=====================  Product Identification  =====================

MSDS NAME:CHLOROAMPHENICOL, 98%, 85744-0
NIIN:00N069770
MSDS Number: CBKVH
=== Responsible Party ===
Company:SIGMA CHEMICAL CO
Box:14508
City:ST LOUIS
State:MO
ZIP:63178
Country:US
Info Phone Num:314-771-5765
Emergency Phone Num:516-467-3535
CAGE:21076
=== Contractor Identification ===
Company:SIGMA CHEMICAL COMPANY
Address:3050 SPRUCE ST
Box:14508
City:ST LOUIS
State:MO
ZIP:63178
Country:US
Phone:314-771-5765
CAGE:21076

=============  Composition/Information on Ingredients  =============

Name:ACETAMIDE, 2,2-DICHLORO-N-(BETA-HYDROXY-ALPHA-
    (HYDROXYMETHYL)-P-NITROPHENETHYL)-, D-(-)-THREO-; (CHLORAMPHENICOL)
CAS:56-75-7
RTECS #:AB6825000
Fraction by Wt: 98%
OSHA PEL:N/K 
ACGIH TLV:N/K 

Name:SUPP DATA:(CARCINOGENIC BY RTECS CRITERIA).
RTECS #:9999999ZZ

Name:EYE PROT:& FULL LENGTH FACESHIELD .
RTECS #:9999999ZZ

=====================  Hazards Identification  =====================

LD50 LC50 Mixture:LD50:(ORAL, RAT) 2500 MG/KG.
Routes of Entry: Inhalation:YES  Skin:YES  Ingestion:YES
Reports of Carcinogenicity:NTP:NO    IARC:YES	 OSHA:NO
Health Hazards Acute and Chronic:ACUTE:HARMFUL IF SWALLOWED, INHALED OR
    ABSORBED THRU SKIN. MAY CAUSE EYE/SKIN IRRIT. CHRONIC:CARCIN. MAY
    ALTER GENETIC MATL. TARGET ORGAN(S):BLOOD, BONE MARROW. TARGET
    ORGAN DATA:BEHAVIORAL (SOMNOLENC E; CONVLS/EFT ON SEIZURE
    THRESHOLD; ATAXIA; COMA). CARDIAC (CARDIAC OUTPUT). VASCULAR (BP
    LOWERING NOT (EFTS OF OVEREXP)
Explanation of Carcinogenicity:CHLORAMPHENICOL:IARC MONOGRAPHS ON EVAL
    OF CARCIN RISK OF CHEMS TO MAN, VOL 50, PG 169, 1990:GROUP 2A.
Effects of Overexposure:HLTH HAZ:CHARACT IN AUTONOMIC SECTION; CHANGE
    IN PLASMA/BLOOD VOL; SHOCK). LUNGS, THORAX/RESP (CYANOSIS; OTHER
    CHANGES). GI (OTHER CHANGES). LIVER (OTHER CHANGES). BLOOD (HEMORR,
    EOSINOPHILIA; APLASTI C ANEMIA; CHANGES IN BONE MARROW NOT INCL IN
    ABOVE; LEUKEMIA). SKIN & APPENDAGES (AFTER SYSTEMIC EXPOS:DERM,
    (SUPP DATA)
Medical Cond Aggravated by Exposure:NONE SPECIFIED BY MANUFACTURER.

=======================  First Aid Measures  =======================

Eyes:IMMEDIATELY FLUSH W/COPIOUS AMOUNTS OF WATER FOR AT
    LEAST 15 MINUTES. SKIN:IMMEDIATELY FLUSH W/COPIOUS AMOUNTS OF WATER
    FOR AT LEAST 15 MINUTES WHILE REMOVING CONTAM CLTHG & SHOES. WASH
    CONTAM CL THG BEFORE REUSE. INHAL:REMOVE TO FRESHAIR. IF NOT
    BREATHING GIVE ARTF RESP. IF BREATHING IS DIFFICULT, GIVE OXYGEN.
    INGEST:WASH OUT MOUTH W/WATER PROVIDED PERSON IS CONSCIOUS. CALL
    MD.

=====================  Fire Fighting Measures  =====================

Extinguishing Media:WATER SPRAY, CARBON DIOXIDE, DRY CHEMICAL POWDER OR
    APPROPRIATE FOAM.
Fire Fighting Procedures:USE NIOSH/MSHA APPROVED SCBA & FULL PROTECTIVE
    EQUIPMENT .
Unusual Fire/Explosion Hazard:EMITS TOXIC FUMES UNDER FIRE CONDITIONS.

==================  Accidental Release Measures  ==================

Spill Release Procedures:EVACUATE AREA. WEAR NIOSH/MSHA APPROVED SCBA,
    RUBBER BOOTS & HEAVY RUBBER GLOVES. SWEEP UP, PLACE IN A BAG & HOLD
    FOR WASTE DISPOSAL. AVOID RAISING DUST. VENTILATE AREA & WASH SPILL
    SITE AFTER MATERIA L PICKUP IS COMPLETE.
Neutralizing Agent:NONE SPECIFIED BY MANUFACTURER.

======================	Handling and Storage  ======================

Handling and Storage Precautions:AVOID INHALATION. DO NOT GET IN EYES,
    ON SKIN, ON CLTHG. AVOID PRLNG/RPTD EXPOS. TOX. CARCIN. MAY CAUSE
    CANCER. MUTAGEN. STORE IN COOL, DRY PLACE.
Other Precautions:MAY CAUSE HERITABLE GENETIC DMG. HARMFUL BY INHAL, IN
    CONT W/SKIN & IF SWALLOWED. IN CASE OF ACCIDENT/IF YOU FEEL UNWELL,
    SEEK MED ADVICE IMMED (SHOW LBL WHERE POSS). DO NOT BREATHE DUST.
    KEEP CNTNR T IGHTLY CLSD IN COOL, WELL VENTED PLACE.

=============  Exposure Controls/Personal Protection  =============

Respiratory Protection:WEAR APPROPRIATE NIOSH/MSHA APPROVED RESPIRATOR.
Ventilation:USE ONLY IN A CHEMICAL FUME HOOD.
Protective Gloves:CHEMICAL-RESISTANT GLOVES.
Eye Protection:ANSI APPROVED CHEM WORKERS GOGGS (ING 3)
Other Protective Equipment:EYE WASH FOUNTAIN & DELUGE SHOWER WHICH MEET
    ANSI DESIGN CRITERIA . WEAR SUITABLE PROTECTIVE CLOTHING.
Work Hygienic Practices:WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health
EFTS OF OVEREXP:ALLERGIC). EFTS ON FERTILITY (OTHER MEASURES OF
    FERTILITY). EFTS ON EMBRYO/FETUS (CYTOLOGICAL CHANGES;
    FETOTOXICITY; FETAL DEATH; OTHER EFTS TO EMBRYO/FETUS). SPECIFIC
    DEVEL ABNORMS (C NS; BODY WALL). EFTS ON NEWBORN (BEHAVIORAL).
    NUTRITIONAL & GROSS METABOLIC (BODY TEMP DECR). TUMORIGENIC (ING 2)

==================  Physical/Chemical Properties  ==================

Melt/Freeze Pt:M.P/F.P Text:>298F,>148C
Appearance and Odor:WHITE POWDER.

=================  Stability and Reactivity Data  =================

Stability Indicator/Materials to Avoid:YES
ACIDS, ACID CHLORIDES, ACID ANHYDRIDES, OXIDIZING AGENTS.
Stability Condition to Avoid:NONE SPECIFIED BY MANUFACTURER.
Hazardous Decomposition Products:CARBON MONOXIDE, CARBON DIOXIDE,
    NITROGEN OXIDES, HYDROGEN CHLORIDE GAS.

====================  Disposal Considerations  ====================

Waste Disposal Methods:DISSOLVE OR MIX MATERIAL W/COMBUSTIBLE SOLVENT &
    BURN IN A CHEMICAL INCINERATOR EQUIPPED W/AFTERBURNER & SCRUBBER.
    OBSERVE ALL FEDERAL, STATE & LOCAL ENVIRONMENTAL REGULATIONS.

 Disclaimer (provided with this information by the compiling agencies):
 This information is formulated for use by elements of the Department
 of Defense.  The United States of America in no manner whatsoever,
 expressly or implied, warrants this information to be accurate and
 disclaims all liability for its use.  Any person utilizing this
 document should seek competent professional advice to verify and
 assume responsibility for the suitability of this information to their
 particular situation.

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