The MSDS format adheres to the standards and regulatory requirements
of the United States and may not meet regulatory requirements
in other countries.
DuPont Page 1
Material Safety Data Sheet
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"DuPont" "FINESSE" GRASS & BROADLEAF (MP) HERBICIDE
M0000593 Revised 5-MAY-2005
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CHEMICAL PRODUCT/COMPANY IDENTIFICATION
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Material Identification
"FINESSE" is a registered trademark of DuPont.
"DuPont" is a trademark of DuPont.
Tradenames and Synonyms
FLUCARBAZONE SODIUM
CHLORSULFURON
"GLEAN"
"EVEREST" HERBICIDE
Tradenames and Synonyms (Remarks)
"GLEAN" is a registered trademark of DuPont.
"EVEREST" is a registered trademark of Arvesta Corporation.
Company Identification
MANUFACTURER/DISTRIBUTOR
DuPont
1007 Market Street
Wilmington, DE 19898
PHONE NUMBERS
Product Information : 1-800-441-7515 (outside the U.S.
302-774-1000)
Transport Emergency : CHEMTREC 1-800-424-9300(outside U.S.
703-527-3887)
Medical Emergency : 1-800-441-3637 (outside the U.S.
302-774-1000)
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COMPOSITION/INFORMATION ON INGREDIENTS
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Components
Material CAS Number %
FLUCARBAZONE SODIUM 181274-17-9 46.7
(4,5-Dihydro-3-methoxy-4-methyl-5-oxo-N-((2-
(trifluoromethoxy)phenyl)sulfonyl)-1H-1,2,4-
triazole-1-carboxamide, sodium salt)
*CHLORSULFURON 64902-72-3 25.0
(2-Chloro-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-
yl)aminocarbonyl]benzenesulfonamide
INERT INGREDIENTS 28.3
M0000593 DuPont Page 2
Material Safety Data Sheet
(COMPOSITION/INFORMATION ON INGREDIENTS - Continued)
* Disclosure as a toxic chemical is required under Section 313 of
Title III of the Superfund Amendments and Reauthorization Act of 1986
and 40 CFR part 372.
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HAZARDS IDENTIFICATION
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Emergency Overview
CAUTION! Causes moderate eye irritation. Harmful if
absorbed through skin. Avoid contact with skin, eyes, or
clothing. Wash thoroughly with soap and water after
handling.
Potential Health Effects
Based on component animal data, eye contact with DuPont
"FINESSE" GRASS & BROADLEAF (MP) HERBICIDE may cause eye
irritation with tearing, pain or blurred vision.
Carcinogenicity Information
None of the components present in this material at concentrations
equal to or greater than 0.1% are listed by IARC, NTP, OSHA or ACGIH
as a carcinogen.
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FIRST AID MEASURES
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First Aid
IF IN EYES: Hold eye open and rinse slowly and gently with
water for 15-20 minutes. Remove contact lenses, if present,
after the first 5 minutes, then continue rinsing eye. Call
a poison control center or doctor for treatment advice.
IF ON SKIN OR CLOTHING: Take off contaminated clothing.
Rinse skin immediately with plenty of water for 15-20
minutes. Call a poison control center or doctor for
treatment advice.
IF INHALED: No specific intervention is indicated as the
compound is not likely to be hazardous by inhalation.
Consult a physician if necessary.
IF INGESTED: No specific intervention is indicated as the
compound is not likely to be hazardous by ingestion.
Consult a physician if necessary.
Have the product container or label with you when calling
a poison control center or doctor, or going for treatment.
You may also contact 1-800-441-3637 for emergency medical
treatment information.
M0000593 DuPont Page 3
Material Safety Data Sheet
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FIRE FIGHTING MEASURES
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Flammable Properties
Not a fire or explosion hazard.
Like most organic powders or crystals, under severe dusting
conditions, this material may form explosive mixtures in air.
Extinguishing Media
Water Spray, Foam, Dry Chemical, CO2.
Fire Fighting Instructions
Evacuate personnel to a safe area. Wear self-contained breathing
apparatus. Wear full protective equipment. Use water spray.
Runoff from fire control may be a pollution hazard.
If area is exposed to fire and conditions permit, let fire burn
itself out. Burning chemicals may produce by-products more toxic
than the original material. If product is on fire, wear
self-contained breathing apparatus and full protective equipment.
Use water spray. Control runoff.
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ACCIDENTAL RELEASE MEASURES
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Safeguards (Personnel)
NOTE: Review FIRE FIGHTING MEASURES and HANDLING (PERSONNEL)
sections before proceeding with clean-up. Use appropriate
PERSONAL PROTECTIVE EQUIPMENT during clean-up.
Emergency Response - Chemical resistant coveralls, waterproof
gloves, waterproof boots and face/eye protection. If dusting
occurs, use NIOSH approved respirator protection.
Initial Containment
Dike spill. Prevent material from entering sewers, waterways, or
low areas.
Follow applicable Federal, State/Provincial and Local laws/
regulations.
Spill Clean Up
Shovel or sweep up.
M0000593 DuPont Page 4
Material Safety Data Sheet
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HANDLING AND STORAGE
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Handling (Personnel)
Avoid breathing vapors or mist. Avoid breathing dust. Avoid
contact with eyes, skin, or clothing. Wash thoroughly after
handling. Wash clothing after use. Do not store or consume food,
drink or tobacco in areas where they may become contaminated with
this material.
USERS SHOULD: Wash hands before eating, drinking, chewing
gum, using tobacco or using the toilet. Remove clothing if
pesticide gets inside. Then wash thoroughly and put on
clean clothing. Remove PPE immediately after handling this
product. Wash the outside of gloves before removing. As
soon as possible, wash thoroughly and change into clean
clothing.
Handling (Physical Aspects)
Keep away from heat, sparks and flames.
Storage
Store product in original container only in a cool, dry,
well-ventilated place. Keep container tightly closed. Do
not store or consume food, drink or tobacco in areas where
they may become contaminated with this material. Do not
contaminate water, other pesticides, fertilizer, food or
feed in storage.
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EXPOSURE CONTROLS/PERSONAL PROTECTION
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Engineering Controls
Use only with adequate ventilation.
When handlers use closed systems, enclosed cabs, or
aircraft in a manner that meets the requirements listed in
the Worker Protection Standard (WPS) for agricultural
pesticides [40 CFR 170.240(d)(4-6)], the handler PPE
requirements may be reduced or modified as specified in
the WPS.
Personal Protective Equipment
Always follow the label instructions when handling this
product.
Some of the materials that are chemical-resistant to this
product are listed below. If you want more options, follow
the instructions for Category A on an EPA chemical-
resistance category selection chart.
M0000593 DuPont Page 5
Material Safety Data Sheet
(EXPOSURE CONTROLS/PERSONAL PROTECTION - Continued)
Applicators and other handlers must wear:
Long-sleeved shirt and long pants.
Chemical-resistant gloves (Category A) made of materials
such as butyl rubber, natural rubber, neoprene rubber,
or nitrile rubber, all greater than or equal to
14 mils.
Shoes plus socks.
Follow manufacturer鈥檚 instructions for cleaning/maintaining
PPE. If no such instructions for washables, use detergent
and hot water. Keep and wash PPE separately from other
laundry.
PPE required for early entry to treated areas that is
permitted under the Worker Protection Standard and that
involves contact with anything that has been treated, such
as plants, soil, or water, is:
Coveralls.
Chemical-resistant gloves (Category A) made of materials
such as butyl rubber, natural rubber, neoprene rubber,
or nitrile rubber, all greater than or equal to
14 mils.
Shoes plus socks.
Exposure Guidelines
Applicable Exposure Limits
CHLORSULFURON
PEL (OSHA) : None Established
TLV (ACGIH) : None Established
AEL * (DuPont) : 10 mg/m3, 8 & 12 Hr. TWA
* AEL is DuPont鈥檚 Acceptable Exposure Limit. Where governmentally
imposed occupational exposure limits which are lower than the AEL
are in effect, such limits shall take precedence.
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PHYSICAL AND CHEMICAL PROPERTIES
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Physical Data
FLUCARBAZONE SODIUM
Solubility in Water : 3.1% (w/w) for flucarbazone-sodium
pH : N/A
Odor : Slight musty odor
Form : Free flowing granule
Color : Tan
Specific Gravity : N/A
Bulk Density : 33-35 lb/cubic foot
CHLORSULFURON
Solubility in Water : Dispersible
M0000593 DuPont Page 6
Material Safety Data Sheet
(PHYSICAL AND CHEMICAL PROPERTIES - Continued)
pH : 4.5-5.5 @ 1% suspension
Odor : None
Form : Solid
Color : Tan
Specific Gravity : 0.69 @ 25掳C (77掳F)
Density : 0.65-0.75 g/mL
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STABILITY AND REACTIVITY
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Chemical Stability
Stable at normal temperatures and storage conditions.
Incompatibility with Other Materials
None reasonably foreseeable.
Decomposition
Decomposition will not occur.
Polymerization
Polymerization will not occur.
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TOXICOLOGICAL INFORMATION
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# Animal Data
CHLORSULFURON COMPONENT:
Oral LD50: > 5000 mg/kg in rats
(Very low toxicity)
Skin Absorption LD50: > 2000 mg/kg in rabbits
(Slightly to moderately toxic)
The Chlorsulfuron component of this product is a mild
reversible skin irritant, and a moderate eye irritant, but
is not a skin sensitizer in animals.
Chlorsulfuron
Inhalation 4 hour LC50: > 5.5 mg/L in rats
(Very low toxicity by inhalation)
The effects in animals from repeated exposures by
inhalation to Chlorsulfuron include decreased weight gain,
reversible kidney and spleen effects, and bone marrow
changes.
Toxicity described in animals from the administration of a
single dose of Chlorsulfuron include lung changes, weakness
and other nonspecific effects. Repeated dosing caused
M0000593 DuPont Page 7
Material Safety Data Sheet
(TOXICOLOGICAL INFORMATION - Continued)
decreased weight gain, and hematological and clinical
chemical changes. Long-term dosing (500 ppm) resulted in
decreased body weight gain, and slight hematological
changes.
Animal testing indicates that Chlorsulfuron, the active
ingredient, did not show carcinogenic effects.
Developmental toxicity has been observed but only at
maternally toxic dose levels.
Chlorsulfuron did not produce genetic damage in bacterial or
mammalian cell cultures. It did not produce heritable
genetic damage.
FLUCARBAZONE SODIUM COMPONENT
ACUTE (Product Specific Information)
Oral Toxicity: The oral LD50 of this product in male and
female rats is > 5,000 mg/kg.
Dermal Toxicity: The dermal LD50 of this product in male and
female rats is > 2,000 mg/kg.
Inhalation Toxicity: The 4 hour inhalation LC50 (dust) of
this product in rats is > 5.113 mg/L.
Eye Irritation: This product is a moderate irritant to the
cornea and iris (rabbit). Irritation
cleared within 24 hours post-treatment.
Skin Irritation: This product is not a dermal irritant
(rabbit).
Skin Sensitization: This product is not a dermal sensitizer
(guinea pig).
The following information pertains to the active ingredient,
flucarbazone-sodium technical.
Subchronic: In a subacute dermal study, rats were exposed to
technical at 1,000 mg/kg for 6 hr/day for 22 applications.
No systemic effects were observed in the treated animals.
Subacute studies were conducted in rats and mice to
investigate the immunotoxicological potential of technical.
Rats were treated by oral gavage for 2 weeks at doses of
100, 300, 600, 1000 or 2500 mg/kg. Mice were administered
dietary concentrations of 30, 100 or 1000 ppm for 2 weeks.
No treatment-related adverse immunotoxic effects were
determined at the end of the study in either species. The
NOELs for overall toxicity were 300 mg/kg and 1000 ppm, for
rats and mice, respectively.
M0000593 DuPont Page 8
Material Safety Data Sheet
(TOXICOLOGICAL INFORMATION - Continued)
In a 28-day subacute feeding study, technical was
administered to rats at dietary concentrations of 100, 250,
2500 or 10000 ppm. The NOEL was 250 ppm based on immunotoxic
effects (decreased splenic cell counts, increased macrophage
activation and decreased lgA titers). In a Plaque-forming-
cell assay conducted to investigate the immunotoxicological
potential of technical, rats were administered dietary
concentrations of 1000, 5000 or 20000 ppm for 4 weeks. A
special function immunotoxicological test was performed at
the end of exposure. There were no treatment-related
findings observed at dietary levels up to and including
20000 ppm. The NOEL in the Plaque-forming-cell assay was
20000 ppm, the highest dose tested.
Subchronic (90 day) feeding studies were conducted on
technical using mice, rats, and dogs at maximum doses of
7000, 20000, and 50000 ppm, respectively. No treatment-
related findings were observed in mice at dietary levels up
to and including the highest dose tested. In rats, effects
observed included clinical signs of toxicity, changes in
clinical chemistries, immunologic changes, reduced spleen
weights and histopathological findings in the forestomach.
The immunologic changes were completely or largely
reversible with only minimal changes observed at the end of
a 5-week recovery period. When dogs were administered
technical, effects observed included changes in clinical
chemistries, hematological changes, red discoloration of the
gastric mucosa at necropsy, increased liver and adrenal
weights, and histopathological findings (stomach, liver,
kidney, adrenals). The overall NOELs established in these
studies were 7000 ppm for mice, 250 ppm for rats, and 1000
ppm for dogs.
Chronic Toxicity: Dogs were administered flucarbazone-sodium
at dietary concentrations of 200, 1000 or 5000 ppm for 1
year. Effects observed in the study included decreased body
weights, increased levels of ALAT, ASAT, GLDH, and
N-Demethylase, transient decreased levels of thyroxine (T4),
and increased liver weights. The decrease in T4 levels was
most likely related to an increased hepatic clearance and
not a primary effect on the thyroid. This was based on the
absence of effects on the other thyroid biomarkers, the
slightly increased N-Demethylase levels, and the increased
liver weights. The overall NOEL in the dog was 200 ppm. In
a 2-year study, rats were administered flucarbazone-sodium
via the diet. The mean daily intake per kg body weight was
adjusted on a weekly basis to achieve a daily exposure of
2.5, 7.5, 125 or 1000 mg/kg. Effects observed at the end
of the study included decreased body weights, increased food
consumption, and an increased incidence of some gross- and
histopathological-findings observed in the stomach. The
NOEL in the rat was 125 mg/kg.
Carcinogenicity: Flucarbazone-sodium was investigated for
M0000593 DuPont Page 9
Material Safety Data Sheet
(TOXICOLOGICAL INFORMATION - Continued)
carcinogenicity in chronic feeding studies using rats and
mice at maximum levels of 1000 mg/kg and 7000 ppm,
respectively. There was no evidence of a carcinogenic
potential observed in either species.
Mutagenicity: The results of in vitro and in vivo
mutagenicity studies on flucarbazone-sodium are all
negative.
Developmental Toxicity: In a developmental toxicity study
in rats, flucarbazone-sodium was administered by oral gavage
during gestation at doses of 100, 300 or 1000 mg/kg.
Flucarbazone-sodium did not induce any maternal or
developmental toxicity at doses up to and including
1000 mg/kg, the limit dose. The NOEL for maternal and
developmental toxicity in the rat was 1000 mg/kg. In a
developmental toxicity study in rabbits, technical was
administered by oral gavage during gestation at doses of
100, 300, 500, or 1000 mg/kg. Developmental effects such
as abortions, decreased fetal weights, and delayed skeletal
ossification occurred in correlation with systemic maternal
toxicity. The NOEL for both maternal and developmental
toxicity in the rabbit was 100 mg/kg.
Reproduction: In a reproduction study, flucarbazone-sodium
was administered to rats for 2 generations at dietary
concentrations of 50, 4000 or 20000/12000 ppm. The high
dose was reduced to 12000 ppm after five weeks due to a
sharp increase in food intake that resulted in
unphysiologically high feces excretion and water consumption
accompanied by diarrhea. Other parental toxicity included
decreased body weights, decreased organ weights (liver,
uterus, spleen), and an increased incidence of caecal
dilatations. Effects observed in the offspring included
decreased pup weights, decreased liver weights and an
increased incidence of a marbled liver surface and
air-filled stomachs in pups necorpsied at culling. The
overall parental NOEL was 50 ppm. The NOEL for reproductive
toxicity was 4000 ppm.
Neurotoxicity: In an acute neurotoxicity screening study
using rats, flucarbazone-sodium was administered as a single
oral dose at levels of 125, 500 or 2000 mg/kg. Transient
clinical signs of toxicity and neurobehavorial effects were
observed at the high dose without correlating micro-
pathological findings. The NOEL for microscopic lesions
was 2000 mg/kg, the highest dose tested. The NOEL for
overall toxicity was 500 mg/kg. In a 13-week neurotoxicity
screening study, flucarbazone-sodium was administered to
rats at dietary concentrations of 250, 2000 or 20000 ppm.
Body weight and food consumption was reduced at the
high-dose level. Functional observational battery (FOB) and
automated measures of motor and locomotor activity were not
affected by treatment. There were no treatment-related
M0000593 DuPont Page 10
Material Safety Data Sheet
(TOXICOLOGICAL INFORMATION - Continued)
microscopic lesions in neural tissues or skeletal muscle in
any of the treated animals. There was no evidence of
neurotoxicity at any dietary level. The NOEL for
microscopic lesions was 20000 ppm, the highest dose tested.
The NOEL for overall toxicity was 2000 ppm.
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ECOLOGICAL INFORMATION
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Ecotoxicological Information
CHLORSULFURON
AQUATIC TOXICITY:
96 hour LC50 - Sheepshead minnow: > 980 mg/L.
48 hour EC50 - Oysters: 385 mg/L.
AVIAN TOXICITY:
Acute Oral LD50 - Mallard Duck: > 5000 mg/kg.
Acute Oral LD50 - Bobwhite Quail: > 5000 mg/kg
FLUCARBAZONE-SODIUM TECHNICAL
AQUATIC ORGANISM TOXICITY: As with any pesticide, this
product should be used according to label directions and
should be kept out of streams, lakes and other aquatic
habitats of concern.
Fish toxicity:
LC50 (96-hr) > 96.7 mg/L (Rainbow trout)
LC50 (96-hr) > 99.3 mg/L (Bluegill sunfish)
Invertebrate toxicity:
EC50 (48-hr) = 38.8 mg/L (Daphnia magna)
EC50 > 10,000 mg/L (bacteria)
IC50 (96-hr) = 6.4 mg/L (green algae)
AVIAN TOXICITY: Flucarbazone-sodium is not toxic to birds
Acute oral LD50 (Bobwhite quail): > 2000 mg/kg
Subchronic oral LC50: > 4646 mg/kg (Bobwhite quail)
> 4969 mg/kg (Mallard duck)
Reproductive toxicity NOEC: 1311 mg/kg (Bobwhite quail)
223 mg/kg (Mallard duck)
OTHER NON-TARGET ORGANISMS: Flucarbazone-sodium is not
toxic to bees.
The acute LD50 is > 445碌g/bee for oral and > 200 碌g/bee
for direct contact.
M0000593 DuPont Page 11
Material Safety Data Sheet
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DISPOSAL CONSIDERATIONS
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Waste Disposal
Treatment, storage, transportation, and disposal must be
in accordance with applicable Federal, State/provincial,
and local regulations.
ENVIRONMENTAL HAZARDS
Do not apply directly to water, or to areas where surface
water is present, or to intertidal areas below the mean
high water mark. Do not apply when weather conditions
favor drift from areas treated. Do not contaminate water
by cleaning of equipment or disposing of equipment
washwaters or wastes.
Do not allow sprays to drift onto adjacent desirable plants.
Container Disposal
Completely empty bag into application equipment. Then
dispose of bag in a sanitary landfill, or by incineration,
or, if allowed by State and local authorities, by burning.
If burned, stay out of smoke.
Pesticide Disposal
Do not contaminate water, food, or feed by disposal.
Wastes resulting from the use of this product may be
disposed of on site or at an approved waste disposal
facility.
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TRANSPORTATION INFORMATION
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Shipping Information
DOT/IMO
Proper Shipping Name : NOT REGULATED
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REGULATORY INFORMATION
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U.S. Federal Regulations
TITLE III HAZARD CLASSIFICATIONS SECTIONS 311, 312
Acute : Yes
Chronic : No
Fire : No
Reactivity : No
Pressure : No
M0000593 DuPont Page 12
Material Safety Data Sheet
(REGULATORY INFORMATION - Continued)
In the United States this product is regulated by the US
Environmental Protection Agency under the Federal Insecticide,
Fungicide and Rodenticide Act. It is a violation of federal law
to use this product in a manner inconsistent with its labeling.
EPA Reg. No. 352-642
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OTHER INFORMATION
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NFPA, NPCA-HMIS
NFPA Rating
Health :1
Flammability :1
Reactivity :0
NPCA-HMIS Rating
Health :1
Flammability :1
Reactivity :0
Personal Protection rating to be supplied by user depending on use
conditions.
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The data in this Material Safety Data Sheet relates only to the
specific material designated herein and does not relate to use in
combination with any other material or in any process.
Responsibility for MSDS: DuPont Crop Protection
Address : Wilmington, DE 19898
Telephone : 1-888-638-7668
# Indicates updated section.
This information is based upon technical information believed to be
reliable. It is subject to revision as additional knowledge and
experience is gained.
End of MSDS
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