SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 21/JUN/2005
Date Updated: 12/MAR/2004
Version 1.3
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name EPSILON-AMINO-N-CAPROIC ACID SIGMAULTRA
Product Number A7824
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Australia
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
6-AMINOCAPROIC ACID 60-32-2 200-469-3 None
Formula C6H13NO2
Molecular Weight 131.18 AMU
Synonyms Acepramin * Acepramine * ACS * Afibrin * Amicar
* Amikar * epsilon-Aminocaproic acid *
omega-Aminocaproic acid * 6-Aminocaproic acid *
omega-Aminohexanoic acid * epsilon-Aminohexanoic
acid * 6-Aminohexanoic acid * Aminokapron *
Capramol * Capralense * Caprocid * Caprolisin *
CL 10304 * CY 116 * EACA * Eaca kabi * EACS *
Epsamon * Epsicapron * Epsikapron *
Epsilcapramin * Epsilon S * Hemocaprol * Hemopar
* Hepin * Ipsilon * 177 J.D. * Kyselina
omega-aminokapronova (Czech) * epsilon-Leucine *
epsilon-Norleucine * NSC-26154 * Respramin
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Irritating to eyes, respiratory system and skin.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact, immediately flush eyes with copious amounts
of water for at least 15 minutes.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Avoid contact
with eyes, skin, and clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Property Value At Temperature or Pressure
pH N/A
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BP/BP Range N/A
MP/MP Range 207 掳C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: MO6300000
ACUTE TOXICITY
LD50
Intraperitoneal
Rat
7 GM/KG
LD50
Intravenous
Rat
3300 MG/KG
LD50
Oral
Mouse
14300 mg/kg
LD50
Subcutaneous
Mouse
5790 MG/KG
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LD50
Intravenous
Mouse
4900 MG/KG
Remarks: Behavioral:Altered sleep time (including change in
righting reflex). Lungs, Thorax, or Respiration:Dyspnea.
LD50
Oral
Dog
> 7000 mg/kg
LD50
Oral
Monkey
> 7000 mg/kg
LD50
Intravenous
Monkey
>2 GM/KG
LD50
Intravenous
Rabbit
2 GM/KG
IRRITATION DATA
Eyes
Rabbit
500 mg
24H
Remarks: Mild irritation effect
SIGNS AND SYMPTOMS OF EXPOSURE
Exposure may cause itching, erythema, skin rash, diuresis,
heartburn, nausea and diarrhea. Blood effects. Other symptoms
include orthostatic hypotension and bradycardia. To the best of
our knowledge, the chemical, physical, and toxicological
properties have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes eye irritation.
Inhalation: Material is irritating to mucous membranes and upper
respiratory tract. May be harmful if inhaled.
Ingestion: May be harmful if swallowed.
TARGET ORGAN INFORMATION
Blood. Kidneys.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 153 GM/KG
Route of Application: Oral
Exposure Time: (40D PRE/1-21D PREG)
Result: Effects on Fertility: Female fertility index (e.g., #
females pregnant per # sperm positive females; # females
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pregnant per # females mated ).
Species: Rat
Dose: 190 GM/KG
Route of Application: Oral
Exposure Time: (38D MALE)
Result: Effects on Fertility: Male fertility index (e.g., #
males impregnating females per # males exposed to fertile
nonpregnant females).
Species: Rat
Dose: 15 MG/KG
Route of Application: Intrauterine
Exposure Time: (6D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: Xi
Irritant.
R-PHRASES: 36/37/38
Irritating to eyes, respiratory system and skin.
S-PHRASES: 26 36
In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice. Wear suitable protective
clothing.
SWITZERLAND
SWISS POISON CLASS: FREI
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
SIGMA - A7824 www.sigma-aldrich.com Page 5
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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