Stock No.: 03-937279-01 Revision Date: 06/01/02
MATERIAL SAFETY DATA SHEET
Section I
Manufacturer's Name: Alltech Associates, Inc.
Address: 2051 Waukegan Road, Deerfield, IL 60015
Emergency Telephone No.: 800-424-9300
Chemical Name: Not applicable
Synonyms: None
Chemical Family: Not applicable
Trade Name: Performance Evaluation Kit
Formula: Not applicable
Formula Weight: Not applicable
CAS Number: None
RTECS Number: None
Section II Hazardous Ingredients
Composition Conc Percent CAS#
reserpine 5 ng/碌L <0.01 50-55-5
methanol solvent 99.9 67-56-1
Section III Physical Data
Melting Point: -137 掳F (-94掳C) [methanol]
Boiling Point: 149掳F (65掳C) [methanol]
Vapor Density (air = 1): 1.11 [methanol]
Solubility in Water: Very Soluble
Specific Gravity (water = 1): 0.7914 [methanol]
Percent Volatile by Volume: 99.9%
Evaporation Rate: (butyl acetate = 1): 4.6 [methanol]
Appearance and Odor: Clear, colorless liquid with characteristic alcoholic odor.
Section IV Fire and Explosion Hazard Data
Flash Point (Method used): 52掳F (-11掳C) (closed cup)
Flammability Limits: Upper 36.0% Lower 6.0%
Extinguishing Media: Dry chemical, carbon dioxide, halon, water spray, or standard foam.
Special Fire Fighting Procedures: None
Unusual Fire and Explosion Hazards: None
Section V Health Hazard Data
Carcinogen Status: None.
Local Effects: Irritant - skin, eyes.
Acute Toxicity Level: Slightly toxic by inhalation, dermal absorption, ingestion.
Target Effects: Neurotoxin, central nervous system depressant.
At Increased Risk from Exposure: Persons with chronic respiratory, liver, kidney, eye or skin diseases.
Inhalation: Narcotic/Neurotoxin
Acute Exposure 鈥? Intoxication may result in a state of inebriation. Within 12-18 hours, coughing,
headache, tinnitus, dullness, anorexia, weakness, vertigo, fatigue, restlessness, insomnia, and leg
cramps may occur, followed by nausea, vomiting, colic, constipation, violent pain in the back, abdomen,
and extremities, muscular incoordination, sweating, cold, clammy extremities, dyspnea, and other signs of
narcosis, then tracheitis, bronchitis, and blepharospasm, apathy or delirium may progress to coma.
Excitement, mania, and convulsions rarely occur. Blurred or dimmed vision with optic neuritis,
nystagmus, dilated, unresponsive pupils, eye pain, concentric constriction of visual fields, photophobia,
and optic nerve atrophy, followed by transient or permanent blindness may occur. Acidosis may result in
rapid and shallow respiration, cyanosis, coma, and hypotension. Mild tachycardia, cardiac depression,
and peripheral neuritis are possible, as well as liver and kidney damage, and cerebral and pulmonary
edema. Death is possible from respiratory failure or circulatory collapse. Prolonged asthenia and partial
or complete loss of vision may be delayed. Irreversible central nervous system effects, including motor
dysfunction with rigidity, spasticity, and hypokinesis, have been reported.
Chronic Exposure - Repeated or prolonged exposure to may cause symptoms such as visual
impairment, possibly blindness, and other effects as in acute exposure. Repeated exposure to 200-375
ppm caused recurrent headaches in workers. Exposure for 4 years to 1200-1800 ppm resulted in marked
diminution of vision and enlargement of the liver in a workman. Fetal developmental abnormalities and
effects on the embryo or fetus have been reported from prolonged exposure to methyl alcohol by
pregnant rats.
First Aid - Remove from exposure area to fresh air immediately. If breathing has stopped, perform
artificial respiration. Keep person warm and at rest. Treat person symptomatically and supportively. Get
medical attention immediately.
Skin Contact: Irritant/ Narcotic/Neurotoxin
Acute Exposure - Contact with liquid may cause irritation. It may be absorbed through the skin to cause
systemic effects including central nervous system depression, narcosis, optic neuritis, and acidosis.
Lethal amounts may be absorbed through intact skin.
Chronic Exposure 鈥? Repeated or prolonged contact with the liquid may cause defatting of the skin
resulting in erythema, scaling, and eczematoid dermatitis. Chronic absorption may result in visual
impairment and optic neuritis and other effects as in acute exposure.
First Aid - Remove contaminated clothing and shoes immediately. Wash affected area with soap or mild
detergent and large amounts of water until no evidence of chemical remains (approximately 15-20
minutes). Get medical attention immediately.
Eye Contact: Irritant
Acute Exposure - Direct contact with the diluted solutions may cause mild irritation and the undiluted
liquid may cause moderate corneal opacity and conjunctival redness in rabbits. Application of a drop of
methanol in rabbits鈥? eyes caused a mild reversible reaction, graded 3 on a scale of 1-10 after 24 hours.
Ingestion, inhalation, or skin absorption may result in blurred or dimmed vision with optic neuritis, eye
pain, atrophy, concentric visual fields, and photophobia, followed by transient or permanent, complete or
bilateral blindness.
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Chronic Exposure - Repeated or prolonged exposure to irritants may cause conjunctivitis. Visual
impairment as described above may indicate chronic exposure by ingestion, inhalation or skin absorption.
First Aid - Wash eyes immediately with large amounts of water or normal saline, occasionally lifting
upper and lower lids, until no evidence of chemical remains (approximately 15-20 minutes). Get medical
attention immediately.
Ingestion: Narcotic/Neurotoxin
Acute Exposure 鈥? Symptoms may be delayed 12-18 hours and may including coughing, headache,
dullness, vertigo, anorexia, weakness, fatigue, vomiting and diarrhea, violent pain in the back, abdomen,
and extremities, muscular incoordination, sweating, cold and clammy extremities, dyspnea, and other
signs of narcosis may occur. Apathy or delirium may progress to coma. Excitement, mania, and
convulsions have occurred rarely. Blurred or dimmed vision with optic neuritis, dilated, unresponsive
pupils, eye pain, concentric constriction of visual fields, photophobia, and optic nerve atrophy, followed by
transient or permanent blindness may occur. Bilateral senorineural deafness has been reported in a
single case. Acidosis may result in rapid, shallow respiration, cyanosis, coma, and hypotension. Mild
tachycardia, cardiac depression, and peripheral neuritis are possible, as well as liver and kidney damage,
and cerebral and pulmonary edema. Death is possible from respiratory failure or circulatory collapse.
The usual fatal dose is 100-250 mL. Prolonged asthenia and partial or complete loss of vision may be
delayed. Irreversible central nervous system effects including motor dysfunction with rigidity, spasticity,
and hypokinesis have been reported.
Chronic Exposure - Repeated or prolonged ingestion may cause visual impairment and, possibly,
blindness. Liver, kidney, and brain damage may occur. Effects on the newborn have been reported
following prolonged exposure to methyl alcohol by pregnant rats.
First Aid 鈥? If ingestion of methanol is discovered within 2 hours, give syrup of ipecac. Lavage thoroughly
with 2-4L of tap water with sodium bicarbonate (20 g/L) added. Get medical attention immediately.
Lavage should be performed by qualified medical personnel.
Antidote:
The following antidote(s) have been recommended. However, the decision whether the severity of
poisoning requires administration of any antidote and actual dose required should be made by qualified
medical personnel.
Methanol Poisoning:
Give ethanol, 50% (100 proof), 1.5 mL/kg orally initially, diluted to not more than 5% solution, followed by
0.5-1.0 mL/kg every 2 hours orally or intravenously for 4 days in order to reduce metabolism of methanol
and to allow time for its excretion. Blood ethanol level should be between 1-1.5 mg/mL.
Oral or intravenous administration of 4-methylpyrazole inhibits alcohol dehydrogenase and has been
used effectively as an antidote for methanol or ethylene glycol poisoning.
Section VI Reactivity Data
Stability: Stable under normal temperatures and pressures in a closed container.
Conditions to Avoid: High temperatures.
Incompatibility (Materials to avoid): Oxidizers, active metals, strong base with halocarbons,
phosphorous trichloride and sodium hypochlorite.
Hazardous Decomposition Products: Toxic oxides of carbon.
Hazardous Polymerization: Has not been reported under normal temperatures and pressures
Conditions to Avoid: Avoid contact with heat, sparks, flames or other sources of ignition. Vapors may
be explosive, avoid overheating of containers.
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Section VII Spill or Leak Procedures
Steps to be taken in case material is released or spilled: Shut off ignition sources. Stop leak if you
can do it without risk. Take up with sand or other absorbent material and place in other containers for
later disposal.
Waste Disposal Method: EPA Hazardous Waste Number D001. Dispose of as an EPA hazardous
waste.
Section VIII Special Protection Information
Respiratory Protection (Specify Type): For large amounts use self-contained breathing apparatus
with full faceplate operated in pressure-demand mode.
Ventilation:
Local Exhaust: Yes Mechanical (General) Yes
Protective Gloves: Impervious to alcohols.
Eye Protection: Splash-proof safety goggles.
Other Protective Equipment: Emergency eyewash.
Section IX Special Precautions
Precautions to be taken in handling and storing: Protect from temperature extremes and direct
sunlight. Should be stored in an acceptably protected and secure flammable liquid storage room.
Other precautions: Emergency eye wash fountains and safety showers should be available in the
vicinity of any potential exposure. Ground and bond metal containers to minimize static sparks.
NOTICE: The information contained in this MSDS description is applicable exclusively to the chemical substances
identified herein and for its intended use as an analytical reference standard or reagent and to the unit quantity
intended for that purpose. The information does not relate to, and may not be appropriate for. any other application
or larger quantity of the substance described. Our products are intended for use by individuals possessing sufficient
technical skill and qualification to use the material with suitable discretion and understanding of risk of handling any
potentially hazardous chemical. The information has been obtained from sources believed to be reliable and
accurate but has not been independently verified by Alltech Associates, Inc. Accordingly, NO REPRESENTATION
OR WARRANTY, EXPRESSED OR IMPLIED. WITH RESPECT TO MERCHANTABILITY AND FITNESS FOR A
PARTICULAR PURPOSE is made with respect to the information contained herein.
ATTENTION: THIS PRODUCT IN TERMS OF CHEMICAL IDENTITY AND THE UNIT AMOUNT PROVIDED IS
INTENDED FOR USE IN CHEMICAL ANALYSIS AND NOT FOR HUMAN CONSUMPTION, NOR ANY OTHER
PURPOSE
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