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MATERIAL SAFETY DATA SHEET
SECTION 1. CHEMICAL IDENTIFICATION
Product Name: Dimethylsulfoxide (DMSO)
ATCC Catalog No.: 4-X
SECTION 2. COMPOSITION/INFORMATION ON INGREDIENTS
HAZARDOUS INGREDIENTS CAS NUMBER EC NUMBER (EINECS) PERCENTAGE
DIMETHYLSULFOXIDE 67-68-5 200-664-3 99 鈥? 100%
SECTION 3. HAZARDS IDENTIFICATION
LABEL PRECAUTIONARY STATEMENTS:
IRRITANT.
IRRITATING TO EYES, RESPIRATORY SYSTEM AND SKIN.
COMBUSTIBLE LIQUID.
READILY ABSORBED THROUGH SKIN.
TARGET ORGAN(S):
EYES.
SKIN.
DO NOT BREATHE VAPOR.
IN CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF WATER AND SEEK
MEDICAL ADVICE.
WEAR SUITABLE PROTECTIVE CLOTHING.
MOISTURE SENSITIVE.
SECTION 4. FIRST-AID MEASURES
IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS. CALL A
PHYSICIAN.
IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING GIVE ARTIFICIAL RESPIRATION. IF
BREATHING IS DIFFICULT, GIVE OXYGEN.
IN CASE OF CONTACT, IMMEDIATELY WASH SKIN WITH SOAP AND COPIOUS AMOUNTS OF
WATER.
IN CASE OF CONTACT, IMMEDIATELY FLUSH EYES WITH COPIOUS AMOUNTS OF WATER FOR
AT LEAST 15 MINUTES.
SECTION 5. FIRE FIGHTING MEASURES
EXTINGUISHING MEDIA:
WATER SPRAY, CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM.
SPECIAL FIREFIGHTING PROCEDURES:
WEAR SELF-CONTAINED BREATHING APPARATUS AND PROTECTIVE CLOTHING TO PREVENT
CONTACT WITH SKIN AND EYES.
American Type Culture Collection Emergency Telephone: (703) 365-2710 (24 hours)
P.O. Box 1549 Information Telephone: (703) 365-2704
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MATERIAL SAFETY DATA SHEET
UNUSUAL FIRE AND EXPLOSIONS HAZARDS:
EMITS TOXIC FUMES UNDER FIRE CONDITIONS.
COMBUSTIBLE LIQUID.
METHYL SULFOXIDE (DMSO) UNDERGOES A VIOLENT EXOTHERMIC REACTION ON MIXING
WITH COPPER WOOL AND TRICHLOROACETIC ACID. ON MIXING WITH POTASSIUM
PERMANGANATE IT WILL FLASH INSTANTANEOUSLY. IT REACTS VIOLENTLY WITH: ACID
HALIDES, CYANURIC CHLORIDE, SILICON TETRACHLORIDE, PHOSPHORUS TRICHLORIDE AND
TRIOXIDE, THIONYL CHLORIDE, MAGNESIUM PERCHLORATE, SILVER FLUORIDE, METHYL
BROMIDE, IODINE PENTAFLUORIDE, NITROGEN PERIODATE, DIBORANE, SODIUM HYDRIDE,
PERCHLORIC AND PERIODIC ACIDS. WHEN HEATED ABOVE ITS BOILING POINT METHYL
SULFOXIDE DEGRADES GIVING OFF FORMALDEHYDE, METHYL MERCAPTAN, AND SULFUR
DIOXIDE.
SECTION 6. ACCIDENTAL RELEASE MEASURES
WEAR RESPIRATOR, CHEMICAL SAFETY GOGGLES, RUBBER BOOTS AND HEAVY RUBBER
GLOVES.
ABSORB ON SAND OR VERMICULITE AND PLACE IN CLOSED CONTAINERS FOR DISPOSAL.
VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE. EVACUATE
AREA.
AVOID CONTAMINATING WATER SUPPLY.
SECTION 7. HANDLING AND STORAGE
REFER TO SECTION 8.
SECTION 8. EXPOSURE CONTROLS/PERSONAL PROTECTION
MECHANICAL EXHAUST REQUIRED.
SAFETY SHOWER AND EYE BATH.
WASH THOROUGHLY AFTER HANDLING.
KEEP TIGHTLY CLOSED.
KEEP AWAY FROM HEAT AND OPEN FLAME.
STORE IN A COOL DRY PLACE AT 2-8掳C.
NIOSH/MSHA-APPROVED RESPIRATOR.
COMPATIBLE CHEMICAL-RESISTANT GLOVES.
CHEMICAL SAFETY GOGGLES.
DO NOT BREATHE VAPOR.
AVOID CONTACT WITH DMSO SOLUTIONS CONTAINING TOXIC MATERIALS OR MATERIALS
WITH UNKNOWN TOXICOLOGICAL PROPERTIES. DIMETHYL SULFOXIDE IS READILY
ABSORBED THROUGH SKIN AND MAY CARRY SUCH MATERIALS INTO THE BODY.
AVOID PROLONGED OR REPEATED EXPOSURE.
SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES
APPEARANCE AND ODOR:
CLEAR, COLORLESS LIQUID.
HYGROSCOPIC.
GARLIC-LIKE ODOR.
American Type Culture Collection Emergency Telephone: (703) 365-2710 (24 hours)
P.O. Box 1549 Information Telephone: (703) 365-2704
Manassas, VA 20108 2 Chemtrec (800) 424-9300
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MATERIAL SAFETY DATA SHEET
BOILING POINT: 189掳C
MELTING POINT: 18.4掳C
FLASHPOINT: 188.60掳F/87掳C
EXPLOSION LIMITS IN AIR:
UPPER 28.5 %
LOWER 2.6 %
VAPOR PRESSURE: 0.42 MMHG @ 20掳C
SOLUBILITY:
WATER -Z1076
ALCOHOLS, ETHYL
SPECIFIC GRAVITY: 1.1 G
VAPOR DENSITY: 2.7 G/L
FREEZING POINT: 18.5掳C
SECTION 10. STABILITY AND REACTIVITY
STABILITY:
STABLE.
INCOMPATIBILITIES:
PROTECT FROM MOISTURE.
ACID CHLORIDES.
PHOSPHORUS HALIDES.
STRONG ACIDS.
STRONG OXIDIZING AGENTS.
STRONG REDUCING AGENTS.
HAZARDOUS COMBUSTION OR DECOMPOSITION PRODUCTS:
CARBON MONOXIDE.
CARBON DIOXIDE.
SULFUR OXIDES.
FORMALDEHYDE.
MERCAPTANS.
HAZARDOUS POLYMERIZATION:
WILL NOT OCCUR.
SECTION 11. TOXICOLOGICAL INFORMATION
ACUTE EFFECTS:
TO THE BEST OF OUR KNOWLEDGE, THE CHEMICAL, PHYSICAL, AND TOXICOLOGICAL
PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED.
CAUSES SKIN IRRITATION.
READILY ABSORBED THROUGH SKIN.
MAY BE HARMFUL IF ABSORBED THROUGH THE SKIN.
CAUSES EYE IRRITATION.
MATERIAL IS IRRITATING TO MUCOUS MEMBRANES AND UPPER RESPIRATORY TRACT.
American Type Culture Collection Emergency Telephone: (703) 365-2710 (24 hours)
P.O. Box 1549 Information Telephone: (703) 365-2704
Manassas, VA 20108 3 Chemtrec (800) 424-9300
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MATERIAL SAFETY DATA SHEET
MAY BE HARMFUL IF INHALED.
MAY BE HARMFUL IF SWALLOWED.
LD.
LC.
AVOID CONTACT WITH DMSO SOLUTIONS CONTAINING TOXIC MATERIALS OR MATERIALS
WITH UNKNOWN TOXICOLOGICAL PROPERTIES. DIMETHYL SULFOXIDE IS READILY
ABSORBED THROUGH SKIN AND MAY CARRY SUCH MATERIALS INTO THE BODY.
CHRONIC EFFECTS.
TARGET ORGAN(S):
EYES.
SKIN.
RTECS #: PV6210000:
METHYL SULFOXIDE.
IRRITATION DATA:
SKN-RBT 10 MG/24H OPEN MLD AIHAAP 23,95,1962
SKN-RBT 500 MG/24H MLD 85JCAE -,1044,1986
EYE-RBT 100 MG TXAPA9 39,129,1977
EYE-RBT 500 MG/24H MLD 85JCAE -,1044,1986
TOXICITY DATA:
ORL-RAT LD50:14500 MG/KG TXAPA9 15,74,1969
SKN-RAT LD50:40 GM/KG ANYAA9 141,96,1967
IPR-RAT LD50:8200 MG/KG FCTOD7 22,665,1984
SCU-RAT LD50:12 GM/KG ARZNAD 14,1050,1964
IVN-RAT LD50:5360 MG/KG TXAPA9 7,104,1965
UNR-RAT LD50:1300 MG/KG NTIS** AD-A159-418
ORL-MUS LD50:7920 MG/KG CHTPBA 3,10,1968
SKN-MUS LD50:50 GM/KG ANYAA9 141,96,1967
IPR-MUS LD50:2500 MG/KG RPTOAN 35,300,1972
SCU-MUS LD50:14 GM/KG ANYAA9 141,96,1967
IVN-MUS LD50:3100 MG/KG TXAPA9 15,74,1969
UNR-MUS LD50:12 GM/KG USXXAM #4767763
ORL-DOG LD50:>10 GM/KG ANYAA9 141,96,1967
IVN-DOG LD50:2500 MG/KG CNCRA6 31,7,1963
ORL-CKN LD50:12 GM/KG JPPMAB 15,688,1963
ORL-MAM LD50:21400 MG/KG GISAAA 39(4),86,1974
ORL-BWD LD50:100 MG/KG TXAPA9 21,315,1972
TARGET ORGAN DATA:
BEHAVIORAL (ALTERED SLEEP TIME).
LUNGS, THORAX OR RESPIRATION (DYSPNAE).
LUNGS, THORAX OR RESPIRATION (CYANOSIS).
GASTROINTESTINAL (NAUSEA OR VOMITING).
LIVER (JAUNDICE, OTHER OR UNCLASSIFIED).
BLOOD (OTHER CHANGES).
American Type Culture Collection Emergency Telephone: (703) 365-2710 (24 hours)
P.O. Box 1549 Information Telephone: (703) 365-2704
Manassas, VA 20108 4 Chemtrec (800) 424-9300
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MATERIAL SAFETY DATA SHEET
EFFECTS ON FERTILITY (PRE-IMPLANTATION MORTALITY).
EFFECTS ON EMBRYO OR FETUS (FETOTOXICITY).
SPECIFIC DEVELOPMENTAL ABNORMALITIES (MUSCULOSKELETAL SYSTEM).
ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES (RTECS) DATA IS
PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR COMPLETE INFORMATION.
SECTION 12. ECOLOGICAL INFORMATION
DATA NOT YET AVAILABLE.
SECTION 13. DISPOSAL CONSIDERATIONS
CONTACT A LICENSED PROFESSIONAL WASTE DISPOSAL SERVICE TO DISPOSE OF THIS
MATERIAL.
THIS COMBUSTIBLE MATERIAL MAY BE BURNED IN A CHEMICAL INCINERATOR EQUIPPED
WITH AN AFTERBURNER AND SCRUBBER.
OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS.
SECTION 14. TRANSPORT INFORMATION
THIS PRODUCT CONTAINS NO HAZARDOUS SUBSTANCES AS DEFINED BY THE DEPARTMENT
OF TRANSPORTATION REGULATIONS, CODIFIED IN TITLE 49 CFR SECTION 171.8 AT
REPORTABLE QUANTITIES ACCORDING TO TABLE 1 OF APPENDIX A OF 49 CFR 搂172.101.
SECTION 15. REGULATORY INFORMATION
EUROPEAN INFORMATION:
IRRITANT.
R 36/37/38
IRRITATING TO EYES, RESPIRATORY SYSTEM AND SKIN.
S 23
DO NOT BREATHE VAPOR.
S 26
IN CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF WATER AND
SEEK MEDICAL ADVICE.
S 36
WEAR SUITABLE PROTECTIVE CLOTHING.
REVIEWS, STANDARDS, AND REGULATIONS:
OEL=MAK.
OEL-GERMANY: NO MAK ESTABLISHED, JAN1999.
OEL-RUSSIA: STEL 20 MG/M3, JAN1993.
OEL-SWEDEN: TWA 50 PPM (150 MG/M3), KTV 150 PPM (500 MG/M3), SKIN, JAN1999.
OEL-SWITZERLAND: MAK-W 50 PPM (160 MG/M3), SKIN, JAN1999.
NOHS 1974: HZD 80564; NIS 11; TNF 476; NOS 25; TNE 22461.
NOES 1983: HZD 80564; NIS 29; TNF 3507; NOS 40; TNE 44947; TFE 16837.
EPA GENETOX PROGRAM 1988, POSITIVE: ASPERGILLUS-ANEUPLOIDY; S CEREVISIAE GENE
CONVERSION.
American Type Culture Collection Emergency Telephone: (703) 365-2710 (24 hours)
P.O. Box 1549 Information Telephone: (703) 365-2704
Manassas, VA 20108 5 Chemtrec (800) 424-9300
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MATERIAL SAFETY DATA SHEET
EPA GENETOX PROGRAM 1988, NEGATIVE: SHE-CLONAL ASSAY; CELL TRANSFORM.-MOUSE
EMBRYO.
EPA GENETOX PROGRAM 1988, NEGATIVE: CELL TRANSFORM.-RLV F344 RAT EMBRYO.
EPA GENETOX PROGRAM 1988, NEGATIVE: D MELANOGASTER-WHOLE SEX CHROM. LOSS;
HOST-MEDIATED ASSAY.
EPA GENETOX PROGRAM 1988, NEGATIVE: N CRASSA-ANEUPLOIDY; E COLI POLA WITH S9.
EPA GENETOX PROGRAM 1988, NEGATIVE: HISTIDINE REVERSION-AMES TEST; IN VITRO SCE-
NONHUMAN.
EPA GENETOX PROGRAM 1988, NEGATIVE: D MELANOGASTER SEX-LINKED LETHAL.
EPA GENETOX PROGRAM 1988, INCONCLUSIVE: ASPERGILLUS-RECOMBINATION;
CARCINOGENICITY-MOUSE/RAT.
EPA GENETOX PROGRAM 1988, INCONCLUSIVE: D MELANOGASTER-RECIPROCAL
TRANSLOCATION.
EPA GENETOX PROGRAM 1988, INCONCLUSIVE: RODENT DOMINANT LETHAL; B SUBTILIS REC
ASSAY.
EPA GENETOX PROGRAM 1988, INCONCLUSIVE: E COLI POLA WITHOUT S9 EPA TSCA SECTION
8(B) CHEMICAL INVENTORY.
EPA TSCA SECTION 8(D) UNPUBLISHED HEALTH/SAFETY STUDIES EPA TSCA TEST SUBMISSION
(TSCATS) DATA BASE, JANUARY 2001.
SECTION 16. OTHER INFORMATION
THE ABOVE INFORMATION IS CORRECT TO THE BEST OF OUR KNOWLEDGE. ALL MATERIALS
AND MIXTURES MAY PRESENT UNKNOWN HAZARDS AND SHOULD BE USED WITH CAUTION.
THE USER SHOULD MAKE INDEPENDENT DECISIONS REGARDING THE COMPLETENESS OF THE
INFORMATION BASED ON ALL SOURCES AVAILABLE. ATCC SHALL NOT BE HELD LIABLE FOR
ANY DAMAGE RESULTING FROM HANDLING OR CONTACT WITH THE ABOVE PRODUCT.
铮? 2002 American Type Culture Collection.
ATCC铮? is a registered trademark of the American Type Culture Collection.
March 2002
American Type Culture Collection Emergency Telephone: (703) 365-2710 (24 hours)
P.O. Box 1549 Information Telephone: (703) 365-2704
Manassas, VA 20108 6 Chemtrec (800) 424-9300
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