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MATERIAL SAFETY DATA SHEET
SECTION 1 - SUBSTANCE IDENTITY AND COMPANY INFORMATION
Product Name: Chloramphenicol
ATCC Catalog Number: 60-2003
COMPANY INFORMATION: AMERICAN TYPE CULTURE COLLECTION
PO BOX 1549
MANASSAS, VA 20108
FOR INFORMATION CALL: 800-638-6597 or 703-365-2700
AFTER-HOURS CONTACT: 703-365-2710
CHEMTREC EMERGENCY: 800-424-9300 or 703-527-3887
SECTION 2 - COMPOSITION/INFORMATION ON INGREDIENTS
HAZARDOUS INGREDIENTS CAS NUMBER EC NUMBER (EINECS)
CHLORAMPHENICOL 56-75-7 200-287-4
SECTION 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW:
TOXIC.
MAY CAUSE CANCER.
MAY CAUSE HERITABLE GENETIC DAMAGE.
POSSIBLE RISK OF HARM TO THE UNBORN CHILD.
MAY CAUSE SENSITIZATION BY INHALATION AND SKIN CONTACT.
PROBABLE CARCINOGEN (US).
IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE IMMEDIATELY
(SHOW LABEL WHERE POSSIBLE).
WEAR SUITABLE PROTECTIVE CLOTHING, GLOVES AND EYE/FACE PROTECTION.
TARGET ORGANS:
RED BLOOD CELLS, BONE MARROW, NERVES, LIVER.
SECTION 4 - FIRST AID MEASURES
EYES: FLUSH WITH PLENTY OF WATER FOR AT LEAST 15 MINUTES. ASSURE ADEQUATE
FLUSHING BY SEPARATING THE EYELIDS WITH FINGERS. CALL A PHYSICIAN.
SKIN: IMMEDIATELY WASH SKIN WITH SOAP AND PLENTY OF WATER.
INGESTION: WASH OUT MOUTH WITH WATER AND SUPPLY 3 CUPFULS TO DRINK PROVIDED
PERSON IS CONSCIOUS. DO NOT INDUCE VOMITING. CALL A PHYSICIAN.
INHALATION: REMOVE TO FRESH AIR. IF BREATHING BECOMES DIFFICULT, CALL A
PHYSICIAN.
SECTION 5 - FIRE FIGHTING MEASURES
EXTINGUISHING MEDIA:
WATER SPRAY.
CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM.
SPECIAL FIREFIGHTING PROCEDURES:
WEAR SELF-CONTAINED BREATHING APPARATUS AND PROTECTIVE CLOTHING TO PREVENT
CONTACT WITH SKIN AND EYES.
UNUSUAL FIRE AND EXPLOSIONS HAZARDS:
EMITS TOXIC FUMES UNDER FIRE CONDITIONS.
SECTION 6 - ACCIDENTAL RELEASE MEASURES
WEAR SELF-CONTAINED BREATHING APPARATUS, RUBBER BOOTS AND HEAVY RUBBER
GLOVES.
WEAR DISPOSABLE COVERALLS AND DISCARD THEM AFTER USE.
SWEEP UP CAREFULLY TO AVOID CREATING AIRBORNE DUST.
PLACE IN A SUITABLE CONTAINER, SEAL, LABEL, AND HOLD FOR WASTE DISPOSAL.
VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE. EVACUATE.
SECTION 7 - HANDLING AND STORAGE
STORE AT ROOM TEMPERATURES (15 to 30 C). KEEP CONTAINER TIGHTLY CLOSED.
SECTION 8 - EXPOSURE CONTROLS/PERSONAL PROTECTION
USE ONLY IN A CHEMICAL FUME HOOD.
EYE WASH STATION AND DELUGE SHOWER.
WASH CONTAMINATED CLOTHING BEFORE REUSE.
WASH THOROUGHLY AFTER HANDLING.
DO NOT BREATHE DUST.
DO NOT GET IN EYES, MOUTH, ON SKIN, OR ON CLOTHING.
AVOID PROLONGED OR REPEATED EXPOSURE.
NIOSH/MSHA-APPROVED RESPIRATOR IN NONVENTILATED AREAS AND/OR FOR EXPOSURE
ABOVE THE ACGIH TLV. FOLLOW OSHA RESPIRATOR REGULATIONS 29 CFR 1910.134.
COMPATIBLE CHEMICAL-RESISTANT GLOVES.
CHEMICAL SAFETY GOGGLES.
SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES
APPEARANCE AND ODOR:
DRY WHITISH POWDER.
SECTION 10 - STABILITY AND REACTIVITY
INCOMPATIBILITIES:
ACIDS, ACID CHLORIDES, ACID ANHYDRIDES, AND OXIDIZING AGENTS.
HAZARDOUS COMBUSTION OR DECOMPOSITION PRODUCTS:
HYDROGEN CHLORIDE GAS, NITROGEN OXIDES,
CARBON MONOXIDE, CARBON DIOXIDE.
HAZARDOUS POLYMERIZATION:
WILL NOT OCCUR.
STABILITY:
STABLE UNDER NORMAL STORAGE AND HANDLING CONDITIONS.
SECTION 11 - TOXICOLOGICAL INFORMATION
ACUTE EFFECTS:
MAY CAUSE SKIN IRRITATION.
MAY BE HARMFUL IF ABSORBED THROUGH THE SKIN.
MAY CAUSE EYE IRRITATION.
MATERIAL MAY BE IRRITATING TO MUCOUS MEMBRANES AND UPPER RESPIRATORY TRACT.
MAY BE HARMFUL IF INHALED.
MAY BE HARMFUL IF SWALLOWED.
MAY CAUSE ALLERGIC RESPIRATORY REACTION.
MAY CAUSE ALLERGIC SKIN REACTION.
EXPOSURE CAN CAUSE NAUSEA, DIARRHEA, HEADACHE AND VOMITING.
CHRONIC EFFECTS:
THIS PRODUCT IS OR CONTAINS A COMPONENT THAT HAS BEEN REPORTED TO BE PROBABLY
CARCINOGENIC BASED ON ITS IARC (GROUP 2A), OSHA, ACGIH, NTP OR EPA CLASSIFICATION.
ANIMAL STUDIES INDICATE THAT REPRODUCTIVE EFFECTS MAY OCCUR.
TARGET ORGANS:
RED BLOOD CELLS, BONE MARROW, NERVES, LIVER.
RTECS #: AB6825000
TOXICITY DATA:
LD 50 - ORAL, MOUSE = 1500 MG/KG
LD 50 - ORAL, RAT = 2500 MG/KG
LD 50 - INTRAVENOUS, RAT = 171 MG/KG
TARGET ORGAN DATA:
BEHAVIORAL (DROWSY, CONVULSIONS, SEIZURE, ATAXIA, COMA)
CARDIAC (CARDIAC OUTPUT)
VASCULAR (BLOOD PRESSURE LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION)
VASCULAR (CHANGE IN PLASMA VOLUME OR BLOOD VOLUME, SHOCK)
LUNGS, THORAX OR RESPIRATION (CYANOSIS, OTHER CHANGES)
GASTROINTESTINAL (OTHER CHANGES)
LIVER (OTHER CHANGES)
BLOOD (HEMORRHAGE, EOSINOPHILIA, APLASTIC ANEMIA, LEUKEMIA)
CHANGES IN BONE MARROW NOT INCLUDED IN ABOVE)
SKIN AND APPENDAGES (AFTER SYSTEMIC EXPOSURE: DERMATITIS, ALLERGIC REACTION)
EFFECTS ON FERTILITY (OTHER MEASURES OF FERTILITY)
EFFECTS ON EMBRYO OR FETUS (CYTOLOGICAL CHANGES, FETOTOXICITY, FETAL DEATH)
SPECIFIC DEVELOPMENTAL ABNORMALITIES (CENTRAL NERVOUS SYSTEM, BODY WALL)
EFFECTS ON NEWBORN (BEHAVIORAL)
NUTRITIONAL AND GROSS METABOLIC (BODY TEMPERATURE DECREASE)
TUMORIGENIC (CARCINOGENIC BY RTECS CRITERIA)
ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES (RTECS) DATA IS
LISTED HEREIN. SEE ACTUAL ENTRY IN RTECS FOR MORE COMPLETE INFORMATION.
SECTION 12 - ECOLOGICAL INFORMATION
DATA NOT AVAILABLE.
SECTION 13 - DISPOSAL CONSIDERATIONS
CONTACT A LICENSED WASTE DISPOSAL SERVICE TO DISPOSE OF THIS MATERIAL.
OBSERVE ALL FEDERAL, STATE, AND LOCAL ENVIRONMENTAL REGULATIONS.
SECTION 14 - TRANSPORT INFORMATION
THIS PRODUCT CONTAINS NO HAZARDOUS SUBSTANCES AS DEFINED BY THE DEPARTMENT
OF TRANSPORTATION REGULATIONS, CODIFIED IN TITLE 49 CFR SECTION 171.8 AT
REPORTABLE QUANTITIES ACCORDING TO TABLE 1 OF APPENDIX A OF 49 CFR 搂172.101.
SCHEDULE B NUMBER: 2941.40.0000
SECTION 15 - REGULATORY INFORMATION
U.S. INFORMATION:
CALIF. PROP. 65 - CARCINOGEN.
EUROPEAN INFORMATION:
SYMBOL OF DANGER - T
TOXIC.
RISK PHRASES - 42/43; 45; 46; 63
MAY CAUSE SENSITIZATION BY INHALATION AND SKIN CONTACT.
MAY CAUSE CANCER.
MAY CAUSE HERITABLE GENETIC DAMAGE.
POSSIBLE RISK OF HARM TO THE UNBORN CHILD.
SAFETY PHRASES - 22; 24/25; 36/37/39; 45
DO NOT BREATHE DUST. AVOID CONTACT WITH SKIN AND EYES.
WEAR SUITABLE PROTECTIVE CLOTHING, GLOVES AND EYE/FACE PROTECTION.
IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE IMMEDIATELY
(SHOW LABEL WHERE POSSIBLE).
EXPOSURE LIMITS:
OEL-RUSSIA - STEL 1 MG/M3, JAN1993
SECTION 16 - OTHER INFORMATION
THE INFORMATION PRESENTED IN THIS DOCUMENT IS BELIEVED TO BE CORRECT BASED
UPON DATA AVAILABLE TO ATCC. USERS SHOULD MAKE AN INDEPENDENT DECISION
REGARDING THE ACCURACY OF THIS INFORMATION BASED ON THEIR NEEDS AND DATA
AVAILABLE TO THEM. ALL SUBSTANCES AND MIXTURES MAY PRESENT UNKNOWN
HAZARDS AND ALL NECESSARY SAFETY PRECAUTIONS SHOULD BE TAKEN. ATCC ASSUMES
NO LIABILITY RESULTING FROM USING OR COMING IN CONTACT WITH THIS SUBSTANCE.
茫 2002 American Type Culture Collection.
ATCC芒 is a registered trademark of the American Type Culture Collection.
July 2002
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