SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 09/JUN/2005
Date Updated: 16/MAR/2004
Version 1.2
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name 1,3-DICYCLOHEXYLCARBODIIMIDE, 99%
Product Number D80002
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
1,3-DICYCLOHEXYLCARBODIIMIDE 538-75-0 208-704-1 615-019-00-5
Formula C13H22N2
Molecular Weight 206.33 AMU
Synonyms Bis(cyclohexyl)carbodiimide * Cyclohexaamine,
N,N'-methanetetraylbis- (9CI) * DCC * DCCD *
DCCI * Dicyclohexylcarbodiimide *
N,N'-Dicyclohexylcarbodiimide *
1,3-Dicyclohexylcarbodiimide *
N,N'-Methanetetrayl biscyclohexanamine
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Harmful if swallowed. Toxic in contact with skin. Risk of serious
damage to eyes. May cause sensitization by skin contact.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Procedure for decontamination of spill site: because of the
hazardous nature of DCC and the corrosive nature of the clean up
reagents, we recommend that the following protective equipment
be used: self-contained breathing apparatus, rubber gloves,
suit, and boots. Carefully pour a sufficient quantity of acetic
acid (10%-20%) or hydrochloric acid (5%) on the spill. Allow to
stand several hours. Scrape off crystallized N,N
dicyclohexylurea into a container and hold for waste disposal.
Wash down spill site with a sufficient quantity of acetic acid
(10%-20%) or hydrochloric acid (5%) followed by a water rinse.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Do not get in
eyes, on skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
SPECIAL REQUIREMENTS: Moisture sensitive.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use only in a chemical fume hood.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
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9 - Physical and Chemical Properties
Appearance Physical State: Solid
Color: Colorless
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 122 - 124 藲C 6 mmHg
MP/MP Range 34 - 35 藲C
Flash Point 113 藲C Method: closed cup
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solvent: 0.1 g/ml CH2Cl2 clear, colorless
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide,
and nitrogen oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: FF2160000
ACUTE TOXICITY
LD50
Oral
rat, male
1,110 mg/kg
LD50
Oral
rat, female
1,110 mg/kg
LD50
Skin
rat, male
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79.4 mg/kg
LD50
Oral
rat, female
70.7 mg/kg
LD50
Oral
Rat
1,499 mg/kg
LD50
Skin
Rabbit
79.1 mg/kg
LD50
Oral
Rat
400 mg/kg
Remarks: Behavioral:Muscle weakness.
Gastrointestinal:Hypermotility, diarrhea. Skin and Appendages:
Other: Hair.
LC50
Inhalation
Rat
159 mg/m3
6H
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Lacrimation. Vascular:Regional or general arteriolar
or venous dilation. Skin and Appendages: Other: Hair.
LD50
Intraperitoneal
Rat
10 MG/KG
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Lungs, Thorax, or Respiration:Dyspnea. Lungs, Thorax, or
Respiration:Cyanosis.
LD50
Oral
Mouse
> 800 mg/kg
Remarks: Behavioral:Muscle weakness. Skin and Appendages: Other:
Hair.
LD50
Intraperitoneal
Mouse
>800 MG/KG
Remarks: Behavioral:Muscle weakness. Skin and Appendages: Other:
Hair.
LD50
Skin
Guinea pig
10 ML/KG
IRRITATION DATA
Skin
Rabbit
500 mg
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4 HR
Remarks: Severe irritation effect
SENSITIZATION
Skin: May cause allergic skin reaction.
SIGNS AND SYMPTOMS OF EXPOSURE
Depending on the intensity and duration of exposure, effects may
vary from mild irritation to severe destruction of tissue. To
the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: Causes severe skin irritation.
Skin Absorption: Toxic if absorbed through skin.
Eye Contact: Causes severe eye irritation.
Inhalation: Toxic if inhaled. Material is irritating to mucous
membranes and upper respiratory tract.
Ingestion: Toxic if swallowed.
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
UN#: 2811
Class: 6.1
PG: II
Proper Shipping Name: Toxic solid, organic, n.o.s.
IMDG
UN#: 2811
Class: 6.1
PG: II
Proper Shipping Name: Toxic solid, organic, n.o.s.
Marine Pollutant: No
Severe Marine Pollutant: No
Technical Name: Required
IATA
UN#: 2811
Class: 6.1
PG: II
Proper Shipping Name: Toxic solid, organic, n.o.s.
Inhalation Packing Group I: No
Technical Name: Required
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 615-019-00-5
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INDICATION OF DANGER: T
Toxic.
R-PHRASES: 22 24 41 43
Harmful if swallowed. Toxic in contact with skin. Risk of
serious damage to eyes. May cause sensitization by skin contact.
S-PHRASES: 24 26 37/39 45
Avoid contact with skin. In case of contact with eyes, rinse
immediately with plenty of water and seek medical advice. Wear
suitable gloves and eye/face protection. In case of accident or
if you feel unwell, seek medical advice immediately (show the
label where possible).
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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