PRODUCT #: 11100 NAME: ARSENIC TRIOXIDE
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Monday, March 10, 1903 1:51PM
Sigma Chemical Co. Aldrich Chemical Co., Inc. Fluka Chemical Corp.
P.O. Box 14508 1001 West St. Paul 1001 West St. Paul
St. Louis, MO 63178 Milwaukee, WI 53233 Milwaukee, WI 53233
Phone: 314-771-5765 Phone: 414-273-3850 Phone: 414-273-3850
SECTION 1. - - - - - - - - - CHEMICAL IDENTIFICATION- - - - - - - - - -
CATALOG #: 11100
NAME: ARSENIC TRIOXIDE
SECTION 2. - - - - - COMPOSITION/INFORMATION ON INGREDIENTS - - - - - -
CAS #: 1327-53-3
MF: AS2O3
EC NO: 215-481-4
SYNONYMS
ACIDE ARSENIEUX (FRENCH) * ANHYDRIDE ARSENIEUX (FRENCH) * ARSENIC
BLANC (FRENCH) * ARSENIC OXIDE * ARSENIC(III) OXIDE * ARSENIC
SESQUIOXIDE * ARSENIC TRIOXIDE (ACGIH:DOT) * ARSENICUM ALBUM *
ARSENIGEN SAURE (GERMAN) * ARSENIOUS ACID * ARSENIOUS OXIDE *
ARSENIOUS TRIOXIDE * ARSENITE * ARSENOLITE * ARSENOUS ACID * ARSENOUS
ACID ANHYDRIDE * ARSENOUS ANHYDRIDE * ARSENOUS OXIDE * ARSENOUS OXIDE
ANHYDRIDE * ARSENTRIOXIDE * ARSODENT * CLAUDELITE * CLAUDETITE *
CRUDE ARSENIC * DIARSENIC TRIOXIDE * RCRA WASTE NUMBER P012 * UN1561
(DOT) * WHITE ARSENIC *
SECTION 3. - - - - - - - - - - HAZARDS IDENTIFICATION - - - - - - - - -
LABEL PRECAUTIONARY STATEMENTS
HIGHLY TOXIC (USA)
VERY TOXIC (EU)
MAY CAUSE CANCER.
MAY CAUSE HERITABLE GENETIC DAMAGE.
VERY TOXIC IF SWALLOWED.
TOXIC BY INHALATION AND IN CONTACT WITH SKIN.
CAUSES BURNS.
DANGER: CONTAINS INORGANIC ARSENIC. CANCER HAZARD. HARMFUL IF
INHALED OR SWALLOWED. USE ONLY WITH ADEQUATE VENTILATION OR
RESPIRATORY PROTECTION.
SENSITIZER.
TARGET ORGAN(S):
G.I. SYSTEM
HEART
AVOID CONTACT WITH METALS.
AVOID CONTACT WITH ACID.
AVOID EXPOSURE - OBTAIN SPECIAL INSTRUCTIONS BEFORE USE.
IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE
IMMEDIATELY (SHOW THE LABEL WHERE POSSIBLE).
WEAR SUITABLE PROTECTIVE CLOTHING, GLOVES AND EYE/FACE
PROTECTION.
DO NOT BREATHE DUST.
SECTION 4. - - - - - - - - - - FIRST-AID MEASURES- - - - - - - - - - -
IN CASE OF CONTACT, IMMEDIATELY FLUSH EYES OR SKIN WITH COPIOUS
AMOUNTS OF WATER FOR AT LEAST 15 MINUTES WHILE REMOVING CONTAMINATED
CLOTHING AND SHOES.
ASSURE ADEQUATE FLUSHING OF THE EYES BY SEPARATING THE EYELIDS
WITH FINGERS.
IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING GIVE ARTIFICIAL
RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.
Page 1
PRODUCT #: 11100 NAME: ARSENIC TRIOXIDE
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Monday, March 10, 1903 1:51PM
IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS.
CALL A PHYSICIAN IMMEDIATELY.
SECTION 5. - - - - - - - - - FIRE FIGHTING MEASURES - - - - - - - - - -
EXTINGUISHING MEDIA
NONCOMBUSTIBLE.
USE EXTINGUISHING MEDIA APPROPRIATE TO SURROUNDING FIRE CONDITIONS.
SPECIAL FIREFIGHTING PROCEDURES
WEAR SELF-CONTAINED BREATHING APPARATUS AND PROTECTIVE CLOTHING TO
PREVENT CONTACT WITH SKIN AND EYES.
UNUSUAL FIRE AND EXPLOSIONS HAZARDS
EMITS TOXIC FUMES UNDER FIRE CONDITIONS.
SECTION 6. - - - - - - - - ACCIDENTAL RELEASE MEASURES- - - - - - - - -
EVACUATE AREA.
WEAR SELF-CONTAINED BREATHING APPARATUS, RUBBER BOOTS AND HEAVY
RUBBER GLOVES.
WEAR DISPOSABLE COVERALLS AND DISCARD THEM AFTER USE.
SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL.
VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE.
SECTION 7. - - - - - - - - - - HANDLING AND STORAGE- - - - - - - - - - -
REFER TO SECTION 8.
SECTION 8. - - - - - - EXPOSURE CONTROLS/PERSONAL PROTECTION- - - - - -
WEAR APPROPRIATE NIOSH/MSHA-APPROVED RESPIRATOR, CHEMICAL-RESISTANT
GLOVES, SAFETY GOGGLES, OTHER PROTECTIVE CLOTHING.
SAFETY SHOWER AND EYE BATH.
USE ONLY IN A CHEMICAL FUME HOOD.
FACESHIELD (8-INCH MINIMUM).
DO NOT BREATHE DUST.
DO NOT GET IN EYES, ON SKIN, ON CLOTHING.
AVOID PROLONGED OR REPEATED EXPOSURE.
WASH THOROUGHLY AFTER HANDLING.
KEEP AWAY FROM COMBUSTIBLE MATERIALS, HEAT, SPARKS, AND OPEN FLAME.
STORE IN A COOL DRY PLACE.
SECTION 9. - - - - - - - PHYSICAL AND CHEMICAL PROPERTIES - - - - - - -
APPEARANCE AND ODOR
WHITE GRANULAR POWDER
SECTION 10. - - - - - - - - -STABILITY AND REACTIVITY - - - - - - - - -
STABILITY
STABLE.
INCOMPATIBILITIES
HEAT
ACIDS
OXIDIZING AGENTS
HALOGENS
METALS
MAY DECOMPOSE ON EXPOSURE TO MOIST AIR OR WATER.
HAZARDOUS COMBUSTION OR DECOMPOSITION PRODUCTS
TOXIC FUMES OF:
ARSENIC OXIDES
HAZARDOUS POLYMERIZATION
WILL NOT OCCUR.
SECTION 11. - - - - - - - - - TOXICOLOGICAL INFORMATION - - - - - - - -
ACUTE EFFECTS
MAY BE FATAL IF SWALLOWED.
HARMFUL IF INHALED OR ABSORBED THROUGH SKIN.
MATERIAL IS EXTREMELY DESTRUCTIVE TO TISSUE OF THE MUCOUS MEMBRANES
AND UPPER RESPIRATORY TRACT, EYES AND SKIN.
INHALATION MAY RESULT IN SPASM, INFLAMMATION AND EDEMA OF THE
Page 2
PRODUCT #: 11100 NAME: ARSENIC TRIOXIDE
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Monday, March 10, 1903 1:51PM
LARYNX AND BRONCHI, CHEMICAL PNEUMONITIS AND PULMONARY EDEMA.
SYMPTOMS OF EXPOSURE MAY INCLUDE BURNING SENSATION, COUGHING,
WHEEZING, LARYNGITIS, SHORTNESS OF BREATH, HEADACHE, NAUSEA AND
VOMITING.
MAY CAUSE ALLERGIC RESPIRATORY REACTION.
EXPOSURE TO ARSENIC COMPOUNDS CAN CAUSE BURNING AND DRYNESS OF THE ORAL
AND NASAL CAVITIES, MUSCLE SPASMS, IRRITATION OF THE GASTROINTESTINAL
TRACT, NAUSEA, VOMITING AND DIARRHEA WHICH CAN PROGRESS TO SHOCK AND
DEATH.
PROLONGED EXPOSURE TO ARSENIC COMPOUNDS CAN CAUSE EXFOLIATION AND
PIGMENTATION OF SKIN, HERPES, INFLAMMATION OF NERVES AND NASAL
SEPTUM ULCERATION.
DRY MOUTH, A METALLIC TASTE, DROWSINESS, LOSS OF APPETITE, EXCESSIVE
SALIVATION, NAUSEA, VOMITING AND A FOUL, GARLIC-LIKE BREATH.
CHRONIC EFFECTS
THIS IS OR CONTAINS A COMPONENT THAT HAS BEEN REPORTED TO BE
CARCINOGENIC BASED ON ITS IARC, OSHA, ACGIH, NTP OR EPA CLASSIFICATION.
MAY ALTER GENETIC MATERIAL.
TARGET ORGAN(S):
G.I. SYSTEM
HEART
BRAIN
KIDNEYS
SKIN
BONE MARROW
PERIPHERAL NERVOUS SYSTEM
TO THE BEST OF OUR KNOWLEDGE, THE CHEMICAL, PHYSICAL, AND
TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED.
RTECS #: CG3325000
ARSENIC TRIOXIDE
TOXICITY DATA
ORL-MAN LDLO:29 MG/KG AEMED3 16,702,1987
ORL-MAN LDLO:286 MG/KG JTCTDW 29,45,1991
ORL-HMN LDLO:1429 UG/KG YKYUA6 31,1247,1980
ORL-MAN LDLO:2857 MG/KG JTCTDW 29,131,1991
UNR-MAN LDLO:2941 UG/KG 85DCAI 2,73,1970
ORL-RAT LD50:14600 UG/KG GISAAA 52(1),21,1987
IPR-RAT LD50:871 MG/KG GTPZAB 19(3),30,1975
ORL-MUS LD50:31500 UG/KG CHYCDW 14,86,1980
SCU-MUS LD50:9800 UG/KG PSEBAA 78,392,1951
IVN-MUS LD50:10700 UG/KG PSEBAA 78,392,1951
ORL-RBT LD50:20190 UG/KG CHYCDW 22,284,1988
TARGET ORGAN DATA
BEHAVIORAL (SLEEP)
BEHAVIORAL (MUSCLE WEAKNESS)
CARDIAC (ARRYTHMIAS)
LUNGS, THORAX OR RESPIRATION (OTHER CHANGES)
LUNGS, THORAX OR RESPIRATION (TUMORS)
GASTROINTESTINAL (HYPERMOTILITY, DIARRHEA)
LIVER (LIVER FUNCTION TESTS IMPAIRED)
BLOOD (OTHER CHANGES)
MUSCULO-SKELETAL (OTHER CHANGES)
SKIN AND APPENDAGES (CORROSIVE)
EFFECTS ON FERTILITY (LITTER SIZE)
EFFECTS ON EMBRYO OR FETUS (CYTOLOGICAL CHANGES)
EFFECTS ON EMBRYO OR FETUS (FETOTOXICITY)
SPECIFIC DEVELOPMENTAL ABNORMALITIES (CENTRAL NERVOUS SYSTEM)
Page 3
PRODUCT #: 11100 NAME: ARSENIC TRIOXIDE
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Monday, March 10, 1903 1:51PM
SPECIFIC DEVELOPMENTAL ABNORMALITIES (MUSCULOSKELETAL SYSTEM)
SPECIFIC DEVELOPMENTAL ABNORMALITIES (IMMUNE AND RETICULOENDOTHELIAL SYST
EFFECTS ON NEWBORN (APGAR SCORE)
EFFECTS ON NEWBORN (OTHER NEONATAL MEASURES OR EFFECTS)
EFFECTS ON NEWBORN (BEHAVIORAL)
TUMORIGENIC (NEOPLASTIC BY RTECS CRITERIA)
TUMORIGENIC (EQUIVOCAL TUMORIGENIC AGENT BY RTECS CRITERIA)
ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES
(RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR
COMPLETE INFORMATION.
SECTION 12. - - - - - - - - - ECOLOGICAL INFORMATION - - - - - - - - - -
DATA NOT YET AVAILABLE.
SECTION 13. - - - - - - - - - DISPOSAL CONSIDERATIONS - - - - - - - - -
BURY IN A LANDFILL SITE APPROVED FOR THE DISPOSAL OF CHEMICAL
AND HAZARDOUS WASTES.
OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS.
SECTION 14. - - - - - - - - - - TRANSPORT INFORMATION - - - - - - - - -
CONTACT FLUKA CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION.
SECTION 15. - - - - - - - - - REGULATORY INFORMATION - - - - - - - - - -
EUROPEAN INFORMATION
EC INDEX NO: 033-003-00-0
VERY TOXIC
R 45
MAY CAUSE CANCER.
R 28
VERY TOXIC IF SWALLOWED.
R 34
CAUSES BURNS.
S 53
AVOID EXPOSURE - OBTAIN SPECIAL INSTRUCTIONS BEFORE USE.
S 45
IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE
IMMEDIATELY (SHOW THE LABEL WHERE POSSIBLE).
REVIEWS, STANDARDS, AND REGULATIONS
OEL=MAK
IARC CANCER REVIEW:HUMAN LIMITED EVIDENCE IMEMDT 2,48,1973
IARC CANCER REVIEW:HUMAN SUFFICIENT EVIDENCE IMEMDT 23,39,1980
IARC CANCER REVIEW:ANIMAL LIMITED EVIDENCE IMSUDL 7,100,1987
IARC CANCER REVIEW:ANIMAL INADEQUATE EVIDENCE IMEMDT 2,48,1973
IARC CANCER REVIEW:ANIMAL INADEQUATE EVIDENCE IMEMDT 23,39,1980
IARC CANCER REVIEW:GROUP 1 IMSUDL 7,100,1987
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC 54,7740,1989
OSHA-CANCER HAZARD
CFRGBR 29,1910.1018,1987
OEL-AUSTRALIA;CARCINOGEN JAN 1993
OEL-BELGIUM;CARCINOGEN JAN 1993
OEL-FINLAND;CARCINOGEN JAN 1993
OEL-FRANCE:STEL 0.2 PPM;CARCINOGEN JAN 1993
OEL-GERMANY;CARCINOGEN JAN 1993
OEL-JAPAN:STEL 0.5 PPM;CARCINOGEN JAN 1993
OEL-THE PHILIPPINES:TWA 0.1 MG/M3;CARCINOGEN JAN 1993
OEL-SWITZERLAND:TWA 0.15 MG/M3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.1 MG/M3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA CHECK ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM CHECK ACGIH TLV
NIOSH REL TO ARSENIC, INORGANIC-AIR:CA CL 0.002 MG(AS)/M3/15M
Page 4
PRODUCT #: 11100 NAME: ARSENIC TRIOXIDE
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Monday, March 10, 1903 1:51PM
NIOSH* DHHS #92-100,1992
NOHS 1974: HZD 07570; NIS 6; TNF 1284; NOS 6; TNE 3980
NOES 1983: HZD 07570; NIS 8; TNF 107; NOS 16; TNE 4657; TFE 2001
EPA GENETOX PROGRAM 1988, POSITIVE: B SUBTILIS REC ASSAY
EPA TSCA SECTION 8(B) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, APRIL 1997
NIOSH CURRENT INTELLIGENCE BULLETIN 14, 1976
NIOSH ANALYTICAL METHOD, 1994: ARSENIC TRIOXIDE AS AS, 7901
NTP 7TH ANNUAL REPORT ON CARCINOGENS, 1992 : KNOWN TO BE CARCINOGENIC
NTP CARCINOGENESIS STUDIES; SELECTED, APRIL 1997
U.S. INFORMATION
THIS PRODUCT IS SUBJECT TO SARA SECTION 313 REPORTING REQUIREMENTS.
OSHA-REGULATED CARCINOGEN. SEE CFR TITLE 29 PART 1910.1018
CALIFORNIA PROPOSITION 65:
THIS PRODUCT IS OR CONTAINS CHEMICAL(S) KNOWN TO THE STATE OF
CALIFORNIA TO CAUSE CANCER.
SECTION 16. - - - - - - - - - - OTHER INFORMATION- - - - - - - - - - - -
THE ABOVE INFORMATION IS BELIEVED TO BE CORRECT BUT DOES NOT PURPORT TO
BE ALL INCLUSIVE AND SHALL BE USED ONLY AS A GUIDE. SIGMA, ALDRICH,
FLUKA SHALL NOT BE HELD LIABLE FOR ANY DAMAGE RESULTING FROM HANDLING
OR FROM CONTACT WITH THE ABOVE PRODUCT. SEE REVERSE SIDE OF INVOICE OR
PACKING SLIP FOR ADDITIONAL TERMS AND CONDITIONS OF SALE.
COPYRIGHT 1997 SIGMA CHEMICAL CO., ALDRICH CHEMICAL CO., INC.,
FLUKA CHEMIE AG
LICENSE GRANTED TO MAKE UNLIMITED PAPER COPIES FOR INTERNAL USE ONLY
Page 5
|