SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 19/OCT/2004
Date Updated: 12/MAR/2004
Version 1.3
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name ACETYLSALICYLIC ACID, 99+%
Product Number 239631
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
ACETYLSALICYLIC ACID 50-78-2 200-064-1 None
Formula C9H8O4
Molecular Weight 180.16 AMU
Synonyms Acenterine * Acesal * Aceticyl *
Acetilsalicilico * Acetilum acidulatum *
Acetisal * Acetol * Acetonyl * Acetophen *
Acetosal * Acetosalic acid * Acetosalin *
o-Acetoxybenzoic acid * 2-Acetoxybenzoic acid *
Acetylin * 2-(Acetyloxy)benzoic acid * Acetylsal
* Acetylsalicylic acid (ACGIH) *
Acetylsalicylsaure (German) * Acido
acetilsalicilico (Italian) * Acimetten * Acide
acetylsalicylique (French) * Acido
O-acetil-benzoico (Italian) * Acidum
acetylsalicylicum * Acisal * Acylpyrin * A.S.A.
empirin * Asagran * Aspergum * Aspirdrops *
Aspirin * Aspirina 03 * Aspro Clear * Asteric *
AC 5230 * Benaspir * Benzoic acid,
2-(acetyloxy)- (9CI) * Bialpirinia * Caprin *
o-Carboxyphenyl acetate * Colfarit * Contrheuma
retard * Delgesic * Dolean pH 8 * Duramax * ECM
* Ecotrin * Empirin * Endydol * Entericin *
Enterosarine * Entrophen * Globoid * Helicon *
Idragin * Istopirin * Kapsazal * Kyselina
2-acetoxybenzoova (Czech) * Kyselina
acetylsalicylova (Czech) * Measurin * Medisyl *
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Irritating to eyes, respiratory system and skin. Harmful if
swallowed.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Avoid contact
with eyes, skin, and clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
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Safety shower and eye bath. Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 5 mg/m3
EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 5 mg/m3, E
Remarks: NL
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 5 mg/m3
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 5 mg/m3
Remarks: E
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL OEL 5 mg/m3
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Color: White
Form: Powder
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range 138 - 140 掳C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
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Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents, Strong acids, Strong
bases.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: VO0700000
ACUTE TOXICITY
LD50
Oral
Rat
*
LD50
Oral
Rat
1,700 mg/kg
LD50
Oral
Rat
1,500 mg/kg
LD50
Oral
Mouse
*
LDLO
Oral
Child
104 mg/kg
Remarks: Lungs, Thorax, or Respiration:Acute pulmonary edema.
Gastrointestinal:Nausea or vomiting. Blood: Hemorrhage.
LD50
Oral
Rat
200 mg/kg
LD50
Intraperitoneal
Rat
340 MG/KG
LD50
Rectal
Rat
790 MG/KG
LD50
Oral
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Mouse
250 mg/kg
LD50
Intraperitoneal
Mouse
167 MG/KG
LD50
Subcutaneous
Mouse
1020 MG/KG
LD50
Oral
Dog
700 mg/kg
Remarks: Behavioral:Altered sleep time (including change in
righting reflex). Lungs, Thorax, or Respiration:Respiratory
depression.
LD50
Intravenous
Dog
681 MG/KG
Remarks: Behavioral:Analgesia.
LD50
Oral
Rabbit
1010 mg/kg
Remarks: Behavioral:Change in motor activity (specific assay).
LD50
Oral
Guinea pig
1075 mg/kg
Remarks: Behavioral:Altered sleep time (including change in
righting reflex). Behavioral:Somnolence (general depressed
activity). Behavioral:Tremor.
LD50
Oral
Hamster
3500 mg/kg
LD50
Oral
Mammal
1750 mg/kg
SENSITIZATION
Sensitization: Prolonged or repeated exposure may cause allergic
reactions in certain sensitive individuals.
SIGNS AND SYMPTOMS OF EXPOSURE
The chemical, physical, and toxicological properties of this
product have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
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Eye Contact: Causes eye irritation.
Inhalation: Material is irritating to mucous membranes and upper
respiratory tract. May be harmful if inhaled.
Ingestion: Harmful if swallowed.
TARGET ORGAN INFORMATION
Blood.
CHRONIC EXPOSURE - MUTAGEN
Human
100 UMOL/L
Cell Type: lymphocyte
DNA inhibition
Human
75 MG/L
Cell Type: lymphocyte
Other mutation test systems
Human
100 MG/L
Cell Type: fibroblast
Cytogenetic analysis
Human
100 UG/L
Cell Type: leukocyte
Cytogenetic analysis
Human
10 MG/L
Cell Type: lymphocyte
Cytogenetic analysis
Rat
108 UG/PLATE
Cell Type: Embryo
Morphological transformation.
Mouse
100 MG/KG
Intraperitoneal
Sister chromatid exchange
Hamster
1660 MG/L
Cell Type: lung
Cytogenetic analysis
CHRONIC EXPOSURE - TERATOGEN
Species: Woman
Dose: 700 MG/KG
Route of Application: Oral
Exposure Time: (35-36W PREG)
Result: Specific Developmental Abnormalities: Central nervous
system. Specific Developmental Abnormalities: Cardiovascular
(circulatory) system. Effects on Newborn: Biochemical and
metabolic.
Species: Woman
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Dose: 546 MG/KG
Route of Application: Oral
Exposure Time: (37-39W PREG)
Result: Specific Developmental Abnormalities: Central nervous
system. Specific Developmental Abnormalities: Craniofacial
(including nose and tongue). Specific Developmental
Abnormalities: Other developmental abnormalities.
Species: Woman
Dose: 17280 MG/KG
Route of Application: Oral
Exposure Time: (1-39W PREG)
Result: Specific Developmental Abnormalities: Cardiovascular
(circulatory) system. Specific Developmental Abnormalities:
Respiratory system. Effects on Newborn: Apgar score (human only).
Species: Rat
Dose: 500 MG/KG
Route of Application: Oral
Exposure Time: (9D PREG)
Result: Effects on Embryo or Fetus: Fetal death.
Species: Rat
Dose: 200 MG/KG
Route of Application: Oral
Exposure Time: (9D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
Species: Rat
Dose: 500 MG/KG
Route of Application: Oral
Exposure Time: (9D PREG)
Result: Specific Developmental Abnormalities: Central nervous
system. Specific Developmental Abnormalities: Eye, ear. Specific
Developmental Abnormalities: Musculoskeletal system.
Species: Rat
Dose: 125 MG/KG
Route of Application: Oral
Exposure Time: (12D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
Species: Rat
Dose: 500 MG/KG
Route of Application: Subcutaneous
Exposure Time: (11D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
Species: Rat
Dose: 500 MG/KG
Route of Application: Subcutaneous
Exposure Time: (11D PREG)
Result: Effects on Embryo or Fetus: Extra embryonic structures
(e.g., placenta, umbilical cord). Effects on Embryo or Fetus:
Fetotoxicity (except death, e.g., stunted fetus). Specific
Developmental Abnormalities: Craniofacial (including nose and
tongue).
Species: Rat
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Dose: 3500 MG/KG
Route of Application: Unreported
Exposure Time: (6-15D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system. Specific Developmental Abnormalities: Other
developmental abnormalities.
Species: Mouse
Dose: 800 MG/KG
Route of Application: Oral
Exposure Time: (17D PREG)
Result: Effects on Embryo or Fetus: Fetal death. Effects on
Embryo or Fetus: Other effects to embryo. Specific Developmental
Abnormalities: Other developmental abnormalities.
Species: Mouse
Dose: 2500 MG/KG
Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Musculoskeletal system.
Species: Dog
Dose: 3200 MG/KG
Route of Application: Oral
Exposure Time: (23-30D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system. Specific Developmental Abnormalities: Cardiovascular
(circulatory) system. Specific Developmental Abnormalities:
Respiratory system.
Species: Dog
Dose: 3 GM/KG
Route of Application: Unreported
Exposure Time: (20-34D PREG)
Result: Effects on Embryo or Fetus: Fetal death.
Species: Cat
Dose: 300 MG/KG
Route of Application: Oral
Exposure Time: (10-15D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Musculoskeletal system.
Species: Rabbit
Dose: 800 MG/KG
Route of Application: Oral
Exposure Time: (8-15D PREG)
Result: Specific Developmental Abnormalities: Body wall.
Specific Developmental Abnormalities: Craniofacial (including
nose and tongue). Specific Developmental Abnormalities:
Musculoskeletal system.
Species: Rabbit
Dose: 1800 MG/KG
Route of Application: Oral
Exposure Time: (8-16D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system. Specific Developmental Abnormalities: Cardiovascular
(circulatory) system. Effects on Embryo or Fetus: Fetal death.
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Species: Rabbit
Dose: 1750 MG/KG
Route of Application: Oral
Exposure Time: (6-12D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
Species: Rabbit
Dose: 11250 MG/KG
Route of Application: Unreported
Exposure Time: (16-30D PREG)
Result: Effects on Embryo or Fetus: Fetal death.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Result: Overexposure may cause reproductive disorder(s) based on
tests with laboratory animals.
Species: Woman
Dose: 7500 MG/KG
Route of Application: Oral
Exposure Time: (34-37W PREG)
Result: Maternal Effects: Other effects. Effects on Newborn:
Stillbirth.
Species: Woman
Dose: 546 MG/KG
Route of Application: Oral
Exposure Time: (37-39W PREG)
Result: Effects on Newborn: Other postnatal measures or effects.
Species: Woman
Dose: 17550 MG/KG
Route of Application: Oral
Exposure Time: (12-39W PREG)
Result: Maternal Effects: Parturition.
Species: Woman
Dose: 100 MG/KG
Route of Application: Oral
Exposure Time: (37W PREG)
Result: Effects on Newborn: Other neonatal measures or effects.
Species: Woman
Dose: 189 MG/KG
Route of Application: Oral
Exposure Time: (12-39W PREG)
Result: Maternal Effects: Parturition. Effects on Embryo or
Fetus: Fetotoxicity (except death, e.g., stunted fetus).
Specific Developmental Abnormalities: Blood and lymphatic system
(including spleen and marrow).
Species: Woman
Dose: 1200 MG/KG
Route of Application: Unreported
Exposure Time: (20D PRE)
Result: Maternal Effects: Menstrual cycle changes or disorders.
Species: Rat
Dose: 1 GM/KG
Route of Application: Oral
Exposure Time: (12D PREG)
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Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetal death.
Species: Rat
Dose: 2100 MG/KG
Route of Application: Oral
Exposure Time: (14D MALE)
Result: Paternal Effects: Testes, epididymis, sperm duct.
Species: Rat
Dose: 10 MG/KG
Route of Application: Oral
Exposure Time: (22D PREG)
Result: Maternal Effects: Parturition. Effects on Newborn:
Stillbirth. Effects on Newborn: Live birth index (# fetuses per
litter; measured after birth).
Species: Rat
Dose: 1 GM/KG
Route of Application: Oral
Exposure Time: (3D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Species: Rat
Dose: 1800 MG/KG
Route of Application: Subcutaneous
Exposure Time: (12D MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count). Paternal
Effects: Testes, epididymis, sperm duct.
Species: Rat
Dose: 380 MG/KG
Route of Application: Subcutaneous
Exposure Time: (9D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetotoxicity (except death, e.g.,
stunted fetus). Specific Developmental Abnormalities: Other
developmental abnormalities.
Species: Rat
Dose: 500 MG/KG
Route of Application: Subcutaneous
Exposure Time: (11D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetal death. Specific Developmental
Abnormalities: Craniofacial (including nose and tongue).
Species: Rat
Dose: 300 MG/KG
Route of Application: Subcutaneous
Exposure Time: (1D PRE)
Result: Effects on Fertility: Other measures of fertility
Species: Rat
Dose: 2 MG/KG
Route of Application: Intrauterine
Exposure Time: (4D PREG)
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Result: Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea).
Species: Mouse
Dose: 1200 MG/KG
Route of Application: Oral
Exposure Time: (8-9D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Specific Developmental Abnormalities: Craniofacial (including
nose and tongue).
Species: Mouse
Dose: 19200 MG/KG
Route of Application: Oral
Exposure Time: (6-21D PREG)
Result: Effects on Newborn: Stillbirth. Effects on Newborn:
Other neonatal measures or effects.
Species: Mouse
Dose: 500 MG/KG
Route of Application: Subcutaneous
Exposure Time: (11D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Species: Rabbit
Dose: 600 MG/KG
Route of Application: Oral
Exposure Time: (2D PRE)
Result: Effects on Fertility: Other measures of fertility
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: Xn
Harmful.
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R-PHRASES: 22 36/37/38
Harmful if swallowed. Irritating to eyes, respiratory system
and skin.
S-PHRASES: 26
In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice.
SWITZERLAND
SWISS POISON CLASS: 3
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2004 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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