MATERIAL SAFETY DATA SHEET 1,2,4-TRICHLOROBENZENE
PRODUCT CODE NUMBER(S): 9280-1
PRODUCT IDENTIFICATION FIRE AND EXPLOSION DATA
Chemical Name and Synonyms: 1,2,4-Trichlorobenzene Flammability: Combustible if strongly heated.
Chemical Family: Chlorinated hydrocarbon, halobenzene Extinguishing Media: Water fog or spray, CO2, foam, dry
chemical. Water, as spray or fog, can also be used to cool
Chemical Formula: C6H3Cl3
containers, knock down mist or vapours, flush chemcial
Product Use: Laboratory solvent away from fire. Fight fire from upwind, from a safe distance.
Manufacturer鈥檚 Name and Address: Fire fighters must wear protective equipment (posi-
Caledon Laboratories Ltd. tive-pressure self-contained breathing apparatus) and
clothing (chemical splash suit) sufficient to prevent inhalation
40 Armstrong Avenue
of mist or fumes, and contact with skin and eyes.
Georgetown, Ontario L7G 4R9
Flash Point (Method Used): 105掳C (CC)
Telephone No: (905) 877-0101
Autoignition Temperature: 571掳C
Fax No: (905) 877-6666
Upper Flammable Limit (% by volume): 6.6
Emergency Telephone No: CANUTEC (613) 996-6666
Lower Flammable Limit (% by volume): 2.5
HAZARDOUS INGREDIENTS OF MATERIALS Hazardous Combustion Products: Hydrogen chloride
gas, phosgene gas, toxic and irritating vapours
Ingredients % TLV Units CAS No. Sensitivity to Impact: None
Sensitivity to Static discharge: None identifed
1,2,4-
Trichlorobenzene ~99 5 ppm 120-82-1
TOXICOLOGICAL PROPERTIES AND HEALTH DATA
PHYSICAL DATA
Toxicological Data:
Physical State: Liquid
LD50: (oral, rat) 756 mg/kg; (dermal, rat) 6.139 mg/kg
Odour and Appearance: Clear, colourless liquid, with a
LC50: (rat) 24,445 ppm/4h, 57,000 ppm/15 min
characteristic, aromatic odour. Crystalline solid <17掳C.
Odour Threshold (ppm): Not available
Effects of Acute Exposure to Product:
Vapour Pressure (mm Hg): 1 mm Hg @ 20掳C
Inhaled: Irritating to upper respiratory tract, causing sore
Vapour Density (Air = 1): 6.3
throat, coughing, shortness of breath. More severe expo-
Evaporation Rate (Bu ac=1): Not available
sures can cause central nervous system depression, with
Boiling Point (掳C): 213掳C dizziness, nausea, vomiting, unconsciousness. Can cause
Freezing Point (掳C): 15 to 17掳C liver damage, cardiac arrhythmia. Extreme exposures could
cause pulmonary edema, and even death.
pH: Not applicable
In contact with skin: No human information available.
Specific Gravity: 1.4542 @ 20掳C
Based on animal information, probably irritating to skin,
Coefficient of Water/Oil distribution: LogP(oct)=4.02 causing redness, itching, pain. Readily absorbed through in-
tact skin, causing symptoms as in 鈥淚nhaled鈥?.
SHIPPING DESCRIPTION In contact with eyes: Vapour and liquid Cause severe irri-
tation,with pain, redness, tearing, blurring of vision.
UN: 2321
Ingested: Based on animal information, probably irritating
T.D.G. Class: 6.1
and moderately toxic. Can cause gastrointestinal irritation
Pkg. Group: III with nausea, vomiting, diarrhea, and systemic effects as in
鈥淚nhaled鈥?.
REACTIVITY DATA
Effects of Chronic Exposure to Product:
Chemical Stability: Stable
Prolonged or repeated exposure can cause damage to liver,
Incompatibility with other substances: Reacts violently
spleen, kidneys, nervous system. Prolonged or repeated
with strong oxidizers; reacts with strong bases, amines, al-
kali metals, pure oxygen, Lewis and mineral acids. Exposure skin exposure may cause dermatitis.
to light may cause reaction leading to formation of PCB鈥檚.
Persons with pre-existing eye or skin conditions, or im-
Reactivity: Avoid excessive heat, exposure to light, all igni- paired liver, kideny, or pulmonary function may be more sus-
tion sources, incompatible materials, generation of mist.
ceptible to the effects of this substance.
Hazardous Decomposition Products: At high tempera-
Carcinogenicity: Tumerogenic in animal testing
tures, gives off HCl vapour and small quantities of other
Teratogenicity: Teratoogenic in animal testing
toxic vapours such as phosgene and chlorine.
Reproductive Effects: Efects in animal testing
MSDS 1,2,4-TRICHLOROBENZENE
CODE: 9280-1
Mutagenicity: Some effects in animal testing care not to flush contaminated water into unafffected eye.
Wear protective gloves to avoid contact during first aid pro-
Synergistic Products: None known
cedures. Get medical attention immediately.
PREVENTIVE MEASURES Skin: Under running water, remove contaminated clothing
(including shoes, watches, belts, and rings). Immediately
Engineering Controls: Local exhaust ventilation required. flush the exposed area with large amounts of running water
for five to ten (5-10) minutes, or until no trace of chemical
Respiratory Protection: NIOSH approved chemical car-
remains. Wear protective gloves and other clothing to avoid
tridge respirator with organic vapour cartirdges, to the
contact. Get medical attention. Decontaminate clothing be-
maximum use specified by the respirator supplier. Higher or
fore reuse, or discard.
unknown concentrations, or fire or spill conditions, posi-
Inhalation: Remove to fresh air (caution must be used by
tive-pressure full face-piece self-contained breathing
rescuers to avoid exposure to contaminating fumes). Give
apparatus or positive-pressure full face-piece supplied-air
oxygen for breathing difficulty. If breathing has STOPPED
respirator with auxilliary positive-pressure self-contained
give artificial respiration. If breathing AND PULSE are ab-
breathing apparatus.
sent give CPR. IMMEDIATELY OBTAIN MEDICAL
Eye Protection: Chemical safety goggles, face shield.
ATTENTION. Stay with casualty until medical assistance is
Skin Protection: Tychem脭BR/LV, or Tychem脭TK gloves;
reached.
Viton脭 is adequate for short-term use (less than 4 hrs).
Ingestion: DO NOT INDUCE VOMITING; damger of aspi-
Other protective impervious clothing, sleeves, coveralls,
ration with vomiting. If the casualty is alert and not
boots, sufficient to prevent contact.
convulsing, have him drink 2 to 3 glasses of water to dilute
Other Personal Protective Equipment: An eyewash and the material. Get medical attention immediately. If sponta-
safety shower should be nearby and ready for use. neous vomiting occurs, have casualty lean forward to avoid
Leak and Spill Procedure: Restrict access to area of spill. breathing in of emesis. Rinse mouth and administer more
Ventilate area. Eliminate all sources of ignition. Cleanup water.
personnel must be thoroughly trained in the hazards of the
REFERENCES USED
product and must wear protective equipment and clothing
sufficient to prevent inhalation of mists or vapours and con-
CCINFO: Cheminfo
tact with skin and eyes. Do not touch spilled material. Dike
spills. Prevent from entering sewers or waterways. Collect Budavari: The Merck Index, 12th ed., 1997
on inert absorbent material and transfer to suitable, labelled, Royal Society of Chemistry: Chemical Safety Data Sheets,
covered containers for recovery or disposal. Contaminated
Vol. 1, 1992
material may pose the same hazards as the chemical; treat
Sax, Lewis: Hawley鈥檚 Condensed Chemical Dictionary, 11th
with caution. Flush area of spill with copious amounts of
ed., 1987
running water.
Waste Disposal: Follow all federal, provincial and local Suppliers鈥? Material Safety Data Sheets
regulations for disposal.
ADDITIONAL INFORMATION
Handling Procedures and Equipment: TOXIC,
SKIN/EYE IRRITANT. Workers handling this material must
Date Issued: March 18, 1999
be thoroughly trained in its hazards and its safe use, and
Revision: March 2008
must wear appropriate protective equipment and clothing.
Keep away from heat and ignition sources, and exposure to MSDS: 9280-1
light. Avoid generating mists or vapours. Concentrated va-
Proposed WHMIS Designation: D1B; D2B
pours are heavier than air and will collect in low areas such
as pits and other confined areas. Do not enter these areas
Prepared by: Caledon Laboratories Ltd. (905) 877-0101
where vapour of this product is suspected unless special
Caledon Laboratories Ltd. believes the information contained
breathing apparatus is used. Use the smallest amount pos-
herein is reliable and accurate. Caledon makes no warranty
sible for the purpose, in a a designated area with adequate
ventilation. Follow good housekeeping procedures; keep with respect thereto and expressly disclaims all liability for reli-
work area free of extraneous, combustible, and incompatible ance thereon. Such information is solely for your consider-
substances. Stand upwind of operations. Do not return con- ation, investigation, and verification.
taminated material to the original containers.
Storage Requirements: Solvents should not be stored in
basement premises (risk of accumulation of heavy solvent
vapour). Store in suitable, labelled containers, in a cool, dry,
well-ventilated place, out of direct sunlight, and away from
ignition sources and incompatible materials. Keep air out of
container. Keep container tightly closed when not in use and
when empty. Protect from exposure to light. Protect from
damage, and inspect frequently for signs of leaking. Storage
facilities should be made of fire-resistant materials, and
have raised sills or ramps, with trenching to a safe area.
FIRST AID MEASURES
Specific Measures:
Eyes: Flush eyes with warm running water for at least fif-
teen (15) minutes, holding eyelids open while flushing. Take
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