MATERIAL SAFETY DATA SHEET
ASCORBIC ACID INJECTION
For use with Sodium Chromate Cr 51 Injection
SECTION 1. CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
Product Name: Ascorbic Acid Revision Date: January 1, 2003
Synonyms: Vitamin C, Cevitamic acid Information Telephone Number: (888) 744-1414
Manufacturer: Mallinckrodt Inc. Emergency Telephone Number: (314) 654-7860
2703 Wagner Place CHEMTREC: 1-800-424-9300
Maryland Heights, MO 63043 CANUTEC: 613-996-6666
SECTION 2. COMPOSITION, INFORMATION ON INGREDIENTS
Chemical Ingredients:
Component CAS #
Ascorbic Acid, 500 mg/mL 50-81-7
Edetate Disodium 139-33-3
Water 7732-18-5
Sodium Bicarbonate 144-55-8
SECTION 3. HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Remove any contamination from the skin, eyes, or clothing.
POTENTIAL HEALTH EFFECTS
Skin Contact:
Inhalation:
Not expected to produce any acute adverse
Not expected to be a health hazard via
health effects.
inhalation.
Eye Contact:
Ingestion:
No adverse effect expected, but may cause
Not expected to produce any acute adverse
mechanical irritation.
health effects. Large doses may cause
gastrointestinal upset.
Chronic Exposure:
Not expected to be a chronic health hazard.
Aggravation of Pre-existing Conditions:
No information found.
ASCORBIC ACID INJECTION for use with Sodium Chromate Cr 51 Injection
ASCORBIC ACID INJECTION
SECTION 4. FIRST AID MEASURES
Inhalation: Skin Exposure:
Not expected to require first aid measures. Wash exposed areas with soap and water. Get
medical advice if irritation develops.
Ingestion:
If large amounts are swallowed, give water to Eye Exposure:
drink and seek medical attention. In case of contact, immediately flush eyes with
running water for at least 15 minutes. Get
medical advice if irritation develops.
SECTION 5. FIRE FIGHTING MEASURES
Fire: Not considered to be a fire hazard.
Explosion: Not considered to be an explosion hazard.
Fire Extinguishing Media: Use any means suitable for extinguishing surrounding fire.
Special Instructions: In the event of a fire, wear full protective clothing and NIOSH-approved
self-contained breathing apparatus with full facepiece operated in the pressure demand or other positive
pressure mode.
SECTION 6. ACCIDENTAL RELEASE MEASURES
Collect all non-radioactive spills and dispose of as non-hazardous waste. For Ascorbic Acid added to
Sodium Chromate Cr 51 Injection: If any loss or release of the radioactive materials occurs, notify your
Radiation Safety Department and Mallinckrodt at (314) 654-7860. All cleanup operations should be
performed according to the Standard Operating Procedures (SOPs) established for your facility and
applicable local, state or federal regulations.
SECTION 7. HANDLING AND STORAGE
Store at 15掳C to 30掳C prior to adding to Sodium Chromate Cr 51. Pressure may develop within the
ampule upon long storage. Precautions should be taken to wrap the container in a protective covering
while it is being opened. After the addition to Sodium Chromate Cr 51, handling time should be kept to a
minimum, and appropriate shielding should be used. Handling devices such as syringe shields and tongs
should be used. Storage and disposal of product should be controlled in a manner which is in compliance
with the appropriate regulations of the federal or state government agency authorized to license the use of
this radionuclide.
SECTION 8. EXPOSURE CONTROLS, PERSONAL PROTECTION
Airborne Exposure Limits: Respiratory Protection:
None established. Not expected to require personal respirator
usage.
Engineering Controls:
Not expected to require any special ventilation. Skin Protection:
Wear protective gloves and clean
body-covering clothing.
Eye/Face Protection:
Safety glasses.
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ASCORBIC ACID INJECTION
SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES
Appearance: Clear, colorless liquid.
Odor: Odorless.
Solubility: Soluble in water.
SECTION 10. STABILITY AND REACTIVITY
Stability: In the dry state, it is reasonably stable in air, but in solution it rapidly oxidizes.
Hazardous Decomposition Products: When heated to decomposition, ascorbic acid emits acrid smoke
and irritating fumes.
Hazardous Polymerization: Should not occur.
Incompatibilities: No information found.
SECTION 11. TOXICOLOGICAL INFORMATION
For detailed toxicological information on specific components, write to the address listed in Section 1 -
Attn: Regulatory Compliance Department.
SECTION 12. ECOLOGICAL INFORMATION
Because this product is intended for use by hospital or clinic patients, it is expected to be treated by
standard wastewater treatment facilities with no adverse environmental impacts.
SECTION 13. DISPOSAL CONSIDERATIONS
Ascorbic Acid added to Sodium Chromate Cr 51 Injection is Radioactive Waste until the activity has
decayed to nondetectable levels. Radioactive waste must be handled in accordance with procedures
established by your Radiation Safety Officer, NRC and other applicable regulations.
If medical waste is involved, such as blood, blood products, or sharps, the waste must be handled as a
Biohazard and disposed of accordingly.
If not radioactive or a biohazard, waste Ascorbic Acid is considered non-hazardous. Consult local, state
and federal regulations for proper disposal.
SECTION 14. TRANSPORT INFORMATION
DOT (Department of Transportation): Not Regulated
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ASCORBIC ACID INJECTION
SECTION 15. REGULATORY INFORMATION
CERCLA Reportable Quantities: None.
SARA Title III
302 Extremely Hazardous Substances: None
311/312 Hazard Categories: None
313 Toxic substances subject to annual release reporting requirements: None.
RCRA Hazardous Waste Status
Non-hazardous (See Section 13 for additional details.)
California Proposition 65 Warning
When radioactive material is added to this product, the resulting product contains a substance known to
the State of California to cause cancer.
Australian Hazchem Code: None allocated.
Australian Poison Schedule: None allocated.
WHMIS: This MSDS has been prepared according to the hazard criteria of the Controlled Products
Regulations (CPR) and the MSDS contains all of the information required by the CPR.
SECTION 16. OTHER INFORMATION
MSDS Status: Revised in accordance with ANSI Guideline Z400.1-1998
NFPA Ratings: Health: 0 Flammability: 0 Reactivity: 0
Product Use: Diagnostic imaging agent
Revision Information: No changes.
Mallinckrodt provides the information contained herein EXPRESS OR IMPLIED, INCLUDING WITHOUT
in good faith but makes no representation as to its LIMITATION ANY WARRANTIES OF MERCHANT-
comprehensiveness or accuracy. This document is ABILITY, FITNESS FOR A PARTICULAR PURPOSE
intended only as a guide to the appropriate WITH RESPECT TO THE INFORMATION SET
precautionary handling of the material by a properly FORTH HEREIN OR THE PRODUCT TO WHICH
trained person using this product. Individuals receiving THE INFORMATION REFERS. ACCORDINGLY,
the information must exercise their independent MALLINCKRODT WILL NOT BE RESPONSIBLE
judgment in determining its appropriateness for a FOR DAMAGES RESULTING FROM USE OF OR
particular purpose. MALLINCKRODT MAKES NO RELIANCE UPON THIS INFORMATION.
REPRESENTATIONS OR WARRANTIES, EITHER
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