Kit components
03/13/2002
Product code Description
459220 CYP2B6/EFC High Throughput InhibitorScreening
InhibitorScreening
459220a CYP2B6 + P450 Reductase + Cytochrome b5
459220b Control Insect Cell Membrane Protein
459220c Buffer Solution: 0.5M Potssium Phosphate
459220d Stop Solution: 0.5M Tris Base
459220e Cofactors
459220f Glucose 6-Phosphate Dehydrogenase
459220g EFC (7-Ethoxy-4-trifluoromethylcoumarin)
459220h TCP (Tranylcypromine)
459220i HFC (7-Hydroxytrifluoromethylcoumarin)
Page 1/4
Material Safety Data Sheet
According to 91/155 EC
Printing date 13.03.2002 Reviewed on 13.03.2002
1 Identification of substance:
路 Product details:
路 Trade name: CYP2B6 + P450 Reductase + Cytochrome b5
(CYP2B6/EFC High Throughput Inhibitor Screening)
路 Article number: 459220
路 Manufacturer/Supplier:
Becton Dickinson Biosciences Centralized European Office
Regulatory Compliance Department
Denderstraat 24
9320 Erembodegem-AALST
Belgium
Tel: 32 53 720402
路 Further information obtainable from: Technical Service Representative
路 Information in case of emergency: Tel: 32 53 720402
2 Composition/Data on components:
路 Chemical characterization
路 Description: Mixture of substances listed below with nonhazardous additions.
路 Dangerous components: Void
3 Hazard identification
路 Hazard description:
This product contains no hazardous constituents, or the concentration of all chemical constituents are
below the regulatory threshold limits described by the Occupational Safety and Health Administration
Hazard Communication Standard or European Directive 91/155/EEC, and 93/112/EC.
路 Classification system
The classification is according to the latest editions of the EU-lists, and extended by company and
literature data.
4 First aid measures
路 General information No special measures required.
路 After inhalation Seek medical treatment in case of complaints.
路 After skin contact Immediately wash with water and soap and rinse thoroughly.
路 After eye contact
Rinse opened eye for several minutes under running water. If symptoms persist, consult a doctor.
路 After swallowing If symptoms persist consult doctor.
5 Fire fighting measures
路 Suitable extinguishing agents
CO2, powder or water spray. Fight larger fires with water spray or alcohol resistant foam.
路 Protective equipment: No special measures required.
EU
(Contd. on page 2)
DR
Page 2/4
Material Safety Data Sheet
According to 91/155 EC
Printing date 13.03.2002 Reviewed on 13.03.2002
Trade name: CYP2B6 + P450 Reductase + Cytochrome b5
(CYP2B6/EFC High Throughput Inhibitor Screening)
(Contd. of page 1)
6 Accidental release measures
路 Person-related safety precautions: Wear protective equipment. Keep unprotected persons away.
路 Measures for environmental protection: Damp down dust with water spray.
路 Measures for cleaning/collecting:
Absorb with liquid-binding material (sand, diatomite, acid binders, universal binders, sawdust).
路 Additional information: No dangerous substances are released.
7 Handling and storage
路 Handling
路 Information for safe handling: No special measures required.
路 Information about fire - and explosion protection: No special measures required.
路 Storage
路 Requirements to be met by storerooms and receptacles: -80 C
路 Information about storage in one common storage facility: Store away from oxidizing agents.
路 Further information about storage conditions: None.
路 Storage class
路 Class according to regulation on flammable liquids: Void
8 Exposure controls and personal protection gear
路 Additional information about design of technical facilities: No further data; see item 7.
路 Ingredients with limit values that require monitoring at the workplace:
The product does not contain any relevant quantities of materials with critical values that have to be
monitored at the workplace.
路 Additional information: The lists valid during the making were used as basis.
路 Personal protective equipment
路 General protective and hygienic measures
The usual precautionary measures are to be adhered to when handling chemicals.
路 Respiratory protection: Not required.
路 Protection of hands:
Protective gloves.
路 Eye protection: Safety glasses
路 Body protection: Protective work clothing.
9 Physical and chemical properties:
Liquid
路 Form:
Brown
路 Colour:
Characteristic
路 Odour:
(Contd. on page 3)
EU
DR
Page 3/4
Material Safety Data Sheet
According to 91/155 EC
Printing date 13.03.2002 Reviewed on 13.03.2002
Trade name: CYP2B6 + P450 Reductase + Cytochrome b5
(CYP2B6/EFC High Throughput Inhibitor Screening)
(Contd. of page 2)
路 Change in condition
Melting point/Melting range: Not determined
Boiling point/Boiling range: Not determined
Not applicable
路 Flash point:
Product is not selfigniting.
路 Self-igniting:
Product does not present an explosion hazard.
路 Danger of explosion:
Not applicable
路 Vapour pressure:
Not determined
路 Density:
路 Solubility in / Miscibility with
Soluble
Water:
Not applicable
路 pH-value:
10 Stability and reactivity
路 Thermal decomposition / conditions to be avoided:
No decomposition if used according to specifications.
路 Materials to be avoided: Incompatible material: strong oxidizers.
路 Dangerous reactions No dangerous reactions known
路 Dangerous decomposition products: No dangerous decomposition products known
11 Toxicological information
路 Acute toxicity:
路 Primary irritant effect:
路 on the skin: No irritant effect.
路 on the eye: No irritating effect.
路 Sensitization: No sensitizing effects known.
路 Additional toxicological information:
The product is not subject to classification according to the calculation method of the General EU
Classification Guidelines for Preparations as issued in the latest version.
When used and handled according to specifications, the product does not have any harmful effects to
our experience and the information provided to us.
12 Ecological information:
路 Ecotoxical effects:
路 Other information:
The ecological effects have not ben thoroughly investigated, but currently none have been identified.
路 General notes: Generally not hazardous for water.
EU
(Contd. on page 4)
DR
Page 4/4
Material Safety Data Sheet
According to 91/155 EC
Printing date 13.03.2002 Reviewed on 13.03.2002
Trade name: CYP2B6 + P450 Reductase + Cytochrome b5
(CYP2B6/EFC High Throughput Inhibitor Screening)
(Contd. of page 3)
13 Disposal considerations
路 Product:
路 Recommendation
Must be specially treated adhering to official regulations.
Smaller quantities can be disposed of with household waste.
路 Uncleaned packaging:
路 Recommendation: Disposal must be made according to official regulations.
路 Recommended cleansing agents: Water, if necessary together with cleansing agents.
14 Transport information
路 Land transport ADR/RID (cross-border)
路 ADR/RID class: -
路 Maritime transport IMDG:
-
路 IMDG Class:
路 Marine pollutant: No
路 Air transport ICAO-TI and IATA-DGR:
路 ICAO/IATA Class: -
15 Regulations
路 Labelling according to EU guidelines:
Observe the general safety regulations when handling chemicals
The product is not subject to identification regulations under EU Directives and the Ordinance on
Hazardous Materials (German GefStoffV).
路 National regulations
路 Classification according to VbF: Void
路 Technical instructions (air):
Class Share in %
NK 1,0
路 Waterhazard class: Generally not hazardous for water.
16 Other information:
Disclaimer:
To the best of our knowledge, the information contained herein is accurate. However, neither Becton
Dickinson or any of its subsidiaries assums any liabilities whatsoever for the accuracy or completeness
of the information contained herein. Final determination of suitability of any material is the sole
responsibility of the user. All materials may present unknown hazards and should be used with caution.
Although certain hazards described herein, we cannot guarantee that these are the only hazards that
exist.
路 Department issuing MSDS: Environment Protection Department
路 Contact: Technical Service Representative
EU
DR
Page 1/4
Material Safety Data Sheet
According to 91/155 EC
Printing date 13.03.2002 Reviewed on 13.03.2002
1 Identification of substance:
路 Product details:
路 Trade name: Control Insect Cell Membrane Protein
(CYP2B6/EFC High Throughput Inhibitor Screening)
路 Article number: 459220
路 Manufacturer/Supplier:
Becton Dickinson Biosciences Centralized European Office
Regulatory Compliance Department
Denderstraat 24
9320 Erembodegem-AALST
Belgium
Tel: 32 53 720402
路 Further information obtainable from: Technical Service Representative
路 Information in case of emergency: Tel: 32 53 720402
2 Composition/Data on components:
路 Chemical characterization
路 Description: Mixture consisting of the following components.
路 Dangerous components: Void
3 Hazard identification
路 Hazard description:
This product contains no hazardous constituents, or the concentration of all chemical constituents are
below the regulatory threshold limits described by the Occupational Safety and Health Administration
Hazard Communication Standard or European Directive 91/155/EEC, and 93/112/EC.
路 Information pertaining to particular dangers for man and environment Not applicable
路 Classification system
The classification is according to the latest editions of the EU-lists, and extended by company and
literature data.
4 First aid measures
路 General information No special measures required.
路 After inhalation Seek medical treatment in case of complaints.
路 After skin contact Immediately wash with water and soap and rinse thoroughly.
路 After eye contact
Rinse opened eye for several minutes under running water. If symptoms persist, consult a doctor.
路 After swallowing If symptoms persist consult doctor.
5 Fire fighting measures
路 Suitable extinguishing agents
CO2, powder or water spray. Fight larger fires with water spray or alcohol resistant foam.
(Contd. on page 2)
EU
DR
Page 2/4
Material Safety Data Sheet
According to 91/155 EC
Printing date 13.03.2002 Reviewed on 13.03.2002
Trade name: Control Insect Cell Membrane Protein
(CYP2B6/EFC High Throughput Inhibitor Screening)
(Contd. of page 1)
路 Protective equipment: No special measures required.
6 Accidental release measures
路 Person-related safety precautions: Wear protective equipment. Keep unprotected persons away.
路 Measures for environmental protection: Damp down dust with water spray.
路 Measures for cleaning/collecting: No special measures required.
路 Additional information: No dangerous substances are released.
7 Handling and storage
路 Handling
路 Information for safe handling: No special measures required.
路 Information about fire - and explosion protection: No special measures required.
路 Storage
路 Requirements to be met by storerooms and receptacles: -80 C
路 Information about storage in one common storage facility: Store away from oxidizing agents.
路 Further information about storage conditions: None.
路 Storage class
路 Class according to regulation on flammable liquids: Void
8 Exposure controls and personal protection gear
路 Additional information about design of technical facilities: No further data; see item 7.
路 Ingredients with limit values that require monitoring at the workplace:
The product does not contain any relevant quantities of materials with critical values that have to be
monitored at the workplace.
路 Additional information: The lists valid during the making were used as basis.
路 Personal protective equipment
路 General protective and hygienic measures
The usual precautionary measures are to be adhered to when handling chemicals.
路 Respiratory protection: Not required.
路 Protection of hands:
Protective gloves.
路 Eye protection: Safety glasses
路 Body protection: Protective work clothing.
9 Physical and chemical properties:
Liquid
路 Form:
Brown
路 Colour:
(Contd. on page 3)
EU
DR
Page 3/4
Material Safety Data Sheet
According to 91/155 EC
Printing date 13.03.2002 Reviewed on 13.03.2002
Trade name: Control Insect Cell Membrane Protein
(CYP2B6/EFC High Throughput Inhibitor Screening)
(Contd. of page 2)
Characteristic
路 Odour:
路 Change in condition
Melting point/Melting range: Not determined
Boiling point/Boiling range: Not determined
Not applicable
路 Flash point:
Product is not selfigniting.
路 Self-igniting:
Product does not present an explosion hazard.
路 Danger of explosion:
Not applicable
路 Vapour pressure:
Not determined
路 Density:
路 Solubility in / Miscibility with
Soluble
Water:
Not applicable
路 pH-value:
10 Stability and reactivity
路 Thermal decomposition / conditions to be avoided:
No decomposition if used according to specifications.
路 Materials to be avoided: Incompatible material: strong oxidizers.
路 Dangerous reactions No dangerous reactions known
路 Dangerous decomposition products: No dangerous decomposition products known
11 Toxicological information
路 Acute toxicity:
路 Primary irritant effect:
路 on the skin: No irritant effect.
路 on the eye: No irritating effect.
路 Sensitization: No sensitizing effects known.
路 Additional toxicological information:
The product is not subject to classification according to the calculation method of the General EU
Classification Guidelines for Preparations as issued in the latest version.
When used and handled according to specifications, the product does not have any harmful effects to
our experience and the information provided to us.
12 Ecological information:
路 Ecotoxical effects:
路 Other information:
The ecological effects have not ben thoroughly investigated, but currently none have been identified.
路 General notes: Generally not hazardous for water.
EU
(Contd. on page 4)
DR
Page 4/4
Material Safety Data Sheet
According to 91/155 EC
Printing date 13.03.2002 Reviewed on 13.03.2002
Trade name: Control Insect Cell Membrane Protein
(CYP2B6/EFC High Throughput Inhibitor Screening)
(Contd. of page 3)
13 Disposal considerations
路 Product:
路 Recommendation
Must be specially treated adhering to official regulations.
Smaller quantities can be disposed of with household waste.
路 Uncleaned packaging:
路 Recommendation: Disposal must be made according to official regulations.
路 Recommended cleansing agents: Water, if necessary together with cleansing agents.
14 Transport information
路 Land transport ADR/RID (cross-border)
路 ADR/RID class: -
路 Maritime transport IMDG:
-
路 IMDG Class:
路 Marine pollutant: No
路 Air transport ICAO-TI and IATA-DGR:
路 ICAO/IATA Class: -
15 Regulations
路 Labelling according to EU guidelines:
Observe the general safety regulations when handling chemicals
The product is not subject to identification regulations under EU Directives and the Ordinance on
Hazardous Materials (German GefStoffV).
路 National regulations
路 Classification according to VbF: Void
路 Waterhazard class: Generally not hazardous for water.
16 Other information:
Disclaimer:
To the best of our knowledge, the information contained herein is accurate. However, neither Becton
Dickinson or any of its subsidiaries assums any liabilities whatsoever for the accuracy or completeness
of the information contained herein. Final determination of suitability of any material is the sole
responsibility of the user. All materials may present unknown hazards and should be used with caution.
Although certain hazards described herein, we cannot guarantee that these are the only hazards that
exist.
路 Department issuing MSDS: Environment Protection Department
路 Contact: Technical Service Representative
EU
DR
Page 1/4
Material Safety Data Sheet
According to 91/155 EC
Printing date 13.03.2002 Reviewed on 13.03.2002
1 Identification of substance:
路 Product details:
路 Trade name: Buffer Solution: 0.5M Potssium Phosphate
(CYP2B6/EFC High Throughput Inhibitor Screening)
路 Article number: 459220
路 Manufacturer/Supplier:
Becton Dickinson Biosciences Centralized European Office
Regulatory Compliance Department
Denderstraat 24
9320 Erembodegem-AALST
Belgium
Tel: 32 53 720402
路 Further information obtainable from: Technical Service Representative
路 Information in case of emergency: Tel: 32 53 720402
2 Composition/Data on components:
路 Chemical characterization
路 Description: Mixture of substances listed below with nonhazardous additions.
路 Dangerous components: Void
3 Hazard identification
路 Hazard description:
This product contains no hazardous constituents, or the concentration of all chemical constituents are
below the regulatory threshold limits described by the Occupational Safety and Health Administration
Hazard Communication Standard or European Directive 91/155/EEC, and 93/112/EC.
路 Classification system
The classification is according to the latest editions of the EU-lists, and extended by company and
literature data.
4 First aid measures
路 General information No special measures required.
路 After inhalation Seek medical treatment in case of complaints.
路 After skin contact Immediately wash with water and soap and rinse thoroughly.
路 After eye contact
Rinse opened eye for several minutes under running water. If symptoms persist, consult a doctor.
路 After swallowing If symptoms persist consult doctor.
5 Fire fighting measures
路 Suitable extinguishing agents
CO2, powder or water spray. Fight larger fires with water spray or alcohol resistant foam.
路 Protective equipment: No special measures required.
EU
(Contd. on page 2)
DR
Page 2/4
Material Safety Data Sheet
According to 91/155 EC
Printing date 13.03.2002 Reviewed on 13.03.2002
Trade name: Buffer Solution: 0.5M Potssium Phosphate
(CYP2B6/EFC High Throughput Inhibitor Screening)
(Contd. of page 1)
6 Accidental release measures
路 Person-related safety precautions: Wear protective equipment. Keep unprotected persons away.
路 Measures for environmental protection: Damp down dust with water spray.
路 Measures for cleaning/collecting:
Absorb with liquid-binding material (sand, diatomite, acid binders, universal binders, sawdust).
路 Additional information: No dangerous substances are released.
7 Handling and storage
路 Handling
路 Information for safe handling: No special measures required.
路 Information about fire - and explosion protection: No special measures required.
路 Storage
路 Requirements to be met by storerooms and receptacles: 4 C
路 Information about storage in one common storage facility: Store away from oxidizing agents.
路 Further information about storage conditions: None.
路 Storage class
路 Class according to regulation on flammable liquids: Void
8 Exposure controls and personal protection gear
路 Additional information about design of technical facilities: No further data; see item 7.
路 Ingredients with limit values that require monitoring at the workplace:
The product does not contain any relevant quantities of materials with critical values that have to be
monitored at the workplace.
路 Additional information: The lists valid during the making were used as basis.
路 Personal protective equipment
路 General protective and hygienic measures
The usual precautionary measures are to be adhered to when handling chemicals.
路 Respiratory protection: Not required.
路 Protection of hands:
Protective gloves.
路 Eye protection: Safety glasses
路 Body protection: Protective work clothing.
9 Physical and chemical properties:
Liquid
路 Form:
Clear
路 Colour:
Odourless
路 Odour:
(Contd. on page 3)
EU
DR
Page 3/4
Material Safety Data Sheet
According to 91/155 EC
Printing date 13.03.2002 Reviewed on 13.03.2002
Trade name: Buffer Solution: 0.5M Potssium Phosphate
(CYP2B6/EFC High Throughput Inhibitor Screening)
(Contd. of page 2)
路 Change in condition
Melting point/Melting range: Not determined
Boiling point/Boiling range: Not determined
Not applicable
路 Flash point:
Product is not selfigniting.
路 Self-igniting:
Product does not present an explosion hazard.
路 Danger of explosion:
Not applicable
路 Vapour pressure:
Not determined
路 Density:
路 Solubility in / Miscibility with
Soluble
Water:
7,4
路 pH-value:
10 Stability and reactivity
路 Thermal decomposition / conditions to be avoided:
No decomposition if used according to specifications.
路 Materials to be avoided: Incompatible material: strong oxidizers.
路 Dangerous reactions No dangerous reactions known
路 Dangerous decomposition products: No dangerous decomposition products known
11 Toxicological information
路 Acute toxicity:
路 Primary irritant effect:
路 on the skin: No irritant effect.
路 on the eye: No irritating effect.
路 Sensitization: No sensitizing effects known.
路 Additional toxicological information:
The product is not subject to classification according to the calculation method of the General EU
Classification Guidelines for Preparations as issued in the latest version.
When used and handled according to specifications, the product does not have any harmful effects to
our experience and the information provided to us.
12 Ecological information:
路 Ecotoxical effects:
路 Other information:
The ecological effects have not ben thoroughly investigated, but currently none have been identified.
路 General notes: Generally not hazardous for water.
EU
(Contd. on page 4)
DR
Page 4/4
Material Safety Data Sheet
According to 91/155 EC
Printing date 13.03.2002 Reviewed on 13.03.2002
Trade name: Buffer Solution: 0.5M Potssium Phosphate
(CYP2B6/EFC High Throughput Inhibitor Screening)
(Contd. of page 3)
13 Disposal considerations
路 Product:
路 Recommendation
Must be specially treated adhering to official regulations.
Smaller quantities can be disposed of with household waste.
路 Uncleaned packaging:
路 Recommendation: Disposal must be made according to official regulations.
路 Recommended cleansing agents: Water, if necessary together with cleansing agents.
14 Transport information
路 Land transport ADR/RID (cross-border)
路 ADR/RID class: -
路 Maritime transport IMDG:
-
路 IMDG Class:
路 Marine pollutant: No
路 Air transport ICAO-TI and IATA-DGR:
路 ICAO/IATA Class: -
15 Regulations
路 Labelling according to EU guidelines:
Observe the general safety regulations when handling chemicals
The product is not subject to identification regulations under EU Directives and the Ordinance on
Hazardous Materials (German GefStoffV).
路 National regulations
路 Classification according to VbF: Void
路 Waterhazard class: Generally not hazardous for water.
16 Other information:
Disclaimer:
To the best of our knowledge, the information contained herein is accurate. However, neither Becton
Dickinson or any of its subsidiaries assums any liabilities whatsoever for the accuracy or completeness
of the information contained herein. Final determination of suitability of any material is the sole
responsibility of the user. All materials may present unknown hazards and should be used with caution.
Although certain hazards described herein, we cannot guarantee that these are the only hazards that
exist.
路 Department issuing MSDS: Environment Protection Department
路 Contact: Technical Service Representative
EU
DR
Page 1/4
Material Safety Data Sheet
According to 91/155 EC
Printing date 13.03.2002 Reviewed on 13.03.2002
1 Identification of substance:
路 Product details:
路 Trade name: Stop Solution: 0.5M Tris Base
(CYP2B6/EFC High Throughput Inhibitor Screening)
路 Article number: 459220
路 Manufacturer/Supplier:
Becton Dickinson Biosciences Centralized European Office
Regulatory Compliance Department
Denderstraat 24
9320 Erembodegem-AALST
Belgium
Tel: 32 53 720402
路 Further information obtainable from: Technical Service Representative
路 Information in case of emergency: Tel: 32 53 720402
2 Composition/Data on components:
路 Chemical characterization
路 Description: Mixture of substances listed below with nonhazardous additions.
路 Dangerous components: Void
3 Hazard identification
路 Hazard description:
This product contains no hazardous constituents, or the concentration of all chemical constituents are
below the regulatory threshold limits described by the Occupational Safety and Health Administration
Hazard Communication Standard or European Directive 91/155/EEC, and 93/112/EC.
路 Classification system
The classification is according to the latest editions of the EU-lists, and extended by company and
literature data.
4 First aid measures
路 General information No special measures required.
路 After inhalation Seek medical treatment in case of complaints.
路 After skin contact Immediately wash with water and soap and rinse thoroughly.
路 After eye contact
Rinse opened eye for several minutes under running water. If symptoms persist, consult a doctor.
路 After swallowing If symptoms persist consult doctor.
5 Fire fighting measures
路 Suitable extinguishing agents
CO2, powder or water spray. Fight larger fires with water spray or alcohol resistant foam.
路 Protective equipment: No special measures required.
EU
(Contd. on page 2)
DR
Page 2/4
Material Safety Data Sheet
According to 91/155 EC
Printing date 13.03.2002 Reviewed on 13.03.2002
Trade name: Stop Solution: 0.5M Tris Base
(CYP2B6/EFC High Throughput Inhibitor Screening)
(Contd. of page 1)
6 Accidental release measures
路 Person-related safety precautions: Wear protective equipment. Keep unprotected persons away.
路 Measures for environmental protection: Damp down dust with water spray.
路 Measures for cleaning/collecting:
Absorb with liquid-binding material (sand, diatomite, acid binders, universal binders, sawdust).
路 Additional information: No dangerous substances are released.
7 Handling and storage
路 Handling
路 Information for safe handling: No special measures required.
路 Information about fire - and explosion protection: No special measures required.
路 Storage
路 Requirements to be met by storerooms and receptacles: 2 - 8 C
路 Information about storage in one common storage facility: Store away from oxidizing agents.
路 Further information about storage conditions: None.
路 Storage class
路 Class according to regulation on flammable liquids: Void
8 Exposure controls and personal protection gear
路 Additional information about design of technical facilities: No further data; see item 7.
路 Ingredients with limit values that require monitoring at the workplace:
The product does not contain any relevant quantities of materials with critical values that have to be
monitored at the workplace.
路 Additional information: The lists valid during the making were used as basis.
路 Personal protective equipment
路 General protective and hygienic measures
The usual precautionary measures are to be adhered to when handling chemicals.
路 Respiratory protection: Not required.
路 Protection of hands:
Protective gloves.
路 Eye protection: Safety glasses
路 Body protection: Protective work clothing.
9 Physical and chemical properties:
Liquid
路 Form:
Clear
路 Colour:
Odourless
路 Odour:
(Contd. on page 3)
EU
DR
Page 3/4
Material Safety Data Sheet
According to 91/155 EC
Printing date 13.03.2002 Reviewed on 13.03.2002
Trade name: Stop Solution: 0.5M Tris Base
(CYP2B6/EFC High Throughput Inhibitor Screening)
(Contd. of page 2)
路 Change in condition
Melting point/Melting range: Not determined
Boiling point/Boiling range: Not determined
Not applicable
路 Flash point:
Product is not selfigniting.
路 Self-igniting:
Product does not present an explosion hazard.
路 Danger of explosion:
Not applicable
路 Vapour pressure:
Not determined
路 Density:
路 Solubility in / Miscibility with
Soluble
Water:
Not applicable
路 pH-value:
10 Stability and reactivity
路 Thermal decomposition / conditions to be avoided:
No decomposition if used according to specifications.
路 Materials to be avoided: Incompatible material: strong oxidizers.
路 Dangerous reactions No dangerous reactions known
路 Dangerous decomposition products: No dangerous decomposition products known
11 Toxicological information
路 Acute toxicity:
路 Primary irritant effect:
路 on the skin: No irritant effect.
路 on the eye: No irritating effect.
路 Sensitization: No sensitizing effects known.
路 Additional toxicological information:
The product is not subject to classification according to the calculation method of the General EU
Classification Guidelines for Preparations as issued in the latest version.
When used and handled according to specifications, the product does not have any harmful effects to
our experience and the information provided to us.
12 Ecological information:
路 Ecotoxical effects:
路 Other information:
The ecological effects have not ben thoroughly investigated, but currently none have been identified.
路 General notes: Generally not hazardous for water.
EU
(Contd. on page 4)
DR
Page 4/4
Material Safety Data Sheet
According to 91/155 EC
Printing date 13.03.2002 Reviewed on 13.03.2002
Trade name: Stop Solution: 0.5M Tris Base
(CYP2B6/EFC High Throughput Inhibitor Screening)
(Contd. of page 3)
13 Disposal considerations
路 Product:
路 Recommendation
Must be specially treated adhering to official regulations.
Smaller quantities can be disposed of with household waste.
路 Uncleaned packaging:
路 Recommendation: Disposal must be made according to official regulations.
路 Recommended cleansing agents: Water, if necessary together with cleansing agents.
14 Transport information
路 Land transport ADR/RID (cross-border)
路 ADR/RID class: -
路 Maritime transport IMDG:
-
路 IMDG Class:
路 Marine pollutant: No
路 Air transport ICAO-TI and IATA-DGR:
路 ICAO/IATA Class: -
15 Regulations
路 Labelling according to EU guidelines:
Observe the general safety regulations when handling chemicals
The product is not subject to identification regulations under EU Directives and the Ordinance on
Hazardous Materials (German GefStoffV).
路 National regulations
路 Classification according to VbF: Void
路 Waterhazard class: Generally not hazardous for water.
16 Other information:
Disclaimer:
To the best of our knowledge, the information contained herein is accurate. However, neither Becton
Dickinson or any of its subsidiaries assums any liabilities whatsoever for the accuracy or completeness
of the information contained herein. Final determination of suitability of any material is the sole
responsibility of the user. All materials may present unknown hazards and should be used with caution.
Although certain hazards described herein, we cannot guarantee that these are the only hazards that
exist.
路 Department issuing MSDS: Environment Protection Department
路 Contact: Technical Service Representative
EU
DR
Page 1/5
Material Safety Data Sheet
According to 91/155 EC
Printing date 13.03.2002 Reviewed on 13.03.2002
1 Identification of substance:
路 Product details:
路 Trade name: Cofactors
(CYP2B6/EFC High Throughput Inhibitor Screening)
路 Article number: 459220
路 Manufacturer/Supplier:
Becton Dickinson Biosciences Centralized European Office
Regulatory Compliance Department
Denderstraat 24
9320 Erembodegem-AALST
Belgium
Tel: 32 53 720402
路 Further information obtainable from: Technical Service Representative
路 Information in case of emergency: Tel: 32 53 720402
2 Composition/Data on components:
路 Chemical characterization
路 Description: Mixture of substances listed below with nonhazardous additions.
路 Dangerous components:
7786-30-3 Magnesium Chloride 41,8%
D-glucose-6-phosphate disodium 31,8%
2646-71-1 dihydronicotinamide-adenine dinucleotidephosphate, tetrasodium salt 16,4%
路 Additional information Biological Activity: unknown
3 Hazard identification
路 Hazard description:
Xn Harmful
路 Information pertaining to particular dangers for man and environment
R 20/21/22 Harmful by inhalation, in contact with skin and if swallowed.
4 First aid measures
路 General information
Symptoms of poisoning may even occur after several hours; therefore medical observation for at least
48 hours after the accident.
路 After inhalation In case of unconsciousness place patient in side position for transportation.
路 After skin contact Immediately wash with water and soap and rinse thoroughly.
路 After eye contact Rinse opened eye for several minutes under running water. Then consult a doctor.
路 After swallowing Call for a doctor immediately.
EU
(Contd. on page 2)
DR
Page 2/5
Material Safety Data Sheet
According to 91/155 EC
Printing date 13.03.2002 Reviewed on 13.03.2002
Trade name: Cofactors
(CYP2B6/EFC High Throughput Inhibitor Screening)
(Contd. of page 1)
5 Fire fighting measures
路 Suitable extinguishing agents
CO2, powder or water spray. Fight larger fires with water spray or alcohol resistant foam.
路 Protective equipment:
Wear self-contained respiratory protective device.
Wear fully protective suit.
6 Accidental release measures
路 Person-related safety precautions: Wear protective equipment. Keep unprotected persons away.
路 Measures for environmental protection: Damp down dust with water spray.
路 Measures for cleaning/collecting:
Ensure adequate ventilation.
Clean the affected area carefully; suitable cleaners are:
warm water and cleansing agent
路 Additional information:
See Section 7 for information on safe handling
See Section 8 for information on personal protection equipment.
See Section 13 for disposal information.
7 Handling and storage
路 Handling
路 Information for safe handling: Ensure good ventilation/exhaustion at the workplace.
路 Information about fire - and explosion protection: No special measures required.
路 Storage
路 Requirements to be met by storerooms and receptacles: - 20 C
路 Information about storage in one common storage facility: Store away from oxidizing agents.
路 Further information about storage conditions: Store in cool, dry conditions in well sealed receptacles.
路 Storage class
路 Class according to regulation on flammable liquids: Void
8 Exposure controls and personal protection gear
路 Additional information about design of technical facilities: No further data; see item 7.
路 Ingredients with limit values that require monitoring at the workplace:
The product does not contain any relevant quantities of materials with critical values that have to be
monitored at the workplace.
路 Additional information: The lists valid during the making were used as basis.
路 Personal protective equipment
路 General protective and hygienic measures
Keep away from foodstuffs, beverages and feed.
Wash hands before breaks and at the end of work.
Avoid contact with the eyes and skin.
(Contd. on page 3)
EU
DR
Page 3/5
Material Safety Data Sheet
According to 91/155 EC
Printing date 13.03.2002 Reviewed on 13.03.2002
Trade name: Cofactors
(CYP2B6/EFC High Throughput Inhibitor Screening)
(Contd. of page 2)
路 Respiratory protection:
In case of brief exposure or low pollution use respiratory filter device. In case of intensive or longer
exposure use self-contained respiratory protective device.
路 Protection of hands:
Protective gloves.
路 Eye protection: Safety glasses
路 Body protection: Protective work clothing.
9 Physical and chemical properties:
Liquid
路 Form:
Clear
路 Colour:
Characteristic
路 Odour:
路 Change in condition
Melting point/Melting range: Not determined
Boiling point/Boiling range: Not determined
Not applicable
路 Flash point:
路 Flammability (solid, gaseous) Product is not flammable.
Product does not present an explosion hazard.
路 Danger of explosion:
Not applicable
路 Vapour pressure:
Not determined
路 Density:
路 Solubility in / Miscibility with
Soluble
Water:
Not applicable
路 pH-value:
10 Stability and reactivity
路 Thermal decomposition / conditions to be avoided:
No decomposition if used according to specifications.
路 Materials to be avoided: Incompatible material: strong oxidizers.
路 Dangerous reactions No dangerous reactions known
路 Dangerous decomposition products: No dangerous decomposition products known
11 Toxicological information
路 Acute toxicity:
路 Primary irritant effect:
路 on the skin: No irritant effect.
路 on the eye: No irritating effect.
(Contd. on page 4)
EU
DR
Page 4/5
Material Safety Data Sheet
According to 91/155 EC
Printing date 13.03.2002 Reviewed on 13.03.2002
Trade name: Cofactors
(CYP2B6/EFC High Throughput Inhibitor Screening)
(Contd. of page 3)
路 Sensitization: No sensitizing effects known.
路 Additional toxicological information:
Harmful
The product shows the following dangers according to the calculation method of the General EU
Classification Guidelines for Preparations as issued in the latest version.
12 Ecological information:
路 Ecotoxical effects:
路 Other information:
The ecological effects have not ben thoroughly investigated, but currently none have been identified.
路 General notes: Not known to be hazardous to water.
13 Disposal considerations
路 Product:
路 Recommendation
Must be specially treated adhering to official regulations.
Must not be disposed together with household garbage. Do not allow product to reach sewage system.
路 Uncleaned packaging:
路 Recommendation: Disposal must be made according to official regulations.
路 Recommended cleansing agents: Water, if necessary together with cleansing agents.
14 Transport information
路 Land transport ADR/RID (cross-border)
路 ADR/RID class: -
路 Maritime transport IMDG:
-
路 IMDG Class:
路 Marine pollutant: No
路 Air transport ICAO-TI and IATA-DGR:
路 ICAO/IATA Class: -
15 Regulations
路 Labelling according to EU guidelines:
The product has been classified and marked in accordance with EU Directives / Ordinance on
Hazardous Materials
路 Code letter and hazard designation of product:
Xn Harmful
路 Risk phrases:
20/21/22 Harmful by inhalation, in contact with skin and if swallowed.
(Contd. on page 5)
EU
DR
Page 5/5
Material Safety Data Sheet
According to 91/155 EC
Printing date 13.03.2002 Reviewed on 13.03.2002
Trade name: Cofactors
(CYP2B6/EFC High Throughput Inhibitor Screening)
(Contd. of page 4)
路 Safety phrases:
7 Keep container tightly closed.
26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
36 Wear suitable protective clothing.
路 National regulations
路 Classification according to VbF: Void
路 Waterhazard class: Generally not hazardous for water.
16 Other information:
Disclaimer:
To the best of our knowledge, the information contained herein is accurate. However, neither Becton
Dickinson or any of its subsidiaries assums any liabilities whatsoever for the accuracy or completeness
of the information contained herein. Final determination of suitability of any material is the sole
responsibility of the user. All materials may present unknown hazards and should be used with caution.
Although certain hazards described herein, we cannot guarantee that these are the only hazards that
exist.
Use of Product:
- Cofactor necessary for xenobiotic metabolism reaction, for research use only.
- NADPH regenerating system for use in conjuction with Solution A, for all NADPH requiring
oxidase assays.
路 Department issuing MSDS: Environment Protection Department
路 Contact: Technical Service Representative
EU
DR
Page 1/5
Material Safety Data Sheet
According to 91/155 EC
Printing date 13.03.2002 Reviewed on 13.03.2002
1 Identification of substance:
路 Product details:
路 Trade name: Glucose 6-Phosphate Dehydrogenase
(CYP2B6/EFC High Throughput Inhibitor Screening)
路 Article number: 459220
路 Manufacturer/Supplier:
Becton Dickinson Biosciences Centralized European Office
Regulatory Compliance Department
Denderstraat 24
9320 Erembodegem-AALST
Belgium
Tel: 32 53 720402
路 Further information obtainable from: Technical Service Representative
路 Information in case of emergency: Tel: 32 53 720402
2 Composition/Data on components:
路 Chemical characterization
路 Description: Mixture of substances listed below with nonhazardous additions.
路 Dangerous components: Void
3 Hazard identification
路 Hazard description:
Xn Harmful
路 Information pertaining to particular dangers for man and environment
R 20/21/22 Harmful by inhalation, in contact with skin and if swallowed.
4 First aid measures
路 General information
Symptoms of poisoning may even occur after several hours; therefore medical observation for at least
48 hours after the accident.
路 After inhalation In case of unconsciousness place patient in side position for transportation.
路 After skin contact Immediately wash with water and soap and rinse thoroughly.
路 After eye contact Rinse opened eye for several minutes under running water. Then consult a doctor.
路 After swallowing Call for a doctor immediately.
5 Fire fighting measures
路 Suitable extinguishing agents
CO2, powder or water spray. Fight larger fires with water spray or alcohol resistant foam.
路 Protective equipment:
Wear self-contained respiratory protective device.
(Contd. on page 2)
EU
DR
Page 2/5
Material Safety Data Sheet
According to 91/155 EC
Printing date 13.03.2002 Reviewed on 13.03.2002
Trade name: Glucose 6-Phosphate Dehydrogenase
(CYP2B6/EFC High Throughput Inhibitor Screening)
(Contd. of page 1)
Wear fully protective suit.
6 Accidental release measures
路 Person-related safety precautions: Wear protective equipment. Keep unprotected persons away.
路 Measures for environmental protection: Damp down dust with water spray.
路 Measures for cleaning/collecting:
Ensure adequate ventilation.
Clean the affected area carefully; suitable cleaners are:
warm water and cleansing agent
路 Additional information:
See Section 7 for information on safe handling
See Section 8 for information on personal protection equipment.
See Section 13 for disposal information.
7 Handling and storage
路 Handling
路 Information for safe handling: Ensure good ventilation/exhaustion at the workplace.
路 Information about fire - and explosion protection: No special measures required.
路 Storage
路 Requirements to be met by storerooms and receptacles: - 20 C
路 Information about storage in one common storage facility: Store away from oxidizing agents.
路 Further information about storage conditions: Store in cool, dry conditions in well sealed receptacles.
路 Storage class
路 Class according to regulation on flammable liquids: Void
8 Exposure controls and personal protection gear
路 Additional information about design of technical facilities: No further data; see item 7.
路 Ingredients with limit values that require monitoring at the workplace:
The product does not contain any relevant quantities of materials with critical values that have to be
monitored at the workplace.
路 Additional information: The lists valid during the making were used as basis.
路 Personal protective equipment
路 General protective and hygienic measures
Keep away from foodstuffs, beverages and feed.
Wash hands before breaks and at the end of work.
Avoid contact with the eyes and skin.
路 Respiratory protection:
In case of brief exposure or low pollution use respiratory filter device. In case of intensive or longer
exposure use self-contained respiratory protective device.
(Contd. on page 3)
EU
DR
Page 3/5
Material Safety Data Sheet
According to 91/155 EC
Printing date 13.03.2002 Reviewed on 13.03.2002
Trade name: Glucose 6-Phosphate Dehydrogenase
(CYP2B6/EFC High Throughput Inhibitor Screening)
(Contd. of page 2)
路 Protection of hands:
Protective gloves.
路 Eye protection: Safety glasses
路 Body protection: Protective work clothing.
9 Physical and chemical properties:
Liquid
路 Form:
Clear
路 Colour:
Characteristic
路 Odour:
路 Change in condition
Melting point/Melting range: Not determined
Boiling point/Boiling range: Not determined
Not applicable
路 Flash point:
路 Flammability (solid, gaseous) Product is not flammable.
Product does not present an explosion hazard.
路 Danger of explosion:
Not applicable
路 Vapour pressure:
Not determined
路 Density:
路 Solubility in / Miscibility with
Soluble
Water:
Not applicable
路 pH-value:
10 Stability and reactivity
路 Thermal decomposition / conditions to be avoided:
No decomposition if used according to specifications.
路 Materials to be avoided: Incompatible material: strong oxidizers.
路 Dangerous reactions No dangerous reactions known
路 Dangerous decomposition products: No dangerous decomposition products known
11 Toxicological information
路 Acute toxicity:
路 Primary irritant effect:
路 on the skin: No irritant effect.
路 on the eye: No irritating effect.
路 Sensitization: No sensitizing effects known.
(Contd. on page 4)
EU
DR
Page 4/5
Material Safety Data Sheet
According to 91/155 EC
Printing date 13.03.2002 Reviewed on 13.03.2002
Trade name: Glucose 6-Phosphate Dehydrogenase
(CYP2B6/EFC High Throughput Inhibitor Screening)
(Contd. of page 3)
路 Additional toxicological information:
Harmful
The product shows the following dangers according to the calculation method of the General EU
Classification Guidelines for Preparations as issued in the latest version.
12 Ecological information:
路 Ecotoxical effects:
路 Other information:
The ecological effects have not ben thoroughly investigated, but currently none have been identified.
路 General notes: Not known to be hazardous to water.
13 Disposal considerations
路 Product:
路 Recommendation
Must be specially treated adhering to official regulations.
Must not be disposed together with household garbage. Do not allow product to reach sewage system.
路 Uncleaned packaging:
路 Recommendation: Disposal must be made according to official regulations.
路 Recommended cleansing agents: Water, if necessary together with cleansing agents.
14 Transport information
路 Land transport ADR/RID (cross-border)
路 ADR/RID class: -
路 Maritime transport IMDG:
-
路 IMDG Class:
路 Marine pollutant: No
路 Air transport ICAO-TI and IATA-DGR:
路 ICAO/IATA Class: -
15 Regulations
路 Labelling according to EU guidelines:
The product has been classified and marked in accordance with EU Directives / Ordinance on
Hazardous Materials
路 Code letter and hazard designation of product:
Xn Harmful
路 Risk phrases:
20/21/22 Harmful by inhalation, in contact with skin and if swallowed.
路 Safety phrases:
7 Keep container tightly closed.
(Contd. on page 5)
EU
DR
Page 5/5
Material Safety Data Sheet
According to 91/155 EC
Printing date 13.03.2002 Reviewed on 13.03.2002
Trade name: Glucose 6-Phosphate Dehydrogenase
(CYP2B6/EFC High Throughput Inhibitor Screening)
(Contd. of page 4)
26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
36 Wear suitable protective clothing.
路 National regulations
路 Classification according to VbF: Void
路 Waterhazard class: Generally not hazardous for water.
16 Other information:
Disclaimer:
To the best of our knowledge, the information contained herein is accurate. However, neither Becton
Dickinson or any of its subsidiaries assums any liabilities whatsoever for the accuracy or completeness
of the information contained herein. Final determination of suitability of any material is the sole
responsibility of the user. All materials may present unknown hazards and should be used with caution.
Although certain hazards described herein, we cannot guarantee that these are the only hazards that
exist.
Use of Product:
- Cofactor necessary for xenobiotic metabolism reaction, for research use only.
- NADPH regenerating system for use in conjuction with Solution A, for all NADPH requiring
oxidase assays.
路 Department issuing MSDS: Environment Protection Department
路 Contact: Technical Service Representative
EU
DR
Page 1/5
Material Safety Data Sheet
According to 91/155 EC
Printing date 13.03.2002 Reviewed on 13.03.2002
1 Identification of substance:
路 Product details:
路 Trade name: EFC (7-Ethoxy-4-trifluoromethylcoumarin)
(CYP2B6/EFC High Throughput Inhibitor Screening)
路 Article number: 459220
路 Manufacturer/Supplier:
Becton Dickinson Biosciences Centralized European Office
Regulatory Compliance Department
Denderstraat 24
9320 Erembodegem-AALST
Belgium
Tel: 32 53 720402
路 Further information obtainable from: Technical Service Representative
路 Information in case of emergency: Tel: 32 53 720402
2 Composition/Data on components:
路 CAS No. Description:
115453-82-2 7-Ethoxy-4-trifluoromethylcoumarin
3 Hazard identification
路 Hazard description:
Xn Harmful
路 Information pertaining to particular dangers for man and environment
R 20/21 Harmful by inhalation and in contact with skin.
4 First aid measures
路 General information No special measures required.
路 After inhalation Seek medical treatment in case of complaints.
路 After skin contact Immediately wash with water and soap and rinse thoroughly.
路 After eye contact
Rinse opened eye for several minutes under running water. If symptoms persist, consult a doctor.
路 After swallowing If symptoms persist consult doctor.
5 Fire fighting measures
路 Suitable extinguishing agents
CO2, powder or water spray. Fight larger fires with water spray or alcohol resistant foam.
路 Protective equipment:
Wear self-contained respiratory protective device.
(Contd. on page 2)
EU
DR
Page 2/5
Material Safety Data Sheet
According to 91/155 EC
Printing date 13.03.2002 Reviewed on 13.03.2002
Trade name: EFC (7-Ethoxy-4-trifluoromethylcoumarin)
(CYP2B6/EFC High Throughput Inhibitor Screening)
(Contd. of page 1)
Wear fully protective suit.
6 Accidental release measures
路 Person-related safety precautions: Wear protective equipment. Keep unprotected persons away.
路 Measures for environmental protection: Damp down dust with water spray.
路 Measures for cleaning/collecting: Ensure adequate ventilation.
路 Additional information: No dangerous substances are released.
7 Handling and storage
路 Handling
路 Information for safe handling: No special measures required.
路 Information about fire - and explosion protection: No special measures required.
路 Storage
路 Requirements to be met by storerooms and receptacles: - 20 C
路 Information about storage in one common storage facility: Store away from oxidizing agents.
路 Further information about storage conditions: None.
路 Storage class
路 Class according to regulation on flammable liquids: Void
8 Exposure controls and personal protection gear
路 Additional information about design of technical facilities: No further data; see item 7.
路 Ingredients with limit values that require monitoring at the workplace: Not required.
路 Additional information: The lists valid during the making were used as basis.
路 Personal protective equipment
路 General protective and hygienic measures
The usual precautionary measures are to be adhered to when handling chemicals.
路 Respiratory protection:
In case of brief exposure or low pollution use respiratory filter device. In case of intensive or longer
exposure use self-contained respiratory protective device.
路 Protection of hands:
Protective gloves.
路 Eye protection: Safety glasses
路 Body protection: Protective work clothing.
9 Physical and chemical properties:
Solid.
路 Form:
Colourless
路 Colour:
(Contd. on page 3)
EU
DR
Page 3/5
Material Safety Data Sheet
According to 91/155 EC
Printing date 13.03.2002 Reviewed on 13.03.2002
Trade name: EFC (7-Ethoxy-4-trifluoromethylcoumarin)
(CYP2B6/EFC High Throughput Inhibitor Screening)
(Contd. of page 2)
Characteristic
路 Odour:
路 Change in condition
Melting point/Melting range: Not determined
Boiling point/Boiling range: Not determined
Not applicable
路 Flash point:
路 Flammability (solid, gaseous) Product is not flammable.
Product does not present an explosion hazard.
路 Danger of explosion:
Not applicable
路 Vapour pressure:
Not determined
路 Density:
路 Solubility in / Miscibility with
Easily soluble
Water:
100,0 %
路 Solids content:
10 Stability and reactivity
路 Thermal decomposition / conditions to be avoided:
No decomposition if used according to specifications.
路 Materials to be avoided: Incompatible material: strong oxidizers.
路 Dangerous reactions No dangerous reactions known
路 Dangerous decomposition products: No dangerous decomposition products known
11 Toxicological information
路 Acute toxicity:
路 Primary irritant effect:
路 on the skin: No irritant effect.
路 on the eye: No irritating effect.
路 Sensitization: No sensitizing effects known.
路 Additional toxicological information:
The product shows the following dangers according to the calculation method of the General EU
Classification Guidelines for Preparations as issued in the latest version.
Harmful
12 Ecological information:
路 Ecotoxical effects:
路 Other information:
The ecological effects have not ben thoroughly investigated, but currently none have been identified.
路 General notes:
Water hazard class 1 (German Regulation) (Self-assessment): slightly hazardous for water.
EU
(Contd. on page 4)
DR
Page 4/5
Material Safety Data Sheet
According to 91/155 EC
Printing date 13.03.2002 Reviewed on 13.03.2002
Trade name: EFC (7-Ethoxy-4-trifluoromethylcoumarin)
(CYP2B6/EFC High Throughput Inhibitor Screening)
(Contd. of page 3)
13 Disposal considerations
路 Product:
路 Recommendation
Must be specially treated adhering to official regulations.
Smaller quantities can be disposed of with household waste.
路 Uncleaned packaging:
路 Recommendation: Disposal must be made according to official regulations.
路 Recommended cleansing agents: Water, if necessary together with cleansing agents.
14 Transport information
路 Land transport ADR/RID (cross-border)
路 ADR/RID class: -
路 Maritime transport IMDG:
-
路 IMDG Class:
路 Marine pollutant: No
路 Air transport ICAO-TI and IATA-DGR:
路 ICAO/IATA Class: -
15 Regulations
路 Labelling according to EU guidelines:
The product has been classified and marked in accordance with EU Directives / Ordinance on
Hazardous Materials
路 Code letter and hazard designation of product:
Xn Harmful
路 Risk phrases:
20/21 Harmful by inhalation and in contact with skin.
路 Safety phrases:
7 Keep container tightly closed.
26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
36 Wear suitable protective clothing.
路 National regulations
路 Classification according to VbF: Void
路 Waterhazard class: Water hazard class 1 (Self-assessment): slightly hazardous for water.
EU
(Contd. on page 5)
DR
Page 5/5
Material Safety Data Sheet
According to 91/155 EC
Printing date 13.03.2002 Reviewed on 13.03.2002
Trade name: EFC (7-Ethoxy-4-trifluoromethylcoumarin)
(CYP2B6/EFC High Throughput Inhibitor Screening)
(Contd. of page 4)
16 Other information:
Disclaimer:
To the best of our knowledge, the information contained herein is accurate. However, neither Becton
Dickinson or any of its subsidiaries assums any liabilities whatsoever for the accuracy or completeness
of the information contained herein. Final determination of suitability of any material is the sole
responsibility of the user. All materials may present unknown hazards and should be used with caution.
Although certain hazards described herein, we cannot guarantee that these are the only hazards that
exist.
路 Department issuing MSDS: Environment Protection Department
路 Contact: Technical Service Representative
EU
DR
Page 1/5
Material Safety Data Sheet
According to 91/155 EC
Printing date 13.03.2002 Reviewed on 13.03.2002
1 Identification of substance:
路 Product details:
路 Trade name: TCP (Tranylcypromine)
(CYP2B6/EFC High Throughput Inhibitor Screening)
路 Article number: 459220
路 Manufacturer/Supplier:
Becton Dickinson Biosciences Centralized European Office
Regulatory Compliance Department
Denderstraat 24
9320 Erembodegem-AALST
Belgium
Tel: 32 53 720402
路 Further information obtainable from: Technical Service Representative
路 Information in case of emergency: Tel: 32 53 720402
2 Composition/Data on components:
路 CAS No. Description:
13492-01-8 tranylcypromine
路 Identification number(s):
路 EINECS Number: 236-807-1
3 Hazard identification
路 Hazard description:
T Toxic
路 Information pertaining to particular dangers for man and environment
R 23/24/25 Toxic by inhalation, in contact with skin and if swallowed.
4 First aid measures
路 General information
Immediately remove any clothing soiled by the product.
Remove breathing equipment only after contaminated clothing have been completely removed.
In case of irregular breathing or respiratory arrest provide artificial respiration.
路 After inhalation
Supply fresh air or oxygen; call for doctor.
In case of unconsciousness place patient in side position for transportation.
路 After skin contact Immediately wash with water and soap and rinse thoroughly.
路 After eye contact Rinse opened eye for several minutes under running water. Then consult a doctor.
路 After swallowing
Do not induce vomiting; call for medical help immediately.
Call for a doctor immediately.
EU
(Contd. on page 2)
DR
Page 2/5
Material Safety Data Sheet
According to 91/155 EC
Printing date 13.03.2002 Reviewed on 13.03.2002
Trade name: TCP (Tranylcypromine)
(CYP2B6/EFC High Throughput Inhibitor Screening)
(Contd. of page 1)
5 Fire fighting measures
路 Suitable extinguishing agents
CO2, powder or water spray. Fight larger fires with water spray or alcohol resistant foam.
路 Protective equipment:
Wear self-contained respiratory protective device.
Wear fully protective suit.
6 Accidental release measures
路 Person-related safety precautions: Wear protective equipment. Keep unprotected persons away.
路 Measures for environmental protection: Damp down dust with water spray.
路 Measures for cleaning/collecting:
Dispose contaminated material as waste according to item 13.
Pick up mechanically.
Ensure adequate ventilation.
路 Additional information:
See Section 7 for information on safe handling
See Section 8 for information on personal protection equipment.
See Section 13 for disposal information.
7 Handling and storage
路 Handling
路 Information for safe handling:
Thorough dedusting.
Ensure good ventilation/exhaustion at the workplace.
Open and handle receptacle with care.
路 Information about fire - and explosion protection: Keep respiratory protective device available.
路 Storage
路 Requirements to be met by storerooms and receptacles: < 20C
路 Information about storage in one common storage facility: Store away from oxidizing agents.
路 Further information about storage conditions: Keep receptacle tightly sealed.
路 Storage class
路 Class according to regulation on flammable liquids: Void
8 Exposure controls and personal protection gear
路 Additional information about design of technical facilities: No further data; see item 7.
路 Ingredients with limit values that require monitoring at the workplace: Not required.
路 Additional information: The lists valid during the making were used as basis.
路 Personal protective equipment
路 General protective and hygienic measures
Keep away from foodstuffs, beverages and feed.
Immediately remove all soiled and contaminated clothing
Wash hands before breaks and at the end of work.
Store protective clothing separately.
(Contd. on page 3)
EU
DR
Page 3/5
Material Safety Data Sheet
According to 91/155 EC
Printing date 13.03.2002 Reviewed on 13.03.2002
Trade name: TCP (Tranylcypromine)
(CYP2B6/EFC High Throughput Inhibitor Screening)
(Contd. of page 2)
Avoid contact with the eyes and skin.
路 Respiratory protection:
In case of brief exposure or low pollution use respiratory filter device. In case of intensive or longer
exposure use self-contained respiratory protective device.
路 Protection of hands:
Protective gloves.
路 Eye protection: Safety glasses
路 Body protection: Protective work clothing.
9 Physical and chemical properties:
Solid.
路 Form:
According to product specification
路 Colour:
Characteristic
路 Odour:
路 Change in condition
Melting point/Melting range: Not determined
Boiling point/Boiling range: Not determined
Not applicable
路 Flash point:
路 Flammability (solid, gaseous) Product is not flammable.
Product does not present an explosion hazard.
路 Danger of explosion:
Not applicable
路 Vapour pressure:
Not determined
路 Density:
路 Solubility in / Miscibility with
Soluble
Water:
100,0 %
路 Solids content:
10 Stability and reactivity
路 Thermal decomposition / conditions to be avoided:
No decomposition if used according to specifications.
路 Materials to be avoided: Incompatible material: strong oxidizers.
路 Dangerous reactions No dangerous reactions known
路 Dangerous decomposition products: No dangerous decomposition products known
EU
(Contd. on page 4)
DR
Page 4/5
Material Safety Data Sheet
According to 91/155 EC
Printing date 13.03.2002 Reviewed on 13.03.2002
Trade name: TCP (Tranylcypromine)
(CYP2B6/EFC High Throughput Inhibitor Screening)
(Contd. of page 3)
11 Toxicological information
路 Acute toxicity:
路 LD/LC50 values relevant for classification:
13492-01-8 tranylcypromine
Oral LD50 38 mg/kg (mus)
路 Primary irritant effect:
路 on the skin: Irritant to skin and mucous membranes.
路 on the eye: Irritating effect.
路 Sensitization: Sensitization possible through inhalation.
12 Ecological information:
路 Ecotoxical effects:
路 Other information:
The ecological effects have not ben thoroughly investigated, but currently none have been identified.
路 General notes:
Water hazard class 1 (German Regulation) (Self-assessment): slightly hazardous for water.
13 Disposal considerations
路 Product:
路 Recommendation
Must be specially treated adhering to official regulations.
Must not be disposed together with household garbage. Do not allow product to reach sewage system.
路 Uncleaned packaging:
路 Recommendation: Disposal must be made according to official regulations.
路 Recommended cleansing agents: Water, if necessary together with cleansing agents.
14 Transport information
路 Land transport ADR/RID (cross-border)
路 ADR/RID class: -
路 Maritime transport IMDG:
-
路 IMDG Class:
路 Marine pollutant: No
路 Air transport ICAO-TI and IATA-DGR:
路 ICAO/IATA Class: -
15 Regulations
路 Labelling according to EU guidelines:
The product has been classified and marked in accordance with EU Directives / Ordinance on
Hazardous Materials
(Contd. on page 5)
EU
DR
Page 5/5
Material Safety Data Sheet
According to 91/155 EC
Printing date 13.03.2002 Reviewed on 13.03.2002
Trade name: TCP (Tranylcypromine)
(CYP2B6/EFC High Throughput Inhibitor Screening)
(Contd. of page 4)
路 Code letter and hazard designation of product:
T Toxic
路 Risk phrases:
23/24/25 Toxic by inhalation, in contact with skin and if swallowed.
路 Safety phrases:
23 Do not breathe gas/fumes/vapour/spray.
24/25 Avoid contact with skin and eyes.
36/37/39 Wear suitable protective clothing, gloves and eye/face protection.
45 In case of accident or if you feel unwell, seek medical advice immediately (show the label
where possible).
路 National regulations
路 Classification according to VbF: Void
路 Waterhazard class: Water hazard class 1 (Self-assessment): slightly hazardous for water.
16 Other information:
Disclaimer:
To the best of our knowledge, the information contained herein is accurate. However, neither Becton
Dickinson or any of its subsidiaries assums any liabilities whatsoever for the accuracy or completeness
of the information contained herein. Final determination of suitability of any material is the sole
responsibility of the user. All materials may present unknown hazards and should be used with caution.
Although certain hazards described herein, we cannot guarantee that these are the only hazards that
exist.
路 Department issuing MSDS: Environment Protection Department
路 Contact: Technical Service Representative
EU
DR
Page 1/5
Material Safety Data Sheet
According to 91/155 EC
Printing date 13.03.2002 Reviewed on 13.03.2002
1 Identification of substance:
路 Product details:
路 Trade name: HFC (7-Hydroxytrifluoromethylcoumarin)
(CYP2B6/EFC High Throughput Inhibitor Screening)
路 Article number: 459220
路 Manufacturer/Supplier:
Becton Dickinson Biosciences Centralized European Office
Regulatory Compliance Department
Denderstraat 24
9320 Erembodegem-AALST
Belgium
Tel: 32 53 720402
路 Further information obtainable from: Technical Service Representative
路 Information in case of emergency: Tel: 32 53 720402
2 Composition/Data on components:
路 Chemical characterization
路 Description: Mixture consisting of the following components.
路 Dangerous components:
575-03-1 7-hydroxy-4-(trifluoromethyl)-coumarin (C10H5F3O3) Xn; R 20/21/22 100,00%
路 Additional information Biological Activity: unknown
3 Hazard identification
路 Hazard description:
Xn Harmful
路 Information pertaining to particular dangers for man and environment
R 20/21/22 Harmful by inhalation, in contact with skin and if swallowed.
4 First aid measures
路 General information
Symptoms of poisoning may even occur after several hours; therefore medical observation for at least
48 hours after the accident.
路 After inhalation In case of unconsciousness place patient in side position for transportation.
路 After skin contact Immediately wash with water and soap and rinse thoroughly.
路 After eye contact Rinse opened eye for several minutes under running water. Then consult a doctor.
路 After swallowing Call for a doctor immediately.
EU
(Contd. on page 2)
DR
Page 2/5
Material Safety Data Sheet
According to 91/155 EC
Printing date 13.03.2002 Reviewed on 13.03.2002
Trade name: HFC (7-Hydroxytrifluoromethylcoumarin)
(CYP2B6/EFC High Throughput Inhibitor Screening)
(Contd. of page 1)
5 Fire fighting measures
路 Suitable extinguishing agents
CO2, powder or water spray. Fight larger fires with water spray or alcohol resistant foam.
路 Protective equipment:
Wear self-contained respiratory protective device.
Wear fully protective suit.
6 Accidental release measures
路 Person-related safety precautions: Wear protective equipment. Keep unprotected persons away.
路 Measures for environmental protection: Damp down dust with water spray.
路 Measures for cleaning/collecting:
Ensure adequate ventilation.
Clean the affected area carefully; suitable cleaners are:
warm water and cleansing agent
路 Additional information:
See Section 7 for information on safe handling
See Section 8 for information on personal protection equipment.
See Section 13 for disposal information.
7 Handling and storage
路 Handling
路 Information for safe handling: Ensure good ventilation/exhaustion at the workplace.
路 Information about fire - and explosion protection: No special measures required.
路 Storage
路 Requirements to be met by storerooms and receptacles: -80 C
路 Information about storage in one common storage facility: Store away from oxidizing agents.
路 Further information about storage conditions: Store in cool, dry conditions in well sealed receptacles.
路 Storage class
路 Class according to regulation on flammable liquids: Void
8 Exposure controls and personal protection gear
路 Additional information about design of technical facilities: No further data; see item 7.
路 Ingredients with limit values that require monitoring at the workplace:
The product does not contain any relevant quantities of materials with critical values that have to be
monitored at the workplace.
路 Additional information: The lists valid during the making were used as basis.
路 Personal protective equipment
路 General protective and hygienic measures
Keep away from foodstuffs, beverages and feed.
Wash hands before breaks and at the end of work.
Avoid contact with the eyes and skin.
(Contd. on page 3)
EU
DR
Page 3/5
Material Safety Data Sheet
According to 91/155 EC
Printing date 13.03.2002 Reviewed on 13.03.2002
Trade name: HFC (7-Hydroxytrifluoromethylcoumarin)
(CYP2B6/EFC High Throughput Inhibitor Screening)
(Contd. of page 2)
路 Respiratory protection:
In case of brief exposure or low pollution use respiratory filter device. In case of intensive or longer
exposure use self-contained respiratory protective device.
路 Protection of hands:
Protective gloves.
路 Eye protection: Safety glasses
路 Body protection: Protective work clothing.
9 Physical and chemical properties:
Liquid
路 Form:
Frozen
White
路 Colour:
Clear
Characteristic
路 Odour:
路 Change in condition
Melting point/Melting range: Not determined
Boiling point/Boiling range: Not determined
Not applicable
路 Flash point:
路 Flammability (solid, gaseous) Product is not flammable.
Product does not present an explosion hazard.
路 Danger of explosion:
Not applicable
路 Vapour pressure:
Not determined
路 Density:
路 Solubility in / Miscibility with
Soluble
Water:
Not applicable
路 pH-value:
230
路 Formula Weight
10 Stability and reactivity
路 Thermal decomposition / conditions to be avoided:
No decomposition if used according to specifications.
路 Materials to be avoided: Incompatible material: strong oxidizers.
路 Dangerous reactions No dangerous reactions known
路 Dangerous decomposition products: No dangerous decomposition products known
EU
(Contd. on page 4)
DR
Page 4/5
Material Safety Data Sheet
According to 91/155 EC
Printing date 13.03.2002 Reviewed on 13.03.2002
Trade name: HFC (7-Hydroxytrifluoromethylcoumarin)
(CYP2B6/EFC High Throughput Inhibitor Screening)
(Contd. of page 3)
11 Toxicological information
路 Acute toxicity:
路 Primary irritant effect:
路 on the skin: No irritant effect.
路 on the eye: No irritating effect.
路 Sensitization: No sensitizing effects known.
路 Additional toxicological information:
The product shows the following dangers according to the calculation method of the General EU
Classification Guidelines for Preparations as issued in the latest version.
Harmful
12 Ecological information:
路 Ecotoxical effects:
路 Other information:
The ecological effects have not ben thoroughly investigated, but currently none have been identified.
路 General notes: Not known to be hazardous to water.
13 Disposal considerations
路 Product:
路 Recommendation
Must be specially treated adhering to official regulations.
Must not be disposed together with household garbage. Do not allow product to reach sewage system.
路 Uncleaned packaging:
路 Recommendation: Disposal must be made according to official regulations.
路 Recommended cleansing agents: Water, if necessary together with cleansing agents.
14 Transport information
路 Land transport ADR/RID (cross-border)
路 ADR/RID class: -
路 Maritime transport IMDG:
-
路 IMDG Class:
路 Marine pollutant: No
路 Air transport ICAO-TI and IATA-DGR:
路 ICAO/IATA Class: -
15 Regulations
路 Labelling according to EU guidelines:
The product has been classified and marked in accordance with EU Directives / Ordinance on
Hazardous Materials
(Contd. on page 5)
EU
DR
Page 5/5
Material Safety Data Sheet
According to 91/155 EC
Printing date 13.03.2002 Reviewed on 13.03.2002
Trade name: HFC (7-Hydroxytrifluoromethylcoumarin)
(CYP2B6/EFC High Throughput Inhibitor Screening)
(Contd. of page 4)
路 Code letter and hazard designation of product:
Xn Harmful
路 Risk phrases:
20/21/22 Harmful by inhalation, in contact with skin and if swallowed.
路 Safety phrases:
7 Keep container tightly closed.
26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
36 Wear suitable protective clothing.
路 National regulations
路 Classification according to VbF: Void
路 Waterhazard class: Generally not hazardous for water.
16 Other information:
Disclaimer:
To the best of our knowledge, the information contained herein is accurate. However, neither Becton
Dickinson or any of its subsidiaries assums any liabilities whatsoever for the accuracy or completeness
of the information contained herein. Final determination of suitability of any material is the sole
responsibility of the user. All materials may present unknown hazards and should be used with caution.
Although certain hazards described herein, we cannot guarantee that these are the only hazards that
exist.
路 Department issuing MSDS: Environment Protection Department
路 Contact: Technical Service Representative
EU
DR
|