SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 10/MAY/2005
Date Updated: 02/APR/2004
Version 1.5
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name PHOSPHORUS OXIDE CHLORIDE
Product Number 04601
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
PHOSPHORUS OXIDE CHLORIDE 10025-87-3 233-046-7 015-009-00-5
Formula POCl3
Molecular Weight 153.33 AMU
Synonyms Fosforoxychlorid (Czech) * Oxychlorid fosforecny
(Czech) * Phosphorus oxychloride (ACGIH) *
Phosphorus oxytrichloride * Phosphoryl
trichloride * Trichlorophosphine oxide *
Trichlorophosphorus oxide
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Reacts violently with water. Harmful if swallowed. Very toxic by
inhalation. Contact with water liberates toxic gas. Causes severe
burns. Toxic: danger of serious damage to health by prolonged
exposure through inhalation.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately. Do not induce vomiting.
5 - Fire Fighting Measures
CONDITIONS OF FLAMMABILITY
Water hydrolyzes material liberating acidic gas which in contact
with metal surfaces can generate flammable and/or explosive
hydrogen gas.
EXTINGUISHING MEDIA
Suitable: Noncombustible. Use extinguishing media appropriate to
surrounding fire conditions.
Unsuitable: Do not use water.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Ventilate area and wash spill site after material pickup is
complete. Absorb on sand or vermiculite and place in closed
containers for disposal.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Do not get
in eyes, on skin, on clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Store under nitrogen.
Incompatible Materials: Do not allow contact with water
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Discard contaminated
shoes. Wash thoroughly after handling.
EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 0.6 mg/m3
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0.1 ppm
EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 1 mg/m3
0.2 ppm
Remarks: 4
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 0.6 mg/m3
0.1 ppm
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 0.6 mg/m3
0.1 ppm
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL OEL 1.3 mg/m3
0.2 ppm
OEL STEL 3.8 mg/m3
0.6 ppm
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
Special Protective Measures: Faceshield (8-inch minimum).
9 - Physical and Chemical Properties
Appearance Physical State: Liquid
Property Value At Temperature or Pressure
pH 1 20 掳C
BP/BP Range 105 - 110 掳C
MP/MP Range 1.25 掳C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure 28 mmHg 20 掳C
SG/Density 1.675 g/cm3
Partition Coefficient N/A
Viscosity N/A
Vapor Density 5.3 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
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10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong bases, Alcohols, Amines, Phenol Avoid
contact with metals., Strong oxidizing agents Reacts violently
with water. Acetone reacts violently with phosphorous oxychloride.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Thermal decomposition may
produce toxic fumes of phosphorus oxides and/or phosphine,
Hydrogen chloride gas.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: TH4897000
ACUTE TOXICITY
LD50
Oral
Rat
36 mg/kg
Remarks: Gastrointestinal:Other changes. Liver:Other changes.
Nutritional and Gross Metabolic:Weight loss or decreased weight
gain.
LC50
Inhalation
Rat
32 ppm
4H
LC50
Inhalation
Guinea pig
53 ppm
4H
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Other. Behavioral:Irritability. Lungs, Thorax, or
Respiration:Dyspnea.
SIGNS AND SYMPTOMS OF EXPOSURE
Material is extremely destructive to tissue of the mucous
membranes and upper respiratory tract, eyes, and skin.
Inhalation may result in spasm, inflammation and edema of the
larynxand bronchi, chemical pneumonitis, and pulmonary edema.
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting. To the best of our knowledge, the chemical, physical,
and toxicological properties have not been thoroughly
investigated.
ROUTE OF EXPOSURE
Skin Contact: Causes severe burns.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Lachrymator. Causes severe burns.
Inhalation: May be fatal if inhaled. Material is extremely
destructive to the tissue of the mucous membranes and upper
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respiratory tract.
Ingestion: Toxic if swallowed.
12 - Ecological Information
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
UN#: 1810
Class: 8
PG: II
Proper Shipping Name: Phosphorus oxychloride
IMDG
UN#: 1810
Class: 8
PG: II
Proper Shipping Name: Phosphorus oxychloride
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 1810
Class: 8
PG: II
Proper Shipping Name: Phosphorus oxychloride
Inhalation Packing Group I: Yes
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 015-009-00-5
INDICATION OF DANGER: T+ C
Very toxic. Corrosive.
R-PHRASES: 14 22 26 29 35 48/23
Reacts violently with water. Harmful if swallowed. Very toxic
by inhalation. Contact with water liberates toxic gas. Causes
severe burns. Toxic: danger of serious damage to health by
prolonged exposure through inhalation.
S-PHRASES: 7/8 26 45
Keep container tightly closed and dry. In case of contact with
eyes, rinse immediately with plenty of water and seek medical
advice. In case of accident or if you feel unwell, seek medical
advice immediately (show the label where possible).
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 1
SWITZERLAND
SWISS POISON CLASS: 1
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16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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