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MSDS Material Safety Data Sheet
CAS

58-55-9

File Name: xenexlabs_com---msds.th060x.asp
                                          MATERIAL SAFETY DATA SHEET
SECTION 1 - PRODUCT IDENTIFICATION AND USE
PRODUCT IDENTIFICATION NUMBER (PIN):
PRODUCT IDENTIFIER
Theophylline TH060X
PRODUCT USE

MANUFACTURERS NAME: SUPPLIERS NAME:
Xenex Labs XENEX LABORATORIES INC.
STREET ADDRESS: STREET ADDRESS:
2402 CANOE AVENUE
CITY: PROVINCE: CITY: PROVINCE:
COQUITLAM B.C.
POSTAL CODE: EMERGENCY TELEPHONE NO: POSTAL CODE: EMERGENCY TELEPHONE NO:
SPE100 V3K 6C2 (CHEMTREC) 1-800-424-9300
SECTION 2 - HAZARDOUS INGREDIENTS
HAZARDOUS INGREDIENTS
% CAS NUMBER LD50 / LC50 OF INGREDIENT
/ CHEMICAL FORMULA
(SPECIFY SPECIES) (SPECIFY ROUTE AND DOSE)

Theophylline 100 58-55-9 RAT 225 mg/kg
C7H8N4O2 MOUSE 235 mg/kg
RABBIT 350 mg/kg



SECTION 3 - PHYSICAL DATA
PHYSICAL STATE AND APPEARANCE ODOR TASTE ODOR THRESHOLD (ppm)
Solid (White crystalline powder) Odorless Bitter Not Available
MELTING POINT (C) BOILING POINT (C) VAPOR PRESSURE VAPOR DENSITY VOLATILITY
274.5掳C (526.1掳F) Not Available Not Available Not Available Not Available
pH SPECIFIC GRAVITY COEFF. WATER/OIL DIST.
Not Available Not Available log (oil/water) = -0.02
DISPERSION PROPERTIES / SOLUBILITY
Partially soluble in cold water. Very slightly soluble in diethyl ether. Soluble in dilute mineral acids. Water solubility: 7,400 mg/l @ 25掳C.
SECTION 4 - FIRE AND EXPLOSION DATA
NO YES
FLAMMABILITY IF YES, UNDER WHAT CONDITIONS?
May be combustible at high temperature - Fine dust dispersed in air in sufficient concentrations, and in the presences of
an ignition source is a potential dust explosion hazard. Material in powder form, capable of creating a dust explosion. As
with most organic solids, fire is possible at elevated temperatures
MEANS OF EXTINCTION
SMALL: Use DRY chemical powder.
LARGE: Use water spray, fog or foam. Do NOT use water jet.
FLASHPOINT (C) AND METHOD FLAMMABLE LIMITS (% BY VOLUME) CRITICAL TEMPERATURE
Not Available UPPER: Not Available LOWER: Not Available Not Available
AUTOIGNITION TEMPERATURE (C) HAZARDOUS COMBUSTION PRODUCTS
Not Available (CO,CO2,NO,NO2) Oxides of carbon, nitrogen. Acrid smoke and fume
SECTION 5 - REACTIVITY DATA
YES NO IF NO, UNDER WHICH CONDITIONS?
CHEMICAL STABILITY
The product is stable - Avoid excess heat, dust generation.

NO YES
INCOMPATIBILITY WITH OTHER SUBSTANCES IF SO, WHICH ONES?
Not Available

REACTIVITY, AND UNDER WHAT CONDITIONS
Not Available

HAZARDOUS DECOMPOSITION PRODUCTS
The products of degradation are as toxic as the product itself
MATERIAL SAFETY DATA SHEET
TH060X
PRODUCT IDENTIFIER
Theophylline
SECTION 6 - TOXICOLOGICAL PROPERTIES
ROUTE OF ENTRY
INGESTION
INHALATION
SKIN CONTACT SKIN ABSORPTION EYE CONTACT
EFFECTS OF ACUTE EXPOSURE TO PRODUCT
Hazardous in case of ingestion. Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of inhalation.
Skin: May cause skin irritation.
Eyes: May cause eye irritation.
Inhalation: May cause respiratory tract irritation.
Ingestion: Harmful if swallowed. Can cause gastrointestinal tract irritation with nausea, vomiting, headache, vague abdominal
discomfort, diarrhea, caffeine-like side effects insomnia, light-headedness, or a feeling of being "spaced-out." Other symptoms may
include excitement, incoordination, tremor, hyperglycemia, metabolic acidosis, cardiac (ventricular)arrhythmias, hypotension,
tachycardia, circulatory failure, respiratory stimulation, seizures/clonic and tonic convulsions, and death.

EFFECTS OF CHRONIC EXPOSURE TO PRODUCT
CARCINOGENIC EFFECTS: Classified 3 (Equivocal evidence.) by NTP. 3 (Not classifiable for human.) by IARC.
MUTAGENIC EFFECTS: Mutagenic for mammalian somatic cells. Mutagenic for bacteria and/or yeast.
The substance may be toxic to kidneys, the nervous system, heart, Smooth Muscle. Repeated or prolonged exposure to
the substance can produce target organs damage. Hazardous in case of ingestion. Slightly hazardous in case of skin
contact (irritant), of inhalation.
Human: passes through the placenta, excreted in maternal milk.
May cause adverse reproductive effects and birth defects (teratogenic) May affect genetic material (mutagenic).
May cause cancer based on animal test data.
Ingestion: Prolonged or repeated ingestion may affect metabolism (weight loss), liver, urinary system (kidneys), blood
(changes in white blood cell count, pigmented or nucleated red blood cells), brain, behavior/central nervous system
(somnolence)
SYNERGISTIC PRODUCTS
EXPOSURE LIMITS IRRITANCY OF PRODUCT SENSITIZATION OF PRODUCT
Not Available Yes Not Available Not Available
REPRODUCTIVE TOXICITY MUTAGENICITY
TERATOGENICITY CARCINOGENICITY
Not Available Not Available As Specified As Specified
SECTION 7 - PREVENTATIVE MEASURE
PERSONAL PROTECTIVE EQUIPMENT
GLOVES (SPECIFY) RESPIRATOR (SPECIFY) EYE (SPECIFY)
Yes ( impervious ) Approved / Certified respirator Safety goggles, face shield
FOOTWEAR (SPECIFY) CLOTHING (SPECIFY) OTHER (SPECIFY)
No Coveralls / Lab coat Eyewash equipment nearby
ENGINEERING CONTROLS (SPECIFY eg. VENTILATION, ENCLOSED PROCESS)
Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
airborne contaminants below the exposure limit.
LEAK AND SPILL PROCEDURE
Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading
water on the contaminated surface.
WASTE DISPOSAL
According to local, provincial, and federal regulations.
HANDLING PROCEDURES AND EQUIPMENT
Keep away from heat. Keep away from sources of ignition. Do not ingest. Do not breathe dust. Avoid contact with skin
and eyes. Wear suitable protective clothing. If feeling unwell seek medical advice immediately and show the container
or label.
STORAGE REQUIREMENTS
Keep container tightly closed. Keep container in a cool, dry, well-ventilated area. Container may be hazardous when
empty since they retain product residues (Dust, Solids) observe all warnings and precautions listed for the product
SPECIAL SHIPPING INFORMATION
Not a DOT controlled material. WHMIS (Canada) CLASS D-1B: Material causing immediate and serious toxic effects
(TOXIC).
MATERIAL SAFETY DATA SHEET
TH060X
PRODUCT IDENTIFIER
Theophylline
SECTION 8 - FIRST AID MEASURES
SPECIFIC MEASURES
Wash with soap and water. Cover the irritated skin with an emollient. Remove contaminated
SKIN
clothing and shoes. Get medical attention if irritation develops. Wash clothing before reuse,
thoroughly clean shoes before reuse.
Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of
EYES
water for at least 15 minutes. Get medical attention if irritation occurs.
If inhaled remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give
INHALATION
oxygen. Get medical attention.
INGESTION Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by
mouth to an unconscious person. Loosen tight clothing such as collar, tie, belt or waistband. If
large quantities of this material are swallowed, call a physician immediately. Get medical attention
if symptoms appear.
IF IRRITATION PERSISTS AND IN ALL OTHER CASES, GET IMMEDIATE MEDICAL ATTENTION.
SECTION 9 - PREPARATION DATE OF M.S.D.S.
All chemicals may pose unknown hazards and should be used with caution. This Material Safety Data Sheet (MSDS) applies only to the material as packa
If this product is combined with other materials, deteriorates, or becomes contaminated, it may pose hazards not mentioned in this MSDS. It shall be the us
responsibility to develop proper methods of handling and personal protection based on the actual conditions of use. While this MSDS is based on technical
data judged to be reliable, Xenex Laboratories Inc. assumes no responsibility for the completeness or accuracy of the information contained herein.


PREPARED BY (GROUP, DEPARTMENT, ETC.) PHONE NUMBER DATE:
CONTROL DEPARTMENT (604) 552 3031 May 09 2007

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