PRODUCT #: 10415 NAME: ANILINE HYDROCHLORIDE
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Monday, March 10, 1903 11:01AM
Sigma Chemical Co. Aldrich Chemical Co., Inc. Fluka Chemical Corp.
P.O. Box 14508 1001 West St. Paul 1001 West St. Paul
St. Louis, MO 63178 Milwaukee, WI 53233 Milwaukee, WI 53233
Phone: 314-771-5765 Phone: 414-273-3850 Phone: 414-273-3850
SECTION 1. - - - - - - - - - CHEMICAL IDENTIFICATION- - - - - - - - - -
CATALOG #: 10415
NAME: ANILINE HYDROCHLORIDE
SECTION 2. - - - - - COMPOSITION/INFORMATION ON INGREDIENTS - - - - - -
CAS #: 142-04-1
MF: C6H7N.HCL
EC NO: 205-519-8
SYNONYMS
ANILINE CHLORIDE * ANILINE HYDROCHLORIDE (DOT) * ANILINIUM CHLORIDE *
CHLORHYDRATE D'ANILINE (FRENCH) * CHLORID ANILINU (CZECH) * C.I.
76001 * NCI-C03736 HYDROCHLORIDE * PHENYLAMINE HYDROCHLORIDE *
PHENYLAMMONIUM CHLORIDE * SUL ANILINOVA (CZECH) * UN1548 (DOT) * USAF
EK-442 *
SECTION 3. - - - - - - - - - - HAZARDS IDENTIFICATION - - - - - - - - -
LABEL PRECAUTIONARY STATEMENTS
HIGHLY TOXIC (USA)
TOXIC (EU)
TOXIC BY INHALATION, IN CONTACT WITH SKIN AND IF SWALLOWED.
IRRITATING TO EYES, RESPIRATORY SYSTEM AND SKIN.
POSSIBLE RISK OF IRREVERSIBLE EFFECTS.
POSSIBLE CARCINOGEN.
POSSIBLE MUTAGEN.
CYANOTIC REAGENT.
TARGET ORGAN(S):
BLOOD
CENTRAL NERVOUS SYSTEM
IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE
IMMEDIATELY (SHOW THE LABEL WHERE POSSIBLE).
IN CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF
WATER AND SEEK MEDICAL ADVICE.
WEAR SUITABLE PROTECTIVE CLOTHING, GLOVES AND EYE/FACE
PROTECTION.
DO NOT BREATHE DUST.
SECTION 4. - - - - - - - - - - FIRST-AID MEASURES- - - - - - - - - - -
IN CASE OF CONTACT, IMMEDIATELY FLUSH EYES OR SKIN WITH COPIOUS
AMOUNTS OF WATER FOR AT LEAST 15 MINUTES WHILE REMOVING CONTAMINATED
CLOTHING AND SHOES.
IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING GIVE ARTIFICIAL
RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.
IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS.
CALL A PHYSICIAN.
WASH CONTAMINATED CLOTHING BEFORE REUSE.
SECTION 5. - - - - - - - - - FIRE FIGHTING MEASURES - - - - - - - - - -
EXTINGUISHING MEDIA
WATER SPRAY.
CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM.
SPECIAL FIREFIGHTING PROCEDURES
WEAR SELF-CONTAINED BREATHING APPARATUS AND PROTECTIVE CLOTHING TO
PREVENT CONTACT WITH SKIN AND EYES.
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PRODUCT #: 10415 NAME: ANILINE HYDROCHLORIDE
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Monday, March 10, 1903 11:01AM
UNUSUAL FIRE AND EXPLOSIONS HAZARDS
EMITS TOXIC FUMES UNDER FIRE CONDITIONS.
SECTION 6. - - - - - - - - ACCIDENTAL RELEASE MEASURES- - - - - - - - -
WEAR SELF-CONTAINED BREATHING APPARATUS, RUBBER BOOTS AND HEAVY
RUBBER GLOVES.
SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL.
AVOID RAISING DUST.
VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE.
SECTION 7. - - - - - - - - - - HANDLING AND STORAGE- - - - - - - - - - -
REFER TO SECTION 8.
SECTION 8. - - - - - - EXPOSURE CONTROLS/PERSONAL PROTECTION- - - - - -
WEAR APPROPRIATE NIOSH/MSHA-APPROVED RESPIRATOR, CHEMICAL-RESISTANT
GLOVES, SAFETY GOGGLES, OTHER PROTECTIVE CLOTHING.
SAFETY SHOWER AND EYE BATH.
USE ONLY IN A CHEMICAL FUME HOOD.
DO NOT BREATHE DUST.
AVOID CONTACT WITH EYES, SKIN AND CLOTHING.
AVOID PROLONGED OR REPEATED EXPOSURE.
WASH THOROUGHLY AFTER HANDLING.
HIGHLY TOXIC.
IRRITANT.
POSSIBLE CARCINOGEN.
POSSIBLE MUTAGEN.
KEEP TIGHTLY CLOSED.
PROTECT FROM LIGHT.
STORE IN A COOL DRY PLACE.
SECTION 9. - - - - - - - PHYSICAL AND CHEMICAL PROPERTIES - - - - - - -
APPEARANCE AND ODOR
GREEN CRYSTALLINE POWDER
PHYSICAL PROPERTIES
MELTING POINT: 196 TO 198C
FLASHPOINT 381.20F
194C
VAPOR DENSITY: 4.46
SECTION 10. - - - - - - - - -STABILITY AND REACTIVITY - - - - - - - - -
CONDITIONS TO AVOID
MAY DISCOLOR ON EXPOSURE TO LIGHT.
INCOMPATIBILITIES
STRONG OXIDIZING AGENTS
HAZARDOUS COMBUSTION OR DECOMPOSITION PRODUCTS
TOXIC FUMES OF:
CARBON MONOXIDE, CARBON DIOXIDE
NITROGEN OXIDES
HYDROGEN CHLORIDE GAS
SECTION 11. - - - - - - - - - TOXICOLOGICAL INFORMATION - - - - - - - -
ACUTE EFFECTS
MAY BE FATAL IF INHALED, SWALLOWED, OR ABSORBED THROUGH SKIN.
VAPOR OR MIST IS IRRITATING TO THE EYES, MUCOUS MEMBRANES AND UPPER
RESPIRATORY TRACT.
CAUSES SKIN IRRITATION.
SYMPTOMS OF EXPOSURE MAY INCLUDE BURNING SENSATION, COUGHING,
WHEEZING, LARYNGITIS, SHORTNESS OF BREATH, HEADACHE, NAUSEA AND
VOMITING.
ABSORPTION INTO THE BODY LEADS TO THE FORMATION OF METHEMOGLOBIN
WHICH IN SUFFICIENT CONCENTRATION CAUSES CYANOSIS. ONSET MAY BE
DELAYED 2 TO 4 HOURS OR LONGER.
CHRONIC EFFECTS
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PRODUCT #: 10415 NAME: ANILINE HYDROCHLORIDE
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Monday, March 10, 1903 11:01AM
POSSIBLE CARCINOGEN.
MAY CAUSE ALLERGIC SKIN REACTION.
LABORATORY EXPERIMENTS HAVE SHOWN MUTAGENIC EFFECTS.
TARGET ORGAN(S):
BLOOD
CENTRAL NERVOUS SYSTEM
BLADDER
RTECS #: CY0875000
BENZENAMINE, HYDROCHLORIDE
IRRITATION DATA
SKN-RBT 500 MG/24H MOD 28ZPAK -,65,1972
EYE-RBT 20 MG/24H MOD 85JCAE -,459,1986
TOXICITY DATA
ORL-RAT LD50:840 MG/KG TXAPA9 42,417,1977
IPR-RAT LD50:460 MG/KG JPETAB 80,31,1944
ORL-MUS LD50:841 MG/KG NTIS** PB214-270
IPR-MUS LD50:300 MG/KG NTIS** AD277-689
TARGET ORGAN DATA
BLOOD (METHEMOGLOBINEMIA-CARBOXHEMOGLOBINEMIA)
MATERNAL EFFECTS (OTHER EFFECTS ON FEMALE)
EFFECTS ON EMBRYO OR FETUS (FETOTOXICITY)
SPECIFIC DEVELOPMENTAL ABNORMALITIES (BLOOD AND LYMPHATIC SYSTEMS)
ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES
(RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR
COMPLETE INFORMATION.
SECTION 12. - - - - - - - - - ECOLOGICAL INFORMATION - - - - - - - - - -
DATA NOT YET AVAILABLE.
SECTION 13. - - - - - - - - - DISPOSAL CONSIDERATIONS - - - - - - - - -
DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE SOLVENT AND BURN IN A
CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER.
OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS.
SECTION 14. - - - - - - - - - - TRANSPORT INFORMATION - - - - - - - - -
CONTACT FLUKA CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION.
SECTION 15. - - - - - - - - - REGULATORY INFORMATION - - - - - - - - - -
EUROPEAN INFORMATION
EC INDEX NO: 612-009-00-2
TOXIC
R 20/21/22
HARMFUL BY INHALATION, IN CONTACT WITH SKIN AND IF SWALLOWED.
R 40
POSSIBLE RISK OF IRREVERSIBLE EFFECTS.
R 48/23/24/25
TOXIC: DANGER OF SERIOUS DAMAGE TO HEALTH BY PROLONGED EXPOSURE
THROUGH INHALATION, IN CONTACT WITH SKIN AND IF SWALLOWED.
S 28
AFTER CONTACT WITH SKIN, WASH IMMEDIATELY WITH PLENTY OF WATER.
S 36/37
WEAR SUITABLE PROTECTIVE CLOTHING AND GLOVES.
S 45
IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE
IMMEDIATELY (SHOW THE LABEL WHERE POSSIBLE).
REVIEWS, STANDARDS, AND REGULATIONS
OEL=MAK
IARC CANCER REVIEW:ANIMAL LIMITED EVIDENCE IMEMDT 27,39,1982
NOHS 1974: HZD M2301; NIS 3; TNF 136; NOS 2; TNE 260
NOES 1983: HZD M2301; NIS 58; TNF 5101; NOS 38; TNE 82371; TFE 47136
EPA GENETOX PROGRAM 1988, POSITIVE: CELL TRANSFORM.-RLV F344 RAT EMBRYO
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PRODUCT #: 10415 NAME: ANILINE HYDROCHLORIDE
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Monday, March 10, 1903 11:01AM
EPA GENETOX PROGRAM 1988, POSITIVE/DOSE RESPONSE: IN VITRO SCE-NONHUMAN
EPA GENETOX PROGRAM 1988, POSITIVE/LIMITED: CARCINOGENICITY-MOUSE/RAT
EPA GENETOX PROGRAM 1988, NEGATIVE: SPERM MORPHOLOGY-MOUSE
EPA TSCA SECTION 8(B) CHEMICAL INVENTORY
EPA TSCA 8(A) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE
FEREAC 47,26992,82
EPA TSCA SECTION 8(D) UNPUBLISHED HEALTH/SAFETY STUDIES
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, APRIL 1997
NCI CARCINOGENESIS BIOASSAY (FEED);CLEAR EVIDENCE:RAT
NCITR* NCI-TR-130,78
NCI CARCINOGENESIS BIOASSAY (FEED);NO EVIDENCE:MOUSE
NCITR* NCI-TR-130,78
SECTION 16. - - - - - - - - - - OTHER INFORMATION- - - - - - - - - - - -
THE ABOVE INFORMATION IS BELIEVED TO BE CORRECT BUT DOES NOT PURPORT TO
BE ALL INCLUSIVE AND SHALL BE USED ONLY AS A GUIDE. SIGMA, ALDRICH,
FLUKA SHALL NOT BE HELD LIABLE FOR ANY DAMAGE RESULTING FROM HANDLING
OR FROM CONTACT WITH THE ABOVE PRODUCT. SEE REVERSE SIDE OF INVOICE OR
PACKING SLIP FOR ADDITIONAL TERMS AND CONDITIONS OF SALE.
COPYRIGHT 1997 SIGMA CHEMICAL CO., ALDRICH CHEMICAL CO., INC.,
FLUKA CHEMIE AG
LICENSE GRANTED TO MAKE UNLIMITED PAPER COPIES FOR INTERNAL USE ONLY
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