The MSDS format adheres to the standards and regulatory requirements
of the United States and may not meet regulatory requirements
in other countries.
DuPont Page 1
Material Safety Data Sheet
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"BENLATE" SP FUNGICIDE - NON-CA USE ONLY
M0000394 Revised 14-AUG-2001
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CHEMICAL PRODUCT/COMPANY IDENTIFICATION
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Material Identification
"BENLATE" is a registered trademark of DuPont.
Corporate MSDS Number : DU008258
Product Use
FOR SALE AND USE IN STATES OTHER THAN CALIFORNIA
Company Identification
MANUFACTURER/DISTRIBUTOR
DuPont
1007 Market Street
Wilmington, DE 19898
PHONE NUMBERS
Product Information : 1-800-441-7515 (outside the U.S.
302-774-1000)
Transport Emergency : CHEMTREC 1-800-424-9300(outside U.S.
703-527-3887)
Medical Emergency : 1-800-441-3637 (outside the U.S.
302-774-1000)
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COMPOSITION/INFORMATION ON INGREDIENTS
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Components
Material CAS Number %
*BENOMYL 17804-35-2 50
(METHYL 1-(BUTYLCARBAMOYL)-2-
BENZIMIDAZOLECARBAMATE)
INERT INGREDIENTS 50
* Disclosure as a toxic chemical is required under Section 313 of
Title III of the Superfund Amendments and Reauthorization Act of 1986
and 40 CFR part 372.
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Material Safety Data Sheet
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HAZARDS IDENTIFICATION
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Potential Health Effects
CAUTION! May irritate eyes, nose, throat and skin.
ROUTES OF EXPOSURES AND EFFECTS
INGESTION
LD50: > 10,000 mg/kg (fasted rats). Very low toxicity.
INHALATION
4-hour LC50: > 4.01 mg/L (rat). Low to moderately toxic.
DERMAL CONTACT
LD50: > 10,000 mg/kg (rabbit). Very low toxicity by
contact.
DERMAL IRRITATION AND SENSITIZATION
Application to shaved skin of male guinea pigs with
formulated product (in distilled water) produced moderate
sensitization. Tests for dermal irritation produced none to
mild responses.
Repeated exposure to this product may cause a temporary
allergic skin reaction in a few susceptible persons. This
condition should be treated as an allergic contact
dermatitis. There is no evidence of persistent effects or
permanent injury.
EYE IRRITATION
(Rabbit): 10 to 27 mg of dry 50% formulation or 0.1 ml of
10% suspension in mineral oil caused only temporary mild
conjunctival irritation.
CHRONIC STUDIES - BENOMYL
FEEDING STUDIES (Rat, Dog and Mouse)
In two-year feeding studies (with 2,500 ppm, the highest
dietary level), the no observable effect level (NOEL) was
2,500 ppm for rats and 500 ppm for dogs. In dogs fed 2,500
ppm, there was biochemical evidence of impaired liver
function and histological evidence of liver cirrhosis. No
oncogenic effects were observed in rats.
In a two-year feeding study with mice, the NOEL was 500 ppm
except for changes in the liver. This NOEL was based on
reduced body weights, weight effects in the liver and testes
and microscopic changes in these tissues at 1,500 and 5,000
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Material Safety Data Sheet
(HAZARDS IDENTIFICATION - Continued)
ppm. Oncogenic effects were observed in the liver of male
and female mice at all dietary levels (500 to 5,000 ppm).
Other studies with the active metabolite of benomyl in
similar mouse strains produced similar results; however,
oncogenicity was not observed at exposures below 500 ppm.
When an unrelated strain of mice was used, i.e., one with a
much lower background liver tumor incidence among untreated
animals, an oncogenic response was not produced. This was
true for exposures up to and including 5,000 ppm.
TERATOGENICITY (Rat, Rabbit)
Benomyl was not embryotoxic or teratogenic to rats by
dietary administration at levels as high as 5,000 ppm
(equivalent to approximately 373 mg/kg/day). No teratogenic
effects were found in studies with rabbits fed 500 ppm in
the diet (equivalent to approximately 20 mg/kg/day). By
gavage administration, a statistically significant
teratogenic response was obtained at dose levels of 62.5
mg/kg/day and above, but not at 30 mg/kg/day and below.
MUTAGENICITY/GENOTOXICITY
Benomyl has been evaluated in numerous tests for
mutagenicity and genotoxicity. The vast majority of these
tests were negative. The weight of evidence from all studies
indicates that benomyl is not a heritable gene mutagen. It
does not interact with cellular DNA, induce point or germ
cell mutations. Benomyl is not considered clastogenic. The
only genotoxic endpoint for which benomyl produces specific
responses is numerical chromosome aberrations or aneuploidy.
This is the mechanism by which benomyl exerts its fungicidal
activity.
REPRODUCTIVE TOXICITY
Excessive exposures of laboratory animals to benomyl has
reduced testicular weight, lowered sperm counts and reduced
fertility. These effects were accompanied by other
indicators of general toxicity and were reversible in tests
that evaluated effects after exposure was discontinued.
In 2- and 3-generation dietary studies in rats the overall
NOELs for parents and their offspring was 500 ppm (20-30
mg/kg/day). Reduced body weights, testicular weights and
sperm counts were observed at 3,000 and 10,000 ppm.
However, there were no compound-related effects on
fertility, mating behavior or gestation length. Benomyl is
not considered to have selective effects on the reproductive
system. The effects occur at doses that also produce
general toxicity in the laboratory animals.
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Material Safety Data Sheet
(HAZARDS IDENTIFICATION - Continued)
Carcinogenicity Information
None of the components present in this material at concentrations
equal to or greater than 0.1% are listed by IARC, NTP, OSHA or ACGIH
as a carcinogen.
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FIRST AID MEASURES
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First Aid
INHALATION
No specific intervention is indicated as the compound is not
likely to be hazardous by inhalation. Consult a physician if
necessary.
EYE CONTACT
In case of contact, immediately flush eyes with plenty of water
for at least 15 minutes. Call a physician.
INGESTION
No specific intervention is indicated as compound is not likely to
be hazardous by ingestion. Consult a physician if necessary.
SKIN CONTACT
In case of contact, flush skin with plenty of water.
This product may cause a temporary allergic skin reaction in
a few susceptible persons. This condition should be treated
as an allergic dermatitis. There is no evidence of after
effects or permanent injury.
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FIRE FIGHTING MEASURES
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Flammable Properties
May be ignited by heat or open flame.
Flammable solid. Like most organic powders or crystals, under
severe dusting conditions, this material may form explosive
mixtures in air.
Hazardous gases/vapors produced in fire are
n-butylisocyanate.
Extinguishing Media
Water Spray, Dry Chemical.
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Material Safety Data Sheet
(FIRE FIGHTING MEASURES - Continued)
Fire Fighting Instructions
Evacuate personnel to a safe area. Keep personnel removed and
upwind of fire. Wear self-contained breathing apparatus. Wear
full protective equipment. Use water spray. Runoff from fire
control may be a pollution hazard.
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ACCIDENTAL RELEASE MEASURES
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Safeguards (Personnel)
NOTE: Review FIRE FIGHTING MEASURES and HANDLING (PERSONNEL)
sections before proceeding with clean-up. Use appropriate
PERSONAL PROTECTIVE EQUIPMENT during clean-up.
Initial Containment
Dike spill. Prevent material from entering sewers, waterways, or
low areas.
Spill Clean Up
Shovel or sweep up.
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HANDLING AND STORAGE
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Handling (Personnel)
Avoid breathing vapors or mist. Avoid breathing dust. Avoid
contact with eyes, skin, or clothing. Wash thoroughly after
handling. Do not store or consume food, drink or tobacco in areas
where they may become contaminated with this material.
USERS SHOULD: Wash hands before eating, drinking, chewing gum,
using tobacco or using the toilet.
Remove clothing immediately if pesticide gets inside. Then wash
thoroughly and put on clean clothing.
Remove personal protective equipment immediately after handling
this product. Wash the outside of gloves before removing. As
soon as possible, wash thoroughly and change into clean clothing.
Handling (Physical Aspects)
Avoid dust generation. Keep away from heat, sparks and flames.
Storage
Do not allow material to become wet during storage.
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Material Safety Data Sheet
(HANDLING AND STORAGE - Continued)
Store in a well ventilated place. Store product in original
container only. Keep container tightly closed. Provide storage
with automatic extinguishing system. Do not store or consume
food, drink or tobacco in areas where they may become contaminated
with this material.
This product should be segregated from flammable gases and
flammable liquids by at least 10 ft. during warehouse
storage.
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EXPOSURE CONTROLS/PERSONAL PROTECTION
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Engineering Controls
Use only with adequate ventilation.
Personal Protective Equipment
Handlers who may be exposed to the dilute through
application or other tasks must wear:
¸Long-sleeved shirt and long pants.
¸Waterproof gloves and chemical-resistant
¸footwear plus socks.
¸Chemical-resistant apron when cleaning equipment.
Handlers who may be exposed to the concentrate through
mixing, loading, application, or other tasks must wear:
¸Long-sleeved shirt and long pants.
¸Waterproof gloves and chemical-resistant footwear
¸plus socks.
¸Chemical-resistant apron when mixing or loading.
¸For exposures in enclosed areas, a respirator with
¸either an organic vapor-removing cartridge with a
¸prefilter approved for pesticides (MSHA/NIOSH)
¸approval number prefix TC-23C), or a canister
¸approved for pesticides (MSHA/NIOSH approval number
¸prefix TC-14G) or a NIOSH approved respirator with
¸an organic vapor (OV) cartridge or canister with any
¸R, P or HE filter.
¸For exposures outdoors, a dust/mist filtering
¸respirator (MSHA/NIOSH approval number prefix
¸TC-21C) or a NIOSH approved respirator with any R,
¸P or HE filter.
Follow manufacturer’s instructions for cleaning/maintaining
PPE. If no such instructions for washables, use detergent
and hot water. Keep and wash PPE separately from other
laundry.
M0000394 DuPont Page 7
Material Safety Data Sheet
(EXPOSURE CONTROLS/PERSONAL PROTECTION - Continued)
Exposure Guidelines
Applicable Exposure Limits
BENOMYL
PEL (OSHA) : 15 mg/m3, total dust, 8 Hr. TWA
5 mg/m3, respirable dust, 8 Hr. TWA
TLV (ACGIH) : 0.84 ppm, 10 mg/m3, 8 Hr. TWA, A4
AEL * (DuPont) : 5 mg/m3, total dust, 8 & 12 Hr. TWA
* AEL is DuPont’s Acceptable Exposure Limit. Where governmentally
imposed occupational exposure limits which are lower than the AEL
are in effect, such limits shall take precedence.
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PHYSICAL AND CHEMICAL PROPERTIES
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Physical Data
Odor : None
Form : Wettable powder in water soluble packets.
Color : Off-white
Bulk Density (Loose) : 24 lb/cu ft
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STABILITY AND REACTIVITY
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Chemical Stability
Stable at normal temperatures and storage conditions.
Moisture will cause breakage of inner bag.
Incompatibility with Other Materials
None reasonably foreseeable.
Decomposition
Decomposes with heat.
Hazardous gases/vapors produced are n-butylisocyanate, a
strong lachrymator. High humidity or moisture levels
and/or high temperatures can also lead to the generation of
n-butyl isocyanate.
Polymerization
Polymerization will not occur.
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Material Safety Data Sheet
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ECOLOGICAL INFORMATION
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Ecotoxicological Information
Aquatic Toxicity
Benomyl
96 hour LC50, rainbow trout: 0.41 ppm
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DISPOSAL CONSIDERATIONS
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Waste Disposal
Do not contaminate water supply, food or feed by storage or
disposal. Treatment, storage, transportation, and disposal must
be in accordance with applicable Federal, State/Provincial, and
Local regulations. Do not flush to surface water or sanitary
sewer system.
Wastes resulting from the use of this product may be disposed of
on site or at an approved waste disposal facility.
Environmental Hazards
This pesticide is toxic to fish. For terrestrial uses, do
not apply directly to water, to areas where surface water is
present, or to intertidal areas below the mean high water
mark, except for the registered aquatic use on rice. Do not
apply where runoff is likely to occur. Drift and runoff
from treated areas may be hazardous to fish in adjacent
areas. Do not contaminate water when disposing of equipment
washwaters. Do not apply when weather conditions favor
drift from areas treated.
Container Disposal
Completely empty contents of envelope into application
equipment. Then dispose of empty envelope in a sanitary
landfill, or, if allowed by State and local authorities, by
burning. If burned, stay out of smoke.
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TRANSPORTATION INFORMATION
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Shipping Information
DOT/IMO
Proper Shipping Name : FLAMMABLE SOLID, ORGANIC, N.O.S.
(benomyl)
Hazard Class : 4.1
UN No. : UN 1325
DOT/IMO Label : FLAMMABLE SOLID
Special Information : MARINE POLLUTANT (water or bulk)
Packing Group : III
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Material Safety Data Sheet
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REGULATORY INFORMATION
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U.S. Federal Regulations
TITLE III HAZARD CLASSIFICATIONS SECTIONS 311, 312
Acute : Yes
Chronic : Yes
Fire : Yes
Reactivity : No
Pressure : No
In the United States this product is regulated by the US
Environmental Protection Agency under the Federal Insecticide,
Fungicide and Rodenticide Act. It is a violation of federal law
to use this product in a manner inconsistent with its labeling.
EPA Reg. No. 352-564
Reportable Quantity (Superfund) = 1 lb. (as Benomyl)
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OTHER INFORMATION
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NFPA, NPCA-HMIS
NFPA Rating
Health :1
Flammability :2
Reactivity :0
NPCA-HMIS Rating
Health :1
Flammability :2
Reactivity :0
Personal Protection rating to be supplied by user depending on use
conditions.
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The data in this Material Safety Data Sheet relates only to the
specific material designated herein and does not relate to use in
combination with any other material or in any process.
Responsibility for MSDS : DuPont Crop Protection
Address : Wilmington, Delaware 19898
Telephone : 1-888-638-7668
This information is based upon technical information believed to be
reliable. It is subject to revision as additional knowledge and
experience is gained.
End of MSDS
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