Page 1 of 63
@Beckman
CoulterTM Kit MSDS
Doc. ID: IM2015-75: Rev. AB
Product Information
Histamine EIA Kit
Product Name Doc. ID IM2015-75 AB
Issued (year/month/day)
Revised (year/month/day) 2004/02/17
Part Number IM2015
Series Name:
Components
Description
This kit contains a microtiter plate that is considered an article
and thereby exempt from MSDS requirements.
Wash Solution
Stop solution NaOH
Substrate tablets pNPP
Substrate Buffer DEA
Conjugate diluent H
Histamine Standard (6 vials)
Alkaline phosphatase conjugate
DMSO 3ml
Control
Histamine Acylation Reagent
Histamine Release Buffer
Histamine Acylation Buffer
Transport Information
Shipping Name Sodium hydroxide solution
ICAO UN/ID Number 1824
IATA Packing Group III
IATA Hazard Class 8 Corrosives
Subsidiary Risk None
Special Provisions Not applicable
IATA ERG Code 8L
IMDG Hazard Class 8 Corrosive substances
Subsidiary Risk None
Special Provisions 223
Marine Pollutant No
US DOT Hazard Class 8 Corrosive material
Subsidiary Risk Not applicable
Special Provisions Not applicable
NAERG Number 154
?2004 Beckman Coulter, Inc.
Global MSDS ? English
Histamine EIA Kit Doc. ID: IM2015-75 AB Page 2 of 63
Transport Information (Continued)
European ADR ADR Classification 8 Corrosive substances
Subsidiary Risk None
Classification Code C5
Canadian TDG PIN 1824
TDG Classification 8 Corrosives
Subsidiary Risk None
Special Provisions None
NAERG Number 154
Page 3 of 63
@Beckman
CoulterTM MATERIAL SAFETY DATA SHEET
Section 1 Company and Product Identification
Wash Solution
Product Name Histamine EIA Kit
Doc. ID IM2015-75 AB
Issued (year/month/day)
Revised (year/month/day) 2004/02/17
Part Number Component of P/N IM2015
Product Use For laboratory use only. See product literature for details.
Manufacturer Distributed by Beckman Coulter, Inc. for
IMMUNOTECH (A Beckman Coulter Company)
130, av.de Lattre de Tassigny—BP 177
13276 Marseille Cedex 09—France Tèl. (33) 4 91 17 27 00
¤
Distributor and Refer to attached list, Document ID: 472050, for local distributor and
Emergency Phone No. emergency phone numbers.
Section 2 Composition and Information on Ingredients
Hazardous Ingredients: Meets Hazardous Criteria:
Chemical Name CAS # % by wt. EU US OSHA WHMIS
Polyoxyethylene (20) sorbitan 9005-65-6 1.0% No Yes Yes
monooleate
See Section 15 Regulatory Information for additional information on hazard classifications.
Section 3 Hazards Identification
Emergency Overview
Colorless; Clear; Liquid; Odorless
Nonflammable aqueous solution.
Skin, eye, respiratory, and gastrointestinal irritant.
Physical Hazards No physical hazards were determined from a review of available literature.
Potential Health Contact may cause irritation to the eyes, skin, and mucous membranes. Inhalation of
Effects Summary mists may cause mucous membrane and upper respiratory irritation.
See Section 11 Toxicological Information for more detailed health information.
Product Hazard EU: WHMIS: US OSHA:
Classifications Not applicable D2B Hazardous
Beckman Coulter Safety Flammability (Section V): 0 Code
Rating Health (Section XI): 1 0=none
Reactivity with Water (Section X): 0 1=slight
Contact (Section VIII): 2 2=caution
3=severe
Section 4 First Aid Measures
Inhalation If product is inhaled, move exposed individual to fresh air. If individual is not
breathing, begin artificial respiration immediately and obtain medical attention.
Histamine EIA Kit Doc. ID: IM2015-75 AB Page 4 of 63
Wash Solution
Section 4 First Aid Measures (Continued)
Eye Contact If product enters eyes, wash eyes gently under running water for 15 minutes or
longer, making sure that the eyelids are held open. If pain or irritation occur, obtain
medical attention.
Skin Contact In case of skin contact, flush with copious amounts of water for at least 15 minutes. If
pain or irritation occur, obtain medical attention.
Ingestion If ingested, wash mouth out with water. If irritation or discomfort occurs, seek medical
attention.
Section 5 Fire Fighting Measures
Flash Point Not applicable
Flammable Limits Not applicable
Autoignition Temp. Not applicable
Extinguishing Media Use extinguishing media suitable for surrounding fire.
Special Fire and None identified.
Explosion Hazards
Hazardous Combustion No combustion products posing significant hazards are expected from this product.
Products
Protective Equipment Self-contained breathing apparatus is recommended for firefighters in all chemical fire
for Firefighters situations.
Section 6 Accidental Release Measures
Personal Precautions No special precautions are necessary. Use good laboratory procedures.
Spill and Leak Absorb spilled material with an appropriate inert, non-flammable absorbent and
Procedures dispose according to local regulations.
Environmental Contain spill to prevent migration.
Precautions
Section 7 Handling and Storage
Handling Precautions No special precautions are necessary; use good laboratory procedures.
Recommended Storage To maintain efficacy, store according to the instructions in the product labeling.
Conditions
Section 8 Exposure Controls and Personal Protection
Exposure Limits
US OSHA: None established
ACGIH: None established
DFG MAK: None established
Engineering Controls No special engineering controls are required. Use with good general ventilation.
Histamine EIA Kit Doc. ID: IM2015-75 AB Page 5 of 63
Wash Solution
Section 8 Exposure Controls and Personal Protection (Continued)
Respiratory Protection Under normal conditions, the use of this product should not require respiratory
protection.
Eye Protection Safety glasses or chemical goggles should be worn to prevent eye contact.
Skin Protection Impervious gloves, such as latex or equivalent, should be worn to prevent skin
contact.
Section 9 Physical and Chemical Properties
Physical State Liquid
Color Colorless
Transparency Clear
Odor Odorless
Odor Threshold Not applicable
pH 5.0?7.0
Boiling Point Not available
Melting Point Not available
Specific Gravity 1.01 @20°C
Vapor Pressure Not available
Vapor Density Not available
Evaporation Rate Not available
Solubility
Water Miscible
Organic Not available
Section 10 Stability and Reactivity
Stability Stable in closed containers under normal temperatures and pressures.
Hazardous Strong acids
Incompatibilities Strong bases
Strong oxidizers
Metals and metallic compounds
Acid anhydrides
Hazardous No decomposition products posing significant hazards would be expected from this
Decomposition Products product (a dilute aqueous solution).
Conditions to Avoid Avoid contact with incompatible materials.
Section 11 Toxicological Information
Toxicity Data
for Hazardous Ingredients
Polyoxyethylene (20) sorbitan Oral LD50 Rat: 34500 µL/kg; Oral LD50 Mouse: 25 g/kg
monooleate
Histamine EIA Kit Doc. ID: IM2015-75 AB Page 6 of 63
Wash Solution
Section 11 Toxicological Information (Continued)
Primary Routes Eye contact, ingestion, inhalation, and skin contact.
of Exposure
Potential Effects of Skin or eye contact may cause irritation. Ingestion may result in gastrointestinal
Acute Exposure discomfort and diarrhea.
Potential Effects of Chronic exposure may result in effects similar to those described for acute exposure.
Chronic Exposure Frequent or long-term contact may dry out the skin resulting in dermatitis.
Symptoms of Symptoms of overexposure may include eye or skin irritation. Ingestion may cause
Overexposure nausea, headache, difficulty in breathing, and diarrhea.
Carcinogenicity No ingredients in this product are listed as carcinogens by ACGIH, IARC, NTP, OSHA
or 67/548/EEC Annex I.
Other Effects None identified.
Conditions Aggravated None identified.
by Exposure
Section 12 Ecological Information
Ecotoxicity Toxic to fish and other water organisms.
Biodegradability No information available.
Mobility No information available.
Section 13 Disposal Considerations
Waste Disposal Dispose of waste product, unused product and contaminated packaging in compliance
with federal, state and local regulations. If unsure of the applicable requirements,
contact the authorities for information.
Section 14 Transport Information
Transportation of this product is not regulated under ICAO, IMDG, US DOT, European ADR or Canadian TDG.
Section 15 Regulatory Information
US Federal and State Regulations
SARA 313 No ingredients listed
CERCLA RG’s, No ingredients listed
40 CFR 302.4
California Proposition 65 No ingredients listed
Massachusetts MSL No ingredients listed
New Jersey Dept. of No ingredients listed
Health RTK List
Pennsylvania RTK No ingredients listed
Histamine EIA Kit Doc. ID: IM2015-75 AB Page 7 of 63
Wash Solution
Section 15 Regulatory Information (Continued)
EU Labeling Classification
Preparation not classified.
Canada
WHMIS Classification: D2B—Poisonous and Infectious Material: Division 2—Other Toxic Effects: Toxic (Skin
Irritation)
PIN: Not applicable
Ingredients on Ingredient None
Disclosure List:
Ingredients with unknown None
toxicological properties:
Section 16 Other Information
For further information, please contact your local Beckman Coulter representative.
WHILE BECKMAN COULTER, INC. BELIEVES THE INFORMATION CONTAINED HEREIN IS VALID AND ACCURATE, BECKMAN COULTER MAKES NO WARRANTY OR
REPRESENTATION AS TO ITS VALIDITY, ACCURACY, OR CURRENCY. BECKMAN COULTER SHALL NOT BE LIABLE OR OTHERWISE RESPONSIBLE IN ANY WAY FOR USE
OF EITHER THIS INFORMATION OR MATERIALS TO WHICH IT APPLIES. DISPOSAL OF HAZARDOUS MATERIALS MAY BE SUBJECT TO LOCAL LAWS OR REGULATIONS.
Printed in U.S.A.
Page 8 of 63
@Beckman
CoulterTM MATERIAL SAFETY DATA SHEET
Section 1 Company and Product Identification
Stop solution NaOH
Product Name Histamine EIA Kit
Doc. ID IM2015-75 AB
Issued (year/month/day)
Revised (year/month/day) 2004/02/17
Part Number Component of P/N IM2015
Manufacturer Distributed by Beckman Coulter, Inc. for
IMMUNOTECH (A Beckman Coulter Company)
130, av.de Lattre de Tassigny—BP 177
13276 Marseille Cedex 09—France Tèl. (33) 4 91 17 27 00
¤
Distributor and Refer to attached list, Document ID: 472050, for local distributor and
Emergency Phone No. emergency phone numbers.
Section 2 Composition and Information on Ingredients
Hazardous Ingredients: Meets Hazardous Criteria:
Chemical Name CAS # % by wt. EU US OSHA WHMIS
<5%
Sodium Hydroxide 1310-73-2 C;R 35 Yes Yes
See Section 15 Regulatory Information for additional information on hazard classifications.
Section 3 Hazards Identification
Emergency Overview
Colorless; Clear; Liquid; Odorless
Nonflammable aqueous solution.
Corrosive. May cause burns to eyes, skin and respiratory tract.
Physical Hazards No physical hazards were determined from a review of available literature.
Potential Health Exposure may result in irritation or burns of skin, eyes, and mucous membranes.
Effects Summary
See Section 11 Toxicological Information for more detailed health information.
Product Hazard EU: WHMIS: US OSHA:
Classifications C;R34 E Hazardous
Beckman Coulter Safety Flammability (Section V): 0 Code
Rating Health (Section XI): 2 0=none
Reactivity with Water (Section X): 0 1=slight
Contact (Section VIII): 2 2=caution
3=severe
Section 4 First Aid Measures
Inhalation If product is inhaled, move exposed individual to fresh air. If individual is not
breathing, begin artificial respiration immediately and obtain medical attention.
Histamine EIA Kit Doc. ID: IM2015-75 AB Page 9 of 63
Stop solution NaOH
Section 4 First Aid Measures (Continued)
Eye Contact If product enters eyes, wash eyes gently under running water for 15 minutes or
longer, making sure that the eyelids are held open. If pain or irritation occur, obtain
medical attention.
Skin Contact In case of skin contact, flush with copious amounts of water for at least 15 minutes. If
pain or irritation occur, obtain medical attention.
Ingestion If ingested, wash mouth out with water. If irritation or discomfort occurs, seek medical
attention.
Section 5 Fire Fighting Measures
Flash Point Not applicable
Flammable Limits Not applicable
Autoignition Temp. Not applicable
Extinguishing Media Use extinguishing media suitable for surrounding fire.
Special Fire and None identified.
Explosion Hazards
Hazardous Combustion No combustion products posing significant hazards are expected from this product (a
Products dilute aqueous solution).
Protective Equipment Self-contained breathing apparatus is recommended for firefighters.
for Firefighters
Section 6 Accidental Release Measures
Personal Precautions Use good laboratory procedures; avoid eye and skin contact.
Spill and Leak Absorb spilled material with an appropriate inert, non-flammable absorbent and
Procedures dispose according to local regulations.
Environmental Contain spill to prevent migration.
Precautions
Section 7 Handling and Storage
Handling Precautions Use good laboratory procedures; avoid eye and skin contact.
Recommended Storage To maintain efficacy, store according to the instructions in the product labeling.
Conditions
Section 8 Exposure Controls and Personal Protection
Exposure Limits
US OSHA:
Sodium Hydroxide 2 mg/m3 TWA
ACGIH:
Sodium Hydroxide 2 mg/m3 Ceiling
DFG MAK: None established
Histamine EIA Kit Doc. ID: IM2015-75 AB Page 10 of 63
Stop solution NaOH
Section 8 Exposure Controls and Personal Protection (Continued)
Engineering Controls No special engineering controls are required. Use with good general ventilation.
Respiratory Protection Under normal conditions, the use of this product should not require respiratory
protection. If overexposure should occur and ventilation is not adequate to maintain
airborne concentrations at acceptable levels, the use of respiratory protection should
be evaluated by a qualified professional.
Eye Protection Safety glasses or chemical goggles should be worn to prevent eye contact.
Skin Protection Impervious gloves, such as latex or equivalent, should be worn to prevent skin
contact.
Section 9 Physical and Chemical Properties
Physical State Liquid
Color Colorless
Transparency Clear
Odor Odorless
Odor Threshold Not applicable
pH 13.0
Boiling Point Not available
Melting Point Not available
Specific Gravity 1.03 @20°C
Vapor Pressure Not available
Vapor Density Not available
Evaporation Rate Not available
Solubility
Water Miscible
Organic Not available
Section 10 Stability and Reactivity
Stability Stable in closed containers under normal temperatures and pressures.
Hazardous Strong acids
Incompatibilities Peroxides
Metals and metallic compounds
Hazardous When stored as labeled, no known hazardous decomposition products are formed
Decomposition Products during the shelf-life of this product.
Conditions to Avoid Avoid contact with incompatible materials.
Section 11 Toxicological Information
Toxicity Data Not applicable
for Hazardous Ingredients
Histamine EIA Kit Doc. ID: IM2015-75 AB Page 11 of 63
Stop solution NaOH
Section 11 Toxicological Information (Continued)
Primary Routes The most likely routes of exposure are skin, eye contact and inhalation.
of Exposure
Potential Effects of Inhalation of dilute alkaline mists may result in irritation of mucous membranes with
Acute Exposure sore throat, coughing, difficulty in breathing; intense exposure, the lungs may fill with
fluid. Contact with dilute solutions may cause irritation or skin injury with redness,
fissures and white patches. Eye contact may result in severe burns with possible loss
of sight, irritation of eyes and eyelids, pain and intense watering. Ingestion may result
in burns to the mouth, throat and stomach with burning sensations in the mouth,
abdominal pain, vomiting, diarrhea, shock and loss of consciousness.
Potential Effects of Repeated skin contact with dilute alkaline may cause irritation with redness and
Chronic Exposure swelling or burns. Repeated eye contact may cause conjunctivitis with redness,
swelling and watering or burns. Depending upon concentration, repeated ingestion
may result in inflammatory or ulcerative effects on the mouth with redness, swelling
and sores in the mouth.
Symptoms of Symptoms may include: coughing, headache, fatigue, nausea, vomiting, dizziness,
Overexposure blurred vision, red and watery eyes, abdominal pain and unconsciousness.
Carcinogenicity No ingredients in this product are listed as carcinogens by ACGIH, IARC, NTP, OSHA
or 67/548/EEC Annex I.
Other Effects None identified.
Conditions Aggravated Individuals with eye, skin or kidney disorders may find these conditions aggravated by
by Exposure exposure to this product.
Section 12 Ecological Information
Ecotoxicity Toxic to fish and other water organisms.
Biodegradability No information available.
Mobility No information available.
Section 13 Disposal Considerations
Waste Disposal Dispose of waste product, unused product and contaminated packaging in compliance
with federal, state and local regulations. If unsure of the applicable requirements,
contact the authorities for information.
Histamine EIA Kit Doc. ID: IM2015-75 AB Page 12 of 63
Stop solution NaOH
Section 14 Transport Information
International Shipping Shipping Name Sodium hydroxide solution
Information
ICAO UN/ID Number 1824
IATA Packing Group III
IATA Hazard Class 8 Corrosives
Subsidiary Risk None
Special Provisions Not applicable
IATA ERG Code 8L
IMDG Hazard Class 8 Corrosive substances
Subsidiary Risk None
Special Provisions 223
Marine Pollutant No
US DOT Hazard Class 8 Corrosive material
Subsidiary Risk Not applicable
Special Provisions Not applicable
NAERG Number 154
European ADR ADR Classification 8Corrosive substances
Subsidiary Risk None
Classification Code C5
Canadian TDG PIN 1824
TDG Classification 8 Corrosives
Subsidiary Risk None
Special Provisions None
NAERG Number 154
Section 15 Regulatory Information
US Federal and State Regulations
SARA 313 No ingredients listed
CERCLA RG’s, Sodium Hydroxide is listed.
40 CFR 302.4
California Proposition 65 No ingredients listed
Massachusetts MSL Sodium Hydroxide is listed.
New Jersey Dept. of Sodium Hydroxide is listed.
Health RTK List
Pennsylvania RTK Sodium Hydroxide is listed.
Histamine EIA Kit Doc. ID: IM2015-75 AB Page 13 of 63
Stop solution NaOH
Section 15 Regulatory Information (Continued)
EU Labeling Classification
Classification Risk and Safety Phrases
C R34 Causes burns.
S26 In case of contact with eyes, rinse immediately with plenty of water and seek
Corrosive
medical advice.
S27 Take off immediately all contaminated clothing.
S28 After contact with skin, wash immediately with plenty of ... (to be specified by
the manufacturer).
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection.
Canada
WHMIS Classification: E—Corrosive Material
PIN: 1824
Ingredients on Ingredient Sodium Hydroxide
Disclosure List:
Ingredients with unknown None
toxicological properties:
Section 16 Other Information
For further information, please contact your local Beckman Coulter representative.
WHILE BECKMAN COULTER, INC. BELIEVES THE INFORMATION CONTAINED HEREIN IS VALID AND ACCURATE, BECKMAN COULTER MAKES NO WARRANTY OR
REPRESENTATION AS TO ITS VALIDITY, ACCURACY, OR CURRENCY. BECKMAN COULTER SHALL NOT BE LIABLE OR OTHERWISE RESPONSIBLE IN ANY WAY FOR USE
OF EITHER THIS INFORMATION OR MATERIALS TO WHICH IT APPLIES. DISPOSAL OF HAZARDOUS MATERIALS MAY BE SUBJECT TO LOCAL LAWS OR REGULATIONS.
Printed in U.S.A.
Page 14 of 63
@Beckman
CoulterTM MATERIAL SAFETY DATA SHEET
Section 1 Company and Product Identification
Substrate tablets pNPP
Product Name Histamine EIA Kit
Doc. ID IM2015-75 AB
Issued (year/month/day)
Revised (year/month/day) 2004/02/17
Part Number Component of P/N IM2015
Manufacturer Distributed by Beckman Coulter, Inc. for
IMMUNOTECH (A Beckman Coulter Company)
130, av.de Lattre de Tassigny—BP 177
13276 Marseille Cedex 09—France Tèl. (33) 4 91 17 27 00
¤
Distributor and Refer to attached list, Document ID: 472050, for local distributor and
Emergency Phone No. emergency phone numbers.
Section 2 Composition and Information on Ingredients
Hazardous Ingredients: None
Section 3 Hazards Identification
Emergency Overview
White;
Opaque; Solid; Odorless
Nonflammable
Does not meet EU, OSHA or WHMIS criteria for hazardous materials.
Physical Hazards No physical hazards were determined from a review of available literature.
Potential Health This product does not meet EU, OSHA or WHMIS criteria for hazardous materials.
Effects Summary
Product Hazard EU: WHMIS: US OSHA:
Classifications Not applicable Not applicable Not applicable
Beckman Coulter Safety Flammability (Section V): 0 Code
Rating Health (Section XI): 0 0=none
Reactivity with Water (Section X): 0 1=slight
Contact (Section VIII): 1 2=caution
3=severe
Section 4 First Aid Measures
Inhalation If product is inhaled, move exposed individual to fresh air. If individual is not
breathing, begin artificial respiration immediately and obtain medical attention.
Eye Contact If product enters eyes, wash eyes gently under running water for 15 minutes or
longer, making sure that the eyelids are held open. If pain or irritation occur, obtain
medical attention.
Skin Contact In case of skin contact, flush with copious amounts of water for at least 15 minutes. If
pain or irritation occur, obtain medical attention.
Histamine EIA Kit Doc. ID: IM2015-75 AB Page 15 of 63
Substrate tablets pNPP
Section 4 First Aid Measures (Continued)
Ingestion If ingested, wash mouth out with water. If irritation or discomfort occurs, seek medical
attention.
Section 5 Fire Fighting Measures
Flash Point Not available
Flammable Limits Not applicable
Autoignition Temp. Not available
Extinguishing Media Use extinguishing media suitable for surrounding fire.
Special Fire and No special hazards determined.
Explosion Hazards
Hazardous Combustion No combustion products posing significant hazards are expected from this product.
Products
Protective Equipment Self-contained breathing apparatus is recommended for firefighters in all chemical fire
for Firefighters situations.
Section 6 Accidental Release Measures
Personal Precautions No special precautions are necessary. Use good laboratory procedures.
Spill and Leak Wipe up spill and place in container suitable for disposal.
Procedures
Environmental Contain spill to prevent migration.
Precautions
Section 7 Handling and Storage
Handling Precautions No special precautions are necessary; use good laboratory procedures.
Recommended Storage To maintain efficacy, store according to the instructions in the product labeling.
Conditions
Section 8 Exposure Controls and Personal Protection
Exposure Limits
US OSHA: None established
ACGIH: None established
DFG MAK: None established
Engineering Controls No special engineering controls are required. Use with good general ventilation.
Respiratory Protection Under normal conditions, the use of this product should not require respiratory
protection.
Eye Protection Safety glasses or chemical goggles should be worn to prevent eye contact.
Skin Protection Impervious gloves, such as latex or equivalent, should be worn to prevent skin
contact.
Histamine EIA Kit Doc. ID: IM2015-75 AB Page 16 of 63
Substrate tablets pNPP
Section 9 Physical and Chemical Properties
Physical State Solid
Color White
Transparency Opaque
Odor Odorless
Odor Threshold Not applicable
pH Not applicable
Boiling Point Not applicable
Melting Point Not available
Specific Gravity Not applicable
Vapor Pressure Not applicable
Vapor Density Not applicable
Evaporation Rate Not applicable
Solubility
Water Solubility in Water
Organic Not available
Section 10 Stability and Reactivity
Stability Stable under normal temperatures and pressures.
Hazardous No hazardous incompatibilities were determined from a review of literature available.
Incompatibilities
Hazardous No decomposition products posing significant hazards would be expected from this
Decomposition Products product.
Conditions to Avoid None determined.
Section 11 Toxicological Information
Toxicity Data Not applicable
for Hazardous Ingredients
Primary Routes The most likely routes of exposure are skin and eye contact.
of Exposure
Potential Effects of None identified.
Acute Exposure
Potential Effects of None identified.
Chronic Exposure
Symptoms of None identified.
Overexposure
Carcinogenicity No ingredients in this product are listed as carcinogens by ACGIH, IARC, NTP, OSHA
or 67/548/EEC Annex I.
Other Effects None identified.
Histamine EIA Kit Doc. ID: IM2015-75 AB Page 17 of 63
Substrate tablets pNPP
Section 11 Toxicological Information (Continued)
Conditions Aggravated None identified.
by Exposure
Section 12 Ecological Information
Ecotoxicity No information available.
Biodegradability No information available.
Mobility No information available.
Section 13 Disposal Considerations
Waste Disposal Dispose of waste product, unused product and contaminated packaging in compliance
with federal, state and local regulations. If unsure of the applicable requirements,
contact the authorities for information.
Section 14 Transport Information
Transportation of this product is not regulated under ICAO, IMDG, US DOT, European ADR or Canadian TDG.
Section 15 Regulatory Information
US Federal and State Regulations
SARA 313 No ingredients listed
CERCLA RG’s, No ingredients listed
40 CFR 302.4
California Proposition 65 No ingredients listed
Massachusetts MSL No ingredients listed
New Jersey Dept. of No ingredients listed
Health RTK List
Pennsylvania RTK No ingredients listed
EU Labeling Classification
Preparation not classified.
Canada
This product does not meet WHMIS criteria for hazardous materials.
PIN: Not applicable
Ingredients on Ingredient None
Disclosure List:
Ingredients with unknown None
toxicological properties:
Histamine EIA Kit Doc. ID: IM2015-75 AB Page 18 of 63
Substrate tablets pNPP
Section 16 Other Information
For further information, please contact your local Beckman Coulter representative.
WHILE BECKMAN COULTER, INC. BELIEVES THE INFORMATION CONTAINED HEREIN IS VALID AND ACCURATE, BECKMAN COULTER MAKES NO WARRANTY OR
REPRESENTATION AS TO ITS VALIDITY, ACCURACY, OR CURRENCY. BECKMAN COULTER SHALL NOT BE LIABLE OR OTHERWISE RESPONSIBLE IN ANY WAY FOR USE
OF EITHER THIS INFORMATION OR MATERIALS TO WHICH IT APPLIES. DISPOSAL OF HAZARDOUS MATERIALS MAY BE SUBJECT TO LOCAL LAWS OR REGULATIONS.
Printed in U.S.A.
Page 19 of 63
@Beckman
CoulterTM MATERIAL SAFETY DATA SHEET
Section 1 Company and Product Identification
Substrate Buffer DEA
Product Name Histamine EIA Kit
Doc. ID IM2015-75 AB
Issued (year/month/day)
Revised (year/month/day) 2004/02/17
Part Number Component of P/N IM2015
Product Use For laboratory use only. See product literature for details.
Manufacturer Distributed by Beckman Coulter, Inc. for
IMMUNOTECH (A Beckman Coulter Company)
130, av.de Lattre de Tassigny—BP 177
13276 Marseille Cedex 09—France Tèl. (33) 4 91 17 27 00
¤
Distributor and Refer to attached list, Document ID: 472050, for local distributor and
Emergency Phone No. emergency phone numbers.
Section 2 Composition and Information on Ingredients
Hazardous Ingredients: Meets Hazardous Criteria:
Chemical Name CAS # % by wt. EU US OSHA WHMIS
<10%
Diethanolamine 111-42-2 Xn;R22-38-41- Yes Yes
48/22
See Section 15 Regulatory Information for additional information on hazard classifications.
Section 3 Hazards Identification
Emergency Overview
Colorless; Clear; Liquid; Odorless
Nonflammable aqueous solution.
Skin, eye and respiratory tract irritant.
Physical Hazards No physical hazards were determined from a review of available literature.
Potential Health Exposure may cause irritation or burns to respiratory tract, skin, and eyes. Corrosive
Effects Summary effects may be delayed.
See Section 11 Toxicological Information for more detailed health information.
Product Hazard EU: WHMIS: US OSHA:
Classifications Xi;R36 D2B Hazardous
Beckman Coulter Safety Flammability (Section V): 0 Code
Rating Health (Section XI): 2 0=none
Reactivity with Water (Section X): 0 1=slight
Contact (Section VIII): 2 2=caution
3=severe
Section 4 First Aid Measures
Inhalation If product is inhaled, move exposed individual to fresh air. If individual is not
breathing, begin artificial respiration immediately and obtain medical attention.
Histamine EIA Kit Doc. ID: IM2015-75 AB Page 20 of 63
Substrate Buffer DEA
Section 4 First Aid Measures (Continued)
Eye Contact If product enters eyes, wash eyes gently under running water for 15 minutes or
longer, making sure that the eyelids are held open. If pain or irritation occur, obtain
medical attention.
Skin Contact In case of skin contact, flush with copious amounts of water for at least 15 minutes. If
pain or irritation occur, obtain medical attention.
Ingestion If ingested, wash mouth out with water. If irritation or discomfort occurs, seek medical
attention.
Section 5 Fire Fighting Measures
Flash Point Not applicable
Flammable Limits Not applicable
Autoignition Temp. Not applicable
Extinguishing Media Use extinguishing media suitable for surrounding fire.
Special Fire and None identified.
Explosion Hazards
Hazardous Combustion No combustion products posing significant hazards are expected from this product.
Products
Protective Equipment Self-contained breathing apparatus is recommended for firefighters in all chemical fire
for Firefighters situations.
Section 6 Accidental Release Measures
Personal Precautions No special precautions are necessary. Use good laboratory procedures.
Spill and Leak Absorb spilled material with an appropriate inert, non-flammable absorbent and
Procedures dispose according to local regulations.
Environmental Contain spill to prevent migration.
Precautions
Section 7 Handling and Storage
Handling Precautions No special precautions are necessary; use good laboratory procedures.
Recommended Storage To maintain efficacy, store according to the instructions in the product labeling.
Conditions
Section 8 Exposure Controls and Personal Protection
Exposure Limits
US OSHA: None established
ACGIH:
Diethanolamine skin—potential for cutaneous absorption; 2 mg/m3 TWA
DFG MAK:
Diethanolamine Skin Absorber
Histamine EIA Kit Doc. ID: IM2015-75 AB Page 21 of 63
Substrate Buffer DEA
Section 8 Exposure Controls and Personal Protection (Continued)
Engineering Controls No special engineering controls are required. Use with good general ventilation.
Respiratory Protection Under normal conditions, the use of this product should not require respiratory
protection.
Eye Protection Safety glasses or chemical goggles should be worn to prevent eye contact.
Skin Protection Impervious gloves, such as latex or equivalent, should be worn to prevent skin
contact.
Section 9 Physical and Chemical Properties
Physical State Liquid
Color Colorless
Transparency Clear
Odor Odorless
Odor Threshold Not applicable
pH 9.8
Boiling Point Not available
Melting Point Not available
Specific Gravity 1.01 @20°C
Vapor Pressure Not available
Vapor Density Not available
Evaporation Rate Not available
Solubility
Water Miscible
Organic Not available
Section 10 Stability and Reactivity
Stability Stable in closed containers under normal temperatures and pressures.
Hazardous Strong acids
Incompatibilities Strong bases
Strong oxidizers
Metals and metallic compounds
Acid anhydrides
Hazardous No decomposition products posing significant hazards would be expected from this
Decomposition Products product (a dilute aqueous solution).
Conditions to Avoid Avoid contact with incompatible materials.
Section 11 Toxicological Information
Toxicity Data
for Hazardous Ingredients
Diethanolamine Oral LD50 Rat: 620 µL/kg; Oral LD50 Mouse: 3300 mg/kg; Dermal LD50
Rabbit: 7640 µL/kg
Histamine EIA Kit Doc. ID: IM2015-75 AB Page 22 of 63
Substrate Buffer DEA
Section 11 Toxicological Information (Continued)
Primary Routes Eye contact, ingestion, inhalation, and skin contact.
of Exposure
Potential Effects of Skin or eye contact may cause irritation. Ingestion may result in gastrointestinal
Acute Exposure discomfort and diarrhea.
Potential Effects of Effects are similar to those for acute exposure.
Chronic Exposure Repeated or prolonged exposure may result in dermatitis and conjunctivitis,
impairment of kidney and liver function and reproductive effects.
Symptoms of Symptoms of overexposure may include: reddening, itching, vomiting, and nausea.
Overexposure
Carcinogenicity No ingredients in this product are listed as carcinogens by ACGIH, IARC, NTP, OSHA
or 67/548/EEC Annex I.
Other Effects Reproductive effects have been reported.
Conditions Aggravated None identified.
by Exposure
Section 12 Ecological Information
Ecotoxicity Toxic to fish and other water organisms.
Biodegradability No information available.
Mobility No information available.
Section 13 Disposal Considerations
Waste Disposal Dispose of waste product, unused product and contaminated packaging in compliance
with federal, state and local regulations. If unsure of the applicable requirements,
contact the authorities for information.
Section 14 Transport Information
Transportation of this product is not regulated under ICAO, IMDG, US DOT, European ADR or Canadian TDG.
Section 15 Regulatory Information
US Federal and State Regulations
SARA 313 Diethanolamine is subject to reporting requirements of Section 313, Title III of SARA.
CERCLA RG’s, Diethanolamine is listed.
40 CFR 302.4
California Proposition 65 No ingredients listed
Massachusetts MSL Diethanolamine is listed.
Magnesium Chloride is listed.
New Jersey Dept. of Diethanolamine is listed.
Health RTK List Magnesium Chloride is listed.
Pennsylvania RTK Diethanolamine is listed.
Magnesium Chloride is listed.
Histamine EIA Kit Doc. ID: IM2015-75 AB Page 23 of 63
Substrate Buffer DEA
Section 15 Regulatory Information (Continued)
EU Labeling Classification
Classification Risk and Safety Phrases
Xi R36 Irritating to eyes.
Irritant
Canada
WHMIS Classification: D2B—Poisonous and Infectious Material: Division 2—Other Toxic Effects: Toxic (Chronic
Toxic Effects)
PIN: Not applicable
Ingredients on Ingredient Diethanolamine
Disclosure List:
Ingredients with unknown None
toxicological properties:
Section 16 Other Information
For further information, please contact your local Beckman Coulter representative.
WHILE BECKMAN COULTER, INC. BELIEVES THE INFORMATION CONTAINED HEREIN IS VALID AND ACCURATE, BECKMAN COULTER MAKES NO WARRANTY OR
REPRESENTATION AS TO ITS VALIDITY, ACCURACY, OR CURRENCY. BECKMAN COULTER SHALL NOT BE LIABLE OR OTHERWISE RESPONSIBLE IN ANY WAY FOR USE
OF EITHER THIS INFORMATION OR MATERIALS TO WHICH IT APPLIES. DISPOSAL OF HAZARDOUS MATERIALS MAY BE SUBJECT TO LOCAL LAWS OR REGULATIONS.
Printed in U.S.A.
Page 24 of 63
@Beckman
CoulterTM MATERIAL SAFETY DATA SHEET
Section 1 Company and Product Identification
Conjugate diluent H
Product Name Histamine EIA Kit
Doc. ID IM2015-75 AB
Issued (year/month/day)
Revised (year/month/day) 2004/02/17
Part Number Component of P/N IM2015
Product Use For laboratory use only. See product literature for details.
Manufacturer Distributed by Beckman Coulter, Inc. for
IMMUNOTECH (A Beckman Coulter Company)
130, av.de Lattre de Tassigny—BP 177
13276 Marseille Cedex 09—France Tèl. (33) 4 91 17 27 00
¤
Distributor and Refer to attached list, Document ID: 472050, for local distributor and
Emergency Phone No. emergency phone numbers.
Section 2 Composition and Information on Ingredients
Hazardous Ingredients: None
Section 3 Hazards Identification
Emergency Overview
Colorless; Clear; Liquid; Odorless
Nonflammable aqueous solution.
Does not meet EU, OSHA or WHMIS criteria for hazardous materials.
Physical Hazards No physical hazards were determined from a review of available literature.
Potential Health This product does not meet EU, OSHA or WHMIS criteria for hazardous materials.
Effects Summary
Product Hazard EU: WHMIS: US OSHA:
Classifications Not applicable Not applicable Not applicable
Beckman Coulter Safety Flammability (Section V): 0 Code
Rating Health (Section XI): 0 0=none
Reactivity with Water (Section X): 0 1=slight
Contact (Section VIII): 1 2=caution
3=severe
Section 4 First Aid Measures
Inhalation If product is inhaled, move exposed individual to fresh air. If individual is not
breathing, begin artificial respiration immediately and obtain medical attention.
Eye Contact If product enters eyes, wash eyes gently under running water for 15 minutes or
longer, making sure that the eyelids are held open. If pain or irritation occur, obtain
medical attention.
Skin Contact In case of skin contact, flush with copious amounts of water for at least 15 minutes. If
pain or irritation occur, obtain medical attention.
Histamine EIA Kit Doc. ID: IM2015-75 AB Page 25 of 63
Conjugate diluent H
Section 4 First Aid Measures (Continued)
Ingestion If ingested, wash mouth out with water. If irritation or discomfort occurs, seek medical
attention.
Section 5 Fire Fighting Measures
Flash Point Not applicable
Flammable Limits Not applicable
Autoignition Temp. Not applicable
Extinguishing Media Use extinguishing media suitable for surrounding fire.
Special Fire and No special hazards determined.
Explosion Hazards
Hazardous Combustion No combustion products posing significant hazards are expected from this product (a
Products dilute aqueous solution).
Protective Equipment Self-contained breathing apparatus is recommended for firefighters in all chemical fire
for Firefighters situations.
Section 6 Accidental Release Measures
Personal Precautions No special precautions are necessary. Use good laboratory procedures.
Spill and Leak Absorb spilled material with an appropriate inert, non-flammable absorbent and
Procedures dispose according to local regulations.
Environmental Contain spill to prevent migration.
Precautions
Section 7 Handling and Storage
Handling Precautions No special precautions are necessary; use good laboratory procedures.
Recommended Storage To maintain efficacy, store according to the instructions in the product labeling.
Conditions
Section 8 Exposure Controls and Personal Protection
Exposure Limits
US OSHA: None established
ACGIH: None established
DFG MAK: None established
Engineering Controls No special engineering controls are required. Use with good general ventilation.
Respiratory Protection Under normal conditions, the use of this product should not require respiratory
protection.
Eye Protection Safety glasses or chemical goggles should be worn to prevent eye contact.
Skin Protection Impervious gloves, such as latex or equivalent, should be worn to prevent skin
contact.
Histamine EIA Kit Doc. ID: IM2015-75 AB Page 26 of 63
Conjugate diluent H
Section 9 Physical and Chemical Properties
Physical State Liquid
Color Colorless
Transparency Clear
Odor Odorless
Odor Threshold Not applicable
pH 8.2
Boiling Point Not available
Melting Point Not available
Specific Gravity 1.015 @20°C
Vapor Pressure Not available
Vapor Density Not available
Evaporation Rate Not available
Solubility
Water Miscible
Organic Not available
Section 10 Stability and Reactivity
Stability Stable under normal temperatures and pressures.
Hazardous Strong acids
Incompatibilities Strong bases
Strong oxidizers
Hazardous No decomposition products posing significant hazards would be expected from this
Decomposition Products product (a dilute aqueous solution).
Conditions to Avoid None determined.
Section 11 Toxicological Information
Toxicity Data Not applicable
for Hazardous Ingredients
Primary Routes The most likely routes of exposure are skin and eye contact.
of Exposure
Potential Effects of None identified.
Acute Exposure
Potential Effects of None identified.
Chronic Exposure
Symptoms of None identified.
Overexposure
Carcinogenicity No ingredients in this product are listed as carcinogens by ACGIH, IARC, NTP, OSHA
or 67/548/EEC Annex I.
Other Effects None identified.
Histamine EIA Kit Doc. ID: IM2015-75 AB Page 27 of 63
Conjugate diluent H
Section 11 Toxicological Information (Continued)
Conditions Aggravated None identified.
by Exposure
Section 12 Ecological Information
Ecotoxicity No information available.
Biodegradability No information available.
Mobility No information available.
Section 13 Disposal Considerations
Waste Disposal Dispose of waste product, unused product and contaminated packaging in compliance
with federal, state and local regulations. If unsure of the applicable requirements,
contact the authorities for information.
Section 14 Transport Information
Transportation of this product is not regulated under ICAO, IMDG, US DOT, European ADR or Canadian TDG.
Section 15 Regulatory Information
US Federal and State Regulations
SARA 313 No ingredients listed
CERCLA RG’s, No ingredients listed
40 CFR 302.4
California Proposition 65 No ingredients listed
Massachusetts MSL Magnesium Chloride is listed.
New Jersey Dept. of Magnesium Chloride is listed.
Health RTK List
Pennsylvania RTK Magnesium Chloride is listed.
EU Labeling Classification
Preparation not classified.
Canada
This product does not meet WHMIS criteria for hazardous materials.
PIN: Not applicable
Ingredients on Ingredient Boric Acid
Disclosure List:
Ingredients with unknown None
toxicological properties:
Histamine EIA Kit Doc. ID: IM2015-75 AB Page 28 of 63
Conjugate diluent H
Section 16 Other Information
For further information, please contact your local Beckman Coulter representative.
WHILE BECKMAN COULTER, INC. BELIEVES THE INFORMATION CONTAINED HEREIN IS VALID AND ACCURATE, BECKMAN COULTER MAKES NO WARRANTY OR
REPRESENTATION AS TO ITS VALIDITY, ACCURACY, OR CURRENCY. BECKMAN COULTER SHALL NOT BE LIABLE OR OTHERWISE RESPONSIBLE IN ANY WAY FOR USE
OF EITHER THIS INFORMATION OR MATERIALS TO WHICH IT APPLIES. DISPOSAL OF HAZARDOUS MATERIALS MAY BE SUBJECT TO LOCAL LAWS OR REGULATIONS.
Printed in U.S.A.
Page 29 of 63
@Beckman
CoulterTM MATERIAL SAFETY DATA SHEET
Section 1 Company and Product Identification
Histamine Standard (6
Product Name
vials) Histamine EIA Kit
Doc. ID IM2015-75 AB
Issued (year/month/day)
Revised (year/month/day) 2004/02/17
Part Number Component of P/N IM2015
Product Use For laboratory use only. See product literature for details.
Manufacturer Distributed by Beckman Coulter, Inc. for
IMMUNOTECH (A Beckman Coulter Company)
130, av.de Lattre de Tassigny—BP 177
13276 Marseille Cedex 09—France Tèl. (33) 4 91 17 27 00
¤
Distributor and Refer to attached list, Document ID: 472050, for local distributor and
Emergency Phone No. emergency phone numbers.
Section 2 Composition and Information on Ingredients
Hazardous Ingredients: None
Section 3 Hazards Identification
Emergency Overview
Colorless; Clear; Liquid; Odorless
Nonflammable aqueous solution.
Does not meet EU, OSHA or WHMIS criteria for hazardous materials.
Contains material of animal origin.
Physical Hazards Sodium azide forms explosive compounds with heavy metals. This product contains
concentrations of azide <0.1% (w/w) which with repeated contact with lead and
copper commonly found in plumbing drains may result in the build up of shock
sensitive compounds.
Potential Health This product does not meet EU, OSHA or WHMIS criteria for hazardous materials.
Effects Summary However, it does contain material of animal origin and should be considered
potentially infectious.
Product Hazard EU: WHMIS: US OSHA:
Classifications Not applicable Not applicable Not applicable
Beckman Coulter Safety Flammability (Section V): 0 Code
Rating Health (Section XI): 1 0=none
Reactivity with Water (Section X): 0 1=slight
Contact (Section VIII): 1 2=caution
3=severe
Histamine EIA Kit Doc. ID: IM2015-75 AB Page 30 of 63
Histamine Standard (6 vials)
Section 4 First Aid Measures
Inhalation If product is inhaled, move exposed individual to fresh air. If individual is not
breathing, begin artificial respiration immediately and obtain medical attention.
Eye Contact If product enters eyes, wash eyes gently under running water for 15 minutes or
longer, making sure that the eyelids are held open. If pain or irritation occur, obtain
medical attention.
Skin Contact Remove any contaminated clothing. Wash affected area with plenty of soap and
water. Use disinfectant if possible.
Ingestion If ingested, wash mouth out with water. If irritation or discomfort occurs, seek medical
attention.
Section 5 Fire Fighting Measures
Flash Point Not applicable
Flammable Limits Not applicable
Autoignition Temp. Not applicable
Extinguishing Media Use extinguishing media suitable for surrounding fire.
Special Fire and No special hazards determined.
Explosion Hazards
Hazardous Combustion Due to the nature and volume of this product, the type and amount of combustion
Products products are negligible.
Protective Equipment Self-contained breathing apparatus is recommended for firefighters.
for Firefighters
Section 6 Accidental Release Measures
Personal Precautions This product contains a material of biological origin. Use universal precautions during
clean up procedures.
Spill and Leak As a precautionary measure, treat spilled material with a 1:10 bleach/water solution.
Procedures Absorb liquid and place in container suitable for disposal. Avoid generation of
aerosols during clean up. Comply with applicable waste disposal regulations.
Environmental Contain spill to prevent migration.
Precautions
Section 7 Handling and Storage
Handling Precautions This product should be handled as though capable of transmitting infectious diseases.
Universal precautions should be followed when using this product.
Recommended Storage Keep away from incompatible material.
Conditions To maintain efficacy, store according to the instructions in the product labeling.
Section 8 Exposure Controls and Personal Protection
Exposure Limits
US OSHA: None established
ACGIH: None established
Histamine EIA Kit Doc. ID: IM2015-75 AB Page 31 of 63
Histamine Standard (6 vials)
Section 8 Exposure Controls and Personal Protection (Continued)
DFG MAK: None established
Engineering Controls No special engineering controls are required. Use with good general ventilation.
Respiratory Protection Under normal conditions, the use of this product should not require respiratory
protection.
Eye Protection Safety glasses or chemical goggles should be worn to prevent eye contact.
Skin Protection Impervious gloves, such as latex or equivalent, should be worn to prevent skin
contact.
Section 9 Physical and Chemical Properties
Physical State Liquid
Color Colorless
Transparency Clear
Odor Odorless
Odor Threshold Not applicable
pH 6.2
Boiling Point Not available
Melting Point Not available
Specific Gravity 1.005 @20°C
Vapor Pressure Not available
Vapor Density Not available
Evaporation Rate Not available
Solubility
Water Miscible
Organic Not available
Section 10 Stability and Reactivity
Stability Stable under normal temperatures and pressures.
Hazardous Strong acids
Incompatibilities Strong bases
Strong oxidizers
Metals and metallic compounds
Sodium azide forms explosive compounds with heavy metals. This product contains
concentrations of azide <0.1% (w/w) which with repeated contact with lead and
copper commonly found in plumbing drains may result in the build up of shock
sensitive compounds.
Hazardous When stored as labeled, no known hazardous decomposition products are formed
Decomposition Products during the shelf-life of this product.
Conditions to Avoid Keep away from incompatible material.
Histamine EIA Kit Doc. ID: IM2015-75 AB Page 32 of 63
Histamine Standard (6 vials)
Section 11 Toxicological Information
Toxicity Data Not applicable
for Hazardous Ingredients
Primary Routes Common routes of entry include inhalation, ingestion and eye/skin contact. Specific
of Exposure paths of concern for potentially infectious materials are skin puncture, contact with
broken skin, contact with mucous membranes and inhalation of aerosolized material.
Potential Effects of This product contains materials of animal origin and should be considered potentially
Acute Exposure infectious. No other health hazards were identified from a review of available
literature.
Potential Effects of Effects are similar to those for acute exposure.
Chronic Exposure
Symptoms of No specific symptoms identified.
Overexposure
Carcinogenicity No ingredients in this product are listed as carcinogens by ACGIH, IARC, NTP, OSHA
or 67/548/EEC Annex I.
Other Effects None identified.
Conditions Aggravated None identified.
by Exposure
Section 12 Ecological Information
Ecotoxicity No information available.
Biodegradability No information available.
Mobility No information available.
Section 13 Disposal Considerations
Waste Disposal Dispose of waste product, unused product and contaminated packaging in compliance
with federal, state and local regulations. If unsure of the applicable requirements,
contact the authorities for information.
Sodium azide preservative may form explosive compounds in metal drain lines. See
NIOSH Bulletin: Explosive Azide Hazard (8/16/76).
Section 14 Transport Information
Transportation of this product is not regulated under ICAO, IMDG, US DOT, European ADR or Canadian TDG.
Section 15 Regulatory Information
US Federal and State Regulations
SARA 313 Sodium Azide is subject to reporting requirements of Section 313, Title III of SARA.
CERCLA RG’s, Edetic Acid is listed.
40 CFR 302.4 Sodium Azide is listed.
California Proposition 65 No ingredients listed
Massachusetts MSL Edetic Acid is listed.
Sodium Azide is listed.
Histamine EIA Kit Doc. ID: IM2015-75 AB Page 33 of 63
Histamine Standard (6 vials)
Section 15 Regulatory Information (Continued)
US Federal and State Regulations
New Jersey Dept. of Edetic Acid is listed.
Health RTK List Sodium Azide is listed.
Pennsylvania RTK Edetic Acid is listed.
Sodium Azide is listed.
EU Labeling Classification
Preparation not classified.
Canada
This product does not meet WHMIS criteria for hazardous materials.
PIN: Not applicable
Ingredients on Ingredient Sodium Azide
Disclosure List:
Ingredients with unknown None
toxicological properties:
Section 16 Other Information
For further information, please contact your local Beckman Coulter representative.
WHILE BECKMAN COULTER, INC. BELIEVES THE INFORMATION CONTAINED HEREIN IS VALID AND ACCURATE, BECKMAN COULTER MAKES NO WARRANTY OR
REPRESENTATION AS TO ITS VALIDITY, ACCURACY, OR CURRENCY. BECKMAN COULTER SHALL NOT BE LIABLE OR OTHERWISE RESPONSIBLE IN ANY WAY FOR USE
OF EITHER THIS INFORMATION OR MATERIALS TO WHICH IT APPLIES. DISPOSAL OF HAZARDOUS MATERIALS MAY BE SUBJECT TO LOCAL LAWS OR REGULATIONS.
Printed in U.S.A.
Page 34 of 63
@Beckman
CoulterTM MATERIAL SAFETY DATA SHEET
Section 1 Company and Product Identification
Alkaline phosphatase
Product Name
conjugate Histamine EIA Kit
Doc. ID IM2015-75 AB
Issued (year/month/day)
Revised (year/month/day) 2004/02/17
Part Number Component of P/N IM2015
Product Use Data given is for reconstituted solution.
For laboratory use only. See product literature for details.
Manufacturer Distributed by Beckman Coulter, Inc. for
IMMUNOTECH (A Beckman Coulter Company)
130, av.de Lattre de Tassigny—BP 177
13276 Marseille Cedex 09—France Tèl. (33) 4 91 17 27 00
¤
Distributor and Refer to attached list, Document ID: 472050, for local distributor and
Emergency Phone No. emergency phone numbers.
Section 2 Composition and Information on Ingredients
Hazardous Ingredients: None
Section 3 Hazards Identification
Emergency Overview
Colorless; Clear; Lyophilized—Liquid after reconstitution.; Odorless
Nonflammable aqueous solution.
Does not meet EU, OSHA or WHMIS criteria for hazardous materials.
Contains material of animal origin.
Physical Hazards No physical hazards were determined from a review of available literature.
Potential Health This product does not meet EU, OSHA or WHMIS criteria for hazardous materials.
Effects Summary However, it does contain material of animal origin and should be considered
potentially infectious.
Product Hazard EU: WHMIS: US OSHA:
Classifications Not applicable Not applicable Not applicable
Beckman Coulter Safety Flammability (Section V): 0 Code
Rating Health (Section XI): 1 0=none
Reactivity with Water (Section X): 0 1=slight
Contact (Section VIII): 1 2=caution
3=severe
Section 4 First Aid Measures
Inhalation If product is inhaled, move exposed individual to fresh air. If individual is not
breathing, begin artificial respiration immediately and obtain medical attention.
Histamine EIA Kit Doc. ID: IM2015-75 AB Page 35 of 63
Alkaline phosphatase conjugate
Section 4 First Aid Measures (Continued)
Eye Contact If product enters eyes, wash eyes gently under running water for 15 minutes or
longer, making sure that the eyelids are held open. If pain or irritation occur, obtain
medical attention.
Skin Contact Remove any contaminated clothing. Wash affected area with plenty of soap and
water. Use disinfectant if possible.
Ingestion If ingested, wash mouth out with water. If irritation or discomfort occurs, seek medical
attention.
Section 5 Fire Fighting Measures
Flash Point Not applicable
Flammable Limits Not applicable
Autoignition Temp. Not applicable
Extinguishing Media Use extinguishing media suitable for surrounding fire.
Special Fire and No special hazards determined.
Explosion Hazards
Hazardous Combustion No combustion products posing significant hazards are expected from this product (a
Products dilute aqueous solution).
Protective Equipment Self-contained breathing apparatus is recommended for firefighters in all chemical fire
for Firefighters situations.
Section 6 Accidental Release Measures
Personal Precautions This product contains a material of biological origin. Use universal precautions during
clean up procedures.
Spill and Leak Absorb spilled material with an appropriate inert, non-flammable absorbent and
Procedures dispose according to local regulations.
Environmental Contain spill to prevent migration.
Precautions
Section 7 Handling and Storage
Handling Precautions No special precautions are necessary; use good laboratory procedures.
Recommended Storage Keep away from incompatible material.
Conditions To maintain efficacy, store according to the instructions in the product labeling.
Section 8 Exposure Controls and Personal Protection
Exposure Limits
US OSHA: None established
ACGIH: None established
DFG MAK: None established
Engineering Controls No special engineering controls are required. Use with good general ventilation.
Histamine EIA Kit Doc. ID: IM2015-75 AB Page 36 of 63
Alkaline phosphatase conjugate
Section 8 Exposure Controls and Personal Protection (Continued)
Respiratory Protection Under normal conditions, the use of this product should not require respiratory
protection.
Eye Protection Safety glasses or chemical goggles should be worn to prevent eye contact.
Skin Protection Impervious gloves, such as latex or equivalent, should be worn to prevent skin
contact.
Section 9 Physical and Chemical Properties
Physical State Lyophilized—Liquid after reconstitution.
Color Colorless
Transparency Clear
Odor Odorless
Odor Threshold Not applicable
pH 8
Boiling Point Not available
Melting Point Not available
Specific Gravity 1.02 @20°C
Vapor Pressure Not available
Vapor Density Not available
Evaporation Rate Not available
Solubility
Water Miscible
Organic Not available
Section 10 Stability and Reactivity
Stability Stable under normal temperatures and pressures.
Hazardous Strong acids
Incompatibilities Strong bases
Strong oxidizers
Hazardous No decomposition products posing significant hazards would be expected from this
Decomposition Products product (a dilute aqueous solution).
Conditions to Avoid None determined.
Section 11 Toxicological Information
Toxicity Data Not applicable
for Hazardous Ingredients
Primary Routes The most likely routes of exposure are skin and eye contact.
of Exposure
Histamine EIA Kit Doc. ID: IM2015-75 AB Page 37 of 63
Alkaline phosphatase conjugate
Section 11 Toxicological Information (Continued)
Potential Effects of This product contains materials of animal origin and should be considered potentially
Acute Exposure infectious. No other health hazards were identified from a review of available
literature.
Potential Effects of None identified.
Chronic Exposure
Symptoms of None identified.
Overexposure
Carcinogenicity No ingredients in this product are listed as carcinogens by ACGIH, IARC, NTP, OSHA
or 67/548/EEC Annex I.
Other Effects None identified.
Conditions Aggravated None identified.
by Exposure
Section 12 Ecological Information
Ecotoxicity No information available.
Biodegradability No information available.
Mobility No information available.
Section 13 Disposal Considerations
Waste Disposal Dispose of waste product, unused product and contaminated packaging in compliance
with federal, state and local regulations. If unsure of the applicable requirements,
contact the authorities for information.
Section 14 Transport Information
Transportation of this product is not regulated under ICAO, IMDG, US DOT, European ADR or Canadian TDG.
Section 15 Regulatory Information
US Federal and State Regulations
SARA 313 Zinc Chloride is subject to reporting requirements of Section 313, Title III of SARA.
CERCLA RG’s, Zinc Chloride is listed.
40 CFR 302.4
California Proposition 65 No ingredients listed
Massachusetts MSL Zinc Chloride is listed.
Magnesium Chloride is listed.
New Jersey Dept. of Zinc Chloride is listed.
Health RTK List Magnesium Chloride is listed.
Pennsylvania RTK Zinc Chloride is listed.
Magnesium Chloride is listed.
Histamine EIA Kit Doc. ID: IM2015-75 AB Page 38 of 63
Alkaline phosphatase conjugate
Section 15 Regulatory Information (Continued)
EU Labeling Classification
Preparation not classified.
Canada
This product does not meet WHMIS criteria for hazardous materials.
PIN: Not applicable
Ingredients on Ingredient Zinc Chloride
Disclosure List: Boric Acid
Ingredients with unknown None
toxicological properties:
Section 16 Other Information
For further information, please contact your local Beckman Coulter representative.
WHILE BECKMAN COULTER, INC. BELIEVES THE INFORMATION CONTAINED HEREIN IS VALID AND ACCURATE, BECKMAN COULTER MAKES NO WARRANTY OR
REPRESENTATION AS TO ITS VALIDITY, ACCURACY, OR CURRENCY. BECKMAN COULTER SHALL NOT BE LIABLE OR OTHERWISE RESPONSIBLE IN ANY WAY FOR USE
OF EITHER THIS INFORMATION OR MATERIALS TO WHICH IT APPLIES. DISPOSAL OF HAZARDOUS MATERIALS MAY BE SUBJECT TO LOCAL LAWS OR REGULATIONS.
Printed in U.S.A.
Page 39 of 63
@Beckman
CoulterTM MATERIAL SAFETY DATA SHEET
Section 1 Company and Product Identification
DMSO 3ml
Product Name Histamine EIA Kit
Doc. ID IM2015-75 AB
Issued (year/month/day)
Revised (year/month/day) 2004/02/17
Part Number Component of P/N IM2015
Manufacturer Distributed by Beckman Coulter, Inc. for
IMMUNOTECH (A Beckman Coulter Company)
130, av.de Lattre de Tassigny—BP 177
13276 Marseille Cedex 09—France Tèl. (33) 4 91 17 27 00
¤
Distributor and Refer to attached list, Document ID: 472050, for local distributor and
Emergency Phone No. emergency phone numbers.
Section 2 Composition and Information on Ingredients
Hazardous Ingredients: Meets Hazardous Criteria:
Chemical Name CAS # % by wt. EU US OSHA WHMIS
Dimethyl Sulfoxide 67-68-5 100% Xi;R36/37/38 Yes Yes
See Section 15 Regulatory Information for additional information on hazard classifications.
Section 3 Hazards Identification
Emergency Overview
Colorless; Clear; Liquid; Pungent
Nonflammable aqueous solution.
May cause irritation of skin, eyes, mucous
membranes and upper respiratory tract.
Physical Hazards No physical hazards were determined from a review of available literature.
Potential Health Contact may cause irritation to the eyes, skin, and mucous membranes. Inhalation of
Effects Summary mists may cause mucous membrane and upper respiratory irritation.
See Section 11 Toxicological Information for more detailed health information.
Product Hazard EU: WHMIS: US OSHA:
Classifications Xi;R36/37/38 B3; D2B Hazardous
Beckman Coulter Safety Flammability (Section V): 0 Code
Rating Health (Section XI): 1 0=none
Reactivity with Water (Section X): 0 1=slight
Contact (Section VIII): 2 2=caution
3=severe
Section 4 First Aid Measures
Inhalation If product is inhaled, move exposed individual to fresh air. If individual is not
breathing, begin artificial respiration immediately and obtain medical attention.
Histamine EIA Kit Doc. ID: IM2015-75 AB Page 40 of 63
DMSO 3ml
Section 4 First Aid Measures (Continued)
Eye Contact If product enters eyes, wash eyes gently under running water for 15 minutes or
longer, making sure that the eyelids are held open. If pain or irritation occur, obtain
medical attention.
Skin Contact In case of skin contact, flush with copious amounts of water for at least 15 minutes.
Remove contaminated clothing and shoes. If pain or irritation occur, obtain medical
attention.
Ingestion If ingested, wash mouth out with water. If irritation or discomfort occurs, seek medical
attention.
Section 5 Fire Fighting Measures
Flash Point 95°C(203°F)
Flammable Limits Not applicable
Autoignition Temp. Not applicable
Extinguishing Media Use extinguishing media suitable for surrounding fire.
Special Fire and No special hazards determined.
Explosion Hazards
Hazardous Combustion Due to the nature and volume of this product, the type and amount of combustion
Products products are negligible.
Protective Equipment Self-contained breathing apparatus is recommended for firefighters in all chemical fire
for Firefighters situations.
Section 6 Accidental Release Measures
Personal Precautions Use universal precautions during clean up procedures.
Spill and Leak Absorb spilled material with an appropriate inert, non-flammable absorbent and
Procedures dispose according to local regulations.
Environmental Contain spill to prevent migration.
Precautions
Section 7 Handling and Storage
Handling Precautions No special precautions are necessary; use good laboratory procedures.
Recommended Storage Keep away from incompatible material.
Conditions To maintain efficacy, store according to the instructions in the product labeling.
Section 8 Exposure Controls and Personal Protection
Exposure Limits
US OSHA: None established
ACGIH: None established
DFG MAK:
Dimethyl Sulfoxide Skin Absorber
Histamine EIA Kit Doc. ID: IM2015-75 AB Page 41 of 63
DMSO 3ml
Section 8 Exposure Controls and Personal Protection (Continued)
Engineering Controls No special engineering controls are required. Use with good general ventilation.
Respiratory Protection Under normal conditions, the use of this product should not require respiratory
protection.
Eye Protection Safety glasses or chemical goggles should be worn to prevent eye contact.
Skin Protection Impervious gloves, such as latex or equivalent, should be worn to prevent skin
contact.
Section 9 Physical and Chemical Properties
Physical State Liquid
Color Colorless
Transparency Clear
Odor Pungent
Odor Threshold Not applicable
pH Not applicable
Boiling Point 189°C(372.2°F)
Melting Point 18.5°C(65.3°F)
Specific Gravity 1.10 @20°C
Vapor Pressure 0.42 mm Hg @25°C
Vapor Density Not available
Evaporation Rate Not available
Solubility
Water Miscible
Organic Not available
Section 10 Stability and Reactivity
Stability Stable under normal temperatures and pressures.
Hazardous Strong oxidizers
Incompatibilities Strong acids
Strong bases
Hazardous When stored as labeled, no known hazardous decomposition products are formed
Decomposition Products during the shelf-life of this product.
Conditions to Avoid Keep away from incompatible material.
Section 11 Toxicological Information
Toxicity Data
for Hazardous Ingredients
Dimethyl Sulfoxide Oral LD50 Rat: 14500 mg/kg; Oral LD50 Mouse: 7920 mg/kg
Primary Routes Eye contact, ingestion, inhalation, and skin contact.
of Exposure
Histamine EIA Kit Doc. ID: IM2015-75 AB Page 42 of 63
DMSO 3ml
Section 11 Toxicological Information (Continued)
Potential Effects of May cause irritation of the eyes, skin, mucous membrane, and upper respiratory tract.
Acute Exposure Dimethyl Sulfoxide (DMSO) is readily absorbed through skin and may act as a carrier
for toxic material.
Potential Effects of Effects are similar to those for acute exposure.
Chronic Exposure
Symptoms of No specific symptoms identified.
Overexposure
Carcinogenicity No ingredients in this product are listed as carcinogens by ACGIH, IARC, NTP, OSHA
or 67/548/EEC Annex I.
Other Effects None identified.
Conditions Aggravated None identified.
by Exposure
Section 12 Ecological Information
Ecotoxicity Toxic to fish and other water organisms.
Biodegradability No information available.
Mobility No information available.
Section 13 Disposal Considerations
Waste Disposal Dispose of waste product, unused product and contaminated packaging in compliance
with federal, state and local regulations. If unsure of the applicable requirements,
contact the authorities for information.
Section 14 Transport Information
Transportation of this product is not regulated under ICAO, IMDG, US DOT, European ADR or Canadian TDG.
Section 15 Regulatory Information
US Federal and State Regulations
SARA 313 No ingredients listed
CERCLA RG’s, No ingredients listed
40 CFR 302.4
California Proposition 65 No ingredients listed
Massachusetts MSL No ingredients listed
New Jersey Dept. of No ingredients listed
Health RTK List
Pennsylvania RTK No ingredients listed
Histamine EIA Kit Doc. ID: IM2015-75 AB Page 43 of 63
DMSO 3ml
Section 15 Regulatory Information (Continued)
EU Labeling Classification
Classification Risk and Safety Phrases
Xi R36/37/38 Irritating to eyes, respiratory system and skin.
Irritant
Canada
WHMIS Classification: B3—Flammable and Combustible Material: Combustible Liquid
D2B—Poisonous and Infectious Material: Division 2—Other Toxic Effects: Toxic (Skin
Irritation)
D2B—Poisonous and Infectious Material: Division 2—Other Toxic Effects: Toxic (Eye
Irritation)
PIN: Not applicable
Ingredients on Ingredient Dimethyl Sulfoxide
Disclosure List:
Ingredients with unknown None
toxicological properties:
Section 16 Other Information
For further information, please contact your local Beckman Coulter representative.
WHILE BECKMAN COULTER, INC. BELIEVES THE INFORMATION CONTAINED HEREIN IS VALID AND ACCURATE, BECKMAN COULTER MAKES NO WARRANTY OR
REPRESENTATION AS TO ITS VALIDITY, ACCURACY, OR CURRENCY. BECKMAN COULTER SHALL NOT BE LIABLE OR OTHERWISE RESPONSIBLE IN ANY WAY FOR USE
OF EITHER THIS INFORMATION OR MATERIALS TO WHICH IT APPLIES. DISPOSAL OF HAZARDOUS MATERIALS MAY BE SUBJECT TO LOCAL LAWS OR REGULATIONS.
Printed in U.S.A.
Page 44 of 63
@Beckman
CoulterTM MATERIAL SAFETY DATA SHEET
Section 1 Company and Product Identification
Control
Product Name Histamine EIA Kit
Doc. ID IM2015-75 AB
Issued (year/month/day)
Revised (year/month/day) 2004/02/17
Part Number Component of P/N IM2015
Product Use For laboratory use only. See product literature for details.
Manufacturer Distributed by Beckman Coulter, Inc. for
IMMUNOTECH (A Beckman Coulter Company)
130, av.de Lattre de Tassigny—BP 177
13276 Marseille Cedex 09—France Tèl. (33) 4 91 17 27 00
¤
Distributor and Refer to attached list, Document ID: 472050, for local distributor and
Emergency Phone No. emergency phone numbers.
Section 2 Composition and Information on Ingredients
Hazardous Ingredients: None
Section 3 Hazards Identification
Emergency Overview
Colorless; Clear; Liquid; Odorless
Nonflammable aqueous solution.
Does not meet EU, OSHA or WHMIS criteria for hazardous materials.
Contains material of animal origin.
Physical Hazards Sodium azide forms explosive compounds with heavy metals. This product contains
concentrations of azide <0.1% (w/w) which with repeated contact with lead and
copper commonly found in plumbing drains may result in the build up of shock
sensitive compounds.
Potential Health This product does not meet EU, OSHA or WHMIS criteria for hazardous materials.
Effects Summary However, it does contain material of animal origin and should be considered
potentially infectious.
Product Hazard EU: WHMIS: US OSHA:
Classifications Not applicable Not applicable Not applicable
Beckman Coulter Safety Flammability (Section V): 0 Code
Rating Health (Section XI): 1 0=none
Reactivity with Water (Section X): 0 1=slight
Contact (Section VIII): 1 2=caution
3=severe
Section 4 First Aid Measures
Inhalation If product is inhaled, move exposed individual to fresh air. If individual is not
breathing, begin artificial respiration immediately and obtain medical attention.
Histamine EIA Kit Doc. ID: IM2015-75 AB Page 45 of 63
Control
Section 4 First Aid Measures (Continued)
Eye Contact If product enters eyes, wash eyes gently under running water for 15 minutes or
longer, making sure that the eyelids are held open. If pain or irritation occur, obtain
medical attention.
Skin Contact Remove any contaminated clothing. Wash affected area with plenty of soap and
water. Use disinfectant if possible.
Ingestion If ingested, wash mouth out with water. If irritation or discomfort occurs, seek medical
attention.
Section 5 Fire Fighting Measures
Flash Point Not applicable
Flammable Limits Not applicable
Autoignition Temp. Not applicable
Extinguishing Media Use extinguishing media suitable for surrounding fire.
Special Fire and No special hazards determined.
Explosion Hazards
Hazardous Combustion Due to the nature and volume of this product, the type and amount of combustion
Products products are negligible.
Protective Equipment Self-contained breathing apparatus is recommended for firefighters.
for Firefighters
Section 6 Accidental Release Measures
Personal Precautions This product contains a material of biological origin. Use universal precautions during
clean up procedures.
Spill and Leak As a precautionary measure, treat spilled material with a 1:10 bleach/water solution.
Procedures Absorb liquid and place in container suitable for disposal. Avoid generation of
aerosols during clean up. Comply with applicable waste disposal regulations.
Environmental Contain spill to prevent migration.
Precautions
Section 7 Handling and Storage
Handling Precautions This product should be handled as though capable of transmitting infectious diseases.
Universal precautions should be followed when using this product.
Recommended Storage Keep away from incompatible material.
Conditions To maintain efficacy, store according to the instructions in the product labeling.
Section 8 Exposure Controls and Personal Protection
Exposure Limits
US OSHA: None established
ACGIH: None established
DFG MAK: None established
Histamine EIA Kit Doc. ID: IM2015-75 AB Page 46 of 63
Control
Section 8 Exposure Controls and Personal Protection (Continued)
Engineering Controls No special engineering controls are required. Use with good general ventilation.
Respiratory Protection Under normal conditions, the use of this product should not require respiratory
protection.
Eye Protection Safety glasses or chemical goggles should be worn to prevent eye contact.
Skin Protection Impervious gloves, such as latex or equivalent, should be worn to prevent skin
contact.
Section 9 Physical and Chemical Properties
Physical State Liquid
Color Colorless
Transparency Clear
Odor Odorless
Odor Threshold Not applicable
pH 6.2
Boiling Point Not available
Melting Point Not available
Specific Gravity 1.005 @20°C
Vapor Pressure Not available
Vapor Density Not available
Evaporation Rate Not available
Solubility
Water Miscible
Organic Not available
Section 10 Stability and Reactivity
Stability Stable under normal temperatures and pressures.
Hazardous Strong acids
Incompatibilities Strong bases
Strong oxidizers
Metals and metallic compounds
Sodium azide forms explosive compounds with heavy metals. This product contains
concentrations of azide <0.1% (w/w) which with repeated contact with lead and
copper commonly found in plumbing drains may result in the build up of shock
sensitive compounds.
Hazardous When stored as labeled, no known hazardous decomposition products are formed
Decomposition Products during the shelf-life of this product.
Conditions to Avoid Keep away from incompatible material.
Histamine EIA Kit Doc. ID: IM2015-75 AB Page 47 of 63
Control
Section 11 Toxicological Information
Toxicity Data Not applicable
for Hazardous Ingredients
Primary Routes Common routes of entry include inhalation, ingestion and eye/skin contact. Specific
of Exposure paths of concern for potentially infectious materials are skin puncture, contact with
broken skin, contact with mucous membranes and inhalation of aerosolized material.
Potential Effects of This product contains materials of animal origin and should be considered potentially
Acute Exposure infectious. No other health hazards were identified from a review of available
literature.
Potential Effects of Effects are similar to those for acute exposure.
Chronic Exposure
Symptoms of No specific symptoms identified.
Overexposure
Carcinogenicity No ingredients in this product are listed as carcinogens by ACGIH, IARC, NTP, OSHA
or 67/548/EEC Annex I.
Other Effects None identified.
Conditions Aggravated None identified.
by Exposure
Section 12 Ecological Information
Ecotoxicity No information available.
Biodegradability No information available.
Mobility No information available.
Section 13 Disposal Considerations
Waste Disposal Dispose of waste product, unused product and contaminated packaging in compliance
with federal, state and local regulations. If unsure of the applicable requirements,
contact the authorities for information.
Sodium azide preservative may form explosive compounds in metal drain lines. See
NIOSH Bulletin: Explosive Azide Hazard (8/16/76).
Section 14 Transport Information
Transportation of this product is not regulated under ICAO, IMDG, US DOT, European ADR or Canadian TDG.
Section 15 Regulatory Information
US Federal and State Regulations
SARA 313 Sodium Azide is subject to reporting requirements of Section 313, Title III of SARA.
CERCLA RG’s, Edetic Acid is listed.
40 CFR 302.4 Sodium Azide is listed.
California Proposition 65 No ingredients listed
Massachusetts MSL Edetic Acid is listed.
Sodium Azide is listed.
Histamine EIA Kit Doc. ID: IM2015-75 AB Page 48 of 63
Control
Section 15 Regulatory Information (Continued)
US Federal and State Regulations
New Jersey Dept. of Edetic Acid is listed.
Health RTK List Sodium Azide is listed.
Pennsylvania RTK Edetic Acid is listed.
Sodium Azide is listed.
EU Labeling Classification
Preparation not classified.
Canada
This product does not meet WHMIS criteria for hazardous materials.
PIN: Not applicable
Ingredients on Ingredient Sodium Azide
Disclosure List:
Ingredients with unknown None
toxicological properties:
Section 16 Other Information
For further information, please contact your local Beckman Coulter representative.
WHILE BECKMAN COULTER, INC. BELIEVES THE INFORMATION CONTAINED HEREIN IS VALID AND ACCURATE, BECKMAN COULTER MAKES NO WARRANTY OR
REPRESENTATION AS TO ITS VALIDITY, ACCURACY, OR CURRENCY. BECKMAN COULTER SHALL NOT BE LIABLE OR OTHERWISE RESPONSIBLE IN ANY WAY FOR USE
OF EITHER THIS INFORMATION OR MATERIALS TO WHICH IT APPLIES. DISPOSAL OF HAZARDOUS MATERIALS MAY BE SUBJECT TO LOCAL LAWS OR REGULATIONS.
Printed in U.S.A.
Page 49 of 63
@Beckman
CoulterTM MATERIAL SAFETY DATA SHEET
Section 1 Company and Product Identification
Histamine Acylation
Product Name
Reagent Histamine EIA Kit
Doc. ID IM2015-75 AB
Issued (year/month/day)
Revised (year/month/day) 2004/02/17
Part Number Component of P/N IM2015
Manufacturer Distributed by Beckman Coulter, Inc. for
IMMUNOTECH (A Beckman Coulter Company)
130, av.de Lattre de Tassigny—BP 177
13276 Marseille Cedex 09—France Tèl. (33) 4 91 17 27 00
¤
Distributor and Refer to attached list, Document ID: 472050, for local distributor and
Emergency Phone No. emergency phone numbers.
Section 2 Composition and Information on Ingredients
Hazardous Ingredients: None
Section 3 Hazards Identification
Emergency Overview
White; Opaque; Lyophilized; Odorless
Nonflammable aqueous solution.
Does not meet EU, OSHA or WHMIS criteria for hazardous materials.
Physical Hazards No physical hazards were determined from a review of available literature.
Potential Health This product does not meet EU, OSHA or WHMIS criteria for hazardous materials.
Effects Summary
Product Hazard EU: WHMIS: US OSHA:
Classifications Not applicable Not applicable Not applicable
Beckman Coulter Safety Flammability (Section V): 0 Code
Rating Health (Section XI): 0 0=none
Reactivity with Water (Section X): 0 1=slight
Contact (Section VIII): 1 2=caution
3=severe
Section 4 First Aid Measures
Inhalation If product is inhaled, move exposed individual to fresh air. If individual is not
breathing, begin artificial respiration immediately and obtain medical attention.
Eye Contact If product enters eyes, wash eyes gently under running water for 15 minutes or
longer, making sure that the eyelids are held open. If pain or irritation occur, obtain
medical attention.
Skin Contact In case of skin contact, wash area with soap and water. Rinse well with water.
Histamine EIA Kit Doc. ID: IM2015-75 AB Page 50 of 63
Histamine Acylation Reagent
Section 4 First Aid Measures (Continued)
Ingestion If ingested, wash mouth out with water. If irritation or discomfort occurs, seek medical
attention.
Section 5 Fire Fighting Measures
Flash Point Not available
Flammable Limits Not applicable
Autoignition Temp. Not available
Extinguishing Media Use extinguishing media suitable for surrounding fire.
Special Fire and No special hazards determined.
Explosion Hazards
Hazardous Combustion No combustion products posing significant hazards are expected from this product.
Products
Protective Equipment Self-contained breathing apparatus is recommended for firefighters in all chemical fire
for Firefighters situations.
Section 6 Accidental Release Measures
Personal Precautions No special precautions are necessary. Use good laboratory procedures.
Spill and Leak Wipe up spill and place in container suitable for disposal.
Procedures
Environmental Contain spill to prevent migration.
Precautions
Section 7 Handling and Storage
Handling Precautions No special precautions are necessary; use good laboratory procedures.
Recommended Storage To maintain efficacy, store according to the instructions in the product labeling.
Conditions
Section 8 Exposure Controls and Personal Protection
Exposure Limits
US OSHA: None established
ACGIH: None established
DFG MAK: None established
Engineering Controls No special engineering controls are required. Use with good general ventilation.
Respiratory Protection Under normal conditions, the use of this product should not require respiratory
protection.
Eye Protection Safety glasses or chemical goggles should be worn to prevent eye contact.
Skin Protection Impervious gloves, such as latex or equivalent, should be worn to prevent skin
contact.
Histamine EIA Kit Doc. ID: IM2015-75 AB Page 51 of 63
Histamine Acylation Reagent
Section 9 Physical and Chemical Properties
Physical State Lyophilized
Color White
Transparency Opaque
Odor Odorless
Odor Threshold Not applicable
pH Not applicable
Boiling Point Not applicable
Melting Point Not available
Specific Gravity Not applicable
Vapor Pressure Not applicable
Vapor Density Not applicable
Evaporation Rate Not applicable
Solubility
Water Miscible
Organic Soluble in DMSO
Section 10 Stability and Reactivity
Stability Stable under normal temperatures and pressures.
Hazardous No hazardous incompatibilities were determined from a review of literature available.
Incompatibilities
Hazardous No decomposition products posing significant hazards would be expected from this
Decomposition Products product.
Conditions to Avoid None determined.
Section 11 Toxicological Information
Toxicity Data Not applicable
for Hazardous Ingredients
Primary Routes The most likely routes of exposure are skin and eye contact.
of Exposure
Potential Effects of None identified.
Acute Exposure
Potential Effects of None identified.
Chronic Exposure
Symptoms of None identified.
Overexposure
Carcinogenicity No ingredients in this product are listed as carcinogens by ACGIH, IARC, NTP, OSHA
or 67/548/EEC Annex I.
Other Effects None identified.
Histamine EIA Kit Doc. ID: IM2015-75 AB Page 52 of 63
Histamine Acylation Reagent
Section 11 Toxicological Information (Continued)
Conditions Aggravated None identified.
by Exposure
Section 12 Ecological Information
Ecotoxicity No information available.
Biodegradability No information available.
Mobility No information available.
Section 13 Disposal Considerations
Waste Disposal Dispose of waste product, unused product and contaminated packaging in compliance
with federal, state and local regulations. If unsure of the applicable requirements,
contact the authorities for information.
Section 14 Transport Information
Transportation of this product is not regulated under ICAO, IMDG, US DOT, European ADR or Canadian TDG.
Section 15 Regulatory Information
US Federal and State Regulations
SARA 313 No ingredients listed
CERCLA RG’s, No ingredients listed
40 CFR 302.4
California Proposition 65 No ingredients listed
Massachusetts MSL No ingredients listed
New Jersey Dept. of No ingredients listed
Health RTK List
Pennsylvania RTK No ingredients listed
EU Labeling Classification
Preparation not classified.
Canada
This product does not meet WHMIS criteria for hazardous materials.
PIN: Not applicable
Ingredients on Ingredient None
Disclosure List:
Ingredients with unknown None
toxicological properties:
Histamine EIA Kit Doc. ID: IM2015-75 AB Page 53 of 63
Histamine Acylation Reagent
Section 16 Other Information
For further information, please contact your local Beckman Coulter representative.
WHILE BECKMAN COULTER, INC. BELIEVES THE INFORMATION CONTAINED HEREIN IS VALID AND ACCURATE, BECKMAN COULTER MAKES NO WARRANTY OR
REPRESENTATION AS TO ITS VALIDITY, ACCURACY, OR CURRENCY. BECKMAN COULTER SHALL NOT BE LIABLE OR OTHERWISE RESPONSIBLE IN ANY WAY FOR USE
OF EITHER THIS INFORMATION OR MATERIALS TO WHICH IT APPLIES. DISPOSAL OF HAZARDOUS MATERIALS MAY BE SUBJECT TO LOCAL LAWS OR REGULATIONS.
Printed in U.S.A.
Page 54 of 63
@Beckman
CoulterTM MATERIAL SAFETY DATA SHEET
Section 1 Company and Product Identification
Histamine Release
Product Name
Buffer Histamine EIA Kit
Doc. ID IM2015-75 AB
Issued (year/month/day)
Revised (year/month/day) 2004/02/17
Part Number Component of P/N IM2015
Product Use Data given is for reconstituted solution.
Manufacturer Distributed by Beckman Coulter, Inc. for
IMMUNOTECH (A Beckman Coulter Company)
130, av.de Lattre de Tassigny—BP 177
13276 Marseille Cedex 09—France Tèl. (33) 4 91 17 27 00
¤
Distributor and Refer to attached list, Document ID: 472050, for local distributor and
Emergency Phone No. emergency phone numbers.
Section 2 Composition and Information on Ingredients
Hazardous Ingredients: None
Section 3 Hazards Identification
Emergency Overview
Colorless; Clear; Lyophilized—Liquid after reconstitution.; Odorless
Nonflammable aqueous solution.
Does not meet EU, OSHA or WHMIS criteria for hazardous materials.
Contains material of animal origin.
Physical Hazards No physical hazards were determined from a review of available literature.
Potential Health This product does not meet EU, OSHA or WHMIS criteria for hazardous materials.
Effects Summary However, it does contain material of animal origin and should be considered
potentially infectious.
Product Hazard EU: WHMIS: US OSHA:
Classifications Not applicable Not applicable Not applicable
Beckman Coulter Safety Flammability (Section V): 0 Code
Rating Health (Section XI): 0 0=none
Reactivity with Water (Section X): 0 1=slight
Contact (Section VIII): 1 2=caution
3=severe
Section 4 First Aid Measures
Inhalation If product is inhaled, move exposed individual to fresh air. If individual is not
breathing, begin artificial respiration immediately and obtain medical attention.
Histamine EIA Kit Doc. ID: IM2015-75 AB Page 55 of 63
Histamine Release Buffer
Section 4 First Aid Measures (Continued)
Eye Contact If product enters eyes, wash eyes gently under running water for 15 minutes or
longer, making sure that the eyelids are held open. If pain or irritation occur, obtain
medical attention.
Skin Contact Remove any contaminated clothing. Wash affected area with plenty of soap and
water. Use disinfectant if possible.
Ingestion If ingested, wash mouth out with water. If irritation or discomfort occurs, seek medical
attention.
Section 5 Fire Fighting Measures
Flash Point Not applicable
Flammable Limits Not applicable
Autoignition Temp. Not applicable
Extinguishing Media Use extinguishing media suitable for surrounding fire.
Special Fire and No special hazards determined.
Explosion Hazards
Hazardous Combustion No combustion products posing significant hazards are expected from this product (a
Products dilute aqueous solution).
Protective Equipment Self-contained breathing apparatus is recommended for firefighters in all chemical fire
for Firefighters situations.
Section 6 Accidental Release Measures
Personal Precautions This product contains a material of biological origin. Use universal precautions during
clean up procedures.
Spill and Leak As a precautionary measure, treat spilled material with a 1:10 bleach/water solution.
Procedures Absorb liquid and place in container suitable for disposal. Avoid generation of
aerosols during clean up. Comply with applicable waste disposal regulations.
Environmental Contain spill to prevent migration.
Precautions
Section 7 Handling and Storage
Handling Precautions This product should be handled as though capable of transmitting infectious diseases.
Universal precautions should be followed when using this product.
Recommended Storage Keep away from incompatible material.
Conditions To maintain efficacy, store according to the instructions in the product labeling.
Section 8 Exposure Controls and Personal Protection
Exposure Limits
US OSHA: None established
ACGIH: None established
DFG MAK: None established
Histamine EIA Kit Doc. ID: IM2015-75 AB Page 56 of 63
Histamine Release Buffer
Section 8 Exposure Controls and Personal Protection (Continued)
Engineering Controls No special engineering controls are required. Use with good general ventilation.
Respiratory Protection Under normal conditions, the use of this product should not require respiratory
protection.
Eye Protection Safety glasses or chemical goggles should be worn to prevent eye contact.
Skin Protection Impervious gloves, such as latex or equivalent, should be worn to prevent skin
contact.
Section 9 Physical and Chemical Properties
Physical State Lyophilized—Liquid after reconstitution.
Color Colorless
Transparency Clear
Odor Odorless
Odor Threshold Not applicable
pH 7.5
Boiling Point Not available
Melting Point Not available
Specific Gravity 1.005 @20°C
Vapor Pressure Not available
Vapor Density Not available
Evaporation Rate Not available
Solubility
Water Miscible
Organic Not available
Section 10 Stability and Reactivity
Stability Stable under normal temperatures and pressures.
Hazardous Strong acids
Incompatibilities Strong bases
Strong oxidizers
Hazardous No decomposition products posing significant hazards would be expected from this
Decomposition Products product (a dilute aqueous solution).
Conditions to Avoid None determined.
Section 11 Toxicological Information
Toxicity Data Not applicable
for Hazardous Ingredients
Primary Routes Common routes of entry include inhalation, ingestion and eye/skin contact. Specific
of Exposure paths of concern for potentially infectious materials are skin puncture, contact with
broken skin, contact with mucous membranes and inhalation of aerosolized material.
Histamine EIA Kit Doc. ID: IM2015-75 AB Page 57 of 63
Histamine Release Buffer
Section 11 Toxicological Information (Continued)
Potential Effects of This product contains materials of animal origin and should be considered potentially
Acute Exposure infectious. No other health hazards were identified from a review of available
literature.
Potential Effects of None identified.
Chronic Exposure
Symptoms of None identified.
Overexposure
Carcinogenicity No ingredients in this product are listed as carcinogens by ACGIH, IARC, NTP, OSHA
or 67/548/EEC Annex I.
Other Effects None identified.
Conditions Aggravated None identified.
by Exposure
Section 12 Ecological Information
Ecotoxicity No information available.
Biodegradability No information available.
Mobility No information available.
Section 13 Disposal Considerations
Waste Disposal Dispose of waste product, unused product and contaminated packaging in compliance
with federal, state and local regulations. If unsure of the applicable requirements,
contact the authorities for information.
Section 14 Transport Information
Transportation of this product is not regulated under ICAO, IMDG, US DOT, European ADR or Canadian TDG.
Section 15 Regulatory Information
US Federal and State Regulations
SARA 313 No ingredients listed
CERCLA RG’s, No ingredients listed
40 CFR 302.4
California Proposition 65 No ingredients listed
Massachusetts MSL Magnesium Chloride is listed.
New Jersey Dept. of Magnesium Chloride is listed.
Health RTK List
Pennsylvania RTK Magnesium Chloride is listed.
EU Labeling Classification
Preparation not classified.
Histamine EIA Kit Doc. ID: IM2015-75 AB Page 58 of 63
Histamine Release Buffer
Section 15 Regulatory Information (Continued)
Canada
This product does not meet WHMIS criteria for hazardous materials.
PIN: Not applicable
Ingredients on Ingredient None
Disclosure List:
Ingredients with unknown None
toxicological properties:
Section 16 Other Information
For further information, please contact your local Beckman Coulter representative.
WHILE BECKMAN COULTER, INC. BELIEVES THE INFORMATION CONTAINED HEREIN IS VALID AND ACCURATE, BECKMAN COULTER MAKES NO WARRANTY OR
REPRESENTATION AS TO ITS VALIDITY, ACCURACY, OR CURRENCY. BECKMAN COULTER SHALL NOT BE LIABLE OR OTHERWISE RESPONSIBLE IN ANY WAY FOR USE
OF EITHER THIS INFORMATION OR MATERIALS TO WHICH IT APPLIES. DISPOSAL OF HAZARDOUS MATERIALS MAY BE SUBJECT TO LOCAL LAWS OR REGULATIONS.
Printed in U.S.A.
Page 59 of 63
@Beckman
CoulterTM MATERIAL SAFETY DATA SHEET
Section 1 Company and Product Identification
Histamine Acylation
Product Name
Buffer Histamine EIA Kit
Doc. ID IM2015-75 AB
Issued (year/month/day)
Revised (year/month/day) 2004/02/17
Part Number Component of P/N IM2015
Manufacturer Distributed by Beckman Coulter, Inc. for
IMMUNOTECH (A Beckman Coulter Company)
130, av.de Lattre de Tassigny—BP 177
13276 Marseille Cedex 09—France Tèl. (33) 4 91 17 27 00
¤
Distributor and Refer to attached list, Document ID: 472050, for local distributor and
Emergency Phone No. emergency phone numbers.
Section 2 Composition and Information on Ingredients
Hazardous Ingredients: Meets Hazardous Criteria:
Chemical Name CAS # % by wt. EU US OSHA WHMIS
<5%
Boric Acid 10043-35-3 No Yes Yes
See Section 15 Regulatory Information for additional information on hazard classifications.
Section 3 Hazards Identification
Emergency Overview
Colorless; Clear; Liquid; Odorless
Nonflammable aqueous solution.
Skin, eye and respiratory tract irritant.
Physical Hazards No physical hazards were determined from a review of available literature.
Potential Health Exposure may result in irritation of skin, eyes, and mucous membranes.
Effects Summary
See Section 11 Toxicological Information for more detailed health information.
Product Hazard EU: WHMIS: US OSHA:
Classifications Not applicable D2B Hazardous
Beckman Coulter Safety Flammability (Section V): 0 Code
Rating Health (Section XI): 1 0=none
Reactivity with Water (Section X): 0 1=slight
Contact (Section VIII): 1 2=caution
3=severe
Section 4 First Aid Measures
Inhalation If product is inhaled, move exposed individual to fresh air. If individual is not
breathing, begin artificial respiration immediately and obtain medical attention.
Histamine EIA Kit Doc. ID: IM2015-75 AB Page 60 of 63
Histamine Acylation Buffer
Section 4 First Aid Measures (Continued)
Eye Contact If product enters eyes, wash eyes gently under running water for 15 minutes or
longer, making sure that the eyelids are held open. If pain or irritation occur, obtain
medical attention.
Skin Contact In case of skin contact, flush with copious amounts of water for at least 15 minutes. If
pain or irritation occur, obtain medical attention.
Ingestion If ingested, wash mouth out with water. If irritation or discomfort occurs, seek medical
attention.
Section 5 Fire Fighting Measures
Flash Point Not applicable
Flammable Limits Not applicable
Autoignition Temp. Not applicable
Extinguishing Media Use extinguishing media suitable for surrounding fire.
Special Fire and No special hazards determined.
Explosion Hazards
Hazardous Combustion Due to the composition and volume of this product, combustion products generated
Products from it are not expected to present a significant hazard.
Protective Equipment Self-contained breathing apparatus is recommended for firefighters.
for Firefighters
Section 6 Accidental Release Measures
Personal Precautions Use universal precautions during clean up procedures.
Spill and Leak Absorb spilled material with an appropriate inert, non-flammable absorbent and
Procedures dispose according to local regulations.
Environmental Contain spill to prevent migration.
Precautions
Section 7 Handling and Storage
Handling Precautions No special precautions are necessary; use good laboratory procedures.
Recommended Storage Keep away from combustible material.
Conditions To maintain efficacy, store according to the instructions in the product labeling.
Section 8 Exposure Controls and Personal Protection
Exposure Limits
US OSHA: None established
ACGIH: None established
DFG MAK: None established
Engineering Controls No special engineering controls are required. Use with good general ventilation.
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Histamine Acylation Buffer
Section 8 Exposure Controls and Personal Protection (Continued)
Respiratory Protection Under normal conditions, the use of this product should not require respiratory
protection.
Eye Protection Safety glasses or chemical goggles should be worn to prevent eye contact.
Skin Protection Impervious gloves, such as latex or equivalent, should be worn to prevent skin
contact.
Section 9 Physical and Chemical Properties
Physical State Liquid
Color Colorless
Transparency Clear
Odor Odorless
Odor Threshold Not applicable
pH 8.2
Boiling Point Not available
Melting Point Not available
Specific Gravity 1.002 @20°C
Vapor Pressure Not available
Vapor Density Not available
Evaporation Rate Not available
Solubility
Water Miscible
Organic Not available
Section 10 Stability and Reactivity
Stability Stable under normal temperatures and pressures.
Hazardous Strong acids
Incompatibilities Strong bases
Strong oxidizers
Hazardous When stored as labeled, no known hazardous decomposition products are formed
Decomposition Products during the shelf-life of this product.
Conditions to Avoid Keep away from incompatible material.
Section 11 Toxicological Information
Toxicity Data
for Hazardous Ingredients
Boric Acid Oral LD50 Rat: 2660 mg/kg; Oral LD50 Mouse: 3450 mg/kg
Primary Routes The most likely routes of exposure are skin, eye contact and inhalation.
of Exposure
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Section 11 Toxicological Information (Continued)
Potential Effects of Contact with the skin or eyes may cause irritation.
Acute Exposure
Potential Effects of Chronic exposure may result in effects similar to those described for acute exposure.
Chronic Exposure Frequent or long-term contact may dry out the skin resulting in dermatitis.
Symptoms of None identified.
Overexposure
Carcinogenicity No ingredients in this product are listed as carcinogens by ACGIH, IARC, NTP, OSHA
or 67/548/EEC Annex I.
Other Effects None identified.
Conditions Aggravated None identified.
by Exposure
Section 12 Ecological Information
Ecotoxicity Toxic to fish and other water organisms.
Biodegradability No information available.
Mobility No information available.
Section 13 Disposal Considerations
Waste Disposal Dispose of waste product, unused product and contaminated packaging in compliance
with federal, state and local regulations. If unsure of the applicable requirements,
contact the authorities for information.
Section 14 Transport Information
Transportation of this product is not regulated under ICAO, IMDG, US DOT, European ADR or Canadian TDG.
Section 15 Regulatory Information
US Federal and State Regulations
SARA 313 No ingredients listed
CERCLA RG’s, No ingredients listed
40 CFR 302.4
California Proposition 65 No ingredients listed
Massachusetts MSL No ingredients listed
New Jersey Dept. of No ingredients listed
Health RTK List
Pennsylvania RTK No ingredients listed
EU Labeling Classification
Preparation not classified.
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Histamine Acylation Buffer
Section 15 Regulatory Information (Continued)
Canada
WHMIS Classification: D2B—Poisonous and Infectious Material: Division 2—Other Toxic Effects: Toxic (Skin
Irritation)
D2B—Poisonous and Infectious Material: Division 2—Other Toxic Effects: Toxic (Eye
Irritation)
PIN: Not applicable
Ingredients on Ingredient Boric Acid
Disclosure List:
Ingredients with unknown None
toxicological properties:
Section 16 Other Information
For further information, please contact your local Beckman Coulter representative.
WHILE BECKMAN COULTER, INC. BELIEVES THE INFORMATION CONTAINED HEREIN IS VALID AND ACCURATE, BECKMAN COULTER MAKES NO WARRANTY OR
REPRESENTATION AS TO ITS VALIDITY, ACCURACY, OR CURRENCY. BECKMAN COULTER SHALL NOT BE LIABLE OR OTHERWISE RESPONSIBLE IN ANY WAY FOR USE
OF EITHER THIS INFORMATION OR MATERIALS TO WHICH IT APPLIES. DISPOSAL OF HAZARDOUS MATERIALS MAY BE SUBJECT TO LOCAL LAWS OR REGULATIONS.
Printed in U.S.A.
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