Material Safety Data Sheet Page 1 of 8
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Material Safety Data Sheet
Nifedipine MSDS
Section 1: Chemical Product and Company Identification
Product Name: Nifedipine Contact Information:
Sciencelab.com, Inc.
Catalog Codes: SLN1105
14025 Smith Rd.
Houston, Texas 77396
CAS#: 21829-25-4
US Sales: 1-800-901-7247
RTECS: US7975000
International Sales: 1-281-441-4400
TSCA: TSCA 8(b) inventory: No products were found. Order Online: ScienceLab.com
CI#: Not available. CHEMTREC (24HR Emergency Telephone),
1-800-424-9300
Synonym: Adalat, Adalate, BAY 1040, BAY A 1040, Citilat,
Corinfar, Fenihidin, Fenihidine, Oxcord, Procardia; International CHEMTREC, call: 1-703-527-3
1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic
acid dimethyl ester; For non-emergency assistance, call: 1-281-441
4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbomethoxy-1,4-dihydropyridine;
Dimethyl
1,4-dihydro-2,6-dimethyl-4-(2'-nitrophenyl)-3,5-pyridinedicarboxylate
Chemical Name: 3,5-Pyridinedicarboxylic
acid,1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, dimethyl
ester
Chemical Formula: C17-H18-N2-O6
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Section 2: Composition and Information on Ingredients
Composition:
Name CAS #
21829-25-4
Nifedipine
Toxicological Data on Ingredients: Nifedipine: ORAL (LD50): Acute: 1022 mg/kg [Rat]. 202 mg/kg [Mouse]. 504 mg/kg
[Rabbit].
Section 3: Hazards Identification
Potential Acute Health Effects: Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of
inhalation.
Potential Chronic Health Effects:
CARCINOGENIC EFFECTS: Not available.
MUTAGENIC EFFECTS: Not available.
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TERATOGENIC EFFECTS: Not available.
DEVELOPMENTAL TOXICITY: Not available.
The substance may be toxic to blood, cardiovascular system, central nervous system (CNS).
Repeated or prolonged exposure to the substance can produce target organs damage.
Section 4: First Aid Measures
Eye Contact:
Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at
least 15 minutes. Get medical attention if irritation occurs.
Skin Contact: Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops.
Serious Skin Contact: Not available.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get
medical attention.
Serious Inhalation: Not available.
Ingestion:
Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an
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unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight
clothing such as a collar, tie, belt or waistband.
Serious Ingestion: Not available.
Section 5: Fire and Explosion Data
Flammability of the Product: May be combustible at high temperature.
Auto-Ignition Temperature: Not available.
Flash Points: Not available.
Flammable Limits: Not available.
Products of Combustion: These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...).
Fire Hazards in Presence of Various Substances:
Slightly flammable to flammable in presence of heat.
Non-flammable in presence of shocks.
Explosion Hazards in Presence of Various Substances:
Slightly explosive in presence of open flames and sparks.
Non-explosive in presence of shocks.
Fire Fighting Media and Instructions:
SMALL FIRE: Use DRY chemical powder.
LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
Special Remarks on Fire Hazards: As with most organic solids, fire is possible at elevated temperatures
Special Remarks on Explosion Hazards:
Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust
explosion hazard.
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Section 6: Accidental Release Measures
Small Spill:
Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by
spreading water on the contaminated surface and dispose of according to local and regional authority
requirements.
Large Spill:
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Large Spill:
Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water
on the contaminated surface and allow to evacuate through the sanitary system.
Section 7: Handling and Storage
Precautions:
Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not
ingest. Do not breathe dust. Wear suitable protective clothing. If ingested, seek medical advice immediately and
show the container or the label.
Storage:
Keep container tightly closed. Keep container in a cool, well-ventilated area. Sensitive to light. Store in
light-resistant containers.
Section 8: Exposure Controls/Personal Protection
Engineering Controls:
Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
airborne contaminants below the exposure limit.
Personal Protection: Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.
Gloves.
Personal Protection in Case of a Large Spill:
Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used
to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist
BEFORE handling this product.
Exposure Limits: Not available.
Section 9: Physical and Chemical Properties
Physical state and appearance: Solid. (Powdered solid.)
Odor: Not available.
Taste: Not available.
Molecular Weight: 346.33 g/mole
Color: Yellow.
pH (1% soln/water): Not applicable.
Boiling Point: Not available.
Melting Point: 173掳C (343.4掳F)
Critical Temperature: Not available.
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Specific Gravity: Not available.
Vapor Pressure: Not applicable.
Vapor Density: Not available.
Volatility: Not available.
Odor Threshold: Not available.
Water/Oil Dist. Coeff.: Not available.
Ionicity (in Water): Not available.
Dispersion Properties: Not available.
Solubility:
Insoluble in cold water, hot water.
Soluble in ethanol, dimethyl sulfoxide
Section 10: Stability and Reactivity Data
Stability: The product is stable.
Instability Temperature: Not available.
Conditions of Instability: Excess heat, light, dust generation.
Incompatibility with various substances: Not available.
Corrosivity: Non-corrosive in presence of glass.
Special Remarks on Reactivity: Sensitive to light.
Special Remarks on Corrosivity: Not available.
Polymerization: Will not occur.
Section 11: Toxicological Information
Routes of Entry: Inhalation. Ingestion.
Toxicity to Animals: Acute oral toxicity (LD50): 202 mg/kg [Mouse].
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Chronic Effects on Humans: May cause damage to the following organs: blood, cardiovascular system, central nervous
system (CNS).
Other Toxic Effects on Humans: Slightly hazardous in case of skin contact (irritant), of ingestion, of inhalation.
Special Remarks on Toxicity to Animals: Not available.
Special Remarks on Chronic Effects on Humans: May cause adverse reproductive effects and birth defects (teratogenic)
Special Remarks on other Toxic Effects on Humans:
Acute Potential Health Effects:
Skin: May cause skin irritation.
Eyes: May cause eye iration.
Inhalation: May cause respirtotary tract irritation.
Ingestion: May be harmful if ingested. May cause upset stomach, vomiting, nausea, heartburn, constipation,
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difficulty swallowing.
May affect behavior/central nervous system (somnolence, dizzziness, lightheadedness, giddiness, fainting,
headach, tremor, muscle cramps, nervousness, mood changes, sleep disturbances, blurred vision, convulsions,
ataxia, depression, paranoid syndrome), cardiovascular system (hypotension, palpitations, fast heartbeat, regional
or general ateriorlar or venous dilation, peripheral edema, myocardial infarction, ventricular arrhythmias or
conduction disturbances, congestive heart failure), liver (elevated liver enzymes, jaundice, cholestasis with or
without jaundice), respiration (dyspnea, respiratory stimulation, coughing, wheezing, pulmonary edema), blood
(decreases platelet aggregation and an increase in bleeding time, anemia, leulopenia, purpura), urinary system
(nocturia, polyuria). May also cause nasal and chest congestion, sore throat, flushing, heat sensation,
angioedema (mostly oropharyngeal edema with breathing difficulty), gingival hyperplasia or enlargement of gum
tissue around teeth, excessive tiredness, weakness, decrease sexual ability.
Section 12: Ecological Information
Ecotoxicity: Not available.
BOD5 and COD: Not available.
Products of Biodegradation:
Possibly hazardous short term degradation products are not likely. However, long term degradation products may
arise.
Toxicity of the Products of Biodegradation: The products of degradation are less toxic than the product itself.
Special Remarks on the Products of Biodegradation: Not available.
Section 13: Disposal Considerations
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Section 13: Disposal Considerations
Waste Disposal:
Waste must be disposed of in accordance with federal, state and local environmental
control regulations.
Section 14: Transport Information
DOT Classification: Not a DOT controlled material (United States).
Identification: Not applicable.
Special Provisions for Transport: Not applicable.
Section 15: Other Regulatory Information
Federal and State Regulations:
California prop. 65: This product contains the following ingredients for which the State of California has found to
cause cancer, birth defects or other reproductive harm, which would require a warning under the statute:
Nifedipine
California prop. 65: This product contains the following ingredients for which the State of California has found to
cause reproductive harm (female) which would require a warning under the statute: Nifedipine
California prop. 65: This product contains the following ingredients for which the State of California has found to
cause reproductive harm (male) which would require a warning under the statute: Nifedipine
California prop. 65: This product contains the following ingredients for which the State of California has found to
cause birth defects which would require a warning under the statute: Nifedipine
Other Regulations:
OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).
EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances.
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Other Classifications:
WHMIS (Canada): Not controlled under WHMIS (Canada).
DSCL (EEC):
R22- Harmful if swallowed.
S25- Avoid contact with eyes.
S26- In case of contact with eyes, rinse
immediately with plenty of water and seek
medical advice.
S36- Wear suitable protective clothing.
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HMIS (U.S.A.):
Health Hazard: 1
Fire Hazard: 1
Reactivity: 0
Personal Protection: E
National Fire Protection Association (U.S.A.):
Health: 1
Flammability: 1
Reactivity: 0
Specific hazard:
Protective Equipment:
Gloves.
Lab coat.
Dust respirator. Be sure to use an
approved/certified respirator or
equivalent.
Safety glasses.
Section 16: Other Information
References: Not available.
Other Special Considerations: Not available.
Created: 10/10/2005 10:58 AM
Last Updated: 10/10/2005 10:58 AM
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