Material Safety Data Sheet
Date Printed: 05/06/2005
Date Updated: 06/25/2004
Version 1.0
Section 1 - Product and Company Information
Product Name QUININE DIHYDROCHLORIDE MONOHY - 250 MG DRATE
Product Number S458104
Brand Aldrich Chemical
Company Sigma-Aldrich
Street Address 3050 Spruce Street
City, State, Zip, Country SAINT LOUIS, MO 63103 US
Technical Phone: 314 771 5765
Fax: 800 325 5052 Emergency Phone: 414 273 3850 Ext. 5996
Section 2 - Composition/Information on Ingredient
Substance Name CAS # EC no Annex I Index
Number
QUININE DIHYDROCHLORIDE MONOHYDRATE 60-93-5 200-493-4
Formula C20H24N2O2
Synonyms Acid quinine hydrochloride, Chinindihydrochlorid (German), Cinchonan-9-ol, 6'-methoxy-,
dihydrochloride, (8-alpha,9R) (9CI), Quinine bimuriate, (-)-Quinine dihydrochloride
Section 3 - Hazards Identification
Emergency Overview
Harmful.
Harmful if swallowed.
HMIS Rating
Health: 1 Flammability: 0 Reactivity: 0
NFPA Rating
Health: 1 Flammability: 0 Reactivity: 0
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
Oral Exposure
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
Inhalation Exposure
If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
Dermal Exposure
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a
physician.
Eye Exposure
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the
eyelids with fingers. Call a physician.
Section 5 - Fire Fighting Measures
Autoignition Temp: N/A
Extinguishing Media
Suitable
Water spray. Carbon dioxide, dry chemical powder, or appropriate foam.
Firefighting
Protective Equipment
Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s)
Emits toxic fumes under fire conditions.
Section 6 - Accidental Release Measures
Procedure to be Followed in Case of Leak or Spill
Evacuate area.
Procedure(s) of Personal Precaution(s)
Wear self-contained breathing apparatus, rubber boots, and heavy rubber gloves.
Methods for Cleaning Up
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is
complete.
Section 7 - Handling and Storage
Handling
User Exposure
Do not breathe dust. Avoid contact with eyes, skin, and clothing. Avoid prolonged or repeated exposure.
Storage
Suitable
Keep tightly closed.
Section 8 - Exposure Controls / PPE
Engineering Controls
Safety shower and eye bath. Mechanical exhaust required.
Personal Protective Equipment
Respiratory
Government approved respirator.
Hand
Compatible chemical-resistant gloves.
Eye
Chemical safety goggles.
Aldrich Chemical - S458104 Sigma-Aldrich Corporation
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General Hygiene Measures
Wash thoroughly after handling.
Section 9 - Physical/Chemical Properties
Appearance
Physical State
Solid
Molecular Weight: 415.36 AMU
N/A
pH
N/A
BP/BP Range
238 - 240 掳C
MP/MP Range
Freezing Point N/A
Vapor Pressure N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
SG/Density N/A
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Partition Coefficient N/A
Decomposition Temp. N/A
Flash Point 掳F N/A
Flash Point 掳C N/A
Explosion Limits N/A
Flammability N/A
Autoignition Temp N/A
Solubility N/A
N/A = not available
Section 10 - Stability and Reactivity
Stability
Stable
Stable.
Materials to Avoid
Strong oxidizing agents.
Hazardous Decomposition Products
Hazardous Decomposition Products
Carbon monoxide, Carbon dioxide, Nitrogen oxides, Hydrogen chloride gas .
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Hazardous Polymerization
Hazardous Polymerization
Will not occur.
Section 11 - Toxicological Information
Route of Exposure
Skin Contact
May cause skin irritation.
Skin Absorption
May be harmful if absorbed through the skin.
Eye Contact
May cause eye irritation.
Inhalation
Material may be irritating to mucous membranes and upper respiratory tract. May be harmful if inhaled.
Ingestion
Harmful if swallowed.
Signs and Symptoms of Exposure
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
RTECS Number: VA6478000
Toxicity Data
Oral - Rat: 1392 mg/kg (LD50)
Oral - Rat: 1392 mg/kg (LD50)
Intravenous - Rat: 78 MG/KG (LD50)
Remarks : Behavioral:Altered sleep time (including change in righting reflex).
Behavioral:Convulsions or effect on seizure threshold.
Intravenous - Rat: 78 MG/KG (LD50)
Remarks : Behavioral:Altered sleep time (including change in righting reflex).
Behavioral:Convulsions or effect on seizure threshold.
Oral - Mouse: 660 mg/kg (LD50)
Oral - Mouse: 660 mg/kg (LD50)
Intravenous - Mouse: 86 MG/KG (LD50)
Intravenous - Mouse: 86 MG/KG (LD50)
Oral - Rabbit: 641 mg/kg (LD50)
Oral - Rabbit: 641 mg/kg (LD50)
Intravenous - Rabbit: 35 MG/KG (LD50)
Remarks : Behavioral:Altered sleep time (including change in righting reflex).
Intravenous - Rabbit: 35 MG/KG (LD50)
Remarks : Behavioral:Altered sleep time (including change in righting reflex).
Intravenous - Guinea pig: 57 MG/KG (LD50)
Remarks : Behavioral:Altered sleep time (including change in righting reflex).
Behavioral:Convulsions or effect on seizure threshold.
Intravenous - Guinea pig: 57 MG/KG (LD50)
Remarks : Behavioral:Altered sleep time (including change in righting reflex).
Behavioral:Convulsions or effect on seizure threshold.
Section 12 - Ecological Information
No data available.
Aldrich Chemical - S458104 Sigma-Aldrich Corporation
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Section 13 - Disposal Considerations
Appropriate Method of Disposal of Substance or Preparation
Contact a licensed professional waste disposal service to dispose of this material.
Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.
Observe all federal, state, and local environmental regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: None
Non-Hazardous for Transport: This substance is considered to be non-hazardous for transport.
IATA
Non-Hazardous for Air Transport: Non-hazardous for air transport.
Section 15 - Regulatory Information
EU Additional Classification
Symbol of Danger: Xn
Indication of Danger
Harmful.
Risk Statements R: 22
Harmful if swallowed.
US Classification and Label Text
Indication of Danger
Harmful.
Risk Statements
Harmful if swallowed.
TSCA Inventory Item: Yes Yes
Canada Regulatory Information
WHMIS Classification
This product has been classified in accordance with the hazard criteria of the CPR, and the MSDS contains all the information
required by the CPR.
DSL: Yes
NDSL: No
Section 16 - Other Information
Disclaimer
For R&D use only. Not for drug, household or other uses.
Warranty
The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate
safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Inc., shall not be held liable for
any damage resulting from handling or from contact with the above product. See reverse side of invoice or packing slip for additional
terms and conditions of sale. Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited paper copies for internal use only.
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www.sigma-aldrich.com
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