Page 1 of 38
Kit MSDS Cover Sheet
Doc. ID: A14208-75: Rev. AC
Product Information
Product Name FOLATE . Doc. ID: A14208-75 AC
. Revised (year/month/day) 2008/02/13
Part Number A14208
ACCESS庐
Series Name
Components
Description
Folate PMP/MxFBP (Compartment R1a)
Ascorbate HCl (Compartment R1b)
Folate Binding Protein (Compartment R1c)
Folate Conjugate (Compartment R1d)
0.6M K3PO4 (Compartment R1e)
Transport Information
Chemical kit
Shipping Name
Shipping Information
3316
UN/ID Number
III
Packing Group
9 Miscellaneous Dangerous Goods
Hazard Class
IATA
None
Subsidiary Risk
A44; A802
Special Provisions
9L
IATA ERG Code
9 Miscellaneous dangerous substances
Hazard Class
IMDG
and articles
None
Subsidiary Risk
251
Special Provisions
No
Marine Pollutant
9 Miscellaneous hazardous material
Hazard Class
US DOT
None
Subsidiary Risk
15
Special Provisions
171
NAERG Number
9 Miscellaneous dangerous substances
ADR Classi飥乧ation
European ADR
and articles
M11
Classi飥乧ation Code/
None
Subsidiary Risk
3316
PIN
Canadian TDG
漏2008 Beckman Coulter, Inc.
Global MSDS 鈥? English
Page 2 of 38
Transport Information (Continued)
9 Miscellaneous Dangerous Goods
TDG Classi飥乧ation
None
Subsidiary Risk
65
Special Provisions
171
NAERG Number
Page 3 of 38
MATERIAL SAFETY DATA SHEET
Section 1 Company and Product Identi飥乧ation
Product Name Folate PMP/MxFBP (Compartment R1a) . FOLATE
.. Doc. ID: A14208-75 AC
. Revised (year/month/day) 2008/02/13
Part Number Component of P/N A14208
Product Use For In Vitro Diagnostic Use. See product literature for details.
Series Name ACCESS庐
Manufacturer Beckman Coulter, Inc.
4300 Harbor Blvd.
Fullerton, CA 92835-3100, U.S.A.
EC REP Address Beckman Coulter Ireland Inc.
Mervue Business Park
Mervue, Galway, Ireland 353 91 774068
Distributor and Refer to attached list, Document ID: 472050, for local distributor
and emergency phone numbers.
Emergency Phone No.
Section 2 Hazards Identi飥乧ation
Emergency Overview
Reddish-brown; Opaque; Liquid - Suspension; Musty
Non飥俛mmable aqueous solution.
Skin, eye and respiratory tract irritant.
Potential sensitizer.
Contains material of human and animal origin.
Physical Hazards Sodium azide forms explosive compounds with heavy metals. This product
contains concentrations of azide <0.1% (w/w) which with repeated contact
with lead and copper commonly found in plumbing drains may result in
the build up of shock sensitive compounds.
Potential Health May cause irritation of respiratory tract, skin and eyes; central nervous system
depression; severe kidney damage and reproductive effects.
Effects Summary
See Section 11 Toxicological Information for more detailed health information.
Potential Not applicable
Environmental Effects
Product Hazard Meets Hazardous Criteria for Preparation/Mixture
Classi飥乧ations
EU: WHMIS: US OSHA:
Xi;R43 Hazardous
Exempt
.
Page 4 of 38
FOLATE Doc. ID: A14208-75 AC
Folate PMP/MxFBP (Compartment R1a)
Section 3 Composition and Information on Ingredients
Hazardous Ingredients: Hazard Classi飥乧ation of Pure Ingredients
EU
Chemical Name CAS # EINECS # % by wt. WHMIS US OSHA
1303-96-4 2375602 <2 Irritant
Sodium Borate Xi;R36/37/38 D2B
Decahydrate
Not available Not available <0.05
ProClin* 300 C;R34 Corrosive
D2B
N;R50-53 Sensitizer
T;R23/24/25-43 Toxic
See Section 15 Regulatory Information for additional information on hazard classi飥乧ations.
See Section 16 for Risk Phrases and WHMIS Classi飥乧ation Description.
Section 4 First Aid Measures
Inhalation If product is inhaled, move exposed individual to fresh air. If individual is not
breathing, begin arti飥乧ial respiration immediately and obtain medical attention.
Eye Contact If product enters eyes, wash eyes gently under running water for 15
minutes or longer, making sure that the eyelids are held open. If pain
or irritation occur, obtain medical attention.
Skin Contact In case of skin contact, 飥倁sh with copious amounts of water for at
least 15 minutes. Remove contaminated clothing and shoes. If pain
or irritation occur, obtain medical attention.
Ingestion If ingested, wash mouth out with water. If irritation or discomfort
occurs, seek medical attention.
Section 5 Fire Fighting Measures
Flammable Properties Non飥俛mmable aqueous solution.
Extinguishing Media Use extinguishing media suitable for surrounding 飥乺e.
No special hazards determined.
Special Fire and Explosion
Hazards
Hazardous Combustion Due to the composition and volume of this product, combustion products
generated from it are not expected to present a signi飥乧ant hazard.
Products
Protective Equipment Self-contained breathing apparatus is recommended for 飥乺e飥乬hters.
for Fire飥乬hters
Section 6 Accidental Release Measures
Personal Precautions This product contains a material of biological origin. Use universal
precautions during clean up procedures.
Page 5 of 38
FOLATE Doc. ID: A14208-75 AC
Folate PMP/MxFBP (Compartment R1a)
Section 6 Accidental Release Measures (Continued)
Spill and Leak As a precautionary measure, treat spilled material with a 1:10 bleach/water solution.
Absorb liquid and place in container suitable for disposal. Avoid generation of
Procedures
aerosols during clean up. Comply with applicable waste disposal regulations.
Environmental Contain spill to prevent migration.
Precautions
Section 7 Handling and Storage
Handling Precautions This product should be handled as though capable of transmitting infectious
diseases. Universal precautions should be followed when using this product.
Recommended Storage Keep away from incompatible material (see Section 10).
Conditions To maintain ef飥乧acy, store according to the instructions in the product labeling.
Section 8 Exposure Controls and Personal Protection
Exposure Limits
None established
US OSHA:
ACGIH:
Sodium Borate Decahydrate 6 mg/m3 STEL (inhalable fraction, listed under Borate compounds, inorganic); 2
mg/m3 TWA (inhalable fraction, listed under Borate compounds, inorganic)
None established
DFG MAK:
NIOSH
Sodium Borate Decahydrate 5 mg/m3 TWA
Japan None established
No special engineering controls are required. Use with good general ventilation.
Engineering Controls
Respiratory Protection Under normal conditions, the use of this product should not require respiratory
protection. If aerosols are generated during use, the use of respiratory
protection should be evaluated by a quali飥乪d professional.
Eye Protection Safety glasses or chemical goggles should be worn to prevent eye contact.
Impervious gloves, such as Nitrile or equivalent, should be worn
Skin Protection
to prevent skin contact.
Section 9 Physical and Chemical Properties
Physical State Liquid - Suspension
Reddish-brown
Color
Transparency Opaque
Musty
Odor
Not applicable
Odor Threshold
Page 6 of 38
FOLATE Doc. ID: A14208-75 AC
Folate PMP/MxFBP (Compartment R1a)
Section 9 Physical and Chemical Properties (Continued)
pH 7.4
Freezing Point Not available
Boiling Point Not available
Flash Point Not applicable
Evaporation Rate Not available
Not applicable
Flammability (Solid, Gas)
Flammable Limits Not applicable
Vapor Pressure Not available
Vapor Density Not available
Speci飥乧 Gravity 1.014 @20掳C
Solubility
Water Miscible
Not available
Organic
Not available
Coef飥乧ient of Water/Oil
Distribution
Autoignition Temp. Not applicable
Decomposition Temperature Not available
Percent Volatiles Not applicable
Section 10 Stability and Reactivity
Stability Stable under normal temperatures and pressures.
Hazardous Incompatibilities Metals and metallic compounds
Strong acids
Strong bases
Strong oxidizers
Sodium azide forms explosive compounds with heavy metals. This product
contains concentrations of azide <0.1% (w/w) which with repeated contact
with lead and copper commonly found in plumbing drains may result in
the build up of shock sensitive compounds.
Hazardous Decomposition When stored as labeled, no known hazardous decomposition products
are formed during the shelf-life of this product.
Products
Conditions to Avoid Keep away from incompatible material.
Page 7 of 38
FOLATE Doc. ID: A14208-75 AC
Folate PMP/MxFBP (Compartment R1a)
Section 11 Toxicological Information
Toxicity Data
for Hazardous Ingredients
Sodium Borate Decahydrate Oral LD50 Rat: 2660 mg/kg
Primary Routes Common routes of entry include inhalation, ingestion and eye/skin contact. Speci飥乧
paths of concern for potentially infectious materials are skin puncture, contact with
of Exposure
broken skin, contact with mucous membranes and inhalation of aerosolized material.
Potential Effects of Ingestion or absorption of concentrated borates through the skin may cause systemic
effects including nausea, vomiting, diarrhea and restlessness. Extremely high
Acute Exposure
concentrations may result in central nervous system and cardiovascular disorders with
delirium, convulsions, coma and kidney damage. May cause skin and eye irritation.
This product contains materials of human and animal origin and should be
considered as potentially capable of transmitting infectious diseases.
Exposure to ProClin 300 may result in irritation of skin, eyes and mucous
membranes. Skin contact may result in possible sensitization. Eye contact may
cause clouding of the cornea. Ingestion may cause gastrointestinal irritation;
large doses given to animals resulted in collapse and coma.
Potential Effects of Chronic Chronic skin absorption or ingestion of borates may result in conditions similar to
those described for acute exposure. Repeated or prolonged skin and eye contact
Exposure
may cause dermatitis and conjunctivitis with irritation and redness.
Frequent or long-term eye and skin exposure to ProClin 300 may
result in conjunctivitis and dermatitis.
Symptoms of Overexposure Symptoms may include: coughing, headache, fatigue, nausea, vomiting, dizziness,
blurred vision, red and watery eyes, abdominal pain and unconsciousness.
Carcinogenicity This product does not contain a reportable concentration (鈮? 0.1%) of any ingredient
listed as carcinogen by ACGIH, IARC, NTP, OSHA or 67/548/EEC Annex I.
Other Effects Reproductive effects have been reported in test animals exposed
to borates by ingestion.
Conditions Aggravated Individuals with respiratory and skin disorders may 飥乶d these conditions
aggravated by exposure to this product.
by Exposure
Section 12 Ecological Information
Ecotoxicity
Sodium Borate Decahydrate 96 Hr LC50 Limanda limanda: 340 mg/L
Biodegradability No information available.
Bioaccumulation No information available.
Mobility No information available.
Other Adverse Effects No information available.
Page 8 of 38
FOLATE Doc. ID: A14208-75 AC
Folate PMP/MxFBP (Compartment R1a)
Section 13 Disposal Considerations
Waste Disposal Dispose of waste product, unused product and contaminated packaging in
compliance with federal, state and local regulations. If unsure of the applicable
requirements, contact the authorities for information.
Sodium azide preservative may form explosive compounds in metal drain lines.
See NIOSH Bulletin: Explosive Azide Hazard (8/16/76).
Section 14 Transport Information
Transportation of this product is not regulated under ICAO, IMDG, US DOT, European ADR or Canadian TDG.
Section 15 Regulatory Information
US Federal and State Regulations
SARA 313 Acetaldehyde is subject to reporting requirements of Section 313, Title III of SARA.
Ethylene Oxide is subject to reporting requirements of Section 313, Title III of SARA.
1,4-Dioxane is subject to reporting requirements of Section 313, Title III of SARA.
Sodium Azide is subject to reporting requirements of Section 313, Title III of SARA.
Zinc Chloride is subject to reporting requirements of Section 313, Title III of SARA.
Acetaldehyde is listed.
CERCLA RG鈥檚,
40 CFR 302.4 Ethylene Oxide is listed.
1,4-Dioxane is listed.
Sodium Phosphate, Dibasic is listed.
Zinc Chloride is listed.
Sodium Azide is listed.
California Proposition 65 Acetaldehyde has been identi飥乪d by the State of California to cause cancer.
The State of California has adopted a regulation which requires a warning
be given to individual who may be exposed to chemicals identi飥乪d by
the State to cause cancer or reproductive harm. Accordingly, Beckman
Coulter advises you of the following warning:
WARNING: This product contains a chemical known to the State
of California to cause cancer.
Ethylene Oxide has been identi飥乪d by the State of California to cause cancer
and reproductive harm. The State of California has adopted a regulation which
requires a warning be given to individual who may be exposed to chemicals
identi飥乪d by the State to cause cancer or reproductive harm. Accordingly,
Beckman Coulter advises you of the following warning:
WARNING: This product contains a chemical known to the State of
California to cause cancer and reproductive harm.
1,4-Dioxane has been identi飥乪d by the State of California to cause cancer.
The State of California has adopted a regulation which requires a warning
be given to individual who may be exposed to chemicals identi飥乪d by
the State to cause cancer or reproductive harm. Accordingly, Beckman
Coulter advises you of the following warning:
WARNING: This product contains a chemical known to the State
of California to cause cancer.
Page 9 of 38
FOLATE Doc. ID: A14208-75 AC
Folate PMP/MxFBP (Compartment R1a)
Section 15 Regulatory Information (Continued)
Acetaldehyde is listed.
Massachusetts MSL
Ethylene Oxide is listed.
1,4-Dioxane is listed.
Sodium Borate Decahydrate is listed.
Sodium Phosphate, Dibasic is listed.
Zinc Chloride is listed.
Sodium Azide is listed.
Acetaldehyde is listed.
New Jersey Dept. of
Health RTK List Ethylene Oxide is listed.
1,4-Dioxane is listed.
Sodium Borate Decahydrate is listed.
Sodium Phosphate, Dibasic is listed.
Zinc Chloride is listed.
Sodium Azide is listed.
Pennsylvania RTK Acetaldehyde is listed.
Ethylene Oxide is listed.
1,4-Dioxane is listed.
Sodium Borate Decahydrate is listed.
Sodium Phosphate, Dibasic is listed.
Zinc Chloride is listed.
Sodium Azide is listed.
Dipropylene Glycol is listed.
EU Labeling Classi飥乧ation
Classi飥乧ation Risk and Safety Phrases
R43 May cause sensitization by skin contact.
S28 After contact with skin, wash immediately with plenty of soap and water.
Irritant
S37 Wear suitable gloves.
Canada
This product is exempt from WHMIS label and MSDS requirements.
Not applicable
PIN:
Ingredients on Ingredient Acetaldehyde
Disclosure List: Ethylene Oxide
1,4-Dioxane
Sodium Borate Decahydrate
Zinc Chloride
Sodium Azide
Ingredients with unknown Product is exempt
toxicological properties:
Some hazardous ingredients listed in Section 15 are below OSHAs and WHMIS鈥? 1.0% w/w (0.1% for carcinogens)
or EU鈥檚 ingredient speci飥乧 concentrations required for reporting in Section 3.
Page 10 of 38
FOLATE Doc. ID: A14208-75 AC
Folate PMP/MxFBP (Compartment R1a)
Section 16 Other Information
Beckman Coulter Safety Flammability (Section V): 0 Code
Health (Section XI): 2 0=none
Rating
Reactivity with Water (Section X): 0 1=slight
Contact (Section VIII): 2 2=caution
3=severe
Revision Changes Reformatted Sections 2, 3, 5, 8, 9, 12, 15, and 16 per ANSI Z400.1-2004 Standard.
Risk Phrases and R23/24/25 Toxic by inhalation, in contact with skin and if swallowed.
WHMIS Classi飥乧ation R34 Causes burns.
Description From R36/37/38 Irritating to eyes, respiratory system and skin.
Section 3 R43 May cause sensitization by skin contact.
R50 Very toxic to aquatic organisms.
R53 May cause long-term adverse effects in the aquatic environment.
D2B - Chronic Toxic Effects
D2B - Skin Or Eye Irritant
D2B - Sensitizer - Skin
* ProClin is a trademark of the Rohm and Haas Company.
For further information, please contact your local Beckman Coulter representative.
WHILE BECKMAN COULTER, INC. BELIEVES THE INFORMATION CONTAINED HEREIN IS VALID AND ACCURATE, BECKMAN COULTER MAKES NO
WARRANTY OR REPRESENTATION AS TO ITS VALIDITY, ACCURACY, OR CURRENCY. BECKMAN COULTER SHALL NOT BE LIABLE OR OTHERWISE
RESPONSIBLE IN ANY WAY FOR USE OF EITHER THIS INFORMATION OR MATERIALS TO WHICH IT APPLIES. DISPOSAL OF HAZARDOUS
MATERIALS MAY BE SUBJECT TO LOCAL LAWS OR REGULATIONS.
Printed in U.S.A.
Page 11 of 38
MATERIAL SAFETY DATA SHEET
Section 1 Company and Product Identi飥乧ation
Product Name Ascorbate HCl (Compartment R1b) . FOLATE
.. Doc. ID: A14208-75 AC
. Revised (year/month/day) 2008/02/13
Part Number Component of P/N A14208
Product Use For In Vitro Diagnostic Use. See product literature for details.
Series Name ACCESS庐
Manufacturer Beckman Coulter, Inc.
4300 Harbor Blvd.
Fullerton, CA 92835-3100, U.S.A.
EC REP Address Beckman Coulter Ireland Inc.
Mervue Business Park
Mervue, Galway, Ireland 353 91 774068
Distributor and Refer to attached list, Document ID: 472050, for local distributor
and emergency phone numbers.
Emergency Phone No.
Section 2 Hazards Identi飥乧ation
Emergency Overview
Yellow; Clear; Liquid; Odorless
Non飥俛mmable aqueous solution.
Does not meet EU, OSHA or WHMIS criteria for hazardous materials.
Physical Hazards No physical hazards were determined from a review of available literature.
Potential Health This product does not meet EU, OSHA or WHMIS criteria for hazardous materials.
Effects Summary
Potential None identi飥乪d.
Environmental Effects
Product Hazard Meets Hazardous Criteria for Preparation/Mixture
Classi飥乧ations
EU: WHMIS: US OSHA:
Not applicable Not applicable
Exempt
.
Section 3 Composition and Information on Ingredients
Hazardous Ingredients: None
Page 12 of 38
FOLATE Doc. ID: A14208-75 AC
Ascorbate HCl (Compartment R1b)
Section 4 First Aid Measures
Inhalation If product is inhaled, move exposed individual to fresh air. If individual is not
breathing, begin arti飥乧ial respiration immediately and obtain medical attention.
Eye Contact If product enters eyes, wash eyes gently under running water for 15
minutes or longer, making sure that the eyelids are held open. If pain
or irritation occur, obtain medical attention.
Skin Contact In case of skin contact, 飥倁sh with copious amounts of water for at
least 15 minutes. Remove contaminated clothing and shoes. If pain
or irritation occur, obtain medical attention.
Ingestion If ingested, wash mouth out with water. If irritation or discomfort
occurs, seek medical attention.
Section 5 Fire Fighting Measures
Flammable Properties Non飥俛mmable aqueous solution.
Extinguishing Media Use extinguishing media suitable for surrounding 飥乺e.
No special hazards determined.
Special Fire and Explosion
Hazards
Hazardous Combustion No combustion products posing signi飥乧ant hazards are expected from this product.
Products
Protective Equipment Self-contained breathing apparatus is recommended for 飥乺e飥乬hters.
for Fire飥乬hters
Section 6 Accidental Release Measures
Personal Precautions No special precautions are necessary. Use good laboratory procedures.
Spill and Leak Absorb spilled material with an appropriate inert, non-飥俛mmable absorbent
and dispose according to local regulations.
Procedures
Environmental Contain spill to prevent migration.
Precautions
Section 7 Handling and Storage
Handling Precautions No special precautions are necessary; use good laboratory procedures.
Recommended Storage To maintain ef飥乧acy, store according to the instructions in the product labeling.
Conditions
Section 8 Exposure Controls and Personal Protection
Exposure Limits
None established
US OSHA:
Page 13 of 38
FOLATE Doc. ID: A14208-75 AC
Ascorbate HCl (Compartment R1b)
Section 8 Exposure Controls and Personal Protection (Continued)
None established
ACGIH:
None established
DFG MAK:
None established
NIOSH
Japan None established
No special engineering controls are required. Use with good general ventilation.
Engineering Controls
Respiratory Protection Under normal conditions, the use of this product should not
require respiratory protection.
Eye Protection Safety glasses or chemical goggles should be worn to prevent eye contact.
Impervious gloves, such as Nitrile or equivalent, should be worn
Skin Protection
to prevent skin contact.
Section 9 Physical and Chemical Properties
Liquid
Physical State
Yellow
Color
Transparency Clear
Odor Odorless
Not applicable
Odor Threshold
鈮? 5.5
pH
Freezing Point Not available
Boiling Point Not available
Flash Point Not applicable
Evaporation Rate Not available
Not applicable
Flammability (Solid, Gas)
Flammable Limits Not applicable
Vapor Pressure Not available
Vapor Density Not available
Speci飥乧 Gravity 1.099 @20掳C
Solubility
Water Miscible
Not available
Organic
Not available
Coef飥乧ient of Water/Oil
Distribution
Autoignition Temp. Not applicable
Page 14 of 38
FOLATE Doc. ID: A14208-75 AC
Ascorbate HCl (Compartment R1b)
Section 9 Physical and Chemical Properties (Continued)
Decomposition Temperature Not available
Percent Volatiles Not applicable
Section 10 Stability and Reactivity
Stability Stable under normal temperatures and pressures.
Hazardous Incompatibilities Strong acids
Strong bases
Strong oxidizers
Hazardous Decomposition When stored as labeled, no known hazardous decomposition products
are formed during the shelf-life of this product.
Products
Conditions to Avoid Keep away from incompatible material.
Section 11 Toxicological Information
Toxicity Data Not applicable
for Hazardous Ingredients
Primary Routes The most likely routes of exposure are skin, eye contact and inhalation.
of Exposure
Potential Effects of None identi飥乪d.
Acute Exposure
Potential Effects of Chronic None identi飥乪d.
Exposure
Symptoms of Overexposure None identi飥乪d.
Carcinogenicity No ingredients in this product are listed as carcinogens by ACGIH,
IARC, NTP, OSHA or 67/548/EEC Annex I.
Other Effects None identi飥乪d.
Conditions Aggravated None identi飥乪d.
by Exposure
Section 12 Ecological Information
Ecotoxicity No information available.
Biodegradability No information available.
Bioaccumulation No information available.
Mobility No information available.
Other Adverse Effects No information available.
Page 15 of 38
FOLATE Doc. ID: A14208-75 AC
Ascorbate HCl (Compartment R1b)
Section 13 Disposal Considerations
Waste Disposal Dispose of waste product, unused product and contaminated packaging in
compliance with federal, state and local regulations. If unsure of the applicable
requirements, contact the authorities for information.
Section 14 Transport Information
Transportation of this product is not regulated under ICAO, IMDG, US DOT, European ADR or Canadian TDG.
Section 15 Regulatory Information
US Federal and State Regulations
SARA 313 Hydrochloric Acid is subject to reporting requirements of Section 313, Title III of SARA.
Hydrochloric Acid is listed.
CERCLA RG鈥檚,
40 CFR 302.4
No ingredients listed.
California Proposition 65
Hydrochloric Acid is listed.
Massachusetts MSL
Hydrochloric Acid is listed.
New Jersey Dept. of
Health RTK List
Pennsylvania RTK Hydrochloric Acid is listed.
EU Labeling Classi飥乧ation
Preparation not classi飥乪d.
Canada
This product is exempt from WHMIS label and MSDS requirements.
Not applicable
PIN:
Ingredients on Ingredient Hydrochloric Acid
Disclosure List:
Ingredients with unknown Product is exempt
toxicological properties:
Some hazardous ingredients listed in Section 15 are below OSHAs and WHMIS鈥? 1.0% w/w (0.1% for carcinogens)
or EU鈥檚 ingredient speci飥乧 concentrations required for reporting in Section 3.
Page 16 of 38
FOLATE Doc. ID: A14208-75 AC
Ascorbate HCl (Compartment R1b)
Section 16 Other Information
Beckman Coulter Safety Flammability (Section V): 0 Code
Health (Section XI): 0 0=none
Rating
Reactivity with Water (Section X): 0 1=slight
Contact (Section VIII): 1 2=caution
3=severe
Revision Changes Reformatted Sections 2, 3, 5, 8, 9, 12, 15, and 16 per ANSI Z400.1-2004 Standard.
For further information, please contact your local Beckman Coulter representative.
WHILE BECKMAN COULTER, INC. BELIEVES THE INFORMATION CONTAINED HEREIN IS VALID AND ACCURATE, BECKMAN COULTER MAKES NO
WARRANTY OR REPRESENTATION AS TO ITS VALIDITY, ACCURACY, OR CURRENCY. BECKMAN COULTER SHALL NOT BE LIABLE OR OTHERWISE
RESPONSIBLE IN ANY WAY FOR USE OF EITHER THIS INFORMATION OR MATERIALS TO WHICH IT APPLIES. DISPOSAL OF HAZARDOUS
MATERIALS MAY BE SUBJECT TO LOCAL LAWS OR REGULATIONS.
Printed in U.S.A.
Page 17 of 38
MATERIAL SAFETY DATA SHEET
Section 1 Company and Product Identi飥乧ation
Product Name Folate Binding Protein (Compartment . FOLATE
.. Doc. ID: A14208-75 AC
R1c) . Revised (year/month/day) 2008/02/13
Part Number Component of P/N A14208
Product Use For In Vitro Diagnostic Use. See product literature for details.
Series Name ACCESS庐
Manufacturer Beckman Coulter, Inc.
4300 Harbor Blvd.
Fullerton, CA 92835-3100, U.S.A.
EC REP Address Beckman Coulter Ireland Inc.
Mervue Business Park
Mervue, Galway, Ireland 353 91 774068
Distributor and Refer to attached list, Document ID: 472050, for local distributor
and emergency phone numbers.
Emergency Phone No.
Section 2 Hazards Identi飥乧ation
Emergency Overview
Colorless; Translucent; Liquid; Musty
Non飥俛mmable aqueous solution.
Skin, eye and respiratory tract irritant.
Potential sensitizer.
Contains material of human and animal origin.
Physical Hazards Sodium azide forms explosive compounds with heavy metals. This product
contains concentrations of azide <0.1% (w/w) which with repeated contact
with lead and copper commonly found in plumbing drains may result in
the build up of shock sensitive compounds.
Potential Health May cause irritation of respiratory tract, skin and eyes; central nervous system
depression; severe kidney damage and reproductive effects.
Effects Summary
See Section 11 Toxicological Information for more detailed health information.
Potential Not applicable
Environmental Effects
Product Hazard Meets Hazardous Criteria for Preparation/Mixture
Classi飥乧ations
EU: WHMIS: US OSHA:
Xi;R43 Hazardous
Exempt
.
Page 18 of 38
FOLATE Doc. ID: A14208-75 AC
Folate Binding Protein (Compartment R1c)
Section 3 Composition and Information on Ingredients
Hazardous Ingredients: Hazard Classi飥乧ation of Pure Ingredients
EU
Chemical Name CAS # EINECS # % by wt. WHMIS US OSHA
1303-96-4 2375602 <2 Irritant
Sodium Borate Xi;R36/37/38 D2B
Decahydrate
Not available Not available <0.05
ProClin* 300 C;R34 Corrosive
D2B
N;R50-53 Sensitizer
T;R23/24/25-43 Toxic
See Section 15 Regulatory Information for additional information on hazard classi飥乧ations.
See Section 16 for Risk Phrases and WHMIS Classi飥乧ation Description.
Section 4 First Aid Measures
Inhalation If product is inhaled, move exposed individual to fresh air. If individual is not
breathing, begin arti飥乧ial respiration immediately and obtain medical attention.
Eye Contact If product enters eyes, wash eyes gently under running water for 15
minutes or longer, making sure that the eyelids are held open. If pain
or irritation occur, obtain medical attention.
Skin Contact In case of skin contact, 飥倁sh with copious amounts of water for at
least 15 minutes. Remove contaminated clothing and shoes. If pain
or irritation occur, obtain medical attention.
Ingestion If ingested, wash mouth out with water. If irritation or discomfort
occurs, seek medical attention.
Section 5 Fire Fighting Measures
Flammable Properties Non飥俛mmable aqueous solution.
Extinguishing Media Use extinguishing media suitable for surrounding 飥乺e.
No special hazards determined.
Special Fire and Explosion
Hazards
Hazardous Combustion Due to the composition and volume of this product, combustion products
generated from it are not expected to present a signi飥乧ant hazard.
Products
Protective Equipment Self-contained breathing apparatus is recommended for 飥乺e飥乬hters.
for Fire飥乬hters
Section 6 Accidental Release Measures
Personal Precautions This product contains a material of biological origin. Use universal
precautions during clean up procedures.
Page 19 of 38
FOLATE Doc. ID: A14208-75 AC
Folate Binding Protein (Compartment R1c)
Section 6 Accidental Release Measures (Continued)
Spill and Leak As a precautionary measure, treat spilled material with a 1:10 bleach/water solution.
Absorb liquid and place in container suitable for disposal. Avoid generation of
Procedures
aerosols during clean up. Comply with applicable waste disposal regulations.
Environmental Contain spill to prevent migration.
Precautions
Section 7 Handling and Storage
Handling Precautions This product should be handled as though capable of transmitting infectious
diseases. Universal precautions should be followed when using this product.
Recommended Storage Keep away from incompatible material (see Section 10).
Conditions To maintain ef飥乧acy, store according to the instructions in the product labeling.
Section 8 Exposure Controls and Personal Protection
Exposure Limits
None established
US OSHA:
ACGIH:
Sodium Borate Decahydrate 6 mg/m3 STEL (inhalable fraction, listed under Borate compounds, inorganic); 2
mg/m3 TWA (inhalable fraction, listed under Borate compounds, inorganic)
None established
DFG MAK:
NIOSH
Sodium Borate Decahydrate 5 mg/m3 TWA
Japan None established
No special engineering controls are required. Use with good general ventilation.
Engineering Controls
Respiratory Protection Under normal conditions, the use of this product should not require respiratory
protection. If aerosols are generated during use, the use of respiratory
protection should be evaluated by a quali飥乪d professional.
Eye Protection Safety glasses or chemical goggles should be worn to prevent eye contact.
Impervious gloves, such as Nitrile or equivalent, should be worn
Skin Protection
to prevent skin contact.
Section 9 Physical and Chemical Properties
Liquid
Physical State
Color Colorless
Transparency Translucent
Musty
Odor
Not applicable
Odor Threshold
Page 20 of 38
FOLATE Doc. ID: A14208-75 AC
Folate Binding Protein (Compartment R1c)
Section 9 Physical and Chemical Properties (Continued)
pH 7.4
Freezing Point Not available
Boiling Point Not available
Flash Point Not applicable
Evaporation Rate Not available
Not applicable
Flammability (Solid, Gas)
Flammable Limits Not applicable
Vapor Pressure Not available
Vapor Density Not available
Speci飥乧 Gravity 1.014 @20掳C
Solubility
Water Miscible
Not available
Organic
Not available
Coef飥乧ient of Water/Oil
Distribution
Autoignition Temp. Not applicable
Decomposition Temperature Not available
Percent Volatiles Not applicable
Section 10 Stability and Reactivity
Stability Stable under normal temperatures and pressures.
Hazardous Incompatibilities Metals and metallic compounds
Strong acids
Strong bases
Strong oxidizers
Sodium azide forms explosive compounds with heavy metals. This product
contains concentrations of azide <0.1% (w/w) which with repeated contact
with lead and copper commonly found in plumbing drains may result in
the build up of shock sensitive compounds.
Hazardous Decomposition When stored as labeled, no known hazardous decomposition products
are formed during the shelf-life of this product.
Products
Conditions to Avoid Keep away from incompatible material.
Page 21 of 38
FOLATE Doc. ID: A14208-75 AC
Folate Binding Protein (Compartment R1c)
Section 11 Toxicological Information
Toxicity Data
for Hazardous Ingredients
Sodium Borate Decahydrate Oral LD50 Rat: 2660 mg/kg
Primary Routes Common routes of entry include inhalation, ingestion and eye/skin contact. Speci飥乧
paths of concern for potentially infectious materials are skin puncture, contact with
of Exposure
broken skin, contact with mucous membranes and inhalation of aerosolized material.
Potential Effects of Ingestion or absorption of concentrated borates through the skin may cause systemic
effects including nausea, vomiting, diarrhea and restlessness. Extremely high
Acute Exposure
concentrations may result in central nervous system and cardiovascular disorders with
delirium, convulsions, coma and kidney damage. May cause skin and eye irritation.
This product contains materials of human and animal origin and should be
considered as potentially capable of transmitting infectious diseases.
Exposure to ProClin 300 may result in irritation of skin, eyes and mucous
membranes. Skin contact may result in possible sensitization. Eye contact may
cause clouding of the cornea. Ingestion may cause gastrointestinal irritation;
large doses given to animals resulted in collapse and coma.
Potential Effects of Chronic Chronic skin absorption or ingestion of borates may result in conditions similar to
those described for acute exposure. Repeated or prolonged skin and eye contact
Exposure
may cause dermatitis and conjunctivitis with irritation and redness.
Frequent or long-term eye and skin exposure to ProClin 300 may
result in conjunctivitis and dermatitis.
Symptoms of Overexposure Symptoms may include: coughing, headache, fatigue, nausea, vomiting, dizziness,
blurred vision, red and watery eyes, abdominal pain and unconsciousness.
Carcinogenicity This product does not contain a reportable concentration (鈮? 0.1%) of any ingredient
listed as carcinogen by ACGIH, IARC, NTP, OSHA or 67/548/EEC Annex I.
Other Effects Reproductive effects have been reported in test animals exposed
to borates by ingestion.
Conditions Aggravated Individuals with respiratory and skin disorders may 飥乶d these conditions
aggravated by exposure to this product.
by Exposure
Section 12 Ecological Information
Ecotoxicity
Sodium Borate Decahydrate 96 Hr LC50 Limanda limanda: 340 mg/L
Biodegradability No information available.
Bioaccumulation No information available.
Mobility No information available.
Other Adverse Effects No information available.
Page 22 of 38
FOLATE Doc. ID: A14208-75 AC
Folate Binding Protein (Compartment R1c)
Section 13 Disposal Considerations
Waste Disposal Dispose of waste product, unused product and contaminated packaging in
compliance with federal, state and local regulations. If unsure of the applicable
requirements, contact the authorities for information.
Sodium azide preservative may form explosive compounds in metal drain lines.
See NIOSH Bulletin: Explosive Azide Hazard (8/16/76).
Section 14 Transport Information
Transportation of this product is not regulated under ICAO, IMDG, US DOT, European ADR or Canadian TDG.
Section 15 Regulatory Information
US Federal and State Regulations
SARA 313 Acetaldehyde is subject to reporting requirements of Section 313, Title III of SARA.
Ethylene Oxide is subject to reporting requirements of Section 313, Title III of SARA.
1,4-Dioxane is subject to reporting requirements of Section 313, Title III of SARA.
Sodium Azide is subject to reporting requirements of Section 313, Title III of SARA.
Zinc Chloride is subject to reporting requirements of Section 313, Title III of SARA.
Acetaldehyde is listed.
CERCLA RG鈥檚,
40 CFR 302.4 Ethylene Oxide is listed.
1,4-Dioxane is listed.
Sodium Phosphate, Dibasic is listed.
Zinc Chloride is listed.
Sodium Azide is listed.
California Proposition 65 Acetaldehyde has been identi飥乪d by the State of California to cause cancer.
The State of California has adopted a regulation which requires a warning
be given to individual who may be exposed to chemicals identi飥乪d by
the State to cause cancer or reproductive harm. Accordingly, Beckman
Coulter advises you of the following warning:
WARNING: This product contains a chemical known to the State
of California to cause cancer.
Ethylene Oxide has been identi飥乪d by the State of California to cause cancer
and reproductive harm. The State of California has adopted a regulation which
requires a warning be given to individual who may be exposed to chemicals
identi飥乪d by the State to cause cancer or reproductive harm. Accordingly,
Beckman Coulter advises you of the following warning:
WARNING: This product contains a chemical known to the State of
California to cause cancer and reproductive harm.
1,4-Dioxane has been identi飥乪d by the State of California to cause cancer.
The State of California has adopted a regulation which requires a warning
be given to individual who may be exposed to chemicals identi飥乪d by
the State to cause cancer or reproductive harm. Accordingly, Beckman
Coulter advises you of the following warning:
WARNING: This product contains a chemical known to the State
of California to cause cancer.
Page 23 of 38
FOLATE Doc. ID: A14208-75 AC
Folate Binding Protein (Compartment R1c)
Section 15 Regulatory Information (Continued)
Acetaldehyde is listed.
Massachusetts MSL
Ethylene Oxide is listed.
1,4-Dioxane is listed.
Sodium Borate Decahydrate is listed.
Sodium Phosphate, Dibasic is listed.
Zinc Chloride is listed.
Sodium Azide is listed.
Acetaldehyde is listed.
New Jersey Dept. of
Health RTK List Ethylene Oxide is listed.
1,4-Dioxane is listed.
Sodium Borate Decahydrate is listed.
Sodium Phosphate, Dibasic is listed.
Zinc Chloride is listed.
Sodium Azide is listed.
Pennsylvania RTK Acetaldehyde is listed.
Ethylene Oxide is listed.
1,4-Dioxane is listed.
Sodium Borate Decahydrate is listed.
Sodium Phosphate, Dibasic is listed.
Zinc Chloride is listed.
Sodium Azide is listed.
Dipropylene Glycol is listed.
EU Labeling Classi飥乧ation
Classi飥乧ation Risk and Safety Phrases
R43 May cause sensitization by skin contact.
S28 After contact with skin, wash immediately with plenty of soap and water.
Irritant
S37 Wear suitable gloves.
Canada
This product is exempt from WHMIS label and MSDS requirements.
Not applicable
PIN:
Ingredients on Ingredient Acetaldehyde
Disclosure List: Ethylene Oxide
1,4-Dioxane
Sodium Borate Decahydrate
Zinc Chloride
Sodium Azide
Ingredients with unknown Product is exempt
toxicological properties:
Some hazardous ingredients listed in Section 15 are below OSHAs and WHMIS鈥? 1.0% w/w (0.1% for carcinogens)
or EU鈥檚 ingredient speci飥乧 concentrations required for reporting in Section 3.
Page 24 of 38
FOLATE Doc. ID: A14208-75 AC
Folate Binding Protein (Compartment R1c)
Section 16 Other Information
Beckman Coulter Safety Flammability (Section V): 0 Code
Health (Section XI): 2 0=none
Rating
Reactivity with Water (Section X): 0 1=slight
Contact (Section VIII): 2 2=caution
3=severe
Revision Changes Reformatted Sections 2, 3, 5, 8, 9, 12, 15, and 16 per ANSI Z400.1-2004 Standard.
Risk Phrases and R23/24/25 Toxic by inhalation, in contact with skin and if swallowed.
WHMIS Classi飥乧ation R34 Causes burns.
Description From R36/37/38 Irritating to eyes, respiratory system and skin.
Section 3 R43 May cause sensitization by skin contact.
R50 Very toxic to aquatic organisms.
R53 May cause long-term adverse effects in the aquatic environment.
D2B - Chronic Toxic Effects
D2B - Skin Or Eye Irritant
D2B - Sensitizer - Skin
* ProClin is a trademark of the Rohm and Haas Company.
For further information, please contact your local Beckman Coulter representative.
WHILE BECKMAN COULTER, INC. BELIEVES THE INFORMATION CONTAINED HEREIN IS VALID AND ACCURATE, BECKMAN COULTER MAKES NO
WARRANTY OR REPRESENTATION AS TO ITS VALIDITY, ACCURACY, OR CURRENCY. BECKMAN COULTER SHALL NOT BE LIABLE OR OTHERWISE
RESPONSIBLE IN ANY WAY FOR USE OF EITHER THIS INFORMATION OR MATERIALS TO WHICH IT APPLIES. DISPOSAL OF HAZARDOUS
MATERIALS MAY BE SUBJECT TO LOCAL LAWS OR REGULATIONS.
Printed in U.S.A.
Page 25 of 38
MATERIAL SAFETY DATA SHEET
Section 1 Company and Product Identi飥乧ation
Product Name Folate Conjugate (Compartment R1d) . FOLATE
.. Doc. ID: A14208-75 AC
. Revised (year/month/day) 2008/02/13
Part Number Component of P/N A14208
Product Use For In Vitro Diagnostic Use. See product literature for details.
Series Name ACCESS庐
Manufacturer Beckman Coulter, Inc.
4300 Harbor Blvd.
Fullerton, CA 92835-3100, U.S.A.
EC REP Address Beckman Coulter Ireland Inc.
Mervue Business Park
Mervue, Galway, Ireland 353 91 774068
Distributor and Refer to attached list, Document ID: 472050, for local distributor
and emergency phone numbers.
Emergency Phone No.
Section 2 Hazards Identi飥乧ation
Emergency Overview
Colorless; Translucent; Liquid; Musty
Non飥俛mmable aqueous solution.
Skin, eye and respiratory tract irritant.
Contains material of human and animal origin.
Physical Hazards Sodium azide forms explosive compounds with heavy metals. This product
contains concentrations of azide <0.1% (w/w) which with repeated contact
with lead and copper commonly found in plumbing drains may result in
the build up of shock sensitive compounds.
Potential Health Exposure may result in irritation of skin, eyes, and mucous membranes.
Effects Summary See Section 11 Toxicological Information for more detailed health information.
Potential No information available.
Environmental Effects
Product Hazard Meets Hazardous Criteria for Preparation/Mixture
Classi飥乧ations
EU: WHMIS: US OSHA:
Not applicable Hazardous
Exempt
.
Page 26 of 38
FOLATE Doc. ID: A14208-75 AC
Folate Conjugate (Compartment R1d)
Section 3 Composition and Information on Ingredients
Hazardous Ingredients: Hazard Classi飥乧ation of Pure Ingredients
EU
Chemical Name CAS # EINECS # % by wt. WHMIS US OSHA
77-86-1 2010644 <2 Irritant
Tris(hydroxymethyl)- Xi;R36/37/38 D2B
aminomethane
See Section 15 Regulatory Information for additional information on hazard classi飥乧ations.
See Section 16 for Risk Phrases and WHMIS Classi飥乧ation Description.
Section 4 First Aid Measures
Inhalation If product is inhaled, move exposed individual to fresh air. If individual is not
breathing, begin arti飥乧ial respiration immediately and obtain medical attention.
Eye Contact If product enters eyes, wash eyes gently under running water for 15
minutes or longer, making sure that the eyelids are held open. If pain
or irritation occur, obtain medical attention.
Skin Contact In case of skin contact, 飥倁sh with copious amounts of water for at
least 15 minutes. Remove contaminated clothing and shoes. If pain
or irritation occur, obtain medical attention.
Ingestion If ingested, wash mouth out with water. If irritation or discomfort
occurs, seek medical attention.
Section 5 Fire Fighting Measures
Flammable Properties Non飥俛mmable aqueous solution.
Extinguishing Media Use extinguishing media suitable for surrounding 飥乺e.
No special hazards determined.
Special Fire and Explosion
Hazards
Hazardous Combustion Due to the composition and volume of this product, combustion products
generated from it are not expected to present a signi飥乧ant hazard.
Products
Protective Equipment Self-contained breathing apparatus is recommended for 飥乺e飥乬hters.
for Fire飥乬hters
Section 6 Accidental Release Measures
Personal Precautions This product contains a material of biological origin. Use universal
precautions during clean up procedures.
Spill and Leak As a precautionary measure, treat spilled material with a 1:10 bleach/water solution.
Absorb liquid and place in container suitable for disposal. Avoid generation of
Procedures
aerosols during clean up. Comply with applicable waste disposal regulations.
Environmental Contain spill to prevent migration.
Precautions
Page 27 of 38
FOLATE Doc. ID: A14208-75 AC
Folate Conjugate (Compartment R1d)
Section 7 Handling and Storage
Handling Precautions This product should be handled as though capable of transmitting infectious
diseases. Universal precautions should be followed when using this product.
Recommended Storage Keep away from incompatible material (see Section 10).
Conditions To maintain ef飥乧acy, store according to the instructions in the product labeling.
Section 8 Exposure Controls and Personal Protection
Exposure Limits
None established
US OSHA:
None established
ACGIH:
None established
DFG MAK:
None established
NIOSH
Japan None established
No special engineering controls are required. Use with good general ventilation.
Engineering Controls
Respiratory Protection Under normal conditions, the use of this product should not require respiratory
protection. If aerosols are generated during use, the use of respiratory
protection should be evaluated by a quali飥乪d professional.
Eye Protection Safety glasses or chemical goggles should be worn to prevent eye contact.
Impervious gloves, such as Nitrile or equivalent, should be worn
Skin Protection
to prevent skin contact.
Section 9 Physical and Chemical Properties
Liquid
Physical State
Color Colorless
Transparency Translucent
Musty
Odor
Not applicable
Odor Threshold
pH 8.05
Freezing Point Not available
Boiling Point Not available
Flash Point Not applicable
Evaporation Rate Not available
Not applicable
Flammability (Solid, Gas)
Flammable Limits Not applicable
Vapor Pressure Not available
Page 28 of 38
FOLATE Doc. ID: A14208-75 AC
Folate Conjugate (Compartment R1d)
Section 9 Physical and Chemical Properties (Continued)
Vapor Density Not available
Speci飥乧 Gravity 1.014 @20掳C
Solubility
Water Miscible
Not available
Organic
Not available
Coef飥乧ient of Water/Oil
Distribution
Autoignition Temp. Not applicable
Decomposition Temperature Not available
Percent Volatiles Not applicable
Section 10 Stability and Reactivity
Stability Stable under normal temperatures and pressures.
Hazardous Incompatibilities Metals and metallic compounds
Strong acids
Strong bases
Strong oxidizers
Sodium azide forms explosive compounds with heavy metals. This product
contains concentrations of azide <0.1% (w/w) which with repeated contact
with lead and copper commonly found in plumbing drains may result in
the build up of shock sensitive compounds.
Hazardous Decomposition When stored as labeled, no known hazardous decomposition products
are formed during the shelf-life of this product.
Products
Conditions to Avoid Keep away from incompatible material.
Section 11 Toxicological Information
Toxicity Data
for Hazardous Ingredients
Tris(hydroxymethyl)- Oral LD50 Rat: 5900 mg/kg
aminomethane
Primary Routes Common routes of entry include inhalation, ingestion and eye/skin contact. Speci飥乧
paths of concern for potentially infectious materials are skin puncture, contact with
of Exposure
broken skin, contact with mucous membranes and inhalation of aerosolized material.
Potential Effects of Exposure to TRIS may result in irritation of skin, eyes and mucous membrane.
Eye contact may result in redness, pain and corneal injury. Inhalation may result
Acute Exposure
in chest pain and tightness, coughing, and dif飥乧ult breathing. Ingestion may
cause gastrointestinal irritation with burns to mouth and stomach, and large doses
may cause weakness, collapse and death in laboratory animals.
This product contains materials of human and animal origin and should be
considered as potentially capable of transmitting infectious diseases.
Page 29 of 38
FOLATE Doc. ID: A14208-75 AC
Folate Conjugate (Compartment R1d)
Section 11 Toxicological Information (Continued)
Potential Effects of Chronic Prolonged or repeated exposure to TRIS by skin contact may result in
dermatitis. Eye contact may cause conjunctivitis.
Exposure
Symptoms of Overexposure Symptoms of overexposure may include: throat irritation and coughing;
dry, red, cracked skin; red irritated eyes; headache, drowsiness,
dizziness, stupor; convulsions and coma.
Carcinogenicity This product does not contain a reportable concentration (鈮? 0.1%) of any ingredient
listed as carcinogen by ACGIH, IARC, NTP, OSHA or 67/548/EEC Annex I.
Other Effects None identi飥乪d.
Conditions Aggravated Individuals with respiratory and skin disorders may 飥乶d these conditions
aggravated by exposure to this product.
by Exposure
Section 12 Ecological Information
Ecotoxicity No information available.
Biodegradability No information available.
Bioaccumulation No information available.
Mobility No information available.
Other Adverse Effects No information available.
Section 13 Disposal Considerations
Waste Disposal Dispose of waste product, unused product and contaminated packaging in
compliance with federal, state and local regulations. If unsure of the applicable
requirements, contact the authorities for information.
Sodium azide preservative may form explosive compounds in metal drain lines.
See NIOSH Bulletin: Explosive Azide Hazard (8/16/76).
Section 14 Transport Information
Transportation of this product is not regulated under ICAO, IMDG, US DOT, European ADR or Canadian TDG.
Section 15 Regulatory Information
US Federal and State Regulations
SARA 313 Acetaldehyde is subject to reporting requirements of Section 313, Title III of SARA.
Ethylene Oxide is subject to reporting requirements of Section 313, Title III of SARA.
1,4-Dioxane is subject to reporting requirements of Section 313, Title III of SARA.
Sodium Azide is subject to reporting requirements of Section 313, Title III of SARA.
Zinc Chloride is subject to reporting requirements of Section 313, Title III of SARA.
Page 30 of 38
FOLATE Doc. ID: A14208-75 AC
Folate Conjugate (Compartment R1d)
Section 15 Regulatory Information (Continued)
Acetaldehyde is listed.
CERCLA RG鈥檚,
40 CFR 302.4 Ethylene Oxide is listed.
1,4-Dioxane is listed.
Zinc Chloride is listed.
Sodium Azide is listed.
California Proposition 65 Acetaldehyde has been identi飥乪d by the State of California to cause cancer.
The State of California has adopted a regulation which requires a warning
be given to individual who may be exposed to chemicals identi飥乪d by
the State to cause cancer or reproductive harm. Accordingly, Beckman
Coulter advises you of the following warning:
WARNING: This product contains a chemical known to the State
of California to cause cancer.
Ethylene Oxide has been identi飥乪d by the State of California to cause cancer
and reproductive harm. The State of California has adopted a regulation which
requires a warning be given to individual who may be exposed to chemicals
identi飥乪d by the State to cause cancer or reproductive harm. Accordingly,
Beckman Coulter advises you of the following warning:
WARNING: This product contains a chemical known to the State of
California to cause cancer and reproductive harm.
1,4-Dioxane has been identi飥乪d by the State of California to cause cancer.
The State of California has adopted a regulation which requires a warning
be given to individual who may be exposed to chemicals identi飥乪d by
the State to cause cancer or reproductive harm. Accordingly, Beckman
Coulter advises you of the following warning:
WARNING: This product contains a chemical known to the State
of California to cause cancer.
Acetaldehyde is listed.
Massachusetts MSL
Ethylene Oxide is listed.
1,4-Dioxane is listed.
Zinc Chloride is listed.
Sodium Azide is listed.
Acetaldehyde is listed.
New Jersey Dept. of
Health RTK List Ethylene Oxide is listed.
1,4-Dioxane is listed.
Zinc Chloride is listed.
Sodium Azide is listed.
Dimethyl Sulfoxide is listed.
Pennsylvania RTK Acetaldehyde is listed.
Ethylene Oxide is listed.
1,4-Dioxane is listed.
Zinc Chloride is listed.
Sodium Azide is listed.
Dipropylene Glycol is listed.
EU Labeling Classi飥乧ation
Preparation not classi飥乪d.
Canada
This product is exempt from WHMIS label and MSDS requirements.
Page 31 of 38
FOLATE Doc. ID: A14208-75 AC
Folate Conjugate (Compartment R1d)
Section 15 Regulatory Information (Continued)
Not applicable
PIN:
Ingredients on Ingredient Dimethyl Sulfoxide
Disclosure List: Acetaldehyde
Ethylene Oxide
1,4-Dioxane
Zinc Chloride
Sodium Azide
Ingredients with unknown Product is exempt
toxicological properties:
Some hazardous ingredients listed in Section 15 are below OSHAs and WHMIS鈥? 1.0% w/w (0.1% for carcinogens)
or EU鈥檚 ingredient speci飥乧 concentrations required for reporting in Section 3.
Section 16 Other Information
Beckman Coulter Safety Flammability (Section V): 0 Code
Health (Section XI): 1 0=none
Rating
Reactivity with Water (Section X): 0 1=slight
Contact (Section VIII): 2 2=caution
3=severe
Revision Changes Reformatted Sections 2, 3, 5, 8, 9, 12, 15, and 16 per ANSI Z400.1-2004 Standard.
Risk Phrases and R36/37/38 Irritating to eyes, respiratory system and skin.
WHMIS Classi飥乧ation D2B - Skin Or Eye Irritant
Description From
Section 3
For further information, please contact your local Beckman Coulter representative.
WHILE BECKMAN COULTER, INC. BELIEVES THE INFORMATION CONTAINED HEREIN IS VALID AND ACCURATE, BECKMAN COULTER MAKES NO
WARRANTY OR REPRESENTATION AS TO ITS VALIDITY, ACCURACY, OR CURRENCY. BECKMAN COULTER SHALL NOT BE LIABLE OR OTHERWISE
RESPONSIBLE IN ANY WAY FOR USE OF EITHER THIS INFORMATION OR MATERIALS TO WHICH IT APPLIES. DISPOSAL OF HAZARDOUS
MATERIALS MAY BE SUBJECT TO LOCAL LAWS OR REGULATIONS.
Printed in U.S.A.
Page 32 of 38
MATERIAL SAFETY DATA SHEET
Section 1 Company and Product Identi飥乧ation
Product Name 0.6M K3PO4 (Compartment R1e) . FOLATE
.. Doc. ID: A14208-75 AC
. Revised (year/month/day) 2008/02/13
Part Number Component of P/N A14208
Product Use For In Vitro Diagnostic Use. See product literature for details.
Series Name ACCESS庐
Manufacturer Beckman Coulter, Inc.
4300 Harbor Blvd.
Fullerton, CA 92835-3100, U.S.A.
EC REP Address Beckman Coulter Ireland Inc.
Mervue Business Park
Mervue, Galway, Ireland 353 91 774068
Distributor and Refer to attached list, Document ID: 472050, for local distributor
and emergency phone numbers.
Emergency Phone No.
Section 2 Hazards Identi飥乧ation
Emergency Overview
Colorless; Clear; Liquid; Odorless
Non飥俛mmable aqueous solution.
May cause severe irritation to respiratory tract, skin and eyes.
Physical Hazards No physical hazards were determined from a review of available literature.
Potential Health Exposure may cause irritation or burns to respiratory tract, skin, and
eyes. Corrosive effects may be delayed.
Effects Summary
See Section 11 Toxicological Information for more detailed health information.
Potential No information available.
Environmental Effects
Product Hazard Meets Hazardous Criteria for Preparation/Mixture
Classi飥乧ations
EU: WHMIS: US OSHA:
Xi;R36/38 Hazardous
Exempt
.
Page 33 of 38
FOLATE Doc. ID: A14208-75 AC
0.6M K3PO4 (Compartment R1e)
Section 3 Composition and Information on Ingredients
Hazardous Ingredients: Hazard Classi飥乧ation of Pure Ingredients
EU
Chemical Name CAS # EINECS # % by wt. WHMIS US OSHA
Potassium Phosphate, 7778-53-2 2319071 < 15 Irritant
Xi;R36/38 E
Tribasic
See Section 15 Regulatory Information for additional information on hazard classi飥乧ations.
See Section 16 for Risk Phrases and WHMIS Classi飥乧ation Description.
Section 4 First Aid Measures
Inhalation If product is inhaled, move exposed individual to fresh air. If individual is not
breathing, begin arti飥乧ial respiration immediately and obtain medical attention.
Eye Contact If product enters eyes, wash eyes gently under running water for 15
minutes or longer, making sure that the eyelids are held open. If pain
or irritation occur, obtain medical attention.
Skin Contact In case of skin contact, 飥倁sh with copious amounts of water for at
least 15 minutes. Remove contaminated clothing and shoes. If pain
or irritation occur, obtain medical attention.
Ingestion If ingested, wash mouth out with water. If irritation or discomfort
occurs, seek medical attention.
Section 5 Fire Fighting Measures
Flammable Properties Non飥俛mmable aqueous solution.
Extinguishing Media Use extinguishing media suitable for surrounding 飥乺e.
Special Fire and Explosion None identi飥乪d.
Hazards
Hazardous Combustion Due to the composition and volume of this product, combustion products
generated from it are not expected to present a signi飥乧ant hazard.
Products
Protective Equipment Self-contained breathing apparatus is recommended for 飥乺e飥乬hters.
for Fire飥乬hters
Section 6 Accidental Release Measures
Personal Precautions Avoid skin contact. Use good laboratory procedures.
Spill and Leak Absorb spilled material with an appropriate inert, non-飥俛mmable absorbent
and dispose according to local regulations.
Procedures
Environmental Contain spill to prevent migration.
Precautions
Page 34 of 38
FOLATE Doc. ID: A14208-75 AC
0.6M K3PO4 (Compartment R1e)
Section 7 Handling and Storage
Handling Precautions Use good laboratory procedures; avoid eye and skin contact.
Recommended Storage Keep away from incompatible material (see Section 10).
Conditions To maintain ef飥乧acy, store according to the instructions in the product labeling.
Section 8 Exposure Controls and Personal Protection
Exposure Limits
None established
US OSHA:
None established
ACGIH:
None established
DFG MAK:
None established
NIOSH
Japan None established
No special engineering controls are required. Use with good general ventilation.
Engineering Controls
Respiratory Protection Under normal conditions, the use of this product should not require respiratory
protection. If overexposure should occur and ventilation is not adequate to
maintain airborne concentrations at acceptable levels, the use of respiratory
protection should be evaluated by a quali飥乪d professional.
Eye Protection Safety glasses or chemical goggles should be worn to prevent eye contact.
Impervious gloves, such as Nitrile or equivalent, should be worn
Skin Protection
to prevent skin contact.
Section 9 Physical and Chemical Properties
Liquid
Physical State
Color Colorless
Transparency Clear
Odor Odorless
Not applicable
Odor Threshold
pH 鈮? 12.3
Freezing Point Not available
Boiling Point Not available
Flash Point Not applicable
Evaporation Rate Not available
Not applicable
Flammability (Solid, Gas)
Flammable Limits Not applicable
Vapor Pressure Not available
Page 35 of 38
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0.6M K3PO4 (Compartment R1e)
Section 9 Physical and Chemical Properties (Continued)
Vapor Density Not available
Speci飥乧 Gravity 1.105 @20掳C
Solubility
Water Miscible
Not available
Organic
Not available
Coef飥乧ient of Water/Oil
Distribution
Autoignition Temp. Not applicable
Decomposition Temperature Not available
Percent Volatiles Not applicable
Section 10 Stability and Reactivity
Stability Stable in closed containers under normal temperatures and pressures.
Hazardous Incompatibilities Strong oxidizers
Strong acids
Strong bases
Hazardous Decomposition When stored as labeled, no known hazardous decomposition products
are formed during the shelf-life of this product.
Products
Conditions to Avoid Keep away from incompatible material.
Section 11 Toxicological Information
Toxicity Data
for Hazardous Ingredients
Potassium Phosphate, Oral LD50 Rat: 2000 mg/kg; Dermal LD50 Rabbit: >4640 mg/kg
Tribasic
Primary Routes The most likely routes of exposure are skin, eye contact and inhalation.
of Exposure
Potential Effects of Inhalation of dilute alkaline mists may result in irritation of mucous membranes with
sore throat, coughing, dif飥乧ulty in breathing; intense exposure, the lungs may 飥乴l with
Acute Exposure
飥倁id. Contact with dilute solutions may cause irritation or skin injury with redness,
飥乻sures and white patches. Eye contact may result in severe burns with possible
loss of sight, irritation of eyes and eyelids, pain and intense watering. Ingestion may
result in burns to the mouth, throat and stomach with burning sensations in the
mouth, abdominal pain, vomiting, diarrhea, shock and loss of consciousness.
Repeated skin contact with dilute alkaline may cause irritation with redness
Potential Effects of Chronic
and swelling or burns. Repeated eye contact may cause conjunctivitis with
Exposure
redness, swelling and watering or burns. Depending upon concentration,
repeated ingestion may result in in飥俛mmatory or ulcerative effects on the
mouth with redness, swelling and sores in the mouth.
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0.6M K3PO4 (Compartment R1e)
Section 11 Toxicological Information (Continued)
Symptoms of Overexposure Symptoms may include redness and itching or burning of the skin and
eyes, and irritation or burning sensation of the upper respiratory tract
with coughing and dif飥乧ulty in breathing.
Carcinogenicity No ingredients in this product are listed as carcinogens by ACGIH,
IARC, NTP, OSHA or 67/548/EEC Annex I.
Other Effects None identi飥乪d.
Conditions Aggravated Individuals with respiratory and skin disorders may 飥乶d these conditions
aggravated by exposure to this product.
by Exposure
Section 12 Ecological Information
Ecotoxicity No information available.
Biodegradability No information available.
Bioaccumulation No information available.
Mobility No information available.
Other Adverse Effects No information available.
Section 13 Disposal Considerations
Waste Disposal Dispose of waste product, unused product and contaminated packaging in
compliance with federal, state and local regulations. If unsure of the applicable
requirements, contact the authorities for information.
Section 14 Transport Information
Chemical kit
Shipping Name
Shipping Information
3316
UN/ID Number
III
Packing Group
9 Miscellaneous Dangerous Goods
Hazard Class
IATA
None
Subsidiary Risk
A44; A802
Special Provisions
9L
IATA ERG Code
9 Miscellaneous dangerous substances
Hazard Class
IMDG
and articles
None
Subsidiary Risk
251
Special Provisions
No
Marine Pollutant
9 Miscellaneous hazardous material
Hazard Class
US DOT
None
Subsidiary Risk
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0.6M K3PO4 (Compartment R1e)
Section 14 Transport Information (Continued)
15
Special Provisions
171
NAERG Number
9 Miscellaneous dangerous substances
ADR Classi飥乧ation
European ADR
and articles
M11
Classi飥乧ation Code/
None
Subsidiary Risk
3316
PIN
Canadian TDG
9 Miscellaneous Dangerous Goods
TDG Classi飥乧ation
None
Subsidiary Risk
65
Special Provisions
171
NAERG Number
Section 15 Regulatory Information
US Federal and State Regulations
No ingredients listed.
SARA 313
No ingredients listed.
CERCLA RG鈥檚,
40 CFR 302.4
No ingredients listed.
California Proposition 65
No ingredients listed.
Massachusetts MSL
No ingredients listed.
New Jersey Dept. of
Health RTK List
Pennsylvania RTK No ingredients listed.
EU Labeling Classi飥乧ation
Classi飥乧ation Risk and Safety Phrases
R36/38 Irritating to eyes and skin.
S26 In case of contact with eyes, rinse immediately with plenty of
Irritant
water and seek medical advice.
S37 Wear suitable gloves.
Canada
This product is exempt from WHMIS label and MSDS requirements.
3316
PIN:
Ingredients on Ingredient None
Disclosure List:
Ingredients with unknown None
toxicological properties:
Some hazardous ingredients listed in Section 15 are below OSHAs and WHMIS鈥? 1.0% w/w (0.1% for carcinogens)
or EU鈥檚 ingredient speci飥乧 concentrations required for reporting in Section 3.
Page 38 of 38
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0.6M K3PO4 (Compartment R1e)
Section 16 Other Information
Beckman Coulter Safety Flammability (Section V): 0 Code
Health (Section XI): 2 0=none
Rating
Reactivity with Water (Section X): 0 1=slight
Contact (Section VIII): 2 2=caution
3=severe
Revision Changes Reformatted Sections 2, 3, 5, 8, 9, 12, 15, and 16 per ANSI Z400.1-2004 Standard.
Risk Phrases and R36/38 Irritating to eyes and skin.
WHMIS Classi飥乧ation E - Corrosive Material
Description From
Section 3
For further information, please contact your local Beckman Coulter representative.
WHILE BECKMAN COULTER, INC. BELIEVES THE INFORMATION CONTAINED HEREIN IS VALID AND ACCURATE, BECKMAN COULTER MAKES NO
WARRANTY OR REPRESENTATION AS TO ITS VALIDITY, ACCURACY, OR CURRENCY. BECKMAN COULTER SHALL NOT BE LIABLE OR OTHERWISE
RESPONSIBLE IN ANY WAY FOR USE OF EITHER THIS INFORMATION OR MATERIALS TO WHICH IT APPLIES. DISPOSAL OF HAZARDOUS
MATERIALS MAY BE SUBJECT TO LOCAL LAWS OR REGULATIONS.
Printed in U.S.A.
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