SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 05/MAY/2005
Date Updated: 10/FEB/2005
Version 1.2
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name PERTUSSIS TOXIN FROM BORDETELLA PER-
TUSSIS, 50 UG TOXIN
Product Number 77339
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
PERTUSSIS TOXIN 70323-44-3 None None
Synonyms Histamine-sensitizing factor * IAP * Islet
activating protein * Lymphocytosis-promoting
factor * Pertussigen
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Toxic by inhalation, in contact with skin and if swallowed.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Inactivate spilled material with 5% sodium hypochlorite. Place
in appropriate container. Ventilate area and wash spill site
after material pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Do not get in
eyes, on skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
Store at -20藲C
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range N/A
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
FLUKA - 77339 www.sigma-aldrich.com Page 2
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: XW5883750
ADDITIONAL INFORMATION
Pertussis toxin is one of the active factors responsible for
whooping cough. This toxin causes potentiation of
insulin-releasing responses, promotion of lipolysis on
adipocytes, inhibition of epinephrine-induced hyperglycemia,
ADP-ribosylation of cell-membrane protein, activation of
adenylate cyclase, lymphocytosis-promoting activity,
histamine-sensitizing activity, hemaggltination activity, and
adjuvant activity.
ACUTE TOXICITY
LD50
Intravenous
Rat
114 UG/KG
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Lacrimation. Behavioral:Change in motor activity
(specific assay). Nutritional and Gross Metabolic:Weight loss or
decreased weight gain.
LD50
Intraperitoneal
Mouse
17160 NG/KG
LD50
FLUKA - 77339 www.sigma-aldrich.com Page 3
Intravenous
Mouse
127 UG/KG
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Lacrimation. Behavioral:Change in motor activity
(specific assay). Nutritional and Gross Metabolic:Weight loss or
decreased weight gain.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: Toxic if absorbed through skin.
Eye Contact: May cause eye irritation.
Inhalation: Toxic if inhaled. Material may be irritating to
mucous membranes and upper respiratory tract.
Ingestion: Toxic if swallowed.
TARGET ORGAN INFORMATION
Pancreas.
CONDITIONS AGGRAVATED BY EXPOSURE
Potentially neurotoxic.
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Disposal should be made in accordance with existing disposal
practices employed for infectious waste at your institution.
Observe all federal, state, and local environmental regulations.
14 - Transport Information
RID/ADR
UN#: 3462
Class: 6.1
PG: I
Proper Shipping Name: Toxins, extracted from living
sources, solid, n.o.s.
IMDG
UN#: 3462
Class: 6.1
PG: I
Proper Shipping Name: Toxins, extracted from living
sources, solid, n.o.s.
Marine Pollutant: No
Severe Marine Pollutant: No
Technical Name: Required
IATA
UN#: 3462
Class: 6.1
PG: I
Proper Shipping Name: Toxins, extracted from living
sources, solid, n.o.s.
Inhalation Packing Group I: No
Technical Name: Required
15 - Regulatory Information
FLUKA - 77339 www.sigma-aldrich.com Page 4
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: T
Toxic.
R-PHRASES: 23/24/25
Toxic by inhalation, in contact with skin and if swallowed.
S-PHRASES: 45 36/37/39
In case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible). Wear suitable
protective clothing, gloves, and eye/face protection.
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
FLUKA - 77339 www.sigma-aldrich.com Page 5
|