION.
DO NOT BREATHE VAPOR.
SECTION 4. - - - - - - - - - - FIRST-AID MEASURES- - - - - - - - - - -
IN CASE OF CONTACT, IMMEDIATELY FLUSH EYES OR SKIN WITH COPIOUS
AMOUNTS OF WATER FOR AT LEAST 15 MINUTES WHILE REMOVING CONTAMINATED
CLOTHING AND SHOES.
IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING GIVE ARTIFICIAL
RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.
IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS.
CALL A PHYSICIAN.
SECTION 5. - - - - - - - - - FIRE FIGHTING MEASURES - - - - - - - - - -
EXTINGUISHING MEDIA
WATER SPRAY.
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PRODUCT #: 4902A NAME: ANILINE
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Monday, March 10, 1903 10:59AM
CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM.
SPECIAL FIREFIGHTING PROCEDURES
WEAR SELF-CONTAINED BREATHING APPARATUS AND PROTECTIVE CLOTHING TO
PREVENT CONTACT WITH SKIN AND EYES.
COMBUSTIBLE LIQUID.
UNUSUAL FIRE AND EXPLOSIONS HAZARDS
EMITS TOXIC FUMES UNDER FIRE CONDITIONS.
SECTION 6. - - - - - - - - ACCIDENTAL RELEASE MEASURES- - - - - - - - -
EVACUATE AREA.
WEAR SELF-CONTAINED BREATHING APPARATUS, RUBBER BOOTS AND HEAVY
RUBBER GLOVES.
ABSORB ON SAND OR VERMICULITE AND PLACE IN CLOSED CONTAINERS FOR
DISPOSAL.
VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE.
SECTION 7. - - - - - - - - - - HANDLING AND STORAGE- - - - - - - - - - -
REFER TO SECTION 8.
SECTION 8. - - - - - - EXPOSURE CONTROLS/PERSONAL PROTECTION- - - - - -
WEAR APPROPRIATE NIOSH/MSHA-APPROVED RESPIRATOR, CHEMICAL-RESISTANT
GLOVES, SAFETY GOGGLES, OTHER PROTECTIVE CLOTHING.
USE ONLY IN A CHEMICAL FUME HOOD.
SAFETY SHOWER AND EYE BATH.
DO NOT BREATHE VAPOR.
DO NOT GET IN EYES, ON SKIN, ON CLOTHING.
AVOID PROLONGED OR REPEATED EXPOSURE.
READILY ABSORBED THROUGH SKIN.
WASH THOROUGHLY AFTER HANDLING.
HIGHLY TOXIC.
IRRITANT.
POSSIBLE CARCINOGEN.
POSSIBLE MUTAGEN.
POSSIBLE SENSITIZER.
CYANOTIC REAGENT.
KEEP TIGHTLY CLOSED.
KEEP AWAY FROM HEAT AND OPEN FLAME.
STORE IN A COOL DRY PLACE.
SECTION 9. - - - - - - - PHYSICAL AND CHEMICAL PROPERTIES - - - - - - -
APPEARANCE AND ODOR
COLORLESS LIQUID
PHYSICAL PROPERTIES
BOILING POINT: 184 C
MELTING POINT: -6 C
FLASHPOINT 158F
70C
EXPLOSION LIMITS IN AIR:
UPPER 11%
LOWER 1.3%
AUTOIGNITION TEMPERATURE: 1139 F 614C
VAPOR PRESSURE: 0.7MM 25 C 4MM 55 C
SPECIFIC GRAVITY: 1.022
VAPOR DENSITY: 3.22 @ 184 C
SECTION 10. - - - - - - - - -STABILITY AND REACTIVITY - - - - - - - - -
CONDITIONS TO AVOID
MAY DISCOLOR ON EXPOSURE TO AIR.
MAY DISCOLOR ON EXPOSURE TO LIGHT.
INCOMPATIBILITIES
OXIDIZING AGENTS
ACIDS
Page 2
PRODUCT #: 4902A NAME: ANILINE
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Monday, March 10, 1903 10:59AM
BASES
IRON AND IRON SALTS
ALUMINUM
ZINC
SENSITIVE TO LIGHT
HAZARDOUS COMBUSTION OR DECOMPOSITION PRODUCTS
THERMAL DECOMPOSITION MAY PRODUCE CARBON MONOXIDE, CARBON DIOXIDE,
AND NITROGEN OXIDES.
SECTION 11. - - - - - - - - - TOXICOLOGICAL INFORMATION - - - - - - - -
ACUTE EFFECTS
MAY BE FATAL IF INHALED, SWALLOWED, OR ABSORBED THROUGH SKIN.
CAUSES SEVERE EYE IRRITATION.
CAUSES SKIN IRRITATION.
MATERIAL IS IRRITATING TO MUCOUS MEMBRANES AND UPPER
RESPIRATORY TRACT.
SYMPTOMS OF EXPOSURE MAY INCLUDE BURNING SENSATION, COUGHING,
WHEEZING, LARYNGITIS, SHORTNESS OF BREATH, HEADACHE, NAUSEA AND
VOMITING.
ABSORPTION INTO THE BODY LEADS TO THE FORMATION OF METHEMOGLOBIN
WHICH IN SUFFICIENT CONCENTRATION CAUSES CYANOSIS. ONSET MAY BE
DELAYED 2 TO 4 HOURS OR LONGER.
CHRONIC EFFECTS
POSSIBLE CARCINOGEN.
MAY CAUSE ALLERGIC SKIN REACTION.
LABORATORY EXPERIMENTS HAVE SHOWN MUTAGENIC EFFECTS.
TARGET ORGAN(S):
BLOOD
CENTRAL NERVOUS SYSTEM
BLADDER
TO THE BEST OF OUR KNOWLEDGE, THE CHEMICAL, PHYSICAL, AND
TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED.
RTECS #: BW6650000
ANILINE
IRRITATION DATA
SKN-RBT 20 MG/24H MOD 85JCAE -,456,1986
EYE-RBT 102 MG SEV BIOFX* 1-5/1969
EYE-RBT 20 MG/24H MOD 85JCAE -,456,1986
TOXICITY DATA
UNR-MAN LDLO:350 MG/KG JIDHAN 13,87,1931
UNR-MAN LDLO:150 MG/KG 85DCAI 2,73,1970
ORL-RAT LD50:250 MG/KG JPETAB 90,260,1947
SKN-RAT LD50:1400 MG/KG AGGHAR 15,447,1957
IPR-RAT LD50:420 MG/KG AGGHAR 15,447,1957
ORL-MUS LD50:464 MG/KG GTPZAB 13(5),29,1969
IHL-MUS LC50:175 PPM/7H NTIS** PB214-270
IPR-MUS LD50:492 MG/KG IZSBAI 3,91,1965
SCU-MUS LD50:200 MG/KG ARZNAD 8,107,1958
ORL-DOG LD50:195 MG/KG NTIS** PB214-270
SKN-CAT LD50:254 MG/KG GTPZAB 13(5),29,1969
SKN-RBT LD50:820 UL/KG TXAPA9 7,559,1965
IVN-RBT LD50:64 MG/KG NTIS** PB214-270
ORL-GPG LD50:400 MG/KG TSCAT* OTS 206512
SKN-GPG LD50:1290 MG/KG TXAPA9 7,559,1965
IPR-GPG LD50:100 MG/KG TSCAT* OTS 206512
ORL-QAL LD50:750 MG/KG AECTCV 12,355,1983
ORL-MAM LD50:500 MG/KG GTPZAB 32(10),25,1988
IHL-MAM LC50:2500 MG/M3 GTPZAB 32(10),25,1988
Page 3
PRODUCT #: 4902A NAME: ANILINE
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Monday, March 10, 1903 10:59AM
ORL-BWD LD50:562 MG/KG AECTCV 12,355,1983
TARGET ORGAN DATA
LUNGS, THORAX OR RESPIRATION (OTHER CHANGES)
ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES
(RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR
COMPLETE INFORMATION.
SECTION 12. - - - - - - - - - ECOLOGICAL INFORMATION - - - - - - - - - -
DATA NOT YET AVAILABLE.
SECTION 13. - - - - - - - - - DISPOSAL CONSIDERATIONS - - - - - - - - -
THIS COMBUSTIBLE MATERIAL MAY BE BURNED IN A CHEMICAL INCINERATOR
EQUIPPED WITH AN AFTERBURNER AND SCRUBBER.
OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS.
SECTION 14. - - - - - - - - - - TRANSPORT INFORMATION - - - - - - - - -
CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION.
SECTION 15. - - - - - - - - - REGULATORY INFORMATION - - - - - - - - - -
EUROPEAN INFORMATION
EC INDEX NO: 612-008-00-7
TOXIC
R 20/21/22
HARMFUL BY INHALATION, IN CONTACT WITH SKIN AND IF SWALLOWED.
R 40
POSSIBLE RISK OF IRREVERSIBLE EFFECTS.
R 48/23/24/25
TOXIC: DANGER OF SERIOUS DAMAGE TO HEALTH BY PROLONGED EXPOSURE
THROUGH INHALATION, IN CONTACT WITH SKIN AND IF SWALLOWED.
R 50
VERY TOXIC TO AQUATIC ORGANISMS.
S 23
DO NOT BREATHE VAPOR SPRAY.
S 36/37
WEAR SUITABLE PROTECTIVE CLOTHING AND GLOVES.
S 45
IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE
IMMEDIATELY (SHOW THE LABEL WHERE POSSIBLE).
S 61
AVOID RELEASE TO THE ENVIRONMENT. REFER TO SPECIAL INSTRUCTIONS/
SAFETY DATA SHEETS.
REVIEWS, STANDARDS, AND REGULATIONS
OEL=MAK
ACGIH TLV-ANIMAL CARCINOGEN DTLVS* TLV/BEI,1996
ACGIH TLV-TWA 7.6 MG/M3 (2 PPM) (SKIN) DTLVS* TLV/BEI,1996
IARC CANCER REVIEW:ANIMAL LIMITED EVIDENCE IMSUDL 7,99,1987
IARC CANCER REVIEW:ANIMAL INADEQUATE EVIDENCE IMEMDT 4,27,1974
IARC CANCER REVIEW:HUMAN INADEQUATE EVIDENCE IMSUDL 7,99,1987
IARC CANCER REVIEW:GROUP 3 IMSUDL 7,99,1987
MSHA STANDARD-AIR:TWA 5 PPM (19 MG/M3)
DTLVS* 3,13,1971
OSHA PEL (GEN INDU):8H TWA 5 PPM (19 MG/M3) (SKIN)
CFRGBR 29,1910.1000,1994
OSHA PEL (CONSTRUC):8H TWA 5 PPM (19 MG/M3) (SKIN)
CFRGBR 29,1926.55,1994
OSHA PEL (SHIPYARD):8H TWA 5 PPM (19 MG/M3) (SKIN)
CFRGBR 29,1915.1000,1993
OSHA PEL (FED CONT):8H TWA 5 PPM (19 MG/M3) (SKIN)
CFRGBR 41,50-204.50,1994
OEL-ARAB REPUBLIC OF EGYPT:TWA 2 PPM (10 MG/M3);SKIN JAN 1993
OEL-AUSTRALIA:TWA 2 PPM (10 MG/M3);SKIN JAN 1993
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PRODUCT #: 4902A NAME: ANILINE
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Monday, March 10, 1903 10:59AM
OEL-AUSTRIA:TWA 2 PPM (8 MG/M3);SKIN JAN 1993
OEL-BELGIUM:TWA 2 PPM (7.6 MG/M3);SKIN JAN 1993
OEL-DENMARK:TWA 1 PPM (4 MG/M3);SKIN JAN 1993
OEL-FINLAND:TWA 2 PPM (7.6 MG/M3);STEL 4 PPM (15 MG/M3);SKIN;CARCINOGEN
JAN 1993
OEL-FRANCE:TWA 2 PPM (10 MG/M3);SKIN JAN 1993
OEL-GERMANY:TWA 2 PPM (8 MG/M3);SKIN;CARCINOGEN JAN 1993
OEL-HUNGARY:TWA 5 MG/M3;STEL 10 MG/M3;SKIN JAN 1993
OEL-INDIA:TWA 0.2 MG/M3;SKIN JAN 1993
OEL-JAPAN:TWA 1 PPM (3.8 MG/M3);SKIN JAN 1993
OEL-THE NETHERLANDS:TWA 5 PPM (19 MG/M3);SKIN JAN 1993
OEL-THE PHILIPPINES:TWA 5 PPM (19 MG/M3);SKIN JAN 1993
OEL-POLAND:TWA 5 MG/M3;STEL 20 MG/M3;SKIN JAN 1993
OEL-RUSSIA:TWA 1 PPM;STEL 0.1 MG/M3;SKIN JAN 1993
OEL-SWEDEN:TWA 1 PPM (4 MG/M3);STEL 2 PPM (8 MG/M3);SKIN JAN 1993
OEL-SWITZERLAND:TWA 2 PPM (8 MG/M3);STEL 10 PPM (40 MG/M3);SKIN JAN
1993
OEL-TURKEY:TWA 5 PPM (19 MG/M3);SKIN JAN 1993
OEL-UNITED KINGDOM:TWA 2 PPM (10 MG/M3);STEL 5 PPM;SKIN JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA CHECK ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM CHECK ACGIH TLV
NIOSH REL TO ANILINE AND HOMOLOGS-AIR:CA LOWEST FEASIBLE CONC.
NIOSH* DHHS #92-100,1992
NOHS 1974: HZD 06580; NIS 25; TNF 1868; NOS 46; TNE 21859
NOES 1983: HZD 06580; NIS 21; TNF 748; NOS 39; TNE 41988; TFE 14949
EPA GENETOX PROGRAM 1988, POSITIVE: E COLI POLA WITHOUT S9
EPA GENETOX PROGRAM 1988, POSITIVE/DOSE RESPONSE: CELL
TRANSFORM.-BALB/C-3T3
EPA GENETOX PROGRAM 1988, NEGATIVE: SHE-CLONAL ASSAY; E COLI POLA WITH
S9
EPA GENETOX PROGRAM 1988, NEGATIVE: HISTIDINE REVERSION-AMES TEST; S
CEREVISIAE-HOMOZYGOSIS
EPA GENETOX PROGRAM 1988, INCONCLUSIVE: CARCINOGENICITY-MOUSE/RAT
EPA TSCA SECTION 8(B) CHEMICAL INVENTORY
EPA TSCA SECTION 8(D) UNPUBLISHED HEALTH/SAFETY STUDIES
ON EPA IRIS DATABASE
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, APRIL 1997
NIOSH ANALYTICAL METHOD, 1994: AMINES, AROMATIC, 2002
U.S. INFORMATION
THIS PRODUCT IS SUBJECT TO SARA SECTION 313 REPORTING REQUIREMENTS.
CALIFORNIA PROPOSITION 65:
THIS PRODUCT IS OR CONTAINS CHEMICAL(S) KNOWN TO THE STATE OF
CALIFORNIA TO CAUSE CANCER.
SECTION 16. - - - - - - - - - - OTHER INFORMATION- - - - - - - - - - - -
THE ABOVE INFORMATION IS BELIEVED TO BE CORRECT BUT DOES NOT PURPORT TO
BE ALL INCLUSIVE AND SHALL BE USED ONLY AS A GUIDE. SIGMA, ALDRICH,
FLUKA SHALL NOT BE HELD LIABLE FOR ANY DAMAGE RESULTING FROM HANDLING
OR FROM CONTACT WITH THE ABOVE PRODUCT. SEE REVERSE SIDE OF INVOICE OR
PACKING SLIP FOR ADDITIONAL TERMS AND CONDITIONS OF SALE.
COPYRIGHT 1997 SIGMA CHEMICAL CO., ALDRICH CHEMICAL CO., INC.,
FLUKA CHEMIE AG
LICENSE GRANTED TO MAKE UNLIMITED PAPER COPIES FOR INTERNAL USE ONLY
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