BASF Corporation
MATERIAL SAFETY DATA SHEET
Date prepared: March 23, 2004 page 1 of 7
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1. Product and Company Identification
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PRODUCT IDENTIFIER: Methoxydiethylborane
SYNONYMS: Methoxydiethylborane (MDEB)
PRODUCT USE: Chemical intermediate
MANUFACTURED BY: BASF Corporation
1424 Mars-Evans City Road
Evans City, PA 16033
Customer Service: 1-866-4BORANES (24-Hour Telephone: 1-724-538-3510)
Transportation Emergency: 1-800-424-9300 in USA or 1-703-527-3887
BASF HOTLINE 24-Hour Emergency Response Information: 1-800-832-HELP
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2. Composition/Information on Ingredients
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wt% Synonym(s)
Methoxydiethylborane (CASRN: 7397-46-8) >99 wt% MDEB, diethylmethoxyborane
Dimethoxyethylborane (CASRN: not found) < 0.5 wt%
Trimethoxyborane (CASRN: 121-43-7) < 0.5 wt% Trimethylborate, Methyl borate
OSHA REGULATORY STATUS: Hazardous by definition of Hazard Communication Standard, 29 CFR
1910.1200.
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3. Hazards Identification
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Indications of danger (Annex II): Highly flammable (F), Corrosive (C)
Nature of special risk attributed to dangerous substances (Annex III): R17, R35, R52/53
Safety advice concerning dangerous chemical substances (Annex IV): S6.1, S36/37/39, S26, S28.2,
S43.4, S45, S61
EMERGENCY OVERVIEW: Clear to slightly amber liquid with pungent odor. Pyrophoric liquid.
Extremely flammable. Catches fire if exposed to air. Causes severe eye, skin, and respiratory tract
burns. Vapor may cause respiratory tract irritation and central nervous system effects such as excitation.
Violent runaway reactions may occur with alcohols in the presence of an acid catalyst.
PHYSICAL HAZARDS: Pyrophoric liquid. Extremely flammable. Catches fire if exposed to air. Violent
runaway reactions may occur with alcohols in the presence of an acid catalyst.
POTENTIAL HEALTH EFFECTS: Causes eye, skin, and respiratory tract burns.
Primary Routes of Entry: Eye and skin contact, inhalation
Target Organs: Eyes, skin, respiratory tract
Medical Conditions Generally Recognized as Aggravated by Exposure: Persons with preexisting
skin and respiratory conditions may be more susceptible to the effects of this product.
Carcinogenicity: Methoxydiethylborane is not listed in the National Toxicology Program (NTP)
Annual Report on Carcinogens, not found to be a potential carcinogen in the
International Agency for Research on Cancer (IARC) Monographs, and not listed as an
OSHA carcinogen.
Methoxydiethylborane
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POTENTIAL ENVIRONMENTAL EFFECTS: Dangerous to the environment per EU guidelines. See
Section 12.
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4. First Aid Measures
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CAUSES THERMAL BURNS! SEND TO A PHYSICIAN IN ALL CASES.
Eyes: Immediately flush eyes with plenty of water for at least 20 minutes while holding eyelids open.
Skin: Immediately flush skin with plenty of cool water for at least 20 minutes while removing contaminated
clothing and shoes. Dispose of contaminated clothing and shoes in compliance with all local, state, and
federal laws and regulations.
Ingestion: For any accidental contamination of the mouth, gargle with water and rinse mouth thoroughly
for at least 20 minutes. If swallowed, do not induce vomiting. Give demulcent such as milk, olive oil, or
margarine in small amounts up to 2 or 3 ounces. Never give anything by mouth to an unconscious
person.
Inhalation: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give
oxygen.
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5. Fire Fighting Measures
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FLAMMABLE PROPERTIES: Pyrophoric liquid. Extremely flammable. Catches fire if exposed to air.
After adding to celite, ignition was observed after 95 seconds. The substance burned with a
green/yellow/orange flame for about 145 seconds.
Flashpoint (Setaflash closed cup): below 7掳C/45掳F
Flammable Limits: Spontaneous ignition in air
Autoignition Temperature: Spontaneous ignition in air
EXTINGUISHING MEDIA: Shut off source as soon as possible without risk. Control and confine the fire.
Use water spray to control heat and protect equipment. If practical, allow fire to burn itself out.
Temporary control may be obtained with foam, water spray, dry chemical, or carbon dioxide; but MDEB
may reignite when extinguisher is discontinued. DO NOT use halogenated fire extinguishing agents.
UNUSUAL FIRE AND EXPLOSION HAZARDS: Catches fire if exposed to air. Detonations or violent
reactions may occur when mixed with strong oxidizing agents or halogenated hydrocarbons. From the
structural formula it can be concluded that MDEB is not explosive. MDEB contains no chemically
unstable or highly energetic groups that might lead to an explosion. MDEB floats on water and use of
water as an extinguishing agent may spread the fire. MDEB burns with a green and yellow flame and
produces a dense black smoke. Containers can buildup pressure if exposed to heat.
PROTECTION OF FIRE FIGHTERS: Wear full protective clothing, including protective gloves and boots.
For respiratory protection, wear a NIOSH approved self-contained breathing apparatus with full
facepiece operated in a positive-pressure mode.
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6. Accidental Release Measures
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PROCEDURES FOR CLEANUP: Wear recommended personal protective equipment. Be prepared to
fight fire. Eliminate ignition sources. Spills of MDEB will ignite. See Section 5, "Fire Fighting Measures".
Properly dispose of all residues immediately. Handle in compliance with all local, state, and federal laws
and regulations.
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7. Handling And Storage
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HYGIENIC PRACTICES: Do not get in eyes, on skin, or on clothing. Wash thoroughly after handling.
Keep container tightly closed. Do not breathe vapor or mist. Use only with adequate ventilation. Do not
take internally.
STORAGE: Store in a cool dry place. Do not expose to air. Handle and store in a DRY closed system
under DRY nitrogen gas. Do not store residues. Properly dispose of all residues immediately.
Methoxydiethylborane
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WORK PRACTICES: Keep away heat, sparks, flame, air, oxidizers, halogenated hydrocarbons, and
combustible materials. Do not expose to air. Handle and store in a DRY closed system under DRY
nitrogen gas in a cool, dry, well-ventilated area. Use only with clean, completely enclosed systems that
have been purged with DRY nitrogen gas to inert containers, transfer lines, vessels, tanks, etc., such that
the atmosphere stays below 3% oxygen. Use packless valves, welded piping, and other leakproof
construction. Maintain a leakproof system. Use non-sparking tools when opening or closing containers.
Bond and ground all systems when handling. Since empty containers retain product residue, follow label
warnings even after container is emptied.
PROTECTIVE MEASURES DURING REPAIR AND MAINTENANCE OF CONTAMINATED
EQUIPMENT: See Section 8.
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8. Exposure Controls/Personal Protection
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ENGINEERING CONTROLS: Maintain a leakproof system. Use packless valves, welded piping, and
other leakproof construction. Use only with clean, completely enclosed systems that have been
thoroughly purged with DRY nitrogen gas including containers, transfer lines, vessels, tanks, etc., such
that the atmosphere stays below 3% oxygen. Handle in a DRY closed system under DRY nitrogen gas.
Provide adequate local exhaust ventilation to minimize worker exposure. Prevent electrostatic charge
buildup by using common bonding and grounding techniques.
EXPOSURE CONTROLS: None established for MDEB.
PERSONAL PROTECTIVE EQUIPMENT:
Normal Use & Handling: When exposure to eyes and skin is possible, wear chemical protective goggles
with a faceshield
and flame-retardant protective clothing. Glove permeation data does not exist for this product. Exposure
limits have not been established for Methoxydiethylborane. When inhalation of vapor or mist is possible,
wear a NIOSH-approved self-contained breathing apparatus with full facepiece operated in a positive-
pressure mode. Eye wash and safety showers must be available and in good working order.
Emergency Handling: For firefighting, wear full protective clothing, including protective gloves and boots.
For chemical spills, wear special protective clothing (vapor-protective suit with additional chemical flash
fire escape protection, as specified in NFPA 1991). For respiratory protection, wear a NIOSH-approved
self-contained breathing apparatus with full facepiece operated in a positive-pressure mode.
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9. Physical And Chemical Properties
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APPEARANCE: Clear to slightly amber liquid
ODOR: Unique, sweet odor
RELATIVE DENSITY: 0.76 @ 20掳C
DENSITY: 0.75 g/ml @ 23掳C
MELTING/FREEZING TEMPERATURE: <-80掳C (in testing, MDEB has solidified between -24掳C and -
81掳C)
BOILING TEMPERATURE: ~90掳C at 101.3kPa (estimate based on vapor pressure)
VAPOR PRESSURE: 8359 Pa @ 26.21掳C (estimate)
SURFACE TENSION: 73.6 mN/m @ 20掳C (concentration 1003 mg/l)
WATER SOLUBILITY: <7.6 mg/l @19掳C at pH~5.6 (solubility estimated by visual observation)
WATER REACTIVITY: Reacts slowly
AIR REACTIVITY: Catches fire if exposed to air
MOLECULAR WEIGHT: 99.9
FORMULA: CH3OB(CH2CH3)2
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10. Stability And Reactivity
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STABILITY (CONDITIONS TO AVOID): Stable if stored and handled as recommended. Keep away from
heat, sparks, and flame.
Methoxydiethylborane
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INCOMPATIBILITY (SPECIFIC MATERIALS TO AVOID): Air, oxidizers, halogenated hydrocarbons,
organic peroxides
HAZARDOUS DECOMPOSITION PRODUCTS: Carbon monoxide, carbon dioxide, boron compounds
HAZARDOUS POLYMERIZATION: Not expected to occur.
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11. Toxicological Information
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MDEB is pyrophoric (although it may not catch fire immediately upon exposure to air) and exposure
can cause eye, skin, and mucous membrane burns.
MDEB was administered orally to Wistar rats in a fixed dose procedure. Results of the preliminary
sighting study are as follows:
(1) 2000 mg/kg (2M/2F tested): The two males died on day 1 and the two females were killed in
extremis within two hours after dosing. Effects noted were: spasms (2M/2F); pale skin (2M),
salivation 2(M). Macroscopic findings were: (1) males: stomach: hemorrhage (glandular
mucosa); thickened, red-brown forestomach; liver: gray-white discoloration, (2) females: same
as males, in addition: red-brown discolored lungs and hemorrhage of the left side cortex of the
adrenal glands.
(2) 500 mg/kg (1M/1F tested): The male and female died within 24 hours after dosing. Effects
noted were: lethargy (1M); spasm (1M/1F), ventro-lateral recumbency (1M); uncoordinated
movements (1M/1F). Macroscopic findings were: (a) male: enlarged stomach, and, (b) female:
dark red discoloration of the glandular mucosa of the stomach and a thickened forestomach.
(3) 50 mg/kg (1M/1F tested): No mortality occurred. Effects noted were: lethargy (M/F);
hunched posture (M/F); uncoordinated movements (M/F); piloerection (M/F). No macroscopic
findings were noted.
As no mortality occurred at 50 mg/kg in the preliminary sighting study, the main study was conducted
with a fixed dose of 50 mg/kg body weight administered to five rats of each sex. The only signs of toxicity
were hunched posture and uncoordinated movements noted in all animals on day 1.
Skin sensitization studies using Himalayan guinea pigs gave equivocal results; however, in view of the
slight irritation seen after epidermal exposure at the induction stage, the substance is not considered to
be a sensitizer.
In 28-day sub-acute toxicity testing of MDEB, no toxic effects were observed at 25 mg/kg/day.
At 125 mg/kg/day, all animals died or were killed in extremis between day 9 and 10 of treatment. Prior
to death or sacrifice, hunched posture or pale skin was observed among males and lethargy, ventro-
lateral recumbency, hunched posture, uncoordinated movements, pale skin, quick breathing, ptosis,
and/or piloerection were observed in all females. Body weights and food consumption reduced in week
1. Macroscopic post mortem examination of the animals revealed changes in the stomach, liver, kidneys,
adrenal glands, spleen, mesenteric lymph node, and lungs. Microscopic correlations to the findings noted
at macroscopic examination were found in the stomach (hyperplasia with hyperkeratosis, inflammation),
liver (vacuolation, hypertrophy, pigment deposits (bile ducts)), coagulative kidneys (tubular degeneration,
females only), spleen (hemopoiesis), mesenteric lymph nodes (hyperplasia)and adrenal glands
(vacuolation of cortex).
The animals receiving 125 mg/kg/day showed very rapid deterioration after the first clinical signs
appeared on day 6.
No mechanism can be proposed for the variety of alterations, but the hepatic changes such as
vacuolation, hypertrophy, and pigment deposits, are considered to play a central role in the toxicity of the
substance. Moreover, vacuolation of the adrenal cortex may lead to depletion of mineralcorticoids and
glucocorticoids, resulting in sodium imbalance and deregulated glucose metabolism, which may lead to
death.
At 25 mg/kg/day only slightly low body weights were found in females in week 4. Laboratory findings
indicated a decrease in erythrocyte cell count, hemoglobin, and hematocrit in females only.
In rats receiving 25 mg/kg/day, only minimal changes were found in body weight and erythrocyte
parameters. No morphologic findings indicative of toxicity were detected microscopically in these
animals. Therefore, a definitive No Observed Adverse Effect Level (NOAEL) of 25 mg/kg/day was
concluded.
At 5 mg/kg/day, no treatment-related findings were noted.
In mutagenicity testing: MDEB gave negative results in Ames testing with and without metabolic
activation. However, in vitro mammalian cytogenicity testing with and without metabolic activation was
Methoxydiethylborane
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classified as positive on the basis of the increase in the number of cells with chromosome aberrations at
the highest, cytotoxic, concentrations of 560 碌g/ml and 750 碌g/ml.
The water solubility of the substance is very low (<7.6 mg/l at 19掳C), and should be considered a
possible rate-limiting factor for the absorption of the compound from the gastro-intestinal tract. Solubility
might be increased by the low pH in the stomach, which then may result in an increased absorption.
Because of the lipophilicity of the substance, it is to be expected that the oral bioavailability will be higher
when the compound is ingested together with food.
Because of the rapid decomposition in water, it is also expected that the substance will be rapidly
decomposed in body fluids such as the gastro-intestinal fluids. Because of the acid environment in the
stomach, this reaction may be even more aggressive. Consequently, besides the possible immediate
toxic local effect of the decomposition reaction, the intestinal and systemic toxicity after administration of
the substance will probably be related to the reaction products methanol, formic acid, and diethylboronic
acid. These reaction products of the substance are expected to be easily metabolized and excreted via
urine or bile.
Since it is generally accepted that a substance with low Po/w ranging from 0.1 to 6 penetrate the skin
easily, it is to be expected that the substance will be absorbed to some extent through the skin.
Taking into account the available physico-chemical data, it is expected that the substance will have a
relatively short elimination half-life in the body.
Based on the expected kinetic behavior in the body, as described above, the substance will not
accumulate in the body after prolonged exposure.
Administration of samples of undiluted MDEB and any of the dilutions of 200 and/or 10mg/ml in
propylene glycol on freshly prepared non-living animal skin via open or occlusive application did not result
in any physico-chemical reaction.
After open application, no biological reactions in the skin were observed in response to the three
concentrations used. The white discoloration, noted during the observation period, after exposure to the
undiluted test substance is an optical effect likely due to (rapid) evaporation and not related to a biological
effect in the skin tissue. Occlusive administration of undiluted MDEB for two hours to a sacrificed, intact
guinea pig, caused corrosion of the skin as observed after removal of the bandages. The skin site
treated with a 200 mg/ml solution showed no visible change as assessed in situ. After excision of the
treated skin, slight effects (a yellowish discoloration of the subcutis) were observed with a 200 mg/ml
solution. The intradermal injections of different concentrations made in the guinea pig showed a dose-
response relationship as a gradual increase of the diameter of the necrosis with increasing
concentrations. At higher concentrations, the maximum diameter of the necrosis was found within 15
minutes after treatment. An increase of the diameter of necrosis after injection of a 10 mg/ml was
observed from <3 mm after 15 minutes to +5 mm after 2 hours.
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12. Ecological Information
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ECOLOGICAL DATA:
In the study with Selenastrum capricornutum, MDEB affected cell growth significantly at nominal
concentrations of 10 mg/l and higher. The EC50 for cell growth inhibition (EBC50: 0-72 hours) was 22
mg/l with a 95% confidence interval ranging from 18 to 27 mg/l. The EC10 for cell growth inhibition
(EBC10: 0-72 hours) was 6.3 mg/l with a 95% confidence interval ranging from 4.0 to 8.4 mg/l. The EC50
growth rate reduction increased from 42 mg/l (ERC50: 0-48 hours) to 190 mg/l which was beyond the
range tested. The EC10 for growth rate reduction (ERC10: 0-72 hours) was 12mg/l (95%-confidence
interval: 10-15 mg/l). Hence, algal growth recovered during the 72-hour period, probably due to
hydrolysis of the MDEB concentrations. The NOEC corresponded with 6.4 mg/l for both cell growth
inhibition and growth rate reduction.
Acute toxicity study of MDEB in Daphnia magna demonstrated that MDEB induced no effects in
Daphnia magna exposed to 100 mg/l, the maximum concentration tested.
MDEB was tested for its ready biodegradability in the closed bottle test at 2 and 5 mg/l. The
theoretical oxygen demand of MDEB was calculated to be 2.48 mg O2 per mg. The relative
biodegradation values calculated from the O2 measurements performed during the test period of 28 days
revealed significant degradation of MDEB at both concentrations. A plateau of degradation was reached
within 7 days. Degradation varied between 31 and 41% for the lowest concentration, and between 29
and 39% for the highest concentration. Thus, biodegradation of at least 60% was not reached within 10
days of biodegradation exceeding 10%. In conclusion, MDEB was not readily biodegradable under the
conditions in the closed bottle test performed.
Methoxydiethylborane
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13. Disposal Considerations
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WASTE DISPOSAL: Do not flush to sewer. Dispose in compliance with all local, state, and federal laws
and regulations.
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14. Transport Information
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UPS and air shipments are forbidden.
HAZARDOUS MATERIALS/DANGEROUS GOODS CLASSIFICATION:
Proper Shipping Name: Pyrophoric liquid, organic, n.o.s. (methoxydiethylborane)
Hazard Class: 4.2
Packaging Group: I
Identification Number: UN2845
Labels: Spontaneously combustible
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15. Regulatory Information
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TSCA: Methoxydiethylborane is listed on the TSCA Public Inventory.
SARA 313 INFORMATION: Methoxydiethylborane does not contain a toxic chemical or chemicals
subject to the reporting requirements of section 313 of Title III of the Superfund Amendments and
Reauthorization Act of 1986 and 40 CFR 372.
CERCLA/SUPERFUND: Contains no CERCLA Extremely Hazardous Substances.
EINECS: Methoxydiethylborane is not listed on EINECS; however, it is on ELINCS.
EUROPEAN LABEL INFORMATION:
Symbols: F, C
Indications of danger (Annex II): Highly flammable, Corrosive
Nature of special risk attributed to dangerous substances (Annex III):
R17 Spontaneously combustible in air.
R35 Causes severe burns.
R52/53 Harmful to aquatic organisms, may cause long-term adverse effects in aquatic
environment.
Safety advice concerning dangerous chemical substances (Annex IV):
S6.1 Keep under nitrogen.
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection.
S26 In case of contact with eyes, rinse immediately with plenty of water and seek
medical advice.
S28.2 After contact with skin, wash immediately with plenty of water.
S43.4 In case of fire, use extinguishing powder or sand.
S45 In case of accident or if you feel unwell, seek medical advice immediately (show
the label where possible).
S61 Avoid release to the environment. Refer to special instructions/Safety data
sheets.
NEW JERSEY: This product does not contain a chemical listed on the New Jersey Department of Health
Hazard Right-to-Know Program Hazardous Substance List.
PENNSYLVANIA: This product does not contain a chemical subject to the Pennsylvania Worker and
Community Right-to-Know Act.
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16. Other Information
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MSDS STATUS: Revised Sections 1, 3, 15, and 16.
Methoxydiethylborane
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IMPORTANT: WHILE THE DESCRIPTIONS, DESIGNS, DATA AND INFORMATION CONTAINED HEREIN ARE PRESENTED
IN GOOD FAITH AND BELIEVED TO BE ACCURATE, IT IS PROVIDED FOR YOUR GUIDANCE ONLY. BECAUSE MANY
FACTORS MAY AFFECT PROCESSING OR APPLICATION/USE, WE RECOMMEND THAT YOU MAKE TESTS TO
DETERMINE THE SUITABILITY OF A PRODUCT FOR YOUR PARTICULAR PURPOSE PRIOR TO USE. NO WARRANTIES
OR ANY KIND, EITHER EXPRESSED OR IMPLIED, INCLUDING WARRANTIES OF MERCHANTABILITY OR FITNESS FOR
A PARTICULAR PURPOSE, ARE MADE REGARDING PRODUCTS DESCRIBED OR DESIGNS, DATA OR INFORMATION
SET FORTH, OR THAT THE PRODUCTS, DESIGNS, DATA OR INFORMATION MAY BE USED WITHOUT INFRINGING THE
INTELLECTUAL PROPERTY RIGHTS OF OTHERS. IN NO CASE SHALL THE DESCRIPTIONS, INFORMATION, DATA OR
DESIGNS PROVIDED BE CONSIDERED A PART OF OUR TERMS AND CONDITION OF SALE. FURTHER, YOU
EXPRESSLY UNDERSTAND AND AGREE THAT THE DESCRIPTIONS, DESIGNS, DATA, AND INFORMATION FURNISHED
BY BASF HEREUNDER ARE GIVEN GRATIS AND BASF ASSUMES NO OBLIGATION OR LIABILITY FOR THE
DESCRIPTION, DESIGNS, DATA AND INFORMATION GIVEN OR RESULTS OBTAINED, ALL SUCH BEING GIVEN AND
ACCEPTED AT YOUR RISK.
漏 2004
file: MDEB-MSDS-ANSI-98-R2-BASF
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