SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 03/20/2005
Date Updated: 03/07/2004
Version 1.3
Section 1 - Product and Company Information
Product Name PYROGALLOL, 99%, A.C.S. REAGENT
Product Number 254002
Brand ALDRICH
Company Sigma-Aldrich
Street Address 3050 Spruce Street
City, State, Zip, Country SAINT LOUIS MO 63103 US
Technical Phone: 314 771 5765
Emergency Phone: 414 273 3850 Ext. 5996
Fax: 800 325 5052
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
PYROGALLOL 87-66-1 No
Formula C6H6O3
Synonyms Benzene, 1,2,3-trihydroxy- * 1,2,3-Benzenetriol *
C.I. 76515 * C.I. Oxidation Base 32 * Fouramine
Brown AP * Fourrine PG * Fourrine 85 * Pyrogallic
acid * 1,2,3-Trihydroxybenzen (Czech) *
1,2,3-Trihydroxybenzene
RTECS Number: UX2800000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Corrosive.
Causes burns. Harmful by inhalation, in contact with skin and if
swallowed. May cause sensitization by skin contact. Limited
evidence of a carcinogenic effect. Harmful to aquatic organisms,
may cause long-term adverse effects in the aquatic environment.
Target organ(s): Blood. Kidneys.
HMIS RATING
HEALTH: 3*
FLAMMABILITY: 0
REACTIVITY: 1
NFPA RATING
HEALTH: 3
FLAMMABILITY: 0
REACTIVITY: 1
*additional chronic hazards present.
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
DERMAL EXPOSURE
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
Section 5 - Fire Fighting Measures
FLASH POINT
N/A
AUTOIGNITION TEMP
N/A
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Emits toxic fumes under fire conditions.
Section 6 - Accidental Release Measures
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
Section 7 - Handling and Storage
HANDLING
User Exposure: Avoid breathing dust. Do not get in eyes, on
skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Suitable: Keep tightly closed.
SPECIAL REQUIREMENTS
Handle and store under inert gas. Air and light sensitive.
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Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Safety shower and eye bath. Use only in a chemical fume hood.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Government approved respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
Other: Faceshield (8-inch minimum).
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Discard contaminated
shoes. Wash thoroughly after handling.
Section 9 - Physical/Chemical Properties
Appearance Physical State: Solid
Color: Faintly beige
Form: Fine crystals
Property Value At Temperature or Pressure
Molecular Weight 126.11 AMU
pH 5.8 Concentration: 10 g/l
BP/BP Range 309 掳C 760 mmHg
MP/MP Range 132 掳C
Freezing Point N/A
Vapor Pressure 10 mmHg 167.7 掳C
Vapor Density 4.4 g/l
Saturated Vapor Conc. N/A
SG/Density 1.45 g/cm3 20 掳C
Bulk Density 600 kg/l
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
Partition Coefficient N/A
Decomposition Temp. N/A
Flash Point N/A
Explosion Limits N/A
Flammability N/A
Autoignition Temp N/A
Refractive Index N/A
Optical Rotation N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Soluble.
Other Solvents: MOSTORGANIC SOLVENTS
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions of Instability: May discolor on exposure to air.
Materials to Avoid: Oxidizing agents.
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HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: Causes burns.
Skin Absorption: Harmful if absorbed through skin.
Eye Contact: Causes burns.
Inhalation: Harmful if inhaled. Material is extremely
destructive to the tissue of the mucous membranes and upper
respiratory tract.
Ingestion: Harmful if swallowed.
SENSITIZATION
Skin: May cause allergic skin reaction.
TARGET ORGAN(S) OR SYSTEM(S)
Blood. Liver. Kidneys.
SIGNS AND SYMPTOMS OF EXPOSURE
Studies in animals have shown edema and hyperemia of the lungs,
moderate fatty degeneration, round cell infiltration, and
necrosis of the liver. The kidney showed hyperemia, necrosis of
the epithelium, granular pigmentation, and glomerular nephritis.
The heart showed separation of fibers of the myocardium,
interfibrillary hemorrhages, infiltration of the endocardium,
lesions of the endothelium, and fibrinous deposits in the
valves. Changes in bone marrow and myeloid changes in the spleen
were observed. Changes in muscle included the disappearance of
nuclei in striated muscle, loss of striation, and the swelling
of the muscle plasma which coagulates and decomposes. Symptoms
of exposure may include burning sensation, coughing, wheezing,
laryngitis, shortness of breath, headache, nausea, and vomiting.
Absorption into the body leads to the formation of methemoglobin
which in sufficient concentration causes cyanosis. Onset may be
delayed 2 to 4 hours or longer.
CONDITIONS AGGRAVATED BY EXPOSURE
Pyrogallol has a tremendous affinity for oxygen of the blood
causing death by respiratory failure. Intoxication signs are
vomiting, hypothermia, weakness, muscular incoordination, fine
tremores, loss of reflexes, diarrhea, and coma.
TOXICITY DATA
Oral
Human
28 mg/kg
LDLO
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Lungs, Thorax, or Respiration:Dyspnea. Gastrointestinal:Other
changes.
Subcutaneous
Man
120 MG/KG
LDLO
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Remarks: Behavioral:Convulsions or effect on seizure threshold.
Behavioral:Excitement. Gastrointestinal:Changes in structure or
function of salivary glands.
Oral
Mouse
300 mg/kg
LD50
Intraperitoneal
Mouse
400 MG/KG
LD50
Subcutaneous
Mouse
566 MG/KG
LD50
Oral
Rabbit
1600 mg/kg
LD50
Remarks: Gastrointestinal:Gastritis. Lungs, Thorax, or
Respiration:Chronic pulmonary edema.
Oral
Bird (wild)
75 mg/kg
LD50
IRRITATION DATA
Skin
Rabbit
2 mg
24H
Remarks: Severe irritation effect
Eyes
Rabbit
20 mg
24H
Remarks: Moderate irritation effect
CHRONIC EXPOSURE - CARCINOGEN
Species: Rat
Route of Application: Subcutaneous
Dose: 3950 MG/KG
Exposure Time: 58W
Frequency: I
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Tumorigenic:Tumors at site or application.
CHRONIC EXPOSURE - MUTAGEN
Species: Mouse
Route: Intraperitoneal
Dose: 252 MG/KG
Mutation test: Micronucleus test
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Species: Mouse
Route: Oral
Dose: 504 MG/KG
Mutation test: Micronucleus test
Species: Mouse
Route: Intraperitoneal
Dose: 100 UMOL/KG
Mutation test: Cytogenetic analysis
Species: Hamster
Dose: 50 UMOL/L
Cell Type: lung
Mutation test: Micronucleus test
Species: Hamster
Dose: 100 MG/L
Cell Type: ovary
Mutation test: Cytogenetic analysis
Species: Hamster
Dose: 25 UMOL/L
Cell Type: lung
Mutation test: Sister chromatid exchange
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 3 GM/KG
Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetotoxicity (except death, e.g.,
stunted fetus).
Species: Rat
Dose: 5 MG/KG
Route of Application: Subcutaneous
Exposure Time: (1D PRE)
Result: Maternal Effects: Ovaries, fallopian tubes.
Section 12 - Ecological Information
ACUTE ECOTOXICITY TESTS
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 24 h
Value: 47.8 mg/l
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 24 h
Value: 10 - 35 mg/l
Test Type: LC50 Fish
Species: Brachydanio rerio
Time: 96 h
Value: 41.8 mg/l
Section 13 - Disposal Considerations
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APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: Toxic solids, organic, n.o.s.
UN#: 2811
Class: 6.1
Packing Group: Packing Group III
Hazard Label: Toxic substances.
PIH: Not PIH
IATA
Proper Shipping Name: Toxic solid, organic, n.o.s.
IATA UN Number: 2811
Hazard Class: 6.1
Packing Group: III
Section 15 - Regulatory Information
EU DIRECTIVES CLASSIFICATION
Symbol of Danger: Xn
Indication of Danger: Harmful.
R: 20/21/22 52/53 68
Risk Statements: Harmful by inhalation, in contact with skin and
if swallowed. Harmful to aquatic organisms, may cause long-term
adverse effects in the aquatic environment. Possible risk of
irreversible effects.
S: 36/37 61
Safety Statements: Wear suitable protective clothing and gloves.
Avoid release to the environment. Refer to special
instructions/safety data sheets.
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Corrosive.
Risk Statements: Causes burns. Harmful by inhalation, in contact
with skin and if swallowed. May cause sensitization by skin
contact. Limited evidence of a carcinogenic effect. Harmful to
aquatic organisms, may cause long-term adverse effects in the
aquatic environment.
Safety Statements: In case of accident or if you feel unwell,
seek medical advice immediately (show the label where possible).
In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice. Wear suitable protective
clothing, gloves, and eye/face protection. Do not breathe dust.
US Statements: Target organ(s): Blood. Kidneys.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: No
TSCA INVENTORY ITEM: Yes
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: Yes
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NDSL: No
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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