DIAZOMETHANE 1256
March 1995
Azimethylene
CAS No: 334-88-3
Diazirine
RTECS No: PA7000000
CH2N2
EC No: 006-068-00-8
Molecular mass: 42.04
TYPES OF
ACUTE HAZARDS/SYMPTOMS PREVENTION FIRST AID/FIRE FIGHTING
HAZARD/
EXPOSURE
Extremely flammable. Many NO open flames, NO sparks, and Shut off supply; if not possible and
FIRE
reactions may cause fire or NO smoking. no risk to surroundings, let the fire
explosion. Gives off irritating or burn itself out; in other cases
toxic fumes (or gases) in a fire. extinguish with powder, carbon
dioxide.
Gas/air mixtures are explosive. Closed system, ventilation, Combat fire from a sheltered
EXPLOSION
explosion-proof electrical equipment position.
and lighting. Do NOT expose to
friction or shock. Prevent build-up of
electrostatic charges (e.g., by
grounding).
EXPOSURE AVOID ALL CONTACT! IN ALL CASES CONSULT A
DOCTOR!
Headache. Laboured breathing. Ventilation, local exhaust, or Fresh air, rest. Half-upright position.
Inhalation
Shortness of breath. Sore throat. breathing protection. Artificial respiration may be needed.
Vomiting. Malaise. Symptoms may Refer for medical attention.
be delayed (see Notes).
Redness. Burning sensation. Pain. Cold-insulating gloves. ON FROSTBITE: rinse with plenty
Skin
Serious frostbite. of water, do NOT remove clothes.
Refer for medical attention. Wear
protective gloves when
administering first aid.
Redness. Pain. Face shield or eye protection in First rinse with plenty of water for
Eyes
combination with breathing several minutes (remove contact
protection. lenses if easily possible), then take
to a doctor.
Do not eat, drink, or smoke during
Ingestion
work.
SPILLAGE DISPOSAL PACKAGING & LABELLING
Evacuate danger area! Consult an expert! T Symbol
Ventilation. Personal protection: complete protective R: 45
clothing including self-contained breathing S: 53-45
apparatus.
EMERGENCY RESPONSE SAFE STORAGE
Solutions of diazomethane should not be stored (see Notes).
IPCS Prepared in the context of cooperation between the International
Programme on Chemical Safety and the European Commission 漏
International IPCS 2005
Programme on
Chemical Safety SEE IMPORTANT INFORMATION ON THE BACK.
1256 DIAZOMETHANE
IMPORTANT DATA
Physical State; Appearance Routes of exposure
YELLOW GAS. The substance can be absorbed into the body by inhalation.
Physical dangers Inhalation risk
The gas is heavier than air and may travel along the ground; A harmful concentration of this gas in the air will be reached
distant ignition possible. very quickly on loss of containment.
Chemical dangers Effects of short-term exposure
May explosively decompose on shock, friction, or concussion. The substance is very corrosive to the eyes, the skin and the
May explode on heating at 100/C, or on contact with rough respiratory tract. Inhalation of the vapour may cause lung
surfaces or if impurities or solids are present in the undiluted oedema (see Notes). Inhalation of the vapour may cause
liquid or in the concentrated solutions, or under high intensity asthmatic reactions (see Notes). The liquid may cause frostbite.
lighting. Contact with alkali metals and calcium sulfate causes Exposure above the OEL may result in death. Medical
explosions. observation is indicated.
Occupational exposure limits Effects of long-term or repeated exposure
TLV: 0.2 ppm as TWA; (ACGIH 2004). Repeated or prolonged inhalation exposure may cause asthma.
MAK: Carcinogen category: 2; (DFG 2004). This substance is possibly carcinogenic to humans.
PHYSICAL PROPERTIES
Boiling point: -23/C Relative vapour density (air = 1): 1.4
Melting point: -145/C Flash point: Flammable Gas
Relative density (water = 1): 1.45 Auto-ignition temperature: (explosion) 100/C
Solubility in water: reaction
ENVIRONMENTAL DATA
NOTES
Because of its toxicity and its explosive nature, diazomethane is freshly prepared in situ and used in solution of ether or dioxane.
The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical
effort. Rest and medical observation are therefore essential.
Immediate administration of an appropriate spray, by a doctor or a person authorized by him/her, should be considered.
The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort.
Rest and medical observation are therefore essential.
The relation between odour and the occupational exposure limit cannot be indicated.
The recommendations on this Card also apply to concentrated solutions of diazomethane.
Card has been partly updated in April 2005. See section Occupational Exposure Limits.
ADDITIONAL INFORMATION
Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible
LEGAL NOTICE
漏IPCS 2005
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