**** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****
+----------------+--------------------------------------+----------+-----------+
| CAS# | Chemical Name | % | EINECS# |
|----------------|--------------------------------------|----------|-----------|
| 75-86-5 |Acetone cyanohydrin | > 98 | 200-909-4 |
+----------------+--------------------------------------+----------+-----------+
Hazard Symbols: T+ N
Risk Phrases: 26/27/28 50
**** SECTION 3 - HAZARDS IDENTIFICATION ****
EMERGENCY OVERVIEW
Very toxic by inhalation, in contact with skin and if swallowed.
Very toxic to aquatic organisms.
Potential Health Effects
Eye:
May cause eye irritation. May cause chemical conjunctivitis and
corneal damage.
Skin:
May be fatal if absorbed through the skin. May be metabolized to
cyanide which in turn acts by inhibiting cytochrome oxidase impairing
cellular respiration. May cause irritation and dermatitis. May cause
cyanosis of the extremities.
Ingestion:
May be fatal if swallowed. May cause gastrointestinal irritation
with nausea, vomiting and diarrhea. May cause liver and kidney
damage. Metabolism may release cyanide, which may result in
headache, dizziness, weakness, collapse, unconsciousness and
possible death. Human fatalities have been reported from acute
poisoning. Ingestion may result in symptoms similar to cyanide
poisoning which is characterized by asphyxiation.
Inhalation:
May cause respiratory tract irritation. May cause liver and kidney
damage. Aspiration may lead to pulmonary edema. May be metabolized to
cyanide which in turns act by inhibiting cytochrome oxidase impairing
cellular respiration. Inhalation may result in symptoms similar to
cyanide poisoning which include tachypnea, hyperpnea (abnormally
rapid or deep breathing), and dyspnea (labored breathing) followed
rapidly by respiratory depression. Pulmonary edema may occur.
Inhalation at high concentrations may cause CNS depression and
asphixiation.
Chronic:
May cause liver and kidney damage. May be metabolized to cyanide
which in turn acts by inhibiting cytochrome oxidase impairing
cellular respiration.
**** SECTION 4 - FIRST AID MEASURES ****
Eyes:
Immediately flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid
immediately.
Skin:
Flush skin with plenty of water for at least 15 minutes while
removing contaminated clothing and shoes. Discard contaminated
clothing in a manner which limits further exposure. SPEEDY ACTION IS
CRITICAL!
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4
cupfuls of milk or water. Never give anything by mouth to an
unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh
air immediately. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen. Do NOT use mouth-to-mouth
resuscitation. If breathing has ceased apply artificial respiration
using oxygen and a suitable mechanical device such as a bag and a
mask.
Notes to Physician:
**** SECTION 5 - FIRE FIGHTING MEASURES ****
General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. Use water spray to keep fire-exposed containers
cool. Water may be ineffective. Material is lighter than water and a
fire may be spread by the use of water. Combustible liquid. Vapors
may be heavier than air. They can spread along the ground and
collect in low or confined areas. Containers may explode when
heated.
Extinguishing Media:
In case of fire, use water, dry chemical, chemical foam, or
alcohol-resistant foam. Use water spray to cool fire-exposed
containers. Water may be ineffective.
**** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth),
then place in suitable container. Avoid runoff into storm sewers and
ditches which lead to waterways. Clean up spills immediately,
observing precautions in the Protective Equipment section. Remove all
sources of ignition. Use a spark-proof tool. Provide ventilation.
**** SECTION 7 - HANDLING and STORAGE ****
Handling:
Wash thoroughly after handling. Wash hands before eating. Remove
contaminated clothing and wash before reuse. Use only in a
well-ventilated area. Empty containers retain product residue,
(liquid and/or vapor), and can be dangerous. Keep container tightly
closed. Keep away from heat, sparks and flame. Do not get on skin or
in eyes. Do not ingest or inhale. Do not pressurize, cut, weld,
braze, solder, drill, grind, or expose empty containers to heat,
sparks or open flames.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of
ignition. Store in a cool, dry place. Store in a tightly closed
container. Store in a cool, dry, well-ventilated area away from
incompatible substances.
**** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****
Engineering Controls:
Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower. Use adequate
ventilation to keep airborne concentrations low.
Exposure Limits
CAS# 75-86-5:
Belgium - STEL: 4.7 ppm VLE; 5.1 mg/m3 VLE
Malaysia: 4.7 ppm Ceiling (as CN); 5 mg/m3 Ceiling (as CN)
Netherlands: 10 ppm STEL; 35 mg/m3 STEL
Netherlands: 1 ppm MAC; 3.5 mg/m3 MAC
Russia: 0.9 mg/m3 TWA
Spain: 5 mg/m3 VLA-EC (as CN)
Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
Follow the OSHA respirator regulations found in 29
CFR 1910.134 or European Standard EN 149. Use a
NIOSH/MSHA or European Standard EN 149 approved
respirator if exposure limits are exceeded or if
irritation or other symptoms are experienced.
**** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****
Physical State: Liquid
Color: colorless
Odor: bitter-almond
pH: Not available.
Vapor Pressure: 1 mbar @ 20 C
Viscosity: Not available.
Boiling Point: 69 deg C
Freezing/Melting Point: -19 deg C
Autoignition Temperature: 688 deg C ( 1,270.40 deg F)
Flash Point: 73.8 deg C ( 164.84 deg F)
Explosion Limits, lower: 2.2
Explosion Limits, upper: 12.0
Decomposition Temperature:
Solubility in water: Freely Soluble.
Specific Gravity/Density: .9320g/cm3
Molecular Formula: C4H7NO
Molecular Weight: 85.11
**** SECTION 10 - STABILITY AND REACTIVITY ****
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, ignition sources, excess heat.
Incompatibilities with Other Materials:
Oxidizing agents
Hazardous Decomposition Products:
Hydrogen cyanide, carbon monoxide, irritating and toxic fumes and
gases, carbon dioxide.
Hazardous Polymerization: Has not been reported.
**** SECTION 11 - TOXICOLOGICAL INFORMATION ****
RTECS#:
CAS# 75-86-5: OD9275000
LD50/LC50:
CAS# 75-86-5: Dermal, guinea pig: LD50 = 150 mg/kg; Oral, mouse:
LD50 = 1898 ug/kg; Oral, rabbit: LD50 = 13500 ug/kg; Oral, rat: LD50
= 18650 ug/kg; Skin, rabbit: LD50 = 17 uL/kg.
Carcinogenicity:
Acetone cyanohydrin -
Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
**** SECTION 12 - ECOLOGICAL INFORMATION ****
Other
For more information, see "HANDBOOK OF ENVIRONMENTAL FATE AND
EXPOSURE DATA."
**** SECTION 13 - DISPOSAL CONSIDERATIONS ****
Dispose of in a manner consistent with federal, state, and local regulations.
**** SECTION 14 - TRANSPORT INFORMATION ****
IATA
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
IMO
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
RID/ADR
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing group:
USA RQ: CAS# 75-86-5: 10 lb final RQ; 4.54 kg final RQ
**** SECTION 15 - REGULATORY INFORMATION ****
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T+ N
Risk Phrases:
R 26/27/28 Very toxic by inhalation, in contact with
skin and if swallowed.
R 50 Very toxic to aquatic organisms.
Safety Phrases:
S 7/9 Keep container tightly closed and in a
well-ventilated place.
S 27 Take off immediately all contaminated clothing.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
S 61 Avoid release to the environment. Refer to
special instructions/safety data sheets.
WGK (Water Danger/Protection)
CAS# 75-86-5: 3
Canada
CAS# 75-86-5 is listed on Canada's DSL List.
CAS# 75-86-5 is listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 75-86-5 is listed on the TSCA inventory.
**** SECTION 16 - ADDITIONAL INFORMATION ****
MSDS Creation Date: 8/24/1997 Revision #6 Date: 3/04/2004
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no way shall the company be
liable for any claims, losses, or damages of any third party or for lost
profits or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if the company has been advised of
the possibility of such damages.
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