- Material Safety Data Sheet
MSDS
Vaxsafe庐 RIS Vaccine (living)
BIOPROPERTIES Pty. Ltd.
ACN 007 303 728
36 Charter Street Telephone: 03 9876 0567
Ringwood VIC 3134 Facsimile: 03 9876 0556
AUSTRALIA Emergency: 0417 548 879
WORK HAZARD ASSESSMENT
The vaccine is not classified as hazardous to health according to criteria of Worksafe
Australia.
Note: This product is stored in liquid nitrogen which can cause frostbite and remove air from
enclosed spaces. Before working with the vaccine it is important to become fully familiar with the safe
use and handling of liquid nitrogen 鈥? see AS 1894 - 1976 Code of practice for the safe handling of
Cryogenic Fluids, and study its MSDS.
PRODUCT IDENTIFICATION
Product Name: Vaxsafe庐 RIS Vaccine (living)
Other Names: Rispens Vaccine, Mareks vaccine.
9503 RIS
Product Code:
None allocated.
UN Number:
Dangerous Goods
None allocated.
Class/Subsidiary Risk:
None allocated.
Hazchem Code:
Poisons Schedule
None allocated.
Number:
Poultry vaccine
Product Type:
The active ingredient consists of an avian herpesvirus in a protective
Chemical Family:
buffer.
As a vaccine to control Marek鈥檚 Disease in chickens.
Use:
Given by injection to day-old chicks.
Method of use:
PHYSICAL DESCRIPTION AND PROPERTIES
Frozen, pale pink or straw-coloured liquid in a labelled, sealed clear-
Appearance:
glass ampoule - stored in liquid nitrogen.
Not relevant.
Melting Point:
Not relevant.
Boiling Point:
Not relevant.
Vapour Pressure:
Not available.
Volatile materials:
Not relevant.
Specific Gravity:
Not relevant.
Flashpoint:
Not relevant.
Flammability Limits:
Fully miscible.
Solubility in Water:
Not available.
pH:
BIOPROPERTIES Pty Ltd Page 1 of 5 Date of Issue: November 2006
MSDS-RIS V4
- Material Safety Data Sheet
MSDS
Vaxsafe庐 RIS Vaccine (living)
INGREDIENTS
Worksafe Exposure Limits
Chemical Name CAS # Proportion TWA ES-STEL
mg/m3 mg/m3
By Volume
Mareks disease virus, Rispens Strain, living, None 96.25% None None
in SPF* chicken embryo cells suspended in allocated allocated allocated
a buffer of ingredients determined not to be
hazardous (including animal tissue
components).
Dimethyl Sulfoxide (DMSO) 67-68-5 3.75% Not set Not set
*SPF = Specific Pathogen Free.
This is a commercial product and the exact ratio of components may vary. Trace quantities of
impurities are also likely.
HEALTH HAZARD INFORMATION
HEALTH EFFECTS
No evidence for humans.
Acute:
No evidence for humans.
Swallowed:
No evidence for humans.
Eye:
Possible mild irritation with redness, itching and urticarial wheals.
Skin:
Not relevant.
Inhaled:
No evidence for humans.
Chronic:
Needlestick injuries can occur when manual vaccination techniques
Injection:
are used. Resultant injuries are due to the effects of the penetration of
the needle, its cleanliness at the time of penetration, the volume
injected, and possibly some effect due to the presence of DMSO in the
inoculum. The inoculum itself is not regarded as toxic (being injected
into day-old chicks as part of normal vaccination procedures).
FIRST AID
Rinse mouth with clean, fresh water and swallow some clean water. If
Swallowed:
symptoms appear, seed medical advice.
Hold eyes open and gently wash material from them with clean running
Eye:
water. Ensure irrigation under eyelids by lifting them. Do not attempt to
remove contact lenses unless trained to do so. If irritation occurs,
seek medical advice.
Wash affected area with soap and cold water. If irritation occurs, seek
Skin:
medical advice.
Direct inhalation is not relevant. If inhaled after generation of a mist,
Inhaled:
remove person to fresh air and observe until recovered. If irritation or
other symptoms persist, seek medical advice.
Wash the wound under clean running water, cover the wound with a
Injection:
band-aid to stop any penetration of dirt and seek medical or
paramedical advice as to the extent of the tissue damaged.
No special facilities are required.
First Aid facilities:
ADVICE TO DOCTOR:
BIOPROPERTIES Pty Ltd Page 2 of 5 Date of Issue: November 2006
MSDS-RIS V4
- Material Safety Data Sheet
MSDS
Vaxsafe庐 RIS Vaccine (living)
The product contains low levels of DMSO which can act as a carrier across cell membranes. It
contains animal proteins that could cause allergic reactions. Apart from the vaccine itself any viable
microorganisms present would have gained access at the time of exposure.
Poisons Information Centre: 13 11 26 (anywhere in Australia)
PRECAUTIONS FOR USE
No time weighted average (TWA) has been set. There is a blanket
Exposure Standards:
recommendation of 10 mg/m3 for inhalable dusts or mists when limits
have not otherwise been established. The nature of this product
makes it unlikely that this level will be approached in normal use.
In normal use concentrations should be well below the TWA value. If
Engineering Controls:
necessary, values may be reduced by process modification, use of
local exhaust ventilation, capturing substances at the source, or other
methods. If you believe airborne concentrations of mists, dusts or
vapours are high, you are advised to modify the process or
environment to reduce the problem.
Segregation of
Store the product and all containers of liquid nitrogen in a storage area
processes from
that is both well-ventilated and well away from staff.
personnel:
Use only approved equipment and processes.
Mechanical handling:
Capture of
Liquid nitrogen: the storage area must be well ventilated so as to
substances at
remove the gas generated to external air without allowing it to
Source and Disposal
penetrate confined areas. Provide adequate local exhaust and dilution
with Local Exhaust
ventilation.
Ventilation:
Liquid nitrogen: ventilation should be such that there is a plentiful back-
Dilution Ventilation:
up supply of fresh air to the storage area.
Personal Protection:
Provided the operator is working in a well-ventilated area, a respirator
Respirator Type:
is not necessary. Do not work with liquid nitrogen in small, poorly-
ventilated areas without air drainage at floor level.
Wear gloves designed for use in freezers and use forceps to handle
Glove type:
the product. Gloves do not allow the wearer to immerse any part of his
or her hands in liquid nitrogen.
Wear a polycarbonate face shield to protect against both splash and
Eye protection:
the shattering of ampoules.
Wear overalls (see AS 2919) and boots capable of protecting against
Clothing:
penetration of liquids (see AS/NZS 2210 - Occupational Protective
Footwear).
Ear plugs or muffs should be worn when removing ampoules from
Other:
liquid nitrogen, as an exploding ampoule may cause hearing loss
and/or 鈥渞inging鈥? in the ears.
Always wash your hands after using the product.
Remove contaminated clothing without delay and wash it and other
personal protective equipment before storing or re-use.
BIOPROPERTIES Pty Ltd Page 3 of 5 Date of Issue: November 2006
MSDS-RIS V4
- Material Safety Data Sheet
MSDS
Vaxsafe庐 RIS Vaccine (living)
Flammability:
Non-flammable.
Fire Hazards:
Sources of ignition
Not relevant.
advice:
SAFE HANDLING INFORMATION
Storage and Transport:
Store the product and all containers of liquid nitrogen in a cool, dry,
Location:
well ventilated area that is segregated from personnel and out of direct
sunlight.
Keep in a secure place with restricted access and away from children.
Security:
Always keep containers with liquid nitrogen in well-ventilated areas
Ventilation:
that allow escape of gas given off (provide drains at floor level) and
never within enclosed spaces such as the cabin of a vehicle.
Type of A 2 mL heat-sealed glass ampoule with clear label, stored in liquid
nitrogen on an aluminium cane.
container/Package:
Keep in well-ventilated areas at all times, never within the driving
Special transport
compartment.
Requirements:
Spills and Disposal:
Allow the liquid nitrogen to evaporate, treat the area with disinfectant
Clean up spills/leaks:
and then mop up all remaining liquids. In the unlikely event of major
run off, advise emergency services if a significant quantity of material
enters drains.
Be careful not to expose yourself to liquid nitrogen and take care that
Precautions for clean up
the area is well-ventilated.
crew:
Mop up liquids and sweep up broken containers. Dispose of solid
Disposal method:
waste by wrapping in paper prior to disposal in compliance with local,
State and Federal regulations.
Fire and Explosion Hazard:
Liquid nitrogen: cracked or improperly-sealed ampoules when placed
Hazards of use/storage:
in liquid nitrogen can cause leakage of liquid nitrogen into the
ampoule. When removed from storage the rapid rise in pressure
caused by the change from liquid to gaseous nitrogen can cause the
ampoule to explode.
List of dangerous
decomposition or
Not available.
combustion products:
Fire-fighting
Not relevant.
recommendations:
Types of
Extinguisher/Fire-fighting
Not relevant.
agents:
Not available.
Precautions:
See above, under Personal Protection.
Protective clothing:
Not relevant.
Reactivity:
None allocated.
Hazchem code:
BIOPROPERTIES Pty Ltd Page 4 of 5 Date of Issue: November 2006
MSDS-RIS V4
- Material Safety Data Sheet
MSDS
Vaxsafe庐 RIS Vaccine (living)
OTHER INFORMATION
This MSDS has been prepared in accord with the Worksafe Australia "National Code for Preparation
of Material Safety Data Sheets", 1994
CONTACT POINT
Technical & Marketing Manager
Title
BIOPROPERTIES Pty Ltd
ACN 007 303 728
36 Charter Street
Ringwood
Victoria 3134, Australia
Australia International
03 9876 0567 +61 3 9876 0567
Telephone:
03 9876 0556 +61 3 9876 0556
Facsimile:
0417 548 879 +61 417 548 879
Emergency telephone:
chris.morrow@bioproperties.com.au
Email:
READ ALL LABELS AND INSTRUCTION LEAFLETS BEFORE USING THIS PRODUCT
WARRANTY AND DISCLAIMER:
To the best of BIOPROPERTIES鈥? knowledge the health, safety and handling information in this MSDS is accurate at the date
hereof. BIOPROPERTIES assumes no responsibility regarding the suitability of this information for the user鈥檚 intended
purposes or for the consequence of such use. If further information is required to ensure an appropriate risk assessment is
made, the user should contact BIOPROPERTIES. BIOPROPERTIES gives no warranty (express or implied) with respect to this
MSDS or the product, including without limitation any warranty as to completeness, merchantability or fitness for a particular
purpose. Under no circumstances shall BIOPROPERTIES be liable for indirect, special, consequential or punitive damages.
BIOPROPERTIES Pty Ltd Page 5 of 5 Date of Issue: November 2006
MSDS-RIS V4
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