SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 15/SEP/2005
Date Updated: 14/MAR/2004
Version 1.4
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name 1,4-PHENYLENEDIAMINE, FLAKES, 99.5+%
Product Number P23962
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Australia
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
1,4-PHENYLENEDIAMINE 106-50-3 203-404-7 612-028-00-6
Formula C6H8N2
Molecular Weight 108.14 AMU
Synonyms p-Aminoaniline * 4-Aminoaniline * BASF ursol D *
p-Benzenediamine * 1,4-Benzenediamine (9CI) *
Benzofur D * C.I. 76060 * C.I. Developer 13 *
C.I. Oxidation Base 10 * Developer 13 *
Developer PF * p-Diaminobenzene *
1,4-Diaminobenzene * Durafur Black R *
p-Fenylendiamin (Czech) * Fenylenodwuamina
(Polish) * Fouramine D * Fourrine D * Fourrine 1
* Fur Black 41867 * FUR Brown 41866 * Furro D *
Fur Yellow * Futramine D * Nako H * Orsin *
Oxidation Base 10 * Paraphenylen-diamine *
Pelagol D * Pelagol DR * Pelagol Grey D * Peltol
D * 1,4-Phenylenediamine * p-Phenylenediamine
(ACGIH:OSHA) * 6PPD * Renal PF * Rodol D *
Santoflex IC * Tertral D * Ursol D * USAF EK-394
* Zoba Black D
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Toxic by inhalation, in contact with skin and if swallowed.
Irritating to eyes. May cause sensitization by skin contact. Very
toxic to aquatic organisms, may cause long-term adverse effects in
the aquatic environment.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Do not get in
eyes, on skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
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EXPOSURE LIMITS
Country Source Type Value
Poland NDS 0.1 MG/M3
Poland NDSCh 0.3 MG/M3
Poland NDSP -
EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 0.1 mg/m3
Remarks: H
EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 0.1 mg/m3, E
Remarks: 4
Remarks: H
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 0.1 mg/m3
Remarks: AH
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 0.1 mg/m3
Remarks: E H S D
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL OEL 0.1 mg/m3
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Property Value At Temperature or Pressure
pH 9 20 藲C Concentration: 50
g/l
BP/BP Range 267 藲C 760 mmHg
MP/MP Range 141 藲C
Flash Point 110 藲C Method: closed cup
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 1.5 %
Vapor Pressure 1.08 mmHg 100 藲C
SG/Density N/A
Partition Coefficient Log Kow: - 0.250
Viscosity N/A
Vapor Density 3.7 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density 600 kg/l
Decomposition Temp. N/A
Solvent Content N/A
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Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:10 mg/ml H2O, 20藲C
Other Solvents: ALCOHOL, CHLOROFORM, ETHER
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions of Instability: May darken on storage
Materials to Avoid: Acid chlorides, Acid anhydrides,
Chloroformates, Strong oxidizing agents, Acids.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Nitrogen oxides Carbon monoxide,
Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: SS8050000
ACUTE TOXICITY
LD50
Oral
Rat
80 mg/kg
LC50
Inhalation
Rat
920 mg/m3
4H
Remarks: Gastrointestinal:Nausea or vomiting. Behavioral:General
anesthetic. Kidney, Ureter, Bladder:Hematuria.
LD50
Intraperitoneal
Rat
37 MG/KG
LD50
Intraperitoneal
Mouse
50 MG/KG
LD50
Oral
Guinea pig
145 mg/kg
LD50
Oral
Quail
100 mg/kg
LD50
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Oral
Bird (wild)
100 mg/kg
IRRITATION DATA
Skin
Human
250 mg
24H
Remarks: Mild irritation effect
Skin
Mouse
250 mg
24H
Remarks: Mild irritation effect
Skin
Dog
250 mg
24H
Remarks: Mild irritation effect
Skin
Rabbit
12.5 mg
24H
Remarks: Mild irritation effect
Skin
Rabbit
250 mg
24H
Remarks: Moderate irritation effect
Skin
Pig
250 mg
24H
Remarks: Mild irritation effect
Skin
Guinea pig
250 mg
24H
Remarks: Mild irritation effect
SENSITIZATION
Skin: May cause allergic skin reaction.
SIGNS AND SYMPTOMS OF EXPOSURE
Absorption into the body leads to the formation of methemoglobin
which in sufficient concentration causes cyanosis. Onset may be
delayed 2 to 4 hours or longer.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: Toxic if absorbed through skin.
Eye Contact: Causes eye irritation.
Inhalation: Toxic if inhaled. Material may be irritating to
mucous membranes and upper respiratory tract.
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Ingestion: Toxic if swallowed.
TARGET ORGAN INFORMATION
Liver. Kidneys.
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that is not
classifiable as to its carcinogenicity based on its IARC, ACGIH,
NTP, or EPA classification.
Rat
Route of Application: Subcutaneous
Exposure Time: 30W
Result: Tumorigenic:Tumors at site or application.
Tumorigenic:Equivocal tumorigenic agent by RTECS criteria.
IARC CARCINOGEN LIST
Rating: Group 3
CHRONIC EXPOSURE - MUTAGEN
Rat
1850 NG/PLATE
Cell Type: Embryo
Morphological transformation.
Mouse
200 MG/KG
Oral
DNA inhibition
Hamster
15 MG/L
Cell Type: ovary
Cytogenetic analysis
12 - Ecological Information
ECOTOXICOLOGICAL EFFECTS
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 48 h
Value: 0.28 mg/l
Test Type: LC50 Fish
Species: Pimephales promelas (Fathead minnow)
Time: 96 h
Value: 0.06 mg/l
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
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RID/ADR
UN#: 1673
Class: 6.1
PG: III
Proper Shipping Name: Phenylendiamines
IMDG
UN#: 1673
Class: 6.1
PG: III
Proper Shipping Name: PHENYLENEDIAMINES
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 1673
Class: 6.1
PG: III
Proper Shipping Name: PHENYLENEDIAMINES
Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 612-028-00-6
INDICATION OF DANGER: T-N
Toxic. Dangerous for the environment.
R-PHRASES: 23/24/25-36-43-50/53
Toxic by inhalation, in contact with skin and if swallowed.
Irritating to eyes. May cause sensitization by skin contact.
Very toxic to aquatic organisms, may cause long-term adverse
effects in the aquatic environment.
S-PHRASES: 28-36/37-45-60-61
After contact with skin, wash immediately with plenty of
soap-suds. Wear suitable protective clothing and gloves. In
case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible). This material and
its container must be disposed of as hazardous waste. Avoid
release to the environment. Refer to special
instructions/safety data sheets.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 3
SWITZERLAND
SWISS POISON CLASS: 2
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
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paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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