NICHINO AMERICA, INC.
MATERIAL SAFETY DATA SHEET
EDICT鈩? Herbicide/Defoliant
(2.5% EC)
March 9, 2004
NICHINO AMERICA, INC.
M013 NICHINO AMERICA, INC.
MATERIAL SAFETY DATA SHEET
Nichino America, Inc.
EDICT鈩erbicide/Defoliant
1. CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
Product Name: EDICT
Chemical Name: (active ingredient) Pyraflufen ethyl (ethyl 2-chloro-5-(4-chloro-
5-difluoromethoxy-1-methyl-1H-pyrazol-3-
yl) 4 fluorophenoxyacetate
Chemical Formula: C15H13CI2F3N2O4
EPA Registration Number: 71711-7
MSDS Identification Code/Number: 013
Synonyms: EDICT, EDICT-751, EDICT-751 2.5%
End-Use Product Description: For Terrestrial Use as a Cotton Harvest
Aid/Defoliant, Potato Harvest Aid/
Desiccant, for Preplant or Preemergence
Burndown in Cotton, Corn, and Soybeans,
Postemergence Weed Control in Cotton, and
for Noncrop Weed Control
Manufacturer
Main Headquarter: Nihon Nohyaku Co., Ltd., 1-2-5,
Nihonbashi, Chuo-ku, Tokyo 103, JAPAN
Non-emergency information:
Phone: 81-3-3278-0461
Facsimile: 81-3-3281-2443
Emergency information:
Phone: 81-3-3281-1887
US Connection: Nichino America Inc.
4550 New Linden Hill Road, Suite 501,
Wilmington, Delaware 19808, USA
Phone: 302-636-9001
Facsimile: 302-636-9122
Emergency and Health and Safety Inquiries: 1-800-348-5832 (24-hours).
In case of fire or spills, information may be obtained by calling (800) 424-9300. In
case of international shipments, call (703) 527-3887.
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2. COMPOSITION/INFORMATION ON INGREDIENTS
Ingredient Name Exposure Limits Concentration
% by Weight
Pyraflufen ethyl OSHA-PEL: not established 2.6
CAS No.: 129630-19-9 ACGIH-TLV: not established
Other Ingredients, including: 13.0
Emulsifying Agents
84.4
Solvents
3. HAZARDS IDENTIFICATION
************************EMERGENCY OVERVIEW************************
鈥? Corrosive. Causes irreversible eye damage.
鈥? Toxic to fish.
************************************************************************
Potential Health Effects:
Primary route(s) of entry: Skin contact
Eyes: Causes irreversible eye damage
Skin: Can cause moderate skin irritation. Harmful if
absorbed through the skin. Does not cause skin
sensitization in animal studies.
Ingestion: No specific health effects are known for ingestion
of a small amount incidental to routine handling and
use.
Inhalation: No specific health effects are known.
Chronic (cancer information): EPA has determined that pyraflufen-ethyl shows
suggestive evidence of carcinogenicity, but not
sufficient to assess human carcinogenic potential.
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4. FIRST AID MEASURES
Inhalation: Move person to fresh air. If person is not breathing, call 911 or an
ambulance, then give artificial respiration, preferably by mouth-to-
mouth, if possible. Call a poison control center or doctor for further
treatment advice.
Eye Contact: Hold eye open and rinse slowly and gently with water for 15-20 minutes.
Remove contact lenses, if present, after the first 5 minutes, then continue
rinsing eye. Call a poison control center or doctor for treatment advice.
Skin/Clothing Take off contaminated clothing. Rinse skin immediately with plenty
Contact: of water for 15-20 minutes. Call a poison control center or doctor for
treatment advice.
Ingestion: Call a poison control center or doctor for treatment advice. Have person
sip a glass of water if able to swallow. Do not induce vomiting unless
told to do so by the poison control center or doctor. Do not give
anything by mouth to an unconscious person. Avoid alcohol.
5. FIRE FIGHTING MEASURES
86.9oC (188.42 oF)
Flash Point:
Fire and Explosion Hazards: No known explosion characteristics. Will burn to give off toxic
oxides of carbon and nitrogen.
Extinguishing Media: Water, foam, carbon dioxide, or dry powder.
Fire Fighting Instructions: Wear positive pressure self-contained breathing apparatus.
Spray containers with water to keep cool. Avoid runoff from
extinguishing media such as water, foam, and dry chemicals into
ponds, rivers, and lakes due to danger of acute toxicity to aquatic
organisms.
6. ACCIDENTAL RELEASE MEASURES
General and Disposal: Use proper protective equipment to minimize personal exposure
(see Section 8). Take all necessary action to prevent and to
remedy the effects of the spill. Ensure that the disposal is in
compliance with federal or local disposal regulations (see
Section 13). Notify the appropriate authorities immediately (see
Section 15 for any applicable Reportable Quantity (RQ)).
Report to authorities if water enters watercourse or sewer.
Land Spill or Leak: Liquid spills on the floor or other impervious surfaces should be
contained or diked and then absorbed with sawdust, sand,
bentonite, or other absorbent clay. Collect contaminated
absorbent, and place it in a metal drum. Thoroughly scrub the
floor or other impervious surface with a strong industrial-type
detergent and rinse with water.
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Liquid spills that soak into the ground should be dug up and
placed in metal drums. When a large spill or leakage is found,
wear protective clothing and self-breathing apparatus to avoid
exposure.
Avoid contaminated absorbents or water flow into ponds, rivers,
and lakes, due to the danger of acute toxicity to aquatic
organisms.
7. HANDLING AND STORAGE
Handling Precautions: Avoid contact with skin, eyes, or clothing. Do not eat, drink,
smoke, or chew gum or tobacco while handling this product and
until hands and face are thoroughly washed with soap and water.
Do not use the toilet before thoroughly washing hands. Remove
contaminated clothing immediately and wash thoroughly before
reuse
Storage Precautions: Store in the original container. Store in a cool place. Protect
from excessive heat. Avoid direct sunlight and freezing.
8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Engineering Controls: Control airborne concentrations below the exposure guideline
(see Section 2 for any applicable OSHA/ACGIH exposure
limits). Local exhaust ventilation may be necessary under certain
confined conditions.
Eye/Face Protection: Safety glasses; chemical workers goggles.
Skin Protection: Chemical resistant gloves
Respiratory Protection: Ensure good ventilation. If not adequate, use a suitable
respirator.
Other/General Protection: The following personal protective equipment (PPE) must be
worn when using product or upon early entry into treated areas
during the Restricted Entry Interval (REI):
鈥? Coveralls
鈥? Chemical-resistant gloves, such as nitrile or butyl
(waterproof gloves for early entry during REI)
鈥? Shoes plus socks
鈥? Protective eyewear
鈥? For overhead exposure, wear chemical resistant headgear for
applicators and other handlers only
Note: Refer to the product label for applicable details
concerning the 鈥淯ser Safety Recommendations鈥? and the use of
PPE under the EPA Worker Protection Standards (40 CFR Part
170).
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MATERIAL SAFETY DATA SHEET
9. PHYSICAL AND CHEMICAL PROPERTIES
Appearance: Brownish yellow mobile liquid
Odor: Similar to paraffin or naphthalene
Basic Physical Properties:
Physical State: Liquid
Boiling Point: Not required
Melting Point: Not applicable
Vapor Pressure: Not required
1.016 g/cm3 at 20掳C
Density:
Viscosity: 5.34 cP at 25掳C
10. STABILITY AND REACTIVITY
Stability: Stable under normal conditions
Conditions to Avoid (Stability): None known
86.9oC (188.42 oF)
Flash Point:
Auto Ignition: No ignition below 400掳C
Hazardous Polymerization: None
11. TOXICOLOGICAL INFORMATION
The following data were developed using EDICT-751 2.5%EC:
Acute Studies:
Oral LD50 (rat): male: > 5,000 mg/kg (practically nontoxic)
female > 3,712 mg/kg (practically nontoxic)
Dermal LD50 (rat): > 2,000 mg/kg (practically nontoxic)
Inhalation LC50 (rat): > 72.03mg/L (practically nontoxic)
Eye irritation (rabbit): Corrosive/severe irritant
Skin irritation (rabbit): Moderate irritant (primary irritation index: 4.0)
Skin sensitization (guinea pig): Not a sensitizer
The following data were developed using EDICT-751 technical (pyraflufen-ethyl)
Subchronic (Target Organ Effects):
A 90-day rat feeding study was conducted at dose levels up to 15,000 ppm pyraflufen-
ethyl. The NOEL in this study was considered to be 1,000 ppm based on slightly
increased phosphorous concentrations and hepatocytic hypertrophy. The highest dose of
15, 000 ppm resulted in erythocyte toxicity, and mitochondrial changes in the hepatocytes
and the presence of Kupffer cells. Also, at the high dose level, increased kidney weights
and increased absolute and relative spleen weights were observed.
In a 90-day oral toxicity study in dogs, pyraflufen-ethyl was administered at dose levels
up to 1,000 mg/kg/day. No effects in body weight or organ weight, clinical chemistry,
hematology, histopathology, or gross pathology were observed.
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Chronic (Cancer Information):
In a combined 2-year chronic toxicity/oncogenicity study, pyraflufen-ethyl was administered to
CD rats at dietary levels up to 10,000 ppm. Mortality was unaffected by treatment The NOEL
was 17.2 mg/kg/day for males and 21.8 mg/kg/day for females. No evidence of carcinogenicity
was observed.
In a 78-week carcinogenicity study, mice were fed pyraflufen-ethyl in the diet at levels up to
5,000 ppm. An MTD was reached at 1,000 ppm, based on increased liver weight and liver
histopathological changes (including necrosis) seen at this feeding level. In the highest dose
group, effects of pyraflufen-ethyl on hematological parameters were observed. The incidence of
hepatocellular adenoma was increased in animals receiving 5,000 ppm, a dose level considered to
be in excess of a MTD. This benign tumor was likely induced by the adaptive response to the
hepatocellular degeneration and not as a result of any genotoxic potential of pyraflufen-ethyl.
Male and female beagle dogs (4/sex/group) were orally administered pyraflufen-ethyl in gelatin
capsules for 52 weeks at concentrations up to 1,000 mg/kg /day. There were no mortalities and
no clinical signs of toxicity. No treatment-related effects were noted on body weights, food
consumption, hematology and clinical chemistry parameters, urinalysis, ophthmoscopy, and
organ weights. No macro- or microscopic lesions were noted. The NOEL was > 1,000
mg/kg/day.
Carcinogenicity: NTP: No IARC: No OSHA: No
Teratogenicity (Birth Defects):
In a developmental toxicity study in rats, pyraflufen-ethyl was administered by gavage on
gestation days 6-15 and showed no adverse effects on dams or fetuses at dose levels up to and
including a limit dose of 1, 000 mg/kg/day. The maternal and developmental toxicity NOELS
were both >1,000 mg/kg/day.
In a developmental toxicity study in rabbits fed pyraflufen-ethyl up to 150 mg/kg/day, pyraflufen-
ethyl resulted in severe maternal toxicity, including lethality, from gastrointestinal irritation at
doses of 60 and 150 mg/kg/day. The maternal NOEL was 20 mg/kg/day. The NOEL for the
offspring was 60 mg/kg/day, based on increased post-implantation loss observed at 150
mg/kg/day. There was no evidence of developmental toxicity or teratogenicity seen in this study.
Neither the rat nor the rabbit developmental study showed evidence of unique fetal susceptibility
to pyraflufen-ethyl.
Reproductive Effects:
In a multigeneration rat reproduction study conducted at dietary concentrations up to 10,000 ppm,
pyraflufen-ethyl had no effect on reproductive parameters, including mating indices, fertility
index, gestation index, duration of gestation, numbers of implantation sites, numbers and
morphology of epididymal sperm, and estrous cycle at any dose level. The NOAEL was 1,000
ppm based on effects on body weight and histopathological changes in liver and kidney.
Reproductive performance was not affected by pyraflufen-ethyl at the highest dose level of
10,000 ppm. The pup NOAEL was 1,000 ppm, based on decreased body weight at the 10,000
ppm dose level.
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Neurotoxicity:
No neurotoxicity studies have been done because there is no indication based on the structure
chemistry of pyraflufen-ethyl that such a study would be required. There was no neurotoxicity
seen in acute, subchronic, chronic, reproduction, and teratology studies conducted with
pyraflufen-ethyl after exposure in the diet.
Mutagenicity (Genetic Effects):
Pyraflufen-ethyl technical was not mutagenic in any of the genotoxicity studies conducted.
12. ECOLOGICAL INFORMATION
Environmental Precautions:
This product is toxic to fish and aquatic invertebrates. This product may contaminate
water through drift of spray in wind or via runoff events. Use care when applying in
areas aadjacent to any body of wter. Do not apply directly to water, to areas where
surface water is present, or to intertidal areas below the mean high water mark. Do not
contaminate water when disposing of equipment washwater or rinsate. Do not apply
when weather conditions favor drift from treated areas. Do not apply if rainfall is
expected within one hour.
13. DISPOSAL CONSIDERATION
General Disposal Guidance: Any disposal practice must be in compliance with all
federal, state/provincial, and local laws and regulations.
State (provincial) and local requirements for waste
disposal may be more restrictive or otherwise different
from federal laws and regulations. Chemical additions,
processing, storage or otherwise altering this material
may make the waste disposal information presented in
this MSDS incomplete, inaccurate, or otherwise
inappropriate. Waste characterization and disposal
compliance are the responsibility solely of the party
generating the waste or deciding to discard or dispose of
the material. Refer to appropriate federal (RCRA: 40
CFR.261), state/provincial, or local requirements for
proper classification information. For regulatory
information on the ingredient components, see
Section 15.
Do not contaminate water, food, or feed by storage or
disposal. Open dumping is prohibited. Pesticide wastes
are toxic. Improper disposal of excess pesticide, pesti-
cide spray, or rinsate is a violation of Federal law. If
these wastes cannot be disposed of by use according to
label instructions, contact your State Pesticide or Envir-
onnmental Control Agency, or the Hazardous Waste
representative at the nearest EPA Regional Office for
guidance.
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Container Disposal: Do not reuse empty container. Triple rinse (or
equivalent). Then offer for recycling or reconditioning,
or puncture and dispose of in a sanitary landfill, or by
incineration, or if allowed by state and local authorities,
by burning. If burned, stay out of smoke.
RCRA Information:
RCRA Hazardous Waste Ingredients: None
14. TRANSPORT INFORMATION
Proper Shipping Name: None
Dot Shipping Label: None
15. REGULATORY INFORMATION
U.S. Federal Regulatory Information:
EPA Registration Number: 71711-7
TSCA Inventory: Registered pesticide; exempt from TSCA.
SARA Title III Notification and Information:
Section 302 (EHS) Ingredients: None
Section 304 (CERCLA & EHS) Ingredients (RQ): naphthalene (RQ 100 lb)
Section 313 Ingredients: pyrrolidone
Section 311/312 Notifications and Information:
Hazard Classes:
Acute Health Hazard: No
Chronic Health Hazard: Yes
Fire Hazard: No
Sudden Release of Pressure Hazard: No
Reactivity Hazard: No
U.S. State Regulatory Information:
U.S. State Right-to-Know (RTK) Ingredients: naphthalene; xylene
Canadian Regulatory Information:.
CPC Number: None
The MSDS contains all CPR required hazard-related information.
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16. OTHER INFORMATION
HMIS Hazard Rating: Health: 2 Moderate
Fire: 2 Moderate
Reactivity: 0 Minimal
NFPA Hazard Rating: Health: 2 Moderate
Fire: 2 Moderate
Reactivity: 0 Minimal
Spec. Haz.: None
MSDS Identification Code/Number: 013
Prepared By: Dept. of Regulatory Affairs
Phone: 302-636-9001
Date of Printing: 12 May 03
MSDS Revision: New MSDS for new product
Disclaimer of Expressed and Implied Warranties:
This information is provided in good faith but without express or
implied warranty. Buyer assumes all responsibility for safety
and use not in accordance with label instructions.
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