SODIUM DIMETHYL DITHIOCARBAMATE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 12-May-2005 CHEMWATCH 12430
NC317TCP Version No:2.0
CD 2007/3 Page 1 of 10
Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
PRODUCT NAME
SODIUM DIMETHYLDITHIOCARBAMATE
SYNONYMS
C3-H6-N-S2-Na, C3-H6-N-S2-Na, (CH3)NCS2Na, "sodium N, N-dimethyldithiocarbamate", "sodium
N, N-dimethyldithiocarbamate", "carbamodithioic acid, dimethyl-, sodium salt",
"carbamic acid, dimethyldithio-, sodium salt", "methyl namate"
PRODUCT USE
Fungicide, corrosion inhibitor, rubber accelerator, intermediate, polymerisation short-
stop, chelator.
SUPPLIER
Company: Quantum Chemicals Pty Ltd
Address:
70 Quantum Close
Dandenong South
Victoria 3175
Telephone: 03 8795 8000
Emergency Tel: 1300 131 001
Fax: 03 8795 8099
HAZARD RATINGS
Flammability
Toxicity
Body Contact
Reactivity
Chronic
SCALE: Min/Nil=0 Low=1 Moderate=2 High=3 Extreme=4
Section 2 - HAZARDS IDENTIFICATION
STATEMENT OF HAZARDOUS NATURE
HAZARDOUS SUBSTANCE. NON-DANGEROUS GOODS. According to the Criteria of
NOHSC, and the ADG Code.
SODIUM DIMETHYL DITHIOCARBAMATE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 12-May-2005 CHEMWATCH 12430
NC317TCP Version No:2.0
CD 2007/3 Page 2 of 10
Section 2 - HAZARDS IDENTIFICATION
POISONS SCHEDULE
None
RISK SAFETY
Harmful if swallowed. Avoid exposure - obtain special instructions
before use.
Cumulative effects may result following To clean the floor and all objects contaminated
exposure*. by this material use water.
Possible respiratory sensitiser*. Keep away from food drink and animal feeding
stuffs.
May possibly affect fertility*. Take off immediately all contaminated clothing.
* (limited evidence). If swallowed IMMEDIATELY contact Doctor or
Poisons Information Centre (show this container
or label).
Section 3 - COMPOSITION / INFORMATION ON INGREDIENTS
NAME CAS RN %
sodium dimethyl dithiocarbamate 128-04-1 >98
NOTE: decomposition or metabolic activity may
result in the formation of
ethylene thiourea 96-45-7
Section 4 - FIRST AID MEASURES
SWALLOWED
For advice, contact a Poisons Information Centre or a doctor.
路 IF SWALLOWED, REFER FOR MEDICAL ATTENTION, WHERE POSSIBLE, WITHOUT DELAY.
路 For advice, contact a Poisons Information Centre or a doctor.
Where Medical attention is not immediately available or where the patient is more than 15
minutes from a hospital or unless instructed otherwise:
路 Induce vomiting with fingers down the back of the of the throat, ONLY IF CONSCIOUS.
路 Lean patient forward or place on left side (head-down position if possible) to maintain
open airway and prevent aspiration.
NOTE: Wear a protective glove when inducing vomiting by mechanical means.
路 In the mean time, qualified first-aid personnel should treat the patient following
observation and employing supportive measures as indicated by the patient's condition.
路 If the services of a medical officer or medical doctor are readily available, the
patient should be placed in his/her care and a copy of the MSDS should be provided.
Further action will be the responsibility of the medical specialist.
路 If medical attention is not available on the worksite or surroundings send the patient
to a hospital together with a copy of the MSDS.
Avoid giving alcohol.
EYE
If this product comes in contact with the eyes:
路 Immediately hold eyelids apart and flush the eye continuously with running water.
路 Ensure complete irrigation of the eye by keeping eyelids apart and away from eye and
SODIUM DIMETHYL DITHIOCARBAMATE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 12-May-2005 CHEMWATCH 12430
NC317TCP Version No:2.0
CD 2007/3 Page 3 of 10
Section 4 - FIRST AID MEASURES
moving the eyelids by occasionally lifting the upper and lower lids.
路 Continue flushing until advised to stop by the Poisons Information Centre or a doctor,
or for at least 15 minutes.
路 Transport to hospital or doctor without delay.
路 Removal of contact lenses after an eye injury should only be undertaken by skilled
personnel.
SKIN
If skin contact occurs:
路 Immediately remove all contaminated clothing, including footwear.
路 Flush skin and hair with running water (and soap if available).
路 Seek medical attention in event of irritation.
INHALED
路 If dust is inhaled, remove from contaminated area.
路 Encourage patient to blow nose to ensure clear passage of breathing.
路 If irritation or discomfort persists seek medical attention.
路 If fumes or combustion products are inhaled remove from contaminated area.
路 Lay patient down. Keep warm and rested.
路 Prostheses such as false teeth, which may block airway, should be removed, where
possible, prior to initiating first aid procedures.
路 Apply artificial respiration if not breathing, preferably with a demand valve
resuscitator, bag-valve mask device, or pocket mask as trained. Perform CPR if necessary.
路 Transport to hospital, or doctor.
NOTES TO PHYSICIAN
Medical literature on human exposure to thiocarbamate derivatives is scarce.
路 Animal studies suggest that contact dermatitis and thyroid hyperplasia may occur
following exposure.
路 These compounds do not have the cholinergic properties of structurally related
carbamate insecticides.
路 The usual measures for gut and skin contamination are recommended for large doses.
路 Some thiocarbamates are structurally similar to disulfiram and may cause the
characteristically unpleasant alcohol type reactions lasting for several hours; they may
respond to fluids, oxygen and analgesics. Dysrhythmias may occur and patients with
serious reactions should have cardiac monitoring.
路 Precautions should be taken to prohibit intake of alcohol for 10 days.
路 Fats, oils and lipid solvents must not be consumed as they may enhance absorption.
As a general rule thiocarbamates can be absorbed by the skin, mucous membranes and
respiratory and gastrointestinal tract. They are eliminated quickly via expired air and
urine. Two major pathways exist for the metabolism of thiocarbamates in mammals. One is
via sulfoxidation and conjugation with glutathione. The conjugation product is cleaved to
the cysteine derivative which is further metabolised to a mercapturic acid compound. The
second route involves oxidation of the sulfur to a sulfoxide which is oxidised to a
sulfone, or hydroxylation to compounds which enter the carbon metabolic pool.
Section 5 - FIRE FIGHTING MEASURES
EXTINGUISHING MEDIA
Water spray or fog.
路 Alcohol stable foam.
Bromochlorodifluoromethane (BCF) (where regulations permit).
Dry chemical powder.
Carbon dioxide.
FIRE FIGHTING
Alert Fire Brigade and tell them location and nature of hazard.
路 Wear full body protective clothing with breathing apparatus.
SODIUM DIMETHYL DITHIOCARBAMATE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 12-May-2005 CHEMWATCH 12430
NC317TCP Version No:2.0
CD 2007/3 Page 4 of 10
Section 5 - FIRE FIGHTING MEASURES
路 Prevent, by any means available, spillage from entering drains or water courses.
Fight fire from a safe distance, with adequate cover.
Cool fire exposed containers with water spray from a protected location.
DO NOT approach containers suspected to be hot.
If safe to do so, remove containers from path of fire.
FIRE/EXPLOSION HAZARD
路 Solid which exhibits difficult combustion or is difficult to ignite.
路 Avoid generating dust, particularly clouds of dust in a confined or unventilated space
as dusts may form an explosive mixture with air, and any source of ignition, i.e.
flame or spark, will cause fire or explosion. Dust clouds generated by the fine
grinding of the solid are a particular hazard; accumulations of fine dust may burn
rapidly and fiercely if ignited.
路 Dry dust can also be charged electrostatically by turbulence, pneumatic transport,
pouring, in exhaust ducts and during transport.
路 Build-up of electrostatic charge may be prevented by bonding and grounding.
路 Powder handling equipment such as dust collectors, dryers and mills may require
additional protection measures such as explosion venting.
路 All movable parts coming in contact with this material should have a speed of less than
1-metre/sec.
Decomposes on heating and produces toxic fumes of sulfur oxides (SOx) and nitrogen oxides
(NOx).
HAZCHEM: None
Section 6 - ACCIDENTAL RELEASE MEASURES
EMERGENCY PROCEDURES
MINOR SPILLS
Clean up all spills immediately.
Avoid contact with skin and eyes.
Wear protective clothing, gloves, safety glasses and dust respirator.
Use dry clean up procedures and avoid generating dust.
Vacuum up or sweep up.
Trowel up/scrape up.
Place spilled material in clean, dry, sealable, labelled container.
MAJOR SPILLS
Clear area of personnel.
Alert Fire Brigade and tell them location and nature of hazard.
路 Wear breathing apparatus plus protective gloves.
路 Prevent, by any means available, spillage from entering drains or water courses.
No smoking, naked lights or ignition sources.
Avoid generating dust.
Collect recoverable product into labelled containers for recycling.
Collect residues and seal in labelled drums for disposal.
Wash area down with large quantity of water and prevent runoff into drains.
After clean up operations, decontaminate and launder all protective clothing and
equipment before storing and re-using.
If contamination of drains or waterways occurs, advise emergency services.
Personal Protective Equipment advice is contained in Section 8 of the MSDS.
SODIUM DIMETHYL DITHIOCARBAMATE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 12-May-2005 CHEMWATCH 12430
NC317TCP Version No:2.0
CD 2007/3 Page 5 of 10
Section 7 - HANDLING AND STORAGE
PROCEDURE FOR HANDLING
路 Limit all unnecessary personal contact.
路 Wear protective clothing when risk of exposure occurs.
路 Use in a well-ventilated area.
路 Avoid contact with incompatible materials.
路 When handling, DO NOT eat, drink or smoke.
路 Keep containers securely sealed when not in use.
路 Avoid physical damage to containers.
路 Always wash hands with soap and water after handling.
路 Work clothes should be laundered separately.
路 Use good occupational work practice.
路 Observe manufacturer's storing and handling recommendations.
路 Atmosphere should be regularly checked against established exposure standards to ensure
safe working conditions are maintained.
SUITABLE CONTAINER
Packaging as recommended by manufacturer.
路 Check that containers are clearly labelled.
Multi-ply woven plastic or paper bag with sealed plastic liner
NOTE: Bags should be stacked, blocked, interlocked, and limited in height so that they
are stable and secure against sliding or collapse.
Plastic container.
Glass container.
Plastic drum.
STORAGE INCOMPATIBILITY
Avoid reaction with oxidising agents.
Avoid strong acids.
STORAGE REQUIREMENTS
Observe manufacturer's storing and handling recommendations.
Store in original containers.
Keep containers securely sealed.
No smoking, naked lights, heat or ignition sources.
Store in a cool, dry place.
Store in a well-ventilated area.
Store away from incompatible materials.
DO NOT store in pits, depressions, basements or areas where vapours may be trapped.
Keep storage area free of debris, waste and combustibles.
Protect containers against physical damage.
Check regularly for spills and leaks.
_____________________________________________________
SAFE STORAGE WITH OTHER CLASSIFIED CHEMICALS
+ X + X 0 +
_____________________________________________________
+: May be stored together
O: May be stored together with specific preventions
X: Must not be stored together
SODIUM DIMETHYL DITHIOCARBAMATE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 12-May-2005 CHEMWATCH 12430
NC317TCP Version No:2.0
CD 2007/3 Page 6 of 10
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
EXPOSURE CONTROLS
Source Material TWA mg/m鲁
_________ _________ _____
Australia Exposure Standards sodium dimethyldithiocarbamate 10
(Inspirable dust (Not
specified))
Australia Exposure Standards ethylene thiourea (Inspirable 10
dust (Not specified))
MATERIAL DATA
These "dusts" have little adverse effect on the lungs and do not produce toxic effects or
organic disease. Although there is no dust which does not evoke some cellular response at
sufficiently high concentrations, the cellular response caused by P.N.O.C.s has the
following characteristics:
路 the architecture of the air spaces remain intact,
路 scar tissue (collagen) is not synthesised to any degree,
路 tissue reaction is potentially reversible.
Extensive concentrations of P.N.O.C.s may:
路 seriously reduce visibility,
路 cause unpleasant deposits in the eyes, ears and nasal passages,
路 contribute to skin or mucous membrane injury by chemical or mechanical action, per se,
or by the rigorous skin cleansing procedures necessary for their removal. [ACGIH]
This limit does not apply:
路 to brief exposures to higher concentrations
路 nor does it apply to those substances that may cause physiological impairment at lower
concentrations but for which a TLV has as yet to be determined.
This exposure standard applies to particles which
路 are insoluble or poorly soluble* in water or, preferably, in aqueous lung fluid (if
data is available) and
路 have a low toxicity (i.e.. are not cytotoxic, genotoxic, or otherwise chemically
reactive with lung tissue, and do not emit ionizing radiation, cause immune sensitization
, or cause toxic effects other than by inflammation or by a mechanism of lung overload).
INGREDIENT DATA
ETHYLENE THIOUREA:
MAK IIIB: Substances suspected of having carcinogenic potential.
MAK values, and categories and groups are those recommended within the
Federal Republic of Germany.
PERSONAL PROTECTION
EYE
路 Chemical goggles.
路 Safety glasses with side shields.
路 Safety glasses.
路 Contact lenses may pose a special hazard; soft contact lenses may absorb and
concentrate irritants. A written policy document, describing the wearing of lens or
restrictions on use, should be created for each workplace or task. This should include a
SODIUM DIMETHYL DITHIOCARBAMATE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 12-May-2005 CHEMWATCH 12430
NC317TCP Version No:2.0
CD 2007/3 Page 7 of 10
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
review of lens absorption and adsorption for the class of chemicals in use and an account
of injury experience. Medical and first-aid personnel should be trained in their removal
and suitable equipment should be readily available. In the event of chemical exposure,
begin eye irrigation immediately and remove contact lens as soon as practicable. Lens
should be removed at the first signs of eye redness or irritation - lens should be
removed in a clean environment only after workers have washed hands thoroughly. [CDC
NIOSH Current Intelligence Bulletin 59].
HANDS/FEET
Plastic gloves.
Rubber gloves.
Impervious gloves.
PVC gloves.
Protective footwear.
OTHER
路 Overalls.
路 Eyewash unit.
RESPIRATOR
Protection Factor Half- Face Respirator Full- Face Respirator Powered Air Respirator
10 x ES P1 Air- line* -- PAPR- P1 -
50 x ES Air- line** P2 PAPR- P2
100 x ES - P3 -
Air- line* -
100+ x ES - Air- line** PAPR- P3
* - Negative pressure demand ** - Continuous flow.
The local concentration of material, quantity and conditions of use determine the type of
personal protective equipment required.
For further information consult site specific
CHEMWATCH data (if available), or your
Occupational Health and Safety Advisor.
ENGINEERING CONTROLS
Local exhaust ventilation may be required for safe working, i.e. to keep exposures below
required standards, otherwise PPE is required.
If exposure to workplace dust is not controlled, respiratory protection is required; wear
SAA approved dust respirator.
Provide adequate ventilation in warehouse or closed storage areas.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
APPEARANCE
Off- white crystalline flakes; mix with water. A 40% solution is amber to light green.
PHYSICAL PROPERTIES
Solid.
Mixes with water.
Molecular Weight: 179.24 Boiling Range (掳C): Not available
Melting Range (掳C): 120- 122 (decomp) Specific Gravity (water=1): 1.17- 1.20
Solubility in water (g/L): Miscible pH (as supplied): Not applicable
pH (1% solution): Not available Vapour Pressure (kPa): Not available
Volatile Component (%vol): Not available Evaporation Rate: Not available
Relative Vapour Density (air=1): Not available Flash Point (掳C): Not available
Lower Explosive Limit (%): Not available Upper Explosive Limit (%): Not available
Autoignition Temp (掳C): Not available Decomposition Temp (掳C): 120
SODIUM DIMETHYL DITHIOCARBAMATE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 12-May-2005 CHEMWATCH 12430
NC317TCP Version No:2.0
CD 2007/3 Page 8 of 10
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
State: Divided solid
Section 10 - CHEMICAL STABILITY AND REACTIVITY INFORMATION
CONDITIONS CONTRIBUTING TO INSTABILITY
路 Presence of incompatible materials.
路 Product is considered stable.
路 Hazardous polymerisation will not occur.
Section 11 - TOXICOLOGICAL INFORMATION
POTENTIAL HEALTH EFFECTS
ACUTE HEALTH EFFECTS
SWALLOWED
The material may be. harmful if swallowed in large quantity.
Considered an unlikely route of entry in commercial/industrial environments.
The acute toxicity of thiocarbamates is generally low, because of their rapid metabolism.
Exposure to high doses may produce signs such as loss of appetite, squinting, excessive
production of saliva, watery eyes, hairs standing on end, laboured breathing, reduced
body temperature, incoordination, depression and rapid muscle twitching.
Lethal doses of some thiocarbamates have produced muscle weakness and ascending paralysis
progressing to respiratory paralysis and death in animals. Exposure to small quantities
of thiocarbamates and intake of small quantities of ethanol may produce flushing,
breathing difficulties, nausea and vomiting and lowered blood pressure. Sensitisation to
alcohol may last as long as 6-14 days following exposure.
EYE
The dust may be discomforting to the eyes.
SKIN
The material may be mildly discomforting to the skin.
INHALED
The dust may be discomforting to the upper respiratory tract.
Persons with impaired respiratory function, airway diseases and conditions such as
emphysema or chronic bronchitis, may incur further disability if excessive concentrations
of particulate are inhaled.
CHRONIC HEALTH EFFECTS
Principal routes of exposure are by accidental skin and eye contact and inhalation of
generated dusts.
Some dithiocarbamates may cause birth defects and cancer and may affect male reproductive
capacity. They may also cause goitre (overactivity of the thyroid gland) and nerve
disorders.
Thiocarbamates have been show to alter sperm form and therefore reproduction.
TOXICITY AND IRRITATION
unless otherwise specified data extracted from RTECS - Register of Toxic Effects of Chemical Substances.
TOXICITY IRRITATION
Oral (rat) LD50: 1000 mg/kg Nil Reported
Intraperitoneal (rat) LD50: 1000 mg/kg
ETHYLENE THIOUREA:
unless otherwise specified data extracted from RTECS - Register of Toxic Effects of Chemical Substances.
TOXICITY IRRITATION
SODIUM DIMETHYL DITHIOCARBAMATE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 12-May-2005 CHEMWATCH 12430
NC317TCP Version No:2.0
CD 2007/3 Page 9 of 10
Section 11 - TOXICOLOGICAL INFORMATION
Oral (rat) LD50: 1832 mg/kg Eye (rabbit): 500 mg/24h - Mild
Oral (rat) LD50: 710 mg/kg *
MATERIAL CARCINOGEN REPROTOXIN SENSITISER SKIN
_______________ ____________ __________ __________ __________
ethylene thiourea IARC:3 NTPB
CARCINOGEN
IARC: International Agency for Research on Cancer (IARC) Carcinogens: ethylene thiourea
Category: 3
CARCINOGEN
NTPB: US National Toxicology Program (NTP) 11th Report Part B. Reasonably Anticipated
to be a Human Carcinogen: ethylene thiourea Category:
Section 12 - ECOLOGICAL INFORMATION
Information on the environmental impact of dithiocarbamates with respect to persistence
and bioaccumulation in different species and food chains is limited. Available
information suggests that these compounds are degraded in the presence of moisture,
oxygen, etc. to form a number of compounds, some of which are toxicologically important.
Soil organisms are capable of metabolising dithiocarbamates; breakdown products appear to
affect enzyme activities, respiration and nitrification at dose levels of the order of 10
mg/kg dry soil or more.
Generally dithiocarbamates have an LC50 of less than 1 mg/l for invertebrates (Daphnia)
and between 1 and 4 mg/l for algae (Chlorella). The acute toxicity in fish is higher. The
sac fry and early fry stages of rainbow trout have a higher sensitivity than other early
life stages and embryotoxic and teratogenic effects have been induced by certain
dithiocarbamates. Bioaccumulation, however, is low (bioconcentration factor <100).
Several dithiocarbamates have been shown to affect testicular development and function
and to cause nerve fibre degeneration in domestic fowl. General information on the
influence of dithiocarbamates on honey-bees is not generally available.
Refer to data for ingredients, which follows:
ETHYLENE THIOUREA:
Hazardous Air Pollutant: Yes
Fish LC50 (96hr.) (mg/l): 6000- 8000(
BCF<100: - 0.73
log Kow (Prager 1995): - 0.66
log Kow (Sangster 1997): - 0.66
log Pow (Verschueren 1983): - 0.66
Half- life Soil - High (hours): 672
Half- life Soil - Low (hours): 168
Half- life Air - High (hours): 4.7
Half- life Air - Low (hours): 0.5
Half- life Surface water - High (hours): 672
Half- life Surface water - Low (hours): 168
Half- life Ground water - High (hours): 1344
Half- life Ground water - Low (hours): 336
Aqueous biodegradation - Aerobic - High (hours): 672
Aqueous biodegradation - Aerobic - Low (hours): 168
Aqueous biodegradation - Anaerobic - High (hours): 2688
Aqueous biodegradation - Anaerobic - Low (hours): 672
Photolysis maximum light absorption - High (nano- m): 239
Photooxidation half- life air - High (hours): 4.7
Photooxidation half- life air - Low (hours): 0.5
DO NOT discharge into sewer or waterways.
SODIUM DIMETHYL DITHIOCARBAMATE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 12-May-2005 CHEMWATCH 12430
NC317TCP Version No:2.0
CD 2007/3 Page 10 of 10
Section 12 - ECOLOGICAL INFORMATION
Half-life (hr) air: 205
Half-life (hr) soil: 168
BCF: 2.3
Toxicity Fish: LD50(24)90mg/L
Bioacculmulation: unlikely
Degradation Biological: sig
processes Abiotic: slow hydrol,Rxn OH*
Section 13 - DISPOSAL CONSIDERATIONS
Recycle wherever possible.
Consult manufacturer for recycling options.
Consult State Land Waste Management Authority for disposal.
Bury or incinerate residue at an approved site.
Decontaminate empty containers.
Return empty containers to supplier or bury empty containers at an
authorised landfill.
Section 14 - TRANSPORTATION INFORMATION
HAZCHEM: None
NOT REGULATED FOR TRANSPORT OF DANGEROUS GOODS:UN, IATA,
IMDG
Section 15 - REGULATORY INFORMATION
POISONS SCHEDULE: None
REGULATIONS
sodium dimethyldithiocarbamate (CAS: 128-04-1) is found on the following regulatory lists;
Australia Exposure Standards
Australia Inventory of Chemical Substances (AICS)
Australia New Zealand Food Standards Code - Maximum Residue Limits (Australia only) - Schedule 3 - Chemical Groups
International Council of Chemical Associations (ICCA) - High Production Volume List
OECD Representative List of High Production Volume (HPV) Chemicals
Section 16 - OTHER INFORMATION
Classification of the preparation and its individual components has drawn on official and
authoritative sources as well as independent review by the Chemwatch Classification
committee using available literature references.
This document is copyright. Apart from any fair dealing for the purposes of private study, research, review or
criticism, as permitted under the Copyright Act, no part may be reproduced by any process without written permission
from CHEMWATCH. TEL (+61 3) 9572 4700.
Issue Date: 12-May-2005
Print Date: 10-Jan-2008
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