SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 31/MAY/2005
Date Updated: 15/MAR/2004
Version 1.3
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name TESTOSTERONE DEA SCHEDULE III
Product Number T1500
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
TESTOSTERONE 58-22-0 200-370-5 None
Formula C19H28O2
Molecular Weight 288.43 AMU
Synonyms Androlin * Androst-4-en-3-one, 17-hydroxy-,
(17-beta)- * Andronaq *
Androst-4-en-17beta-ol-3-one * delta(sup
4)-Androsten-17(beta)-ol-3-one *
Androst-4-en-3-one, 17-beta-hydroxy- * Andrusol
* Cristerone T * Geno-cristaux gremy *
Homosteron * Homosterone *
17-beta-Hydroxy-delta(sup 4)-androsten-3-one *
17-beta-Hydroxyandrost-4-en-3-one *
17-beta-Hydroxy-4-androsten-3-one *
7-beta-Hydroxyandrost-4-en-3-one * Malestrone
(amps) * Mertestate * Neo-testis * Oreton-F *
Orquisteron * Perandren * Percutacrine
androgenique * Primotest * Primoteston *
Sustanone * Synandrol F * Teslen * Testandrone *
Testiculosterone * Testobase * Testopropon *
Testosteroid * Testosteron * trans-Testosterone
* Testosterone hydrate * Testostosterone *
Testoviron schering * Testoviron T * Testrone *
Testryl * Virormone * Virosterone
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
May cause cancer. Possible risk of harm to the unborn child.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves. Wear disposable coveralls and discard them after
use.
ENVIRONMENTAL PRECAUTION(S)
Avoid contaminating water supply. Avoid contaminating sewers and
waterways with this material.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Do not get in
eyes, on skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
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Use only in a chemical fume hood. Safety shower and eye bath.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range 152 掳C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Insoluble.
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: XA3030000
ACUTE TOXICITY
LD50
Oral
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Mammal
> 5000 mg/kg
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.
TARGET ORGAN INFORMATION
Reproductive system.
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that has been
reported to be probably carcinogenic based on its IARC, OSHA,
ACGIH, NTP, or EPA classification.
Mouse
Route of Application: Oral
Exposure Time: 52D
Result: Tumorigenic:Neoplastic by RTECS criteria. Tumorigenic
Effects: 0varian tumors.
Mouse
Route of Application: Subcutaneous
Exposure Time: 5D
Result: Tumorigenic:Neoplastic by RTECS criteria.
Endocrine:Adrenal cortex tumors. Tumorigenic Effects: Other
reproductive system tumors.
Mouse
Route of Application: Implant
Exposure Time: 50D
Result: Tumorigenic:Neoplastic by RTECS criteria. Tumorigenic
Effects: 0varian tumors.
IARC CARCINOGEN LIST
Rating: Group 2A Group 2A
CHRONIC EXPOSURE - MUTAGEN
Human
50 UMOL/L
Cell Type: lymphocyte
DNA inhibition
Human
100 UG/L
Cell Type: kidney
DNA inhibition
Human
100 UG/L
Cell Type: kidney
Cytogenetic analysis
Rat
10 MG/KG
Parenteral
Unscheduled DNA synthesis
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Rat
100 UMOL/L
Cell Type: liver
DNA inhibition
Mouse
100 UMOL/L
Cell Type: liver
DNA damage
Hamster
5 MG/L
Cell Type: Embryo
Morphological transformation.
Mammal
10 UMOL/L
Cell Type: lymphocyte
DNA damage
Mammal
1 UMOL/L
Cell Type: liver
DNA damage
CHRONIC EXPOSURE - TERATOGEN
Result: Possible risk of congenital malformation in the fetus.
Species: Woman
Dose: 34600 UG/KG
Route of Application: Unreported
Exposure Time: (7-13W PREG)
Result: Specific Developmental Abnormalities: Urogenital system.
Species: Rat
Dose: 100 MG/KG
Route of Application: Oral
Exposure Time: (17-20D PREG)
Result: Specific Developmental Abnormalities: Urogenital system.
Species: Rat
Dose: 8 MG/KG
Route of Application: Intramuscular
Exposure Time: (13-20D PREG)
Result: Specific Developmental Abnormalities: Skin and skin
appendages. Specific Developmental Abnormalities: Urogenital
system.
Species: Guinea pig
Dose: 86 MG/KG
Route of Application: Subcutaneous
Exposure Time: (18-60D PREG)
Result: Specific Developmental Abnormalities: Endocrine system.
Specific Developmental Abnormalities: Urogenital system.
Species: Domestic Animals
Dose: 6398 UG/KG
Route of Application: Implant
Exposure Time: (30-80D PREG)
Result: Specific Developmental Abnormalities: Urogenital system.
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Species: Domestic Animals
Dose: 6491 UG/KG
Route of Application: Implant
Exposure Time: (13-20W PREG)
Result: Effects on Embryo or Fetus: Fetal death.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Result: Overexposure may cause reproductive disorder(s) based on
tests with laboratory animals.
Species: Man
Dose: 17 MG/KG
Route of Application: Implant
Exposure Time: (26W MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count). Paternal
Effects: Other effects on male.
Species: Rat
Dose: 64 MG/KG
Route of Application: Oral
Exposure Time: (10D MALE)
Result: Paternal Effects: Prostate, seminal vessicle, Cowper's
gland, accessory glands.
Species: Rat
Dose: 25 MG/KG
Route of Application: Subcutaneous
Exposure Time: (17D PREG)
Result: Effects on Newborn: Physical. Effects on Newborn:
Delayed effects.
Species: Rat
Dose: 7 MG/KG
Route of Application: Subcutaneous
Exposure Time: (10-16D PREG)
Result: Effects on Fertility: Abortion.
Species: Rat
Dose: 4 MG/KG
Route of Application: Subcutaneous
Exposure Time: (9D PREG)
Result: Maternal Effects: Parturition. Effects on Fertility:
Post-implantation mortality (e.g., dead and/or resorbed implants
per total number of implants).
Species: Rat
Dose: 20 MG/KG
Route of Application: Subcutaneous
Exposure Time: (5D PREG)
Result: Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea).
Species: Rat
Dose: 8400 UG/KG
Route of Application: Subcutaneous
Exposure Time: (21D MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count). Paternal
Effects: Testes, epididymis, sperm duct. Paternal Effects:
Prostate, seminal vessicle, Cowper's gland, accessory glands.
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Species: Rat
Dose: 1400 UG/KG
Route of Application: Subcutaneous
Exposure Time: (14D PRE)
Result: Effects on Fertility: Other measures of fertility
Species: Rat
Dose: 700 UG/KG
Route of Application: Subcutaneous
Exposure Time: (14D PRE)
Result: Maternal Effects: Ovaries, fallopian tubes. Maternal
Effects: Uterus, cervix, vagina.
Species: Rat
Dose: 60 MG/KG
Route of Application: Intramuscular
Exposure Time: (3-7D PREG)
Result: Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea).
Species: Rat
Dose: 280 UG/KG
Route of Application: Intramuscular
Exposure Time: (14D MALE)
Result: Paternal Effects: Testes, epididymis, sperm duct.
Paternal Effects: Prostate, seminal vessicle, Cowper's gland,
accessory glands.
Species: Rat
Dose: 2500 UG/KG
Route of Application: Parenteral
Exposure Time: (10D PRE)
Result: Maternal Effects: Ovaries, fallopian tubes.
Species: Rat
Dose: 4 MG/KG
Route of Application: Parenteral
Exposure Time: (3W MALE)
Result: Paternal Effects: Testes, epididymis, sperm duct.
Species: Rat
Dose: 8 MG/KG
Route of Application: Parenteral
Exposure Time: (3W MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count).
Species: Rat
Dose: 10440 UG/KG
Route of Application: Implant
Exposure Time: (30D MALE)
Result: Paternal Effects: Testes, epididymis, sperm duct.
Species: Rat
Dose: 27 MG/KG
Route of Application: Implant
Exposure Time: (90D MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count). Paternal
Effects: Testes, epididymis, sperm duct. Effects on Fertility:
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Male fertility index (e.g., # males impregnating females per #
males exposed to fertile nonpregnant females).
Species: Rat
Dose: 10920 UG/KG
Route of Application: Implant
Exposure Time: (91D MALE)
Result: Paternal Effects: Prostate, seminal vessicle, Cowper's
gland, accessory glands.
Species: Rat
Dose: 33300 UG/KG
Route of Application: Implant
Exposure Time: (15W MALE)
Result: Paternal Effects: Other effects on male. Effects on
Fertility: Pre-implantation mortality (e.g., reduction in number
of implants per female; total number of implants per corpora
lutea). Effects on Fertility: Litter size (e.g.; # fetuses per
litter; measured before birth).
Species: Rat
Dose: 24 MG/KG
Route of Application: Intratesticular
Exposure Time: (30D MALE)
Result: Paternal Effects: Testes, epididymis, sperm duct.
Paternal Effects: Prostate, seminal vessicle, Cowper's gland,
accessory glands.
Species: Mouse
Dose: 15 GM/KG
Route of Application: Oral
Exposure Time: (8-12D PREG)
Result: Effects on Newborn: Live birth index (# fetuses per
litter; measured after birth). Effects on Newborn: Viability
index (e.g., # alive at day 4 per # born alive).
Species: Mouse
Dose: 40 MG/KG
Route of Application: Subcutaneous
Exposure Time: (10D PRE)
Result: Maternal Effects: Uterus, cervix, vagina. Maternal
Effects: Other effects.
Species: Mouse
Dose: 168 MG/KG
Route of Application: Subcutaneous
Exposure Time: (3D PRE)
Result: Maternal Effects: Uterus, cervix, vagina.
Species: Mouse
Dose: 10 MG/KG
Route of Application: Subcutaneous
Exposure Time: (5D PRE)
Result: Maternal Effects: Uterus, cervix, vagina. Effects on
Fertility: Female fertility index (e.g., # females pregnant per
# sperm positive females; # females pregnant per # females mated
).
Species: Mouse
Dose: 4524 MG/KG
Route of Application: Parenteral
Exposure Time: (19D MALE)
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Result: Paternal Effects: Testes, epididymis, sperm duct.
Species: Mouse
Dose: 9583 NG/KG
Route of Application: Parenteral
Exposure Time: (1D PRE)
Result: Maternal Effects: Uterus, cervix, vagina.
Species: Monkey
Dose: 1426 UG/KG
Route of Application: Implant
Exposure Time: (70D MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count).
Species: Rabbit
Dose: 30 MG/KG
Route of Application: Subcutaneous
Exposure Time: (1-3D PREG)
Result: Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea).
Species: Rabbit
Dose: 6 MG/KG
Route of Application: Unreported
Exposure Time: (1-3D PREG)
Result: Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea).
Species: Hamster
Dose: 180 MG/KG
Route of Application: Subcutaneous
Exposure Time: (3-8D PREG)
Result: Effects on Fertility: Female fertility index (e.g., #
females pregnant per # sperm positive females; # females
pregnant per # females mated ).
Species: Domestic Animals
Dose: 13333 UG/KG
Route of Application: Subcutaneous
Exposure Time: (50D PREG)
Result: Effects on Newborn: Behavioral.
Species: Domestic Animals
Dose: 18 UG/KG
Route of Application: Implant
Exposure Time: (7-14W PREG)
Result: Effects on Fertility: Mating performance (e.g., # sperm
positive females per # females mated; # copulations per # estrus
cycles).
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact the Drug Enforcement Administration concerning the
disposal of controlled substances. Observe all federal, state, and
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local environmental regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: T
Toxic.
R-PHRASES: 45 63
May cause cancer. Possible risk of harm to the unborn child.
S-PHRASES: 53 36/37 45
Avoid exposure - obtain special instructions before use. Wear
suitable protective clothing and gloves. In case of accident or
if you feel unwell, seek medical advice immediately (show the
label where possible).
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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