SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 16/JUN/2005
Date Updated: 13/MAR/2004
Version 1.2
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name 2-NITROPROPANE, 97%
Product Number 130265
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Australia
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
2-NITROPROPANE 79-46-9 201-209-1 609-002-00-1
Formula C3H7NO2
Molecular Weight 89.09 AMU
Synonyms Dimethylnitromethane * Isonitropropane * Nipar
S-20 * Nipar S-20 solvent * Nipar S-30 solvent *
Nitroisopropane * beta-Nitropropane *
2-Nitropropane (ACGIH:OSHA) * 2-NP * RCRA waste
number U171
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
May cause cancer. Flammable. Also harmful by inhalation and if
swallowed.
Carc. Cat.2
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
Flammable liquid.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Absorb on sand or vermiculite and place in closed containers for
disposal.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Do not get
in eyes, on skin, on clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Keep away from heat,
sparks, and open flame. Store in a cool dry place.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use only in a chemical fume hood.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 18 mg/m3
5 ppm
Remarks: K
EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 18 mg/m3
5 ppm
Remarks: 4
Remarks: TRK,TRGS 901-8
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 35 mg/m3
10 ppm
Remarks: K
EXPOSURE LIMITS - SWEDEN
Source Type Value
LLV (Level7 mg/m3
2 ppm
Remarks: K
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EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL TWA 19 mg/m3
5 ppm
Remarks: Carcinogen.
PERSONAL PROTECTIVE EQUIPMENT
Hand Protection: Rubber gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance N/A
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 120 掳C 760 mmHg
MP/MP Range -93 掳C
Flash Point 26 掳C Method: closed cup
Flammability N/A
Autoignition Temp 428 掳C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 2.6 %
Vapor Pressure 13 mmHg 20 掳C
SG/Density 0.992 g/cm3
Partition Coefficient N/A
Viscosity N/A
Vapor Density 3 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Materials to Avoid: Strong oxidizing agents, Strong bases, Copper.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide,
and nitrogen oxides.
11 - Toxicological Information
RTECS NUMBER: TZ5250000
ACUTE TOXICITY
LD50
Oral
Rat
720 mg/kg
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LC50
Inhalation
Rat
400 ppm
6H
LC50
Inhalation
Mouse
10,000 mg/m3
2H
LD50
Intraperitoneal
Mouse
75 MG/KG
SIGNS AND SYMPTOMS OF EXPOSURE
Warning: overexposure may cause serious liver disorders.
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting. Damage to the liver. To the best of our knowledge, the
chemical, physical, and toxicological properties have not been
thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Multiple Routes: Harmful if swallowed, inhaled, or absorbed
through skin. Vapor or mist is irritating to the eyes, mucous
membranes, and upper respiratory tract.
TARGET ORGAN INFORMATION
Liver. Blood. Damage to the liver.
CHRONIC EXPOSURE - CARCINOGEN
Result: Carcinogen.
Rat
Route of Application: Oral
Exposure Time: 16W
Result: Tumorigenic:Carcinogenic by RTECS criteria. Liver:Tumors.
Rat
Route of Application: Inhalation
Exposure Time: 7H/26W
Result: Tumorigenic:Carcinogenic by RTECS criteria. Liver:Tumors.
Rat
Route of Application: Inhalation
Exposure Time: 26W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Liver:Tumors.
IARC CARCINOGEN LIST
Rating: Group 2B
CHRONIC EXPOSURE - MUTAGEN
Human
60 MMOL/L
Cell Type: lymphocyte
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Cytogenetic analysis
Human
7500 UMOL/L
Cell Type: lymphocyte
Sister chromatid exchange
Rat
25 MG/KG
Oral
Micronucleus test
Rat
20 MG/KG
Intraperitoneal
DNA repair
Rat
30 UMOL/L
Cell Type: liver
DNA repair
Rat
44555 UG/KG
Oral
DNA damage
Rat
100 MG/KG
Intraperitoneal
DNA damage
Rat
1 UMOL/L
Cell Type: liver
Unscheduled DNA synthesis
Rat
20 MG/KG
Intraperitoneal
Unscheduled DNA synthesis
Rat
50 MG/KG
Oral
Unscheduled DNA synthesis
Domestic Animals
2 MMOL/L
Cell Type: Other cell types
DNA repair
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 2550 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (1-15D PREG)
Result: Specific Developmental Abnormalities: Cardiovascular
(circulatory) system.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
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Species: Rat
Dose: 2550 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (1-15D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetotoxicity (except death, e.g.,
stunted fetus).
CMR CAT.: Carc. Cat.2
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Burn in a chemical incinerator equipped with an afterburner and
scrubber but exert extra care in igniting as this material is
highly flammable. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
UN#: 2608
Class: 3
PG: III
Proper Shipping Name: Nitropropanes
IMDG
UN#: 2608
Class: 3
PG: III
Proper Shipping Name: Nitropropanes
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 2608
Class: 3
PG: III
Proper Shipping Name: Nitropropanes
Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 609-002-00-1
NOTA: E
INDICATION OF DANGER: T
Toxic.
R-PHRASES: 45 10 20/22
May cause cancer. Flammable. Also harmful by inhalation and if
swallowed.
S-PHRASES: 53 45
Restricted to professional users. Attention - Avoid exposure -
obtain special instructions before use. In case of accident or
if you feel unwell, seek medical advice immediately (show the
label where possible).
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COUNTRY SPECIFIC INFORMATION
Germany
WGK: 2 (self-classification)
SWITZERLAND
SWISS POISON CLASS: 1*
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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