SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 03/20/2005
Date Updated: 04/04/2004
Version 1.3
Section 1 - Product and Company Information
Product Name INDOLE-3-ACETIC ACID, 98%
Product Number I3750
Brand ALDRICH
Company Sigma-Aldrich
Street Address 3050 Spruce Street
City, State, Zip, Country SAINT LOUIS MO 63103 US
Technical Phone: 314 771 5765
Emergency Phone: 414 273 3850 Ext. 5996
Fax: 800 325 5052
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
3-INDOLYLACETIC ACID 87-51-4 No
Formula C10H9NO2
Synonyms Indol-3-ylacetic acid * Acetic acid, indolyl- *
Heteroauxin * Hexteroauxin * IAA * 3-Iaa *
beta-Indoleacetic acid * beta-Indole-3-acetic
acid * 3-Indoleacetic acid *
alpha-Indol-3-yl-acetic acid * beta-Indolylacetic
acid * Indolyl-3-acetic acid * 3-Indolylacetic
acid * Kyselina 3-indolyloctova (Czech) *
Rhizopin * Rhizopon A * omega-Skatole carboxylic
acid
RTECS Number: NL3150000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Caution: Avoid contact and inhalation.
HMIS RATING
HEALTH: 1
FLAMMABILITY: 0
REACTIVITY: 0
NFPA RATING
HEALTH: 1
FLAMMABILITY: 0
REACTIVITY: 0
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If breathing becomes difficult,
call a physician.
DERMAL EXPOSURE
In case of contact, immediately wash skin with soap and copious
amounts of water.
EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
Section 5 - Fire Fighting Measures
FLASH POINT
N/A
AUTOIGNITION TEMP
N/A
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Emits toxic fumes under fire conditions.
Section 6 - Accidental Release Measures
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Exercise appropriate precautions to minimize direct contact with
skin or eyes and prevent inhalation of dust.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
Section 7 - Handling and Storage
HANDLING
User Exposure: Avoid inhalation. Avoid contact with eyes, skin,
and clothing. Avoid prolonged or repeated exposure.
STORAGE
Suitable: Keep tightly closed.
Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Wear dust mask.
Hand: Protective gloves.
Eye: Chemical safety goggles.
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GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
Section 9 - Physical/Chemical Properties
Appearance Physical State: Solid
Color: Light brown
Form: Powder
Property Value At Temperature or Pressure
Molecular Weight 175.19 AMU
pH N/A
BP/BP Range N/A
MP/MP Range 165 掳C
Freezing Point N/A
Vapor Pressure N/A
Vapor Density 5 g/l
Saturated Vapor Conc. N/A
SG/Density N/A
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
Partition Coefficient N/A
Decomposition Temp. N/A
Flash Point N/A
Explosion Limits N/A
Flammability N/A
Autoignition Temp N/A
Refractive Index N/A
Optical Rotation N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Insoluble.
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
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Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.
SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
TOXICITY DATA
Intraperitoneal
Mouse
150 MG/KG
LD50
CHRONIC EXPOSURE - CARCINOGEN
Species: Mouse
Route of Application: Subcutaneous
Dose: 2000 MG/KG
Exposure Time: 20W
Frequency: I
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Tumorigenic:Tumor types after systemic administration
not seen spontaneously.
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 4500 MG/KG
Route of Application: Oral
Exposure Time: (7-15D PREG)
Result: Specific Developmental Abnormalities: Craniofacial
(including nose and tongue).
Species: Rat
Dose: 450 MG/KG
Route of Application: Oral
Exposure Time: (7-15D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
Species: Mouse
Dose: 4500 MG/KG
Route of Application: Oral
Exposure Time: (7-15D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Effects on Embryo or Fetus: Fetal death.
Specific Developmental Abnormalities: Central nervous system.
Species: Mouse
Dose: 4500 MG/KG
Route of Application: Oral
Exposure Time: (7-15D PREG)
Result: Specific Developmental Abnormalities: Eye, ear. Specific
Developmental Abnormalities: Craniofacial (including nose and
tongue). Specific Developmental Abnormalities: Musculoskeletal
system.
CHRONIC EXPOSURE - MUTAGEN
Species: Human
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Dose: 100 NMOL/L
Cell Type: leukocyte
Mutation test: Other mutation test systems
Species: Human
Dose: 10 MG/L
Cell Type: lymphocyte
Mutation test: Sister chromatid exchange
Species: Mammal
Dose: 250 UMOL/L
Cell Type: lymphocyte
Mutation test: DNA damage
Section 12 - Ecological Information
No data available.
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: None
Non-Hazardous for Transport: This substance is
considered to be non-hazardous for transport.
IATA
Non-Hazardous for Air Transport: Non-hazardous for air
transport.
Section 15 - Regulatory Information
EU ADDITIONAL CLASSIFICATION
S: 22 24/25
Safety Statements: Do not breathe dust. Avoid contact with skin
and eyes.
US CLASSIFICATION AND LABEL TEXT
US Statements: Caution: Avoid contact and inhalation.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: No
TSCA INVENTORY ITEM: Yes
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: Yes
NDSL: No
Section 16 - Other Information
DISCLAIMER
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For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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