LTIMSDS1
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MATERIAL SAFETY DATA SHEET
__________________________ Page 1 of 8
Revised 8/22/03
IL-1 BLA ECV304 CELLS Replaces (None)
INVITROGEN CORPORATION Printed 8/22/03
MSDS ID: K1054
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1. PRODUCT AND COMPANY INFORMATION
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INVITROGEN CORPORATION GIBCO PRODUCTS
1600 FARADAY AVE. INVITROGEN CORPORATION
CARLSBAD, CA 92008 3175 STALEY ROAD P.O. BOX 68
760/603-7200 GRAND ISLAND, NY 14072
716/774-6700
INVITROGEN CORPORATION INVITROGEN CORPORATION
3 FOUNTAIN DR. P.O. BOX 12-502
INCHINNAN BUSINESS PARK PENROSE
PAISLEY, PA4 9RF AUCKLAND 1135
SCOTLAND NEW ZEALAND
44-141 814-6100 64-9-579-3024
INVITROGEN CORPORATION
2270 INDUSTRIAL ST.
BURLINGTON, ONT
CANADA L7P 1A1
905/335-2255
EMERGENCY NUMBER (SPILLS, EXPOSURES): 301/431-8585 (24 HOUR)
800/451-8346 (24 HOUR)
NON-EMERGENCY INFORMATION: 800/955-6288
Product Name: IL-1 BLA ECV304 CELLS
Stock Number: K1054
NOTE: If this product is a kit or is supplied with more than one material,
please refer to the MSDS for each component for hazard information.
Product Use:
These products are for laboratory research use only and are not intended for
human or animal diagnostics, therpeutic, or other clinical uses.
Synonyms:
Not available.
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2. COMPOSITION, INFORMATION ON INGREDIENTS
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The following list shows components of this product classified as hazardous
based on physical properties and health effects:
Component CAS No. Percent
DIMETHYL SULFOXIDE 67-68-5 1-5
LTIMSDS2
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MATERIAL SAFETY DATA SHEET
__________________________ Page 2 of 8
Revised 8/22/03
IL-1 BLA ECV304 CELLS Replaces (None)
INVITROGEN CORPORATION Printed 8/22/03
MSDS ID: K1054
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3. HAZARDS IDENTIFICATION
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***************************** EMERGENCY OVERVIEW ****************************
Warning!
Irritant.
Harmful if absorbed.
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Potential Health Effects:
Eye:
Can cause moderate irritation, tearing and reddening, but not likely to
permanently injure eye tissue.
Skin:
Can cause moderate skin irritation, defatting, and dermatitis. Not likely
to cause permanent damage.
Upon prolonged or repeated exposure, harmful if absorbed through the skin.
May cause minor systemic damage.
Inhalation:
Can cause moderate respiratory irritation, dizziness, weakness, fatigue,
nausea and headache.
No toxicity expected from inhalation.
Ingestion:
Irritating to mouth, throat, and stomach. Can cause abdominal discomfort,
nausea, vomiting and diarrhea.
Chronic:
No data on cancer.
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4. FIRST AID MEASURES
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Eye:
Flush eyes with plenty of water for at least 20 minutes retracting eyelids
often. Tilt the head to prevent chemical from transferring to the
uncontaminated eye. Get immediate medical attention.
Skin:
Wash with soap and water. Get medical attention if irritation develops or
persists.
Inhalation:
Remove to fresh air. If breathing is difficult, have a trained individual
administer oxygen. If not breathing, give artificial respiration and have
a trained individual administer oxygen. Get medical attention immediately.
Ingestion:
Do not induce vomiting and seek medical attention immediately. Drink two
LTIMSDS2
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MATERIAL SAFETY DATA SHEET
__________________________ Page 3 of 8
Revised 8/22/03
IL-1 BLA ECV304 CELLS Replaces (None)
INVITROGEN CORPORATION Printed 8/22/03
MSDS ID: K1054
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4. FIRST AID MEASURES (CONT.)
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glasses of water or milk to dilute. Provide medical care provider with
this MSDS.
Note To Physician:
Treat symptomatically.
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5. FIRE FIGHTING MEASURES
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Flashpoint Deg C:
Not available.
Upper Flammable Limit %:
Not available.
Lower Flammable Limit %:
Not available.
Autoignition Temperature Deg C:
Not available.
Extinguishing Media:
Use alcohol resistant foam, carbon dioxide, dry chemical, or water spray
when fighting fires. Water or foam may cause frothing if liquid is burning
but it still may be a useful extinguishing agent if carefully applied to
the fire. Do not direct a water stream directly into the hot burning liquid.
DMSO undergoes a violent exothermic reaction on mixing with copper wool and
trichloroacetic acid. On mixing with potassium permanganate it will flash
instantaneously. It reacts violently with: acid halides, cyanuric chloride,
silicon tetrachloride, phosphorus trichloride and trioxide, thionyl chloride,
magnesium perchlorate, silver fluoride, methyl bromide, iodine pentafluoride,
nitrogen periodate, diborane, sodium hydride, perchloric and periodic acids.
When heated above its boiling point, DMSO degrades giving off formaldehyde,
methyl mercaptan, and sulfur dioxide.
Firefighting Techniques/Equipment:
Do not enter fire area without proper protection including self-contained
breathing apparatus and full protective equipment. Fight fire from a safe
distance and a protected location due to the potential of hazardous vapors
and decomposition products.
Hazardous Combustion Products:
Carbon dioxide Carbon monoxide Sulfur containing gases
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6. ACCIDENTAL RELEASE MEASURES
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Accidental releases may be subject to special reporting requirements and other
regulatory mandates. Refer to Section 8 for personal protection equipment
recommendations.
LTIMSDS2
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MATERIAL SAFETY DATA SHEET
__________________________ Page 4 of 8
Revised 8/22/03
IL-1 BLA ECV304 CELLS Replaces (None)
INVITROGEN CORPORATION Printed 8/22/03
MSDS ID: K1054
______________________________________________________________________________
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6. ACCIDENTAL RELEASE MEASURES (CONT.)
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Spill Cleanup:
Exposure to the spilled material may be irritating or harmful. Follow
personal protective equipment recommendations found in Section VIII of
this MSDS. Additional precautions may be necessary based on special
circumstances created by the spill including; the material spilled, the
quantity of the spill, the area in which the spill occurred. Also consider
the expertise of employees in the area responding to the spill.
Ventilate the contaminated area.
Absorb spill. Common absorbent materials should be effective. Deposit in
appropriate containers for removal and disposal.
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7. HANDLING AND STORAGE
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Storage of some materials is regulated by federal, state, and/or local laws.
Storage Pressure:
Ambient
Handling Procedures:
Harmful or irritating material. Avoid contacting and avoid breathing the
material. Use only in a well ventilated area.
Keep closed or covered when not in use.
Storage Procedures:
Store in a cool dry ventilated location. Isolate from incompatible
materials and conditions. Keep container(s) closed.
Suitable for most general chemical storage areas.
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8. EXPOSURE CONTROLS, PERSONAL PROTECTION
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Exposure Limits:
OSHA PEL AGCIH TWA
Component (ppm) (ppm)
DIMETHYL SULFOXIDE Not established. Not established.
Engineering Controls:
Local exhaust ventilation or other engineering controls are normally
required when handling or using this product to avoid overexposure.
Personal Protective Equipment:
Eye:
Safety glasses should be the minimum eye protection.
Wear chemically resistant safety glasses with side shields when handling
this product. Wear additional eye protection such as chemical splash
LTIMSDS2
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MATERIAL SAFETY DATA SHEET
__________________________ Page 5 of 8
Revised 8/22/03
IL-1 BLA ECV304 CELLS Replaces (None)
INVITROGEN CORPORATION Printed 8/22/03
MSDS ID: K1054
______________________________________________________________________________
______________________________________________________________________________
8. EXPOSURE CONTROLS, PERSONAL PROTECTION (CONT.)
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goggles and/or face shield when the possibility exists for eye contact
with splashing or spraying liquid, or airborne material. Do not wear
contact lenses. Have an eye wash station available.
Skin:
Avoid skin contact by wearing chemically resistant gloves, an apron and
other protective equipment depending upon conditions of use. Inspect
gloves for chemical break-through and replace at regular intervals. Clean
protective equipment regularly. Wash hands and other exposed areas with
mild soap and water before eating, drinking, and when leaving work.
Gloves should be used as minimum hand protection.
Respiratory:
Use supplied-air respiratory equipment as required.
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9. PHYSICAL AND CHEMICAL PROPERTIES
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Appearance/physical state: Liquid solution / suspension
Odor: No odor.
Not established.
Not established.
Not established.
Not established.
Not established.
Not established.
Specific Gravity/Density: Not established.
Octanol/water Partition Coeff: Not established.
Volatiles: Not established.
Evaporation Rate: Not established.
Viscosity: Not established.
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10. STABILITY AND REACTIVITY
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Stability:
Stable under normal conditions.
Conditions to Avoid:
Strong oxidizing agents. Temperatures above the high flash point of this
combustible material in combination with sparks, open flames, or other sources
of ignition. Strong alkalies. DMSO undergoes a violent exothermic reaction
on mixing with copper wool and trichloroacetic acid. On mixing with potassium
permanganate it will flash instantaneously. It reacts violently with: acid
halides, cyanuric chloride, silicon tetrachloride, phosphorus trichloride and
trioxide, thionyl chloride, magnesium perchlorate, silver fluoride, methyl
bromide, iodine pentafluoride, nitrogen periodate, diborane, sodium hydride,
perchloric and periodic acids. When heated above its boiling point, DMSO
LTIMSDS2
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MATERIAL SAFETY DATA SHEET
__________________________ Page 6 of 8
Revised 8/22/03
IL-1 BLA ECV304 CELLS Replaces (None)
INVITROGEN CORPORATION Printed 8/22/03
MSDS ID: K1054
______________________________________________________________________________
______________________________________________________________________________
10. STABILITY AND REACTIVITY (CONT.)
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degrades giving off formaldehyde, methyl mercaptan, and sulfur dioxide.
Hazardous Decomposition Products:
Carbon monoxide. Carbon dioxide. Sulfur containing gases.
Hazardous Polymerization:
Hazardous polymerization will not occur.
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11. TOXICOLOGICAL INFORMATION
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Acute Toxicity:
Dermal/Skin:
DIMETHYL SULFOXIDE: 40 GM/KG
Inhalation/Respiratory:
Not determined.
Oral/Ingestion:
DIMETHYL SULFOXIDE: 14,500 MG/KG
Target Organs: Blood. Eyes. Skin.
Carcinogenicity:
NTP:
Not tested.
IARC:
Not listed.
OSHA:
Not regulated.
Other Toxicological Information
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12. Ecological Information
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Ecotoxicological Information: No ecological information available.
Environmental Fate (Degradation, Transformation, and Persistence):
Bioconcentration is not expected to occur.
Biodegrades slowly.
LTIMSDS2
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MATERIAL SAFETY DATA SHEET
__________________________ Page 7 of 8
Revised 8/22/03
IL-1 BLA ECV304 CELLS Replaces (None)
INVITROGEN CORPORATION Printed 8/22/03
MSDS ID: K1054
______________________________________________________________________________
______________________________________________________________________________
13. DISPOSAL CONSIDERATIONS
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Regulatory Information:
Not applicable.
Disposal Method:
Clean up and dispose of waste in accordance with all federal, state, and
local environmental regulations.
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14. TRANSPORT INFORMATION
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Proper Shipping Name: Not Determined.
Subsidiary Hazards:
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15. REGULATORY INFORMATION
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UNITED STATES:
TSCA:
This product is solely for research and development purposes only and may not
be used, processed or distributed for a commercial purpose. It may only be
handled by technically qualified individuals.
Prop 65 Listed Chemicals: PROP 65 PERCENT
No Prop 65 Chemicals.
No 313 Chemicals
CANADA:
DSL/NDSL:
Not determined.
COMPONENT WHMIS Classification
DIMETHYL SULFOXIDE D2B
EUROPEAN UNION:
PRODUCT RISK PHRASES:
None assigned.
PRODUCT SAFETY PHRASES:
Not applicable.
PRODUCT CLASSIFICATION:
Not classified
LTIMSDS2
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MATERIAL SAFETY DATA SHEET
__________________________ Page 8 of 8
Revised 8/22/03
IL-1 BLA ECV304 CELLS Replaces (None)
INVITROGEN CORPORATION Printed 8/22/03
MSDS ID: K1054
______________________________________________________________________________
______________________________________________________________________________
15. REGULATORY INFORMATION (CONT.)
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EINECS
Component Number
DIMETHYL SULFOXIDE 200-664-3
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16. OTHER INFORMATION
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HMIS Rating 0-4:
FIRE: Not determined.
HEALTH: Not determined.
REACTIVITY: Not determined.
Abbreviations
N/A - Data is not applicable or not available
SARA - Superfund and Reauthorization Act
HMIS - Hazard Material Information System
WHMIS - Workplace Hazard Materials Information System
NTP - National Toxicology Program
OSHA - Occupational Health and Safety Administration
IARC - International Agency for Research on Cancer
PROP 65 - California Safe Drinking Water and
Toxic Enforcement Act of 1986
EINECS - European Inventory of Existing Commercial
Chemical Substances
The above information was acquired by diligent search and/or investigation
and the recommendations are based on prudent application of professional
judgment. The information shall not be taken as being all inclusive and is
to be used only as a guide. All materials and mixtures may present unknown
hazards and should be used with caution. Since Invitrogen Corporation cannot
control the actual methods, volumes, or conditions of use, the Company shall
not be held liable for any damages or losses resulting from the handling or
from contact with the product as described herein. THE INFORMATION IN THIS
MSDS DOES NOT CONSTITUTE A WARRANTY, EXPRESS OR IMPLIED, INCLUDING ANY
IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR ANY PARTICULAR PURPOSE.
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