Page 1 of 5
@Beckman
CoulterTM MATERIAL SAFETY DATA SHEET
Section 1 Company and Product Identi铿乧ation
7-AAD Viability Dye
Product Name
Doc. ID A07704-75 AA
Issued (year/month/day) 2003/12/16
Part Number A07704
Product Use For In Vitro Diagnostic Use. See product literature for details.
Manufacturer Distributed by Beckman Coulter, Inc. for
IMMUNOTECH (A Beckman Coulter Company)
130, av.de Lattre de Tassigny鈥擝P 177
13276 Marseille Cedex 09鈥擣rance T猫l. (33) 4 91 17 27 00
陇
Distributor and Refer to attached list, Document ID: 472050, for local distributor and
Emergency Phone No. emergency phone numbers.
Section 2 Composition and Information on Ingredients
Hazardous Ingredients: Meets Hazardous Criteria:
Chemical Name CAS # % by wt. EU US OSHA WHMIS
Dimethyl Sulfoxide 67-68-5 1% No Yes Yes
See Section 15 Regulatory Information for additional information on hazard classi铿乧ations.
Section 3 Hazards Identi铿乧ation
Emergency Overview
Violet; Clear; Liquid; Odorless
Non铿俛mmable aqueous solution.
Skin, eye and respiratory tract irritant.
This product contains 0.005% 7-Aminoactinomycin (CAS# 7240-37-1). Although
not considered hazardous at this concentration, pure 7-AAD is classi铿乪d as T+;
R26/27/28-45-46-61 within the meaning of European Directive 88/379/EEC.
Physical Hazards No physical hazards were determined from a review of available literature.
Potential Health Exposure may result in irritation of skin, eyes, and mucous membranes.
Effects Summary
See Section 11 Toxicological Information for more detailed health information.
Product Hazard EU: WHMIS: US OSHA:
Classi铿乧ations Not applicable D2B Hazardous
Beckman Coulter Safety Flammability (Section V): 0 Code
Rating Health (Section XI): 1 0=none
Reactivity with Water (Section X): 0 1=slight
Contact (Section VIII): 2 2=caution
3=severe
铮?2003 Beckman Coulter, Inc.
Global MSDS 鈥? English
7-AAD Viability Dye MSDS # A07704-75 AA Page 2 of 5
Section 4 First Aid Measures
Inhalation If product is inhaled, move exposed individual to fresh air. If individual is not
breathing, begin arti铿乧ial respiration immediately and obtain medical attention.
Eye Contact If product enters eyes, wash eyes gently under running water for 15 minutes or
longer, making sure that the eyelids are held open. If pain or irritation occur, obtain
medical attention.
Skin Contact In case of skin contact, 铿倁sh with copious amounts of water for at least 15 minutes.
Remove contaminated clothing and shoes. If pain or irritation occur, obtain medical
attention.
Ingestion If ingested, wash mouth out with water. If irritation or discomfort occurs, seek medical
attention.
Section 5 Fire Fighting Measures
Flash Point Not applicable
Flammable Limits Not applicable
Autoignition Temp. Not applicable
Extinguishing Media Use extinguishing media suitable for surrounding 铿乺e.
Special Fire and No special hazards determined.
Explosion Hazards
Hazardous Combustion No combustion products posing signi铿乧ant hazards are expected from this product (a
Products dilute aqueous solution).
Protective Equipment Self-contained breathing apparatus is recommended for 铿乺e铿乬hters.
for Fire铿乬hters
Section 6 Accidental Release Measures
Personal Precautions No special precautions are necessary. Use good laboratory procedures.
Spill and Leak Absorb spilled material with an appropriate inert, non-铿俛mmable absorbent and
Procedures dispose according to local regulations.
Environmental Contain spill to prevent migration.
Precautions
Section 7 Handling and Storage
Handling Precautions Use good laboratory procedures; avoid eye and skin contact.
Recommended Storage Keep away from incompatible material.
Conditions To maintain ef铿乧acy, store according to the instructions in the product labeling.
Section 8 Exposure Controls and Personal Protection
Exposure Limits
US OSHA: None established
ACGIH: None established
7-AAD Viability Dye MSDS # A07704-75 AA Page 3 of 5
Section 8 Exposure Controls and Personal Protection (Continued)
DFG MAK:
Dimethyl Sulfoxide danger of percutaneous absorption
Engineering Controls No special engineering controls are required. Use with good general ventilation.
Respiratory Protection Under normal conditions, the use of this product should not require respiratory
protection. If overexposure should occur and ventilation is not adequate to maintain
airborne concentrations at acceptable levels, the use of respiratory protection should
be evaluated by a quali铿乪d professional.
Eye Protection Safety glasses or chemical goggles should be worn to prevent eye contact.
Skin Protection Impervious gloves, such as latex or equivalent, should be worn to prevent skin
contact.
Section 9 Physical and Chemical Properties
Physical State Liquid
Color Violet
Transparency Clear
Odor Odorless
Odor Threshold Not applicable
pH 7
Boiling Point Not available
Melting Point Not available
Speci铿乧 Gravity 1 @20掳C
Vapor Pressure Not available
Vapor Density Not available
Evaporation Rate Not available
Solubility
Water Miscible
Organic Not available
Section 10 Stability and Reactivity
Stability Stable under normal temperatures and pressures.
Hazardous Strong oxidizers
Incompatibilities Strong acids
Strong bases
Hazardous No decomposition products posing signi铿乧ant hazards would be expected from this
Decomposition Products product (a dilute aqueous solution).
Conditions to Avoid Keep away from incompatible material.
7-AAD Viability Dye MSDS # A07704-75 AA Page 4 of 5
Section 11 Toxicological Information
Toxicity Data
for Hazardous Ingredients
Dimethyl Sulfoxide Oral LD50 Rat: 14500 mg/kg; Oral LD50 Mouse: 7920 mg/kg
Primary Routes The most likely routes of exposure are skin, eye contact and inhalation; material may
of Exposure be absorbed through the skin.
Potential Effects of May cause irritation of the eyes, skin, mucous membrane, and upper respiratory tract.
Acute Exposure Dimethyl Sulfoxide (DMSO) is readily absorbed through skin and may act as a carrier
for toxic material.
Potential Effects of Effects are similar to those for acute exposure.
Chronic Exposure
Symptoms of No speci铿乧 symptoms identi铿乪d.
Overexposure
Carcinogenicity This product does not contain a reportable concentration (鈮? 0.1%) of any ingredient
listed as carcinogen by ACGIH, IARC, NTP, OSHA or 67/548/EEC Annex I.
Other Effects None identi铿乪d.
Conditions Aggravated Individuals with skin, eye, or respiratory tract disorders may 铿乶d these conditions
by Exposure aggravated by exposure to this product.
Section 12 Ecological Information
Ecotoxicity Toxic to 铿乻h and other water organisms.
Biodegradability No information available.
Mobility No information available.
Section 13 Disposal Considerations
Waste Disposal Dispose of waste product, unused product and contaminated packaging in compliance
with federal, state and local regulations. If unsure of the applicable requirements,
contact the authorities for information.
Section 14 Transport Information
Transportation of this product is not regulated under ICAO, IMDG, US DOT, European ADR or Canadian TDG.
Section 15 Regulatory Information
US Federal and State Regulations
SARA 313 No ingredients listed
CERCLA RG鈥檚, No ingredients listed
40 CFR 302.4
California Proposition 65 No ingredients listed
Massachusetts MSL No ingredients listed
New Jersey Dept. of No ingredients listed
Health RTK List
Pennsylvania RTK No ingredients listed
7-AAD Viability Dye MSDS # A07704-75 AA Page 5 of 5
Section 15 Regulatory Information (Continued)
US Federal and State Regulations
EU Labeling Classi铿乧ation
Preparation not classi铿乪d.
Canada
WHMIS Classi铿乧ation: D2B鈥擯oisonous and Infectious Material: Division 2鈥擮ther Toxic Effects: Toxic (Skin
Irritation)
D2B鈥擯oisonous and Infectious Material: Division 2鈥擮ther Toxic Effects: Toxic (Eye
Irritation)
PIN: Not applicable
Ingredients on Ingredient Dimethyl Sulfoxide
Disclosure List:
Ingredients with unknown None
toxicological properties:
Section 16 Other Information
For further information, please contact your local Beckman Coulter representative.
WHILE BECKMAN COULTER, INC. BELIEVES THE INFORMATION CONTAINED HEREIN IS VALID AND ACCURATE, BECKMAN COULTER MAKES NO WARRANTY OR
REPRESENTATION AS TO ITS VALIDITY, ACCURACY, OR CURRENCY. BECKMAN COULTER SHALL NOT BE LIABLE OR OTHERWISE RESPONSIBLE IN ANY WAY FOR USE
OF EITHER THIS INFORMATION OR MATERIALS TO WHICH IT APPLIES. DISPOSAL OF HAZARDOUS MATERIALS MAY BE SUBJECT TO LOCAL LAWS OR REGULATIONS.
Printed in U.S.A.
|