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Material Safety Data Sheet
acc. to ISO/DIS 11014
Printing date 02/27/2008 Reviewed on 02/27/2008
1 Identification of substance:
路 Product name: Protease Inhibitor Cocktail
路 Catalog number: 554779
路 Manufacturer/Supplier:
BD Biosciences, Pharmingen
10975 Torreyana Road
San Diego, CA 92121-1106
Tel. (877)232-8995
路 Information department: Technical Services
路 Emergency information:
In case of a chemical emergency, spill, fire, exposure, or accident please call ChemTrec at (800)424-9300 or 911
2 Composition/Data on components:
路 Chemical characterization
路 Description: Mixture of the substances listed below with nonhazardous additions.
路 Dangerous components:
329-98-6 Phenylmethylsulfonylflouride T, C; R 23/25-34 75.8%
9087-70-1 Aprotinin Xn; R 22 4.3%
5144-89-8 Phenentroline Xn; R 20/21/22 4.3%
3 Hazards identification
路 Hazard description:
T Toxic
路 Information pertaining to particular dangers for man and environment
R 23/25 Toxic by inhalation and if swallowed.
R 34 Causes burns.
路 Classification system
The classification was made according to the latest editions of international substances lists, and expanded upon
from company and literature data.
路 NFPA ratings (scale 0-4)
Health = 3
0 Fire = 0
3 0 Reactivity = 0
4 First aid measures
路 General information
Immediately remove contaminated clothing.
Remove breathing apparatus only after contaminated clothing have been completely removed.
In case of irregular breathing or respiratory arrest provide artificial respiration.
(Contd. on page 2)
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Material Safety Data Sheet
acc. to ISO/DIS 11014
Printing date 02/27/2008 Reviewed on 02/27/2008
Product name: Protease Inhibitor Cocktail
(Contd. of page 1)
路 After inhalation
Supply fresh air or oxygen; and immediately call for a doctor.
In case of unconsciousness place patient on side position for transportation.
路 After skin contact Immediately wash with water and soap and rinse thoroughly.
路 After eye contact Rinse opened eye for 15 minutes under running water. Then consult a doctor.
路 After swallowing
If swallowed, rinse mouth with water (only if the person is conscious)
Drink copious amounts of water and provide fresh air. Immediately call a doctor.
Seek immediate medical advice.
路 Information for doctor Show the product label or this MSDS.
5 Fire fighting measures
路 Suitable extinguishing agents
CO2, ABC multipurpose dry chemical or water spray. Fight larger fires with water spray or alcohol resistant
foam.
路 Protective equipment: No special measures required.
6 Accidental release measures
路 Person-related safety precautions: Not required.
路 Measures for environmental protection: Wipe up with damp sponge or mop.
路 Measures for cleaning/collecting:
Absorb with liquid-binding material (sand, diatomite, acid binders, universal binders).
Use neutralizing agent.
Dispose contaminated material as waste according to item 13.
Ensure adequate ventilation.
路 Additional information:
See Section 7 for information on safe handling.
See Section 8 for information on personal protection equipment.
See Section 13 for disposal information.
7 Handling and storage
路 Handling
路 Information for safe handling:
Ensure good ventilation/exhaustion at the workplace.
Open and handle receptacle with care.
Prevent formation of aerosols.
路 Information about protection against explosions and fires: Keep respiratory protective device available.
路 Storage
路 Requirements to be met by storerooms and receptacles: -20潞 C
路 Information about storage in one common storage facility: Store away from oxidizing agents.
路 Further information about storage conditions: Store in cool, dry conditions in well sealed containers.
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Material Safety Data Sheet
acc. to ISO/DIS 11014
Printing date 02/27/2008 Reviewed on 02/27/2008
Product name: Protease Inhibitor Cocktail
(Contd. of page 2)
8 Exposure controls and personal protection
路 Additional information about design of technical systems: No further data; see item 7.
路 Components with limit values that require monitoring at the workplace:
The product does not contain any relevant quantities of materials with critical values that have to be monitored at
the workplace.
路 Additional information: The lists that were valid during the creation were used as basis.
路 Personal Protective Equipment
路 General protective and hygienic measures
Keep away from foodstuffs, beverages and feed.
Immediately remove all soiled and contaminated clothing.
Wash hands before breaks and at the end of work.
Store protective clothing separately.
Avoid contact with the eyes and skin.
路 Breathing equipment:
In case of brief exposure, use a chemical fume hood or a NIOSH/MSHA-approved respirator.
路 Protection of hands:
Chemical resistant gloves (i.e. nitrile, or equivalent).
路 Eye protection:
Safety glasses
Tightly sealed goggles.
路 Body protection: Protective work clothing (lab coat).
9 Physical and chemical properties:
路 General Information
Powder
Form:
Whitish
Color:
Odorless
Odor:
路 Change in condition
Melting point/Melting range: Not determined
Boiling point/Boiling range: Not determined
Not applicable
路 Flash point:
Product is not self igniting.
路 Auto igniting:
Product does not present an explosion hazard.
路 Danger of explosion:
Not applicable
路 Vapor pressure:
Not determined
路 Density:
路 Solubility in / Miscibility with
Soluble
Water:
(Contd. on page 4)
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Material Safety Data Sheet
acc. to ISO/DIS 11014
Printing date 02/27/2008 Reviewed on 02/27/2008
Product name: Protease Inhibitor Cocktail
(Contd. of page 3)
Not applicable
路 pH-value:
10 Stability and reactivity
路 Thermal decomposition / conditions to be avoided: No decomposition if used according to specifications.
路 Materials to be avoided: Incompatible material: strong oxidizers.
路 Dangerous reactions No dangerous reactions known
路 Dangerous products of decomposition: No dangerous decomposition products known.
11 Toxicological information
路 Acute toxicity:
路 Primary irritant effect:
路 on the skin: Caustic effect on skin and mucous membranes.
路 on the eye: Strong caustic effect.
路 Sensitization: No sensitizing effects known.
路 Additional toxicological information:
The product shows the following dangers according to internally approved calculation methods for preparations:
Toxic
Corrosive (causes skin burns)
Swallowing will lead to a strong caustic effect on mouth and throat and to the danger of perforation of esophagus
and stomach.
12 Ecological information:
路 Ecotoxical effects:
路 Other information:
The ecological effects have not been thoroughly investigated, but currently none have been identified.
路 General notes:
Water hazard class 1 (Self-assessment): slightly hazardous for water.
Must not reach bodies of water or drainage ditch undiluted or unneutralized.
13 Disposal considerations
路 Product:
路 Recommendation
Must not be disposed of with solid waste.
Dispose of material in accordance with federal (40 CFR 261), state and local requirements.
This product is not considered a RCRA hazardous waste.
路 Uncleaned packagings:
路 Recommendation: Disposal must be made according to state and federal regulations.
路 Recommended cleansing agent: Water, if necessary with cleansing agents.
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(Contd. on page 5)
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Material Safety Data Sheet
acc. to ISO/DIS 11014
Printing date 02/27/2008 Reviewed on 02/27/2008
Product name: Protease Inhibitor Cocktail
(Contd. of page 4)
14 Transport information
路 DOT regulations:
8
路 Hazard class:
路 Land transport ADR/RID (cross-border)
8 (C9) Corrosive substances
路 ADR/RID class:
路 Maritime transport IMDG:
8
路 IMDG Class:
路 Marine pollutant: No
路 Air transport ICAO-TI and IATA-DGR:
路 ICAO/IATA Class: 8
路 Transport/Additional information:
If a dashed line appears in the Hazard Class section for the type of transportation, this indicates the product is
not regulated for transportation. However, if a Hazard Class Number is listed the product is regulated.
15 Regulations
路 SARA Section 355 (extremely hazardous substances)
None of the ingredients is listed.
路 SARA Section 313 (specific toxic chemical listings)
None of the ingredients is listed.
路 TSCA (Toxic Substances Control Act)
329-98-6 Phenylmethylsulfonylflouride
1670-14-0 benzamidinium chloride
路 California Proposition 65 - Chemicals known to cause cancer
None of the ingredients is listed.
路 Chemicals known to cause reproductive toxicity for females:
None of the ingredients is listed.
(Contd. on page 6)
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Material Safety Data Sheet
acc. to ISO/DIS 11014
Printing date 02/27/2008 Reviewed on 02/27/2008
Product name: Protease Inhibitor Cocktail
(Contd. of page 5)
路 Chemicals known to cause reproductive toxicity for males:
None of the ingredients is listed.
路 Chemicals known to cause developmental toxicity:
None of the ingredients is listed.
路 Carcinogenicity categories
路 IARC (International Agency for Research on Cancer)
None of the ingredients is listed.
路 NTP (National Toxicology Program)
None of the ingredients is listed.
路 TLV (Threshold Limit Value established by ACGIH)
None of the ingredients is listed.
路 Product related hazard information:
The product has been classified and marked in accordance with regulations on hazardous materials.
路 Hazard symbols:
T Toxic
路 Hazard-determining components of labeling:
Phenylmethylsulfonylflouride
路 Risk phrases:
23/25 Toxic by inhalation and if swallowed.
34 Causes burns.
路 Safety phrases:
4 Keep away from living quarters.
9 Keep container in a well-ventilated place.
26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
36/37/39 Wear suitable protective clothing, gloves and eye/face protection.
45 In case of accident or if you feel unwell, seek medical advice immediately.
60 This material and its container must be disposed of as hazardous waste.
路 National regulations
路 Water hazard class: Water hazard class 1 (Self-assessment): slightly hazardous for water.
16 Other information:
To the best of our knowledge, the information contained herein is accurate. However, neither Becton,Dickinson
and Company or any of its subsidiaries assumes any liabilities whatsoever for the accuracy or completeness of
the information contained herein. Final determination of suitability of any material is the sole responsibility of
the user. All materials may present unknown hazards and should be used with caution. Although certain hazards
are described herein, we cannot guarantee that these are the only hazards that exist.
路 Department issuing MSDS: Safety and Environment Department
路 Contact: Technical Service Representative
路 * Data compared to the previous version altered. Rev01
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